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1. 发明授权

US09139614B2 Modular linkers for conjugation of organic substances to substantially inorganic substances and methods of manufacture and use thereof 有权
标题翻译：用于将有机物质与基本上无机物质共轭的模块化接头及其制造方法和用途
公开(公告)号：US09139614B2
公开(公告)日：2015-09-22
申请号：US11739969
申请日：2007-04-25
申请人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
发明人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
IPC分类号： A61K38/00 , C07K7/06
CPC分类号： C07K7/06
摘要： A modular linker includes an inorganic binding entity having an affinity for a substantially inorganic substance, and an organic binding entity capable of binding with an organic substance covalently bonded thereto. The modular linker is capable of being stored in a stable condition for later use. The modular linker may be synthesized by modifying the inorganic binding entity to be covalently bonded to an organic binding entity and storing the modular linker in an inert environment from about a day up to at least 1 week. The modular linker may be conjugated to an organic substance and to a substantially inorganic substance in substantially a 1:1 ratio. The modular linker may have more than one organic binding entity covalently bonded to an inorganic binding entity or vice-versa. Also, a particular modular linker may have an organic binding entity capable of binding with a nucleic acid sequence.
摘要翻译：模块化接头包括对基本上无机物质具有亲和力的无机结合实体，以及能够与共价键合的有机物结合的有机结合实体。模块化连接器能够在稳定的条件下储存以供以后使用。可以通过将无机结合实体改性为共价键合到有机结合实体并将模块化连接体从大约一天至少至少1周存储在惰性环境中来合成模块化接头。模块化接头可以以基本上1:1的比例与有机物质和基本上无机物质缀合。模块化接头可以具有多于一个共价结合到无机结合实体的有机结合实体，反之亦然。而且，特定的模块化接头可以具有能够与核酸序列结合的有机结合实体。

2. 发明申请

US20090159842A1 MODULAR LINKERS FOR CONJUGATION OF ORGANIC SUBSTANCES TO SUBSTANTIALLY INORGANIC SUBSTANCES AND METHODS OF MANUFACTURE AND USE THEREOF 有权
标题翻译：有机物质与无机物质结合的模块化连接方法及其制造及其使用方法
公开(公告)号：US20090159842A1
公开(公告)日：2009-06-25
申请号：US11739969
申请日：2007-04-25
申请人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
发明人： Igor L. Medintz , Lorenzo Berti , Paolo Facci , Hedi M. Mattoussi
IPC分类号： C09K3/00 , C07K17/06 , C07H21/04
CPC分类号： C07K7/06
摘要： A modular linker includes an inorganic binding entity having an affinity for a substantially inorganic substance, and an organic binding entity capable of binding with an organic substance covalently bonded thereto. The modular linker is capable of being stored in a stable condition for later use. The modular linker may be synthesized by modifying the inorganic binding entity to be covalently bonded to an organic binding entity and storing the modular linker in an inert environment from about a day up to at least 1 week. The modular linker may be conjugated to an organic substance and to a substantially inorganic substance in substantially a 1:1 ratio. The modular linker may have more than one organic binding entity covalently bonded to an inorganic binding entity or vice-versa. Also, a particular modular linker may have an organic binding entity capable of binding with a nucleic acid sequence.
摘要翻译：模块化接头包括对基本上无机物质具有亲和力的无机结合实体，以及能够与共价键合的有机物结合的有机结合实体。模块化连接器能够在稳定的条件下储存以供以后使用。可以通过将无机结合实体改性为共价键合到有机结合实体并将模块化连接体从大约一天至少至少1周存储在惰性环境中来合成模块化接头。模块化接头可以以基本上1:1的比例与有机物质和基本上无机物质缀合。模块化接头可以具有多于一个共价结合到无机结合实体的有机结合实体，反之亦然。而且，特定的模块化接头可以具有能够与核酸序列结合的有机结合实体。

3. 发明授权

US08859284B2 Delivery of nanoparticles to neurons 有权
标题翻译：纳米颗粒递送到神经元
公开(公告)号：US08859284B2
公开(公告)日：2014-10-14
申请号：US13679335
申请日：2012-11-16
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
IPC分类号： C12N5/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K47/20 , C12Q1/02 , B82Y5/00 , A61K47/48 , A61K49/00 , G01N33/50
CPC分类号： A61K47/20 , A61K47/48192 , A61K47/4823 , A61K47/48238 , A61K47/48861 , A61K47/48884 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0067 , B82Y5/00 , C12Q1/02 , G01N33/5058
摘要： A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
摘要翻译：连接到纳米颗粒（例如量子点）的肽选择性地将纳米颗粒引导到组织或生物体中的神经元。

