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1. 发明授权

US08083706B2 Apparatus and systems for membraneless separation of fluids 失效
标题翻译：用于液体无膜分离的装置和系统
公开(公告)号：US08083706B2
公开(公告)日：2011-12-27
申请号：US12499038
申请日：2009-07-07
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M37/00 , A61M29/00 , G10N21/00 , G01N31/00 , G01N33/00 , B01D21/24 , B01D25/30 , B01D33/70 , B01D11/00 , B01D12/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

2. 发明授权

US07850633B2 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device 失效
标题翻译：具有微流体无膜交换装置的血液疗法的系统和方法
公开(公告)号：US07850633B2
公开(公告)日：2010-12-14
申请号：US12509395
申请日：2009-07-24
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/34 , B01D61/24 , B01D61/14 , B01D61/38
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

3. 发明申请

US20100004578A1 APPARATUS AND SYSTEMS FOR MEMBRANELESS SEPARATION OF FLUIDS 失效
标题翻译：用于液体无菌分离的装置和系统
公开(公告)号：US20100004578A1
公开(公告)日：2010-01-07
申请号：US12499038
申请日：2009-07-07
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/14
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

4. 发明授权

US08491516B2 Systems and methods for membraneless dialysis 失效
标题翻译：无膜透析的系统和方法
公开(公告)号：US08491516B2
公开(公告)日：2013-07-23
申请号：US13298344
申请日：2011-11-17
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/00 , A61M1/14 , A61M1/34 , A61M1/36 , B01D63/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：公开了用于通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。这些实施例可用于从尺寸变化的样品流体中去除组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

5. 发明申请

US20120061304A1 SYSTEMS AND METHODS FOR MEMBRANELESS DIALYSIS 失效
标题翻译：用于无膜透析的系统和方法
公开(公告)号：US20120061304A1
公开(公告)日：2012-03-15
申请号：US13298344
申请日：2011-11-17
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/16 , B01D36/02 , B81B1/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：公开了用于通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。这些实施例可用于从尺寸变化的样品流体中去除组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

6. 发明授权

US08021318B2 Methods of blood-based therapies having a microfluidic membraneless exchange device 有权
标题翻译：具有微流体无膜交换装置的血液疗法的方法
公开(公告)号：US08021318B2
公开(公告)日：2011-09-20
申请号：US12942519
申请日：2010-11-09
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/34 , B01D61/24 , B01D61/14 , B01D61/38
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

7. 发明申请

US20090292234A1 SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE 失效
标题翻译：具有微流控无菌交换装置的血液系统和方法
公开(公告)号：US20090292234A1
公开(公告)日：2009-11-26
申请号：US12509395
申请日：2009-07-24
申请人： Edward F. Leonard , Alan C. West , Nina C. Siiapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Siiapley , Zhongliang Tang
IPC分类号： A61M1/16
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

8. 发明授权

US07588550B2 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device 失效
标题翻译：具有微流体无膜交换装置的血液疗法的系统和方法
公开(公告)号：US07588550B2
公开(公告)日：2009-09-15
申请号：US11776360
申请日：2007-07-11
申请人： Edward F. Leonard , Alan C. West , Nina C. Shaplely , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shaplely , Zhongliang Tang
IPC分类号： A61M37/00 , B32B27/04 , B32B27/12
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

9. 发明授权

US08158410B2 Recovery of rare cells using a microchannel apparatus with patterned posts 有权
标题翻译：使用具有图案柱的微通道装置回收稀有电池
公开(公告)号：US08158410B2
公开(公告)日：2012-04-17
申请号：US11038920
申请日：2005-01-18
申请人： Zhongliang Tang , Ram S. Bhatt , Pavel Tsinberg
发明人： Zhongliang Tang , Ram S. Bhatt , Pavel Tsinberg
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N1/40 , G01N1/405 , Y10T436/25375
摘要： A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, have arcuate cross-sections, and are randomly arranged so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic coating, preferably a hydrogel containing isocyanate moieties or a PEG or polyglycine of substantial length, and are highly effective in capturing cells or other targeted biomolecules as a result of such streamlined flow disruption.
摘要翻译：用于从体液或其他液体样品中分离或分离细胞的微流装置使用流线，其中直线流被横向柱的图案中断。柱在流动路径中的收集区域的宽度上间隔开，并在其上表面和下表面之间延伸; 它们具有直线表面，具有弧形横截面，并且被随机排列以便破坏流线型流动。螯合剂如Abs通过亲水涂层，优选含有非常长的异氰酸酯部分或PEG或聚甘氨酸的水凝胶附着在收集区域中的所有表面上，因此在捕获细胞或其它靶向生物分子中是非常有效的这种流线型流动中断。

10. 发明授权

US07695956B2 Device for cell separation and analysis and method of using 有权
标题翻译：用于细胞分离和分析的装置及其使用方法
公开(公告)号：US07695956B2
公开(公告)日：2010-04-13
申请号：US11331988
申请日：2006-01-12
申请人： Pavel Tsinberg , Zhongliang Tang
发明人： Pavel Tsinberg , Zhongliang Tang
IPC分类号： C12M3/00
CPC分类号： G01N1/40 , B01L3/5027 , G01N1/2813
摘要： A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic permeable hydrogel coating. The collection region is formed as a cavity in a body molded from PDMS, which flexible body is sandwiched between a glass slide or comparable flat plate and a rigid top cap plate, both of which are pressed into abutting relation with the PDMS body by a heat-shrunk polymeric sleeve. Following cell separation and washing, cells can be released from the sequestering agents and the device centrifuged to force said cells to collect adjacent the hydrogel-coated slide or plate. Slitting the polymeric sleeve allows the body to then be peeled from the slide or plate, using an integral tab, to expose the separated cells on the top surface thereof for ready microscopic examination.
摘要翻译：用于从体液或其他液体样品中分离或分离细胞的微流装置使用流动路径，其中直线流被横向柱的图案中断，所述横向柱横跨收集区域的宽度以不规则或设置的随机图案以便破坏流线型流程。螯合剂如Abs通过亲水可渗透的水凝胶涂层附着在收集区域中的所有表面上。收集区域形成为由PDMS成型的主体中的空腔，该柔性体被夹在玻璃滑块或类似的平板和刚性顶盖板之间，两者都通过热量与PDMS体压接成邻接关系 -shrunk聚合物套管。细胞分离和洗涤后，细胞可以从多价螯合剂中释放出来，离心的装置迫使细胞收集在水凝胶涂层的载玻片或板附近。分开聚合物套筒可以使用整体制表片将身体从滑块或板上剥离，以暴露其顶部表面上的分离的细胞，以进行显微镜检查。

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