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1. 发明申请

US20130129627A1 Delivery of Nanoparticles to Neurons 有权
标题翻译：将纳米颗粒交付给神经元
公开(公告)号：US20130129627A1
公开(公告)日：2013-05-23
申请号：US13679335
申请日：2012-11-16
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
IPC分类号： A61K47/20 , C12Q1/02
CPC分类号： A61K47/20 , A61K47/48192 , A61K47/4823 , A61K47/48238 , A61K47/48861 , A61K47/48884 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0067 , B82Y5/00 , C12Q1/02 , G01N33/5058
摘要： A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
摘要翻译：连接到纳米颗粒（例如量子点）的肽选择性地将纳米颗粒引导到组织或生物体中的神经元。

2. 发明授权

US08921140B2 Simultaneous modulation of quantum dot photoluminescence using orthogonal fluorescence resonance energy transfer (FRET) and charge transfer quenching (CTQ) 有权
标题翻译：使用正交荧光共振能量转移（FRET）和电荷转移淬灭（CTQ）同时调制量子点光致发光
公开(公告)号：US08921140B2
公开(公告)日：2014-12-30
申请号：US14174125
申请日：2014-02-06
申请人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
发明人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
IPC分类号： H01L21/00 , H01L33/06 , H01L33/26 , H01L51/56 , H01L27/32
CPC分类号： H01L33/06 , C09K11/06 , H01L27/3244 , H01L33/26 , H01L51/56
摘要： Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (FRET), so that the modified quantum dots have a plurality of photophysical properties. The FRET and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties.
摘要翻译：用不同量的（a）有效进行电荷转移淬灭的氧化还原活性部分修饰量子点，和（b）有效进行荧光共振能量转移（FRET）的荧光染料，使得修饰的量子点具有多个的光物理性质。 FRET和电荷转移通路独立运行，为具有相同固有特性的量子点的变化发光提供两个通道控制。

3. 发明授权

US08680506B2 Simultaneous modulation of quantum dot photoluminescence using orthogonal fluorescence resonance energy transfer (FRET) and charge transfer quenching (CTQ) 有权
公开(公告)号：US08680506B2
公开(公告)日：2014-03-25
申请号：US13439003
申请日：2012-04-04
申请人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
发明人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
IPC分类号： H01L33/06
CPC分类号： H01L33/06 , C09K11/06 , H01L27/3244 , H01L33/26 , H01L51/56
摘要： Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (FRET), so that the modified quantum dots have a plurality of photophysical properties. The FRET and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties.

4. 发明申请

US20130323777A1 Compact Multifunctional Ligand to Enhance Colloidal Stability of Nanoparticles 审中-公开
公开(公告)号：US20130323777A1
公开(公告)日：2013-12-05
申请号：US13942983
申请日：2013-07-16
申请人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
发明人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
IPC分类号： G01N33/50
CPC分类号： G01N33/5005 , A61K9/14 , B82Y5/00 , B82Y15/00 , C07D251/70 , C07D295/13 , C07D339/04 , C07D409/12 , C07K17/14 , Y10S977/774 , Y10S977/788
摘要： A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.

5. 发明授权

US08512755B2 Compact multifunctional ligand to enhance colloidal stability of nanoparticles 有权
标题翻译：紧凑的多功能配体，增强纳米粒子的胶体稳定性
公开(公告)号：US08512755B2
公开(公告)日：2013-08-20
申请号：US13209974
申请日：2011-08-15
申请人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
发明人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
IPC分类号： C07D339/04 , C07D293/00 , C07D285/16 , C07D487/00 , A61K9/14
CPC分类号： G01N33/5005 , A61K9/14 , B82Y5/00 , B82Y15/00 , C07D251/70 , C07D295/13 , C07D339/04 , C07D409/12 , C07K17/14 , Y10S977/774 , Y10S977/788
摘要： A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.
摘要翻译：配体设计允许紧凑的纳米颗粒材料，例如量子点（QD），在宽的pH范围和高盐浓度下具有优异的胶体稳定性。可以获得在生物环境中稳定的与量子点的自组装生物分子缀合物。通过最小化直接连接到配体上或组装在其表面上的量子点/纳米颗粒和供体/受体之间的距离来最大化与这些配体的能量转移。

6. 发明授权

US4017646A Process for producing pH modified protein filaments 失效
标题翻译：生产pH改性蛋白丝的方法
公开(公告)号：US4017646A
公开(公告)日：1977-04-12
申请号：US639721
申请日：1975-12-11
申请人： Ralph A. Hoer , Michael H. Stewart
发明人： Ralph A. Hoer , Michael H. Stewart
IPC分类号： A23J3/00 , A23J3/28
CPC分类号： A23J3/28 , Y10S426/802
摘要： A process of continuously forming pH modified protein filaments from a proteinaceous material is disclosed wherein an aqueous slurry of the proteinaceous material is formed having a proteinaceous solids content of between about 0.5 and 35% by weight. Discrete filaments are formed by conducting the slurry under pressure through a heat exchange zone and heating the slurry to a temperature which is above 240.degree. F. whereby the protein is subjected to such temperature for a sufficient period of time so that elongated filaments are thereafter separated from the remaining constituents of the slurry. The heated slurry is then continuously removed from said heat exchange zone through a back pressure creating orifice whereby discharge of said filaments from the heat exchange zone to a collecting zone is controlled by confining the stream of said filaments to within a total angle of between about 4.degree. and 90.degree.. A pH elevating material is then injected into the stream of filaments during confinement in order to modify the pH of the filaments to a pH of above about 6.0 and preferably between about 6.0 and 7.0. It has been determined that pH modified filaments produced in the above manner are highly functional for meat extender applications, yet pH modification in the above manner provides the maximum yield of protein filaments from a given weight of proteinaceous slurry since the pH of the slurry is not altered prior to filament formation.
摘要翻译：公开了从蛋白质材料连续形成pH修饰的蛋白质长丝的方法，其中形成蛋白质物质的含水浆料，其蛋白质固体含量为约0.5至35重量％。通过在压力下通过热交换区导入浆料并将浆料加热到高于240°F的温度来形成离散长丝，由此蛋白质经受这样的温度足够的时间，以便之后分离细长丝从浆料的剩余组分。然后通过背压产生孔将所加热的浆料从所述热交换区域连续地移出，从而通过将所述长丝的流限制在约4的总角度内来控制所述长丝从热交换区向收集区的排放 DEG和90°。然后在限制期间将pH升高材料注入到细丝流中，以便将长丝的pH调节至高于约6.0，优选约6.0至7.0的pH。已经确定，以上述方式生产的pH改性长丝对于肉类增量剂应用具有高度的功能，但是以上述方式进行的pH修饰提供了从给定重量的蛋白质浆料中蛋白丝的最大产量，因为浆料的pH不是在丝形成之前改变。