4. 发明申请

US20100075361A1 METHODS OF GENERATING FLORESCENCE RESONANCE ENERGY TRANSFER (FRET) BETWEEN SEMICONDUCTOR QUANTUM DOTS AND FLUORESCENT DYES/PROTEINS VIA MULTI-PHOTON EXCITATION, ACHIEVING ZERO BACKGROUND OR DIRECT EXCITATION CONTRIBUTIONS TO THE FRET SIGNATURE 审中-公开
标题翻译：通过多光子激发产生半导体量子点和荧光染料/蛋白质之间的花色共振能量转移（FRET）的方法，实现零背景或直接激发对FRET签名的贡献
公开(公告)号：US20100075361A1
公开(公告)日：2010-03-25
申请号：US12421034
申请日：2009-04-09
申请人： Hedi M. Mattoussi , Igor L. Medintz , Aaron R. Clapp
发明人： Hedi M. Mattoussi , Igor L. Medintz , Aaron R. Clapp
IPC分类号： C12Q1/02 , G01N21/62 , G06F19/00
CPC分类号： G01N21/6428 , G01N21/6408 , G01N21/6458 , G01N21/6489 , G01N33/542 , Y02A90/26
摘要： A system and method of sensing physiological conditions in biological applications includes a laser source for optically exciting a plurality of luminescent quantum dots and a plurality of biomolecules in a nanoscale sensing system having a nanocrystal structure, where the plurality of biomolecules is stained with dye. In a multi-photon excitation process, a laser system optically excites, the plurality of luminescent quantum dots and the plurality of biomolecules in the nanoscale sensing system, where fluorescence resonance energy transfer (FRET) occurs between the plurality of quantum dots and the plurality of biomolecules. Stability of self assembly of quantum dot peptide conjugates within the plurality of biomolecules is investigated. Physiological conditions at the cellular level are determined, using a spectrometer to sense fluorosence spectra. The sensing of physiological conditions includes transducing signals into immunoassays, clinical diagnostics and cellular imaging to provide treatment to biological subjects including human patients.
摘要翻译：在生物学应用中感测生理条件的系统和方法包括用于在具有纳米晶体结构的纳米级感测系统中光学激发多个发光量子点的激光源和多个生物分子，其中多个生物分子被染料染色。在多光子激发过程中，激光系统在纳米级感测系统中光学激发多个发光量子点和多个生物分子，其中在多个量子点与多个量子点之间发生荧光共振能量转移（FRET）生物分子。研究了多个生物分子内量子点肽缀合物自组装的稳定性。使用光谱仪检测荧光光谱，测定细胞水平的生理条件。对生理条件的检测包括将信号转导到免疫测定，临床诊断和细胞成像中，以向包括人类患者在内的生物学受试者提供治疗。

5. 发明申请

US20130158244A1 Modular Functional Peptides for the Intracellular Delivery of Nanoparticles 有权
标题翻译：用于纳米颗粒细胞内递送的模块化功能肽
公开(公告)号：US20130158244A1
公开(公告)日：2013-06-20
申请号：US13774493
申请日：2013-02-22
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译：描述了编码用于将纳米颗粒递送到细胞溶质的多肽的核酸，所述肽包含：（a）纳米颗粒缔合结构域，（b）间隔区，（c）摄取结构域，和（d）囊泡逸出结构域，其中所述结构域（a）至（d）以与上述相同的顺序出现，并且其中所述肽在向囊泡逸出结构域加入不可水解的亲脂性部分并与纳米颗粒结合时有效诱导摄取的纳米颗粒，并将纳米颗粒递送到细胞的胞质溶胶。还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。示例性纳米颗粒包括量子点。

6. 发明授权

US08409858B2 Modular functional peptides for the intracellular delivery of nanoparticles 有权
标题翻译：模块化功能肽用于纳米颗粒的细胞内递送
公开(公告)号：US08409858B2
公开(公告)日：2013-04-02
申请号：US12908601
申请日：2010-10-20
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C12N5/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译：描述了用于将纳米颗粒递送到细胞溶质的肽，所述肽包含：（a）纳米颗粒缔合结构域; （b）富含脯氨酸的间隔区; （c）摄取域; 和（d）包含不可水解脂质部分的囊泡逃逸结构域，其中所述间隔区位于纳米颗粒缔合结构域和吸收和囊泡逸出结构域之间，并且其中所述肽在附着于细胞外纳米颗粒时有效诱导通过细胞摄取纳米颗粒并将纳米颗粒递送到细胞的胞质溶胶。还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。示例性纳米颗粒包括量子点。

