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1. 发明授权

US4738967A Imidazoisoquinoline compounds useful as anti-ulcerative agents 失效
标题翻译：咪唑并异喹啉化合物可用作抗溃疡剂
公开(公告)号：US4738967A
公开(公告)日：1988-04-19
申请号：US945788
申请日：1986-12-23
申请人： Ikuo Ueda , Youichi Shiokawa , Masayuki Kato , Nobukiyo Konishi , Atsushi Akahane
发明人： Ikuo Ueda , Youichi Shiokawa , Masayuki Kato , Nobukiyo Konishi , Atsushi Akahane
IPC分类号： C07D471/04 , A61K31/47 , A61P1/04 , C07D487/04 , A61K31/40
CPC分类号： C07D487/04
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in which A is lower alkylene andR.sup.2 is di(lower) alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino(lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof. pa The compounds are useful as anti ulcer agents.

2. 发明授权

US4686227A Imidazoisoquinoline compounds useful as anti-ulcerative agents 失效
标题翻译：咪唑并异喹啉化合物可用作抗溃疡剂
公开(公告)号：US4686227A
公开(公告)日：1987-08-11
申请号：US745638
申请日：1985-06-17
申请人： Ikuo Ueda , Youichi Shiokawa , Masayuki Kato , Nobukiyo Konishi , Atsushi Akahane
发明人： Ikuo Ueda , Youichi Shiokawa , Masayuki Kato , Nobukiyo Konishi , Atsushi Akahane
IPC分类号： C07D471/04 , A61K31/47 , A61P1/04 , C07D487/04 , A61K31/395 , C07D405/04
CPC分类号： C07D487/04
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in whichA is lower alkylene andR.sup.2 is di(lower)alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino (lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof.The compounds are useful as anti ulcer agents.
摘要翻译：下式的化合物，其中R 1为低级烷基，R 3为氢，卤素或芳（低级）烷氧基，R为低级烷酰基，亚硝基，氨基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，卤代甲酰基，氨基亚甲基氨基可以被氰基或低级烷基取代，可以被氰基或低级烷基取代的亚氨基甲基氨基，或下列基团：其中A是低级亚烷基，R2是二（低级）烷基氨基，氰基，低级烷氧基，可具有适当取代基的含N杂环基，低级炔氧基，低级烯氧基，低级烷硫基，氨基（低级）烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，羟基，低级烷酰氧基，具有两个氧代基的杂环氨基（低级）烷硫基，氢或下式的基团：其中R 4，R 5和R 6各自为低级烷基，X为酸残基，及其药学上可接受的盐。该化合物可用作抗溃疡剂。

3. 发明授权

US4563455A Antiulcer fused imidazole compounds 失效
标题翻译：抗溃疡融合咪唑化合物
公开(公告)号：US4563455A
公开(公告)日：1986-01-07
申请号：US587981
申请日：1984-03-09
申请人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano , Atsushi Akahane
发明人： Ikuo Ueda , Masayuki Kato , Masanobu Nagano , Atsushi Akahane
IPC分类号： A61K31/415 , A61P1/04 , C07D235/10 , C07D235/12 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04 , C07D521/00 , A61K31/53
CPC分类号： C07D231/12 , C07D233/56 , C07D235/10 , C07D235/12 , C07D249/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04
摘要： New fused imidazole compounds of the formula: ##STR1## wherein A is lower alkylene,R.sup.1 is hydrogen, lower alkyl, lower alkoxy or halogen,R.sup.2 is hydrogen, lower alkyl, cyclo(lower)alkyl, pyridyl, ar(lower)alkyl which may be substituted with halogen, or aryl which may be substituted with lower alkyl, lower alkoxy, hydroxy or halogen,R.sup.3 is N-containing unsaturated heterocyclic group which may be substituted with lower alkyl or amino, andY is .dbd.C-- or .dbd.N--,and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents.
摘要翻译：其中A为低级亚烷基，R 1为氢，低级烷基，低级烷氧基或卤素，R 2为氢，低级烷基，环（低级）烷基，吡啶基，Ar（低级）烷基，可以被卤素取代，或可以被低级烷基，低级烷氧基，羟基或卤素取代的芳基，R3是可被低级烷基或氨基取代的含N不饱和杂环基，Y是=或= N - 及其药学上可接受的盐，及其制备方法和包含其的药物组合物。这些衍生物和其盐可用作抗溃疡剂。

