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1. 发明授权

US06956046B2 4-hydroxypiperidine derivatives having analgesic activity 失效
标题翻译：具有止痛活性的4-羟基哌啶衍生物
公开(公告)号：US06956046B2
公开(公告)日：2005-10-18
申请号：US10478845
申请日：2002-05-17
申请人： Ichiro Yamamoto , Kazuyuki Matsuura , Kazuhiro Suzuki , Kazuo Kato , Yasushige Akada , Hidenori Mochizuki , Akihito Shimoi
发明人： Ichiro Yamamoto , Kazuyuki Matsuura , Kazuhiro Suzuki , Kazuo Kato , Yasushige Akada , Hidenori Mochizuki , Akihito Shimoi
IPC分类号： A61P29/00 , C07D211/48 , C07D401/12 , A61K31/44 , A61K31/4412
CPC分类号： C07D401/12 , C07D211/48
摘要： A compound represented by the following Formula (I): (wherein A represents oxygen atom or —NR3— (R3 represents hydrogen atom or lower alkyl group); R1 represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R2 represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is —NR3—, it is excluded that R1 represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.
摘要翻译：由下式（I）表示的化合物：其中A表示氧原子或-NR 3 - （R 3表示氢原子或低级烷基） SUP> 1表示硝基，低级烷氧基羰基，未取代的或被低级烷基单取代或未被保护或被保护的羟基，未被保护或保护的羧基，未被保护或被保护的羟基取代的低级烷基的氨基甲酰基羟基或四唑基; R 2表示氢原子，氰基或低级烷基磺酰基，条件是当A是-NR 3 - 时，排除R 代表未被保护或保护的羟基或被未保护或被保护的羟基取代的低级烷基）或其盐，以及制备该化合物的方法，以及含有该化合物作为活性成分的药物组合物。

2. 发明授权

US5643920A Tricyclic compound having anti-allergic activities 失效
标题翻译：三环化合物具有抗过敏活性
公开(公告)号：US5643920A
公开(公告)日：1997-07-01
申请号：US325339
申请日：1994-10-27
申请人： Hidenori Mochizuki , Kazuo Kato , Ichiro Yamamoto , Kiyoshi Mizuguchi
发明人： Hidenori Mochizuki , Kazuo Kato , Ichiro Yamamoto , Kiyoshi Mizuguchi
IPC分类号： C07D471/06 , A61K31/44 , C07D221/06 , C07D455/03
CPC分类号： C07D471/06
摘要： A nitrogen-containing tricyclic compound represented by formula (I): ##STR1## a salt thereof, or a solvate of said compound or said salt, wherein R represents phenyl or naphthyl group which is unsubstituted or substituted at one to five sites with a group such as a halogen atom; a straight chain or branched alkyl group containing 1 to 10 carbon atoms which is unsubstituted or substituted with one or more halogen atoms; or the like; Y represents hydrogen atom; and Z represents a group such as hydrogen atom, hydroxyl group, or the like; or Y and Z together represent a group such as hydrazono group, hydroxyimino group, or the like which is unsubstituted or substituted with a particular group; and X.sup.1 -X.sup.2 .about.C.about.X.sup.3 represents CH--N--C.dbd.C or N--C.dbd.C--N; provided that when X.sup.1 -X.sup.2 .about.C.about.X.sup.3 represents N--C.dbd.C--N, Y and Z does not together represent hydroxyimino group or oxygen atom; is capable of inhibiting the production of IgE antibody, and therefore, is useful as a prophylactic and/or therapeutic agent for allergic diseases.
摘要翻译： PCT No.PCT / JP93 / 00549 Sec。 371日期：1994年10月27日 102（e）日期1994年10月27日PCT提交1993年4月27日PCT公布。公开号WO93 / 22313 日本公开号为1993年11月11日，由式（I）表示的含氮三环化合物：其中R 1表示未取代或取代的苯基或萘基的化合物或其盐的溶剂化物在一至五个具有卤素原子的位置; 含有1至10个碳原子的直链或支链烷基，其未被取代或被一个或多个卤素原子取代; 或类似物; Y表示氢原子; Z表示氢原子，羟基等基团，或Y和Z一起表示未被取代或被特定基团取代的亚氨基，羟基亚氨基等基团; X1-X2差异C差异X3表示CH-N-C = C或N-C = C-N; 条件是当X 1 -X 2差异C差异X3表示N-C = C-N时，Y和Z不一起表示羟基亚氨基或氧原子; 能够抑制IgE抗体的产生，因此可用作过敏性疾病的预防和/或治疗剂。