7. 发明授权

US08226015B2 Orthogonal charge-based spectral coding with quantum dot conjugates 失效
标题翻译：量子点共轭的基于正交电荷的光谱编码
公开(公告)号：US08226015B2
公开(公告)日：2012-07-24
申请号：US12907200
申请日：2010-10-19
申请人： Igor L. Medintz , Dorothy Farrell , Hedi M. Mattoussi
发明人： Igor L. Medintz , Dorothy Farrell , Hedi M. Mattoussi
IPC分类号： G06K19/06
CPC分类号： B82Y30/00 , B01J2219/00547 , B01J2219/00576 , B82Y10/00 , B82Y20/00 , C40B70/00
摘要： Populations of quantum dots are combined with quantities of a modulator of photoluminescence to produce a plurality of optical barcodes having at least two distinguishable colors arising from varying quantities of a modulator of photoluminescence bound to the populations of quantum dots.
摘要翻译：量子点的数量与光致发光的调制器的数量组合，以产生多个具有至少两种可分辨颜色的光学条形码，这些光学条形码是由与量子点群体结合的光致发光调制器的不同数量引起的。

8. 发明申请

US20110089241A1 Orthogonal Charge-Based Spectral Coding with Quantum Dot Conjugates 失效
标题翻译：量子点共轭的基于正交电荷的光谱编码
公开(公告)号：US20110089241A1
公开(公告)日：2011-04-21
申请号：US12907200
申请日：2010-10-19
申请人： Igor L. Medintz , Dorothy Farrell , Hedi M. Mattoussi
发明人： Igor L. Medintz , Dorothy Farrell , Hedi M. Mattoussi
IPC分类号： G06K7/12 , G06K19/06 , G06K19/02 , H01L51/56 , B82Y10/00 , B82Y40/00 , B82Y20/00
CPC分类号： B82Y30/00 , B01J2219/00547 , B01J2219/00576 , B82Y10/00 , B82Y20/00 , C40B70/00
摘要： Populations of quantum dots are combined with quantities of a modulator of photoluminescence to produce a plurality of optical barcodes having at least two distinguishable colors arising from varying quantities of a modulator of photoluminescence bound to the populations of quantum dots.
摘要翻译：量子点的数量与光致发光的调制器的数量组合，以产生多个具有至少两种可分辨颜色的光学条形码，这些光学条形码是由与量子点群体结合的光致发光调制器的不同数量引起的。

9. 发明授权

US08835172B2 Modular functional peptides for delivery of nanoparticles 有权
标题翻译：用于递送纳米颗粒的模块化功能性肽
公开(公告)号：US08835172B2
公开(公告)日：2014-09-16
申请号：US13621880
申请日：2012-09-18
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K49/00 , G01N33/58 , C07K17/14 , B82Y5/00
CPC分类号： C12N5/0006 , A61K49/0054 , A61K49/0056 , A61K49/0067 , B82Y5/00 , B82Y15/00 , C07K17/14 , G01N33/588
摘要： A peptide directs nanoparticles (such as quantum dots) to the plasma membrane of mammalian cells. A method of delivery of a nanoparticle to a plasma membrane of a cell includes providing to the cell a nanoparticle attached to a peptide configured to direct the nanoparticle the plasma membrane, and allowing the cell to take up the nanoparticle. The nanoparticle can be a FRET donor to an organic dye.
摘要翻译：肽将纳米颗粒（例如量子点）引导到哺乳动物细胞的质膜。将纳米颗粒递送到细胞的质膜的方法包括向细胞提供与配置成将纳米颗粒引导质膜的肽结合的纳米颗粒，并允许细胞吸收纳米颗粒。纳米颗粒可以是有机染料的FRET供体。

10. 发明授权

US08796435B2 Modular functional peptides for the intracellular delivery of nanoparticles 有权
标题翻译：用于纳米颗粒的细胞内递送的模块化功能性肽
公开(公告)号：US08796435B2
公开(公告)日：2014-08-05
申请号：US13774493
申请日：2013-02-22
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman
IPC分类号： C07H21/02 , C07H21/04 , B82Y5/00 , A61K47/48 , A61K49/00 , C07H19/00
CPC分类号： C07H21/04 , A61K47/6921 , A61K49/0093 , B82Y5/00 , C07H19/00
摘要： Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
摘要翻译：描述了编码用于将纳米颗粒递送到细胞溶质的多肽的核酸，所述肽包含：（a）纳米颗粒缔合结构域，（b）间隔区，（c）摄取结构域，和（d）囊泡逸出结构域，其中所述结构域（a）至（d）以与上述相同的顺序出现，并且其中所述肽在向囊泡逸出结构域加入不可水解的亲脂性部分并与纳米颗粒结合时有效诱导摄取的纳米颗粒，并将纳米颗粒递送到细胞的胞质溶胶。还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。示例性纳米颗粒包括量子点。

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