4. 发明授权

US4367238A Phenyl-alkanoic acid derivative and preparation thereof 失效
标题翻译：苯基 - 链烷酸衍生物及其制备
公开(公告)号：US4367238A
公开(公告)日：1983-01-04
申请号：US226908
申请日：1981-01-21
申请人： Ikuo Ueda , Yoshihiko Kitaura , Masaaki Matsuo , Nobukiyo Konishi
发明人： Ikuo Ueda , Yoshihiko Kitaura , Masaaki Matsuo , Nobukiyo Konishi
IPC分类号： A61K31/095 , C07C45/40 , C07C45/71 , C07C47/575 , C07C51/09 , C07C59/52 , C07C59/56 , C07C59/64 , C07C59/68 , C07C317/00 , C07D307/83 , C07D307/86 , C07D311/18 , A61K31/365
CPC分类号： C07D311/18 , C07C255/00 , C07C317/00 , C07C323/00 , C07C45/40 , C07C45/71 , C07C47/575 , C07C59/68 , C07D307/83 , C07D307/86
摘要： This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.
摘要翻译：本发明涉及具有抗炎，止痛和解热活性的新的苯基 - 链烷酸，它们在羧基上的衍生物及其药学上可接受的盐。

5. 发明授权

US4472433A Phenoxyphenyl acetic acids and their medicinal use 失效
标题翻译：苯氧基苯乙酸及其药用
公开(公告)号：US4472433A
公开(公告)日：1984-09-18
申请号：US291498
申请日：1981-08-10
申请人： Ikuo Ueda , Yoshihiko Kitaura , Nobukiyo Konishi
发明人： Ikuo Ueda , Yoshihiko Kitaura , Nobukiyo Konishi
IPC分类号： A61K31/165 , A61K31/192 , A61K31/195 , A61K31/215 , A61K31/255 , A61P25/04 , A61P29/00 , C07C57/32 , C07C67/00 , C07C201/00 , C07C205/55 , C07C205/56 , C07C227/00 , C07C229/42 , C07C231/00 , C07C233/54 , C07C301/00 , C07C313/00 , C07C315/04 , C07C317/00 , C07C317/44 , C07C317/48 , C07C319/20 , C07C323/63 , C07D209/34 , C07D211/46 , C07D213/64 , C07D213/643 , C07D295/18 , C07D295/185 , C07D401/12 , C07C101/72
CPC分类号： C07D213/643 , C07C205/56 , C07C253/14 , C07C323/00 , C07D209/34 , C07D295/185 , Y10S514/916
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is phenyl substituted with halogen or lower alkyl, and R.sup.4 is a group of the formula C.sub.n H.sub.2n in which n is an integer of 1 to 7; or a pharmaceutically acceptable salt thereof. The compound exhibits antipyretic, analgesic and anti-inflammatory properties.
摘要翻译：下式的化合物：其中R 1是被卤素或低级烷基取代的苯基，R 4是式C n H 2n的基团，其中n是1至7的整数; 或其药学上可接受的盐。该化合物具有解热，镇痛和抗炎特性。

6. 发明授权

US4782055A Imidazopyridine compounds useful in the treatment of ulcers 失效
标题翻译：用于治疗溃疡的咪唑并吡啶化合物
公开(公告)号：US4782055A
公开(公告)日：1988-11-01
申请号：US942379
申请日：1986-12-16
申请人： Ikuo Ueda , Youichi Shiokawa , Kazuhiko Take , Hiromichi Itani
发明人： Ikuo Ueda , Youichi Shiokawa , Kazuhiko Take , Hiromichi Itani
IPC分类号： C07D471/04 , C07D487/04 , A61K31/435
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to imidazopyridine compounds of the formula: ##STR1## wherein R.sup.1 is lower alkynyl or lower alkynyloxy(lower)-alkyl,R.sup.2 is lower alkyl, andR.sup.3 is ar(lower)alkyl having lower alkoxy, lower alkylthio, nitro or lower alkanesulfonyl, ar(lower)alkyl having nitro and one or two additional substituent(s) selected from nitro and lower alkyl, or heterocyclic(lower)alkyl which may have suitable substituent(s), and to their utility.The compounds have antiulcerative properties.
摘要翻译：本发明涉及下式的咪唑并吡啶化合物：其中R 1是低级炔基或低级炔氧基（低级） - 烷基，R 2是低级烷基，R 3是具有低级烷氧基，低级烷硫基，硝基或低级烷基磺酰基，具有硝基的芳（低级）烷基和选自硝基和低级烷基的一个或两个另外的取代基或可具有合适取代基的杂环（低级）烷基，以及它们的用途。该化合物具有抗溃疡性质。