3. 发明授权

US5856334A Imidazoquinoline derivatives 失效
标题翻译：咪唑喹啉衍生物
公开(公告)号：US5856334A
公开(公告)日：1999-01-05
申请号：US776435
申请日：1997-01-28
申请人： Hidenori Mochizuki , Kazuo Kato , Ichiro Yamamoto , Kiyoshi Mizuguchi
发明人： Hidenori Mochizuki , Kazuo Kato , Ichiro Yamamoto , Kiyoshi Mizuguchi
IPC分类号： C07D471/06 , A61K31/435 , A61K31/44 , C07D471/04
CPC分类号： C07D471/06
摘要： Specified imidazoquinoline derivatives represented by the formula (I): ##STR1## where Q represents an optionally substituted phenyl, pyridyl or furyl group; Y represents either a hydrogen atom or, when taken together with Z, an oxygen atom and a methylene group; Z represents a hydrogen atom, a hydroxymethyl group, a carboxymethyl group, a 2-oxo-1-pyrrolidinyl group or the following formula (III):--A--R.sup.2 (III)(where A represents an oxygen atom, a sulfur atom or the group --NH--);or salts of such derivatives inhibit the increase of eosinophils and are useful as agents for preventing and/or treating diseases that manifest the increase of eosinophils.
摘要翻译： PCT No.PCT / JP94 / 01900 Sec。 371日期1997年1月28日 102（e）日期1997年1月28日PCT 1994年11月10日PCT公布。公开号WO96 / 04279 日期：1996年2月15日由式（I）表示的规格咪唑并喹啉衍生物：其中Q表示任选取代的苯基，吡啶基或呋喃基; Y表示氢原子，或与Z一起形成氧原子和亚甲基时; Z表示氢原子，羟甲基，羧甲基，2-氧代-1-吡咯烷基或下式（III）：-A-R2（III）（其中A表示氧原子，硫原子或基团-NH-）; 或这些衍生物的盐抑制嗜酸性粒细胞的增加，并且可用作预防和/或治疗表现嗜酸性粒细胞增加的疾病的药剂。

4. 发明授权

US6040331A Nerve cell protective agents 失效
标题翻译：神经细胞保护剂
公开(公告)号：US6040331A
公开(公告)日：2000-03-21
申请号：US11260
申请日：1998-01-30
申请人： Ichiro Yamamoto , Manabu Itoh , Masato Shimojo , Yasunobu Yumiya , Takafumi Mukaihira , Yasushige Akada
发明人： Ichiro Yamamoto , Manabu Itoh , Masato Shimojo , Yasunobu Yumiya , Takafumi Mukaihira , Yasushige Akada
IPC分类号： C07D209/90 , C07D401/04 , C07D491/06 , A61K31/40 , A61K31/425 , C07D403/00 , C07D417/00
CPC分类号： C07D401/04 , C07D209/90 , C07D491/06
摘要： The invention provides novel benzindole derivatives, processes for producing them, as well as a neuroprotective agent, an agent to prevent or treat diseases involving the degeneration, retraction or death of neurons, and an analgesic, each containing the benzindole derivatives as an active ingredient. ##STR1##
摘要翻译： PCT No.PCT / JP97 / 01828 Sec。 371日期1998年1月30日 102（e）1998年1月30日PCT PCT 1997年5月29日PCT公布。出版物WO97 / 45410 PCT 日期1997年12月4日本发明提供新颖的苯并吲哚衍生物，其制备方法以及神经保护剂，预防或治疗涉及神经元变性，缩回或死亡的疾病的试剂，以及各自含有苯并吲哚衍生物作为活性成分。