7. 发明授权

US09304124B2 Compact multifunctional ligand to enhance colloidal stability of nanoparticles 有权
公开(公告)号：US09304124B2
公开(公告)日：2016-04-05
申请号：US13942983
申请日：2013-07-16
申请人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
发明人： Igor L. Medintz , Kimihiro Susumu , Michael H. Stewart
IPC分类号： C07D339/04 , C07D293/00 , C07D285/16 , C07D487/00 , A61K9/14 , G01N33/50 , C07K17/14 , C07D409/12 , C07D251/70 , C07D295/13 , B82Y5/00 , B82Y15/00
CPC分类号： G01N33/5005 , A61K9/14 , B82Y5/00 , B82Y15/00 , C07D251/70 , C07D295/13 , C07D339/04 , C07D409/12 , C07K17/14 , Y10S977/774 , Y10S977/788
摘要： A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.

8. 发明授权

US08859284B2 Delivery of nanoparticles to neurons 有权
标题翻译：纳米颗粒递送到神经元
公开(公告)号：US08859284B2
公开(公告)日：2014-10-14
申请号：US13679335
申请日：2012-11-16
申请人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
发明人： James B. Delehanty , Igor L. Medintz , Hedi M. Mattoussi , Jeffrey R. Deschamps , Glyn Dawson , Philip E. Dawson , Juan Bautista Blanco-Canosa , Kelly Boeneman , Kimihiro Susumu , Michael H. Stewart , Ryan Walters
IPC分类号： C12N5/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K47/20 , C12Q1/02 , B82Y5/00 , A61K47/48 , A61K49/00 , G01N33/50
CPC分类号： A61K47/20 , A61K47/48192 , A61K47/4823 , A61K47/48238 , A61K47/48861 , A61K47/48884 , A61K47/59 , A61K47/61 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0067 , B82Y5/00 , C12Q1/02 , G01N33/5058
摘要： A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
摘要翻译：连接到纳米颗粒（例如量子点）的肽选择性地将纳米颗粒引导到组织或生物体中的神经元。

9. 发明申请

US20120248409A1 Simultaneous Modulation of Quantum Dot Photoluminescence using Orthogonal Fluorescence Resonance Energy Transfer (FRET) and Charge Transfer Quenching (CTQ) 有权
标题翻译：使用正交荧光共振能量转移（FRET）和电荷转移淬火（CTQ）同时调制量子点光致发光
公开(公告)号：US20120248409A1
公开(公告)日：2012-10-04
申请号：US13439003
申请日：2012-04-04
申请人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
发明人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
IPC分类号： H01L33/06 , H01L33/26
CPC分类号： H01L33/06 , C09K11/06 , H01L27/3244 , H01L33/26 , H01L51/56
摘要： Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (FRET), so that the modified quantum dots have a plurality of photophysical properties. The FRET and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties.
摘要翻译：用不同量的（a）有效进行电荷转移淬灭的氧化还原活性部分修饰量子点，和（b）有效进行荧光共振能量转移（FRET）的荧光染料，使得修饰的量子点具有多个的光物理性质。 FRET和电荷转移通路独立运行，为具有相同固有特性的量子点的变化发光提供两个通道控制。

10. 发明申请

US20140256073A1 Simultaneous Modulation of Quantum Dot Photoluminescence using Orthogonal Fluorescence Resonance Energy Transfer (FRET) and Charge Transfer Quenching (CTQ) 有权
标题翻译：使用正交荧光共振能量转移（FRET）和电荷转移淬火（CTQ）同时调制量子点光致发光
公开(公告)号：US20140256073A1
公开(公告)日：2014-09-11
申请号：US14174125
申请日：2014-02-06
申请人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
发明人： Igor L. Medintz , W. Russ Algar , Michael H. Stewart , Kimihiro Susumu
IPC分类号： H01L33/06 , H01L33/26
CPC分类号： H01L33/06 , C09K11/06 , H01L27/3244 , H01L33/26 , H01L51/56
摘要： Quantum dots are modified with varying amounts of (a) a redox-active moiety effective to perform charge transfer quenching, and (b) a fluorescent dye effective to perform fluorescence resonance energy transfer (FRET), so that the modified quantum dots have a plurality of photophysical properties. The FRET and charge transfer pathways operate independently, providing for two channels of control for varying luminescence of quantum dots having the same innate properties.
摘要翻译：用不同量的（a）有效进行电荷转移淬灭的氧化还原活性部分修饰量子点，和（b）有效进行荧光共振能量转移（FRET）的荧光染料，使得修饰的量子点具有多个的光物理性质。 FRET和电荷转移通路独立运行，为具有相同固有特性的量子点的变化发光提供两个通道控制。

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