7. 发明授权

US4692444A 1,4-Dihydro[1]benzothiopyrano[4,3-c]pyrazole derivatives, compositions containing them, and pharmacological methods of using them 失效
标题翻译： 1,4-二氢[1]苯并噻喃并[4,3-c]吡唑衍生物，含有它们的组合物和使用它们的药理学方法
公开(公告)号：US4692444A
公开(公告)日：1987-09-08
申请号：US836402
申请日：1986-03-05
申请人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
发明人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
IPC分类号： A61K31/415 , A61P7/10 , A61P9/12 , A61P19/06 , C07D495/04
CPC分类号： C07D495/04
摘要： This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,X is --S--, ##STR2## n is an integer of 1 or 2 and A is a group of the formula: ##STR3## in which R.sup.2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.
摘要翻译：本发明提供下式的苯稠稠杂环化合物：其中R1是卤素，硝基，氨基，羟基，低级烷基，低级烷氧基或酰基氨基，X是-S-，n是其中R 2为氢，低级烷基，低级炔基，羧基（低级）烷基或被保护的羧基（低级）烷基）或其药学上可接受的盐。该化合物具有利尿，尿酸和血管扩张活性，因此可用作利尿剂，尿酸血症药和抗高血压药。本发明还提供了制备该化合物的方法和包含上式化合物的药物组合物。

8. 发明授权

US4725601A Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers 失效
标题翻译：某些咪唑并[1,2-a]吡啶可用于治疗溃疡
公开(公告)号：US4725601A
公开(公告)日：1988-02-16
申请号：US865331
申请日：1986-05-21
申请人： Ikuo Ueda , Youichi Shiokawa , Kazuhiko Take , Hiromichi Itani
发明人： Ikuo Ueda , Youichi Shiokawa , Kazuhiko Take , Hiromichi Itani
IPC分类号： A61K31/44 , A61K31/495 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Certain imidazo[1,2-a]heterocyclic compounds useful in the treatment of ulcers are provided.
摘要翻译：提供了可用于治疗溃疡的某些咪唑并[1,2-a]杂环化合物。

9. 发明授权

US4675324A Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents 失效
标题翻译：取代的吡唑并[4,3-c]吡啶并且其用作尿酸，利尿和抗高血压药
公开(公告)号：US4675324A
公开(公告)日：1987-06-23
申请号：US780582
申请日：1985-09-26
申请人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
发明人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
IPC分类号： C07D311/22 , A61K31/415 , A61K31/4162 , A61K31/435 , A61K31/47 , A61K31/4745 , A61P7/10 , A61P9/02 , A61P9/08 , A61P9/12 , A61P19/06 , C07D215/22 , C07D215/233 , C07D215/38 , C07D311/56 , C07D471/04 , C07D491/04 , C07D491/052 , A61K31/395
CPC分类号： C07D215/233 , C07D311/56 , C07D471/04 , C07D491/04
摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.
摘要翻译：本发明提供了下式的有益稠合的杂环化合物：其中R 1是卤素，硝基，氨基，羟基，低级烷基，被羧基或被保护的羧基取代的低级烷氧基，在氨基部分上可以具有低级烷基的酰基氨基，或可具有卤素的芳氧基，R 2是氢或卤素，X是-O-或者其中R 3是氢，低级烷基或酰基，和A是下式的基团：其中R 4是氢，低级烯基，低级炔基或烷基，其可以具有选自羟基，酰基，低级烷氧基，二（低级）烷基氨基，羧基，保护的羧基和芳基的合适取代基。或R 1为氢或低级烷氧基，R 2为氢，X为R a为低级烷酰基，A为下式基团：及其药学上可接受的盐。该化合物具有利尿活性，尿酸活性和血管舒张活性，可用作利尿剂，尿酸血症药和抗高血压药。本发明还涉及制备该化合物的方法和包含上式化合物的药物组合物。

10. 发明授权

US4767780A Benzene-fused heterocyclic compound and their use as diuretics 失效
标题翻译：苯稠合杂环化合物及其作为利尿剂的用途
公开(公告)号：US4767780A
公开(公告)日：1988-08-30
申请号：US42299
申请日：1987-04-24
申请人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
发明人： Ikuo Ueda , Youichi Shiokawa , Takashi Manabe , Yousuke Katsura
IPC分类号： C07D311/22 , A61K31/415 , A61K31/4162 , A61K31/435 , A61K31/47 , A61K31/4745 , A61P7/10 , A61P9/02 , A61P9/08 , A61P9/12 , A61P19/06 , C07D215/22 , C07D215/233 , C07D215/38 , C07D311/56 , C07D471/04 , C07D491/04 , C07D491/052 , A61K31/35 , C07D487/04
CPC分类号： C07D215/233 , C07D311/56 , C07D471/04 , C07D491/04
摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower, alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

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