5. 发明授权

US06642257B2 Agents for treating neuropathic pain 失效
标题翻译：用于治疗神经性疼痛的药剂
公开(公告)号：US06642257B2
公开(公告)日：2003-11-04
申请号：US09969644
申请日：2001-10-04
申请人： Ichiro Yamamoto , Manabu Itoh , Fumiaki Yamasaki , Yasushige Akada , Yutaka Miyazaki , Shinichi Ogawa
发明人： Ichiro Yamamoto , Manabu Itoh , Fumiaki Yamasaki , Yasushige Akada , Yutaka Miyazaki , Shinichi Ogawa
IPC分类号： A61K3144
CPC分类号： C07D405/06 , C07D211/48 , C07D407/06 , C07D409/06
摘要： The present invention relates to a compound represented by Formula (I) below: (wherein A represents, for example, phenyl group substituted by R1 and R2, or an unsubstituted furyl group or an unsubstitued thienyl group; R1 represents, for example, hydrogen atom, fluorine atom, chlorine atom, trifluoromethyl group, nitro group, cyano group or methyl group while R2 represents, for example, hydrogen atom; R3 represents, for example, hydrogen atom or methyl group; R4 represents, for example, hydrogen atom or methyl group; R5 represents ethoxy group or isopropoxy group; X represents group: —CH(OH)— or methylene group; and Z represents, for example, a single bond or methylene group unsubstituted or substituted by hydroxyl group), and its salts, and medicinal compositions containing, as their active ingredient, the above compound or its salts. The compound of this invention, which is orally applicable, is highly effective for treating neuroapthic pain while presenting with fewer side-effects than do the conventional analgesics.
摘要翻译：本发明涉及由下式（I）表示的化合物：其中A表示例如被R 1和R 2取代的苯基或未取代的呋喃基或未取代的噻吩基; 1表示例如氢原子，氟原子，氯原子，三氟甲基，硝基，氰基或甲基，而R 2表示例如氢原子; R 3表示例如氢原子或甲基; R 4表示例如氢原子或甲基; R 5表示乙氧基或异丙氧基; X表示基团：-CH（OH） - 或亚甲基; Z表示对于例如，未取代或被羟基取代的单键或亚甲基）及其盐，以及含有作为其活性成分的上述化合物或其盐的药物组合物。口服适用的本发明化合物对于治疗神经痛与非常有效，同时具有比常规止痛剂更少的副作用。

6. 发明授权

US5583227A Antiulcer compounds having a substituted alkynyl or quinoxaline nucleus and methods of making thereof 失效
标题翻译：具有取代的炔基或喹喔啉核的抗溃疡化合物及其制备方法
公开(公告)号：US5583227A
公开(公告)日：1996-12-10
申请号：US458871
申请日：1995-06-02
申请人： Takeshi Niho , Ichiro Yamamoto , Hidenori Mochizuki , Ikuo Kimura , Akihiro Imai , Tetsuyuki Nakase
发明人： Takeshi Niho , Ichiro Yamamoto , Hidenori Mochizuki , Ikuo Kimura , Akihiro Imai , Tetsuyuki Nakase
IPC分类号： C07D241/24 , C07D241/42 , C07D241/44 , A61K31/33
CPC分类号： C07D241/24 , C07D241/42 , C07D241/44
摘要： This invention relates to a novel compound which is useful as a drug in preventing and/or treating peptic ulcer-related diseases, to a production process thereof and to a pharmaceutical composition containing the same.Particularly, it provides a compound which has a specified substituted alkynylpyrazine nucleus or a specified substituted alkynylquinoxaline nucleus, represented by the following formula (I) ##STR1## wherein A is represented by the following formula (II) or (III) ##STR2## and R.sup.1 is represented by the following formula (IV), ##STR3## and the salts thereof, a production process thereof and a pharmaceutical composition containing the same.The inventive compound is useful as a drug in preventing and/or treating peptic ulcer-related diseases.
摘要翻译：本发明涉及可用作预防和/或治疗消化性溃疡相关疾病的药物的新型化合物及其制备方法和含有该化合物的药物组合物。特别地，其提供具有指定的取代的炔基吡嗪核的化合物或由下式（I）表示的特定的取代的炔基喹喔啉核，其中A由下式（II）或（III）表示：（II）＆lt; IMAGE＆gt;（III），R1由下式（Ⅳ），ⅩⅧ及其盐表示，其制备方法和含有该化合物的药物组合物。本发明化合物可用作预防和/或治疗消化性溃疡相关疾病的药物。

7. 发明授权

US5151431A 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives useful for treating hypertension or edema 失效
标题翻译：用于治疗高血压或EDEMA的4,5-DIHYDRO-6H-IMIDAZO（4,5,1-IJ）喹啉-6-酮-6-氧代-O-硫代酸衍生物
公开(公告)号：US5151431A
公开(公告)日：1992-09-29
申请号：US540950
申请日：1990-06-20
申请人： Hitoshi Inaba , Kazumi Nishijima , Kazuo Kato , Ichiro Yamamoto , Ei Mochida , Kikuo Ohtomo
发明人： Hitoshi Inaba , Kazumi Nishijima , Kazuo Kato , Ichiro Yamamoto , Ei Mochida , Kikuo Ohtomo
IPC分类号： A61K31/47 , A61P3/00 , A61P7/10 , A61P9/12 , C07D471/06
CPC分类号： C07D471/06
摘要： The present invention relates to novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid compounds, processes for producing said compounds, intermediate compounds, i.e. novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one compounds and 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime compounds in the synthesis of said compounds, processes for producing said intermediate compounds, and pharmaceutical or veterinary compositions containing said compounds.The present invention is based on the selection of the substituents of 4,5-dihydro-6H-imidazo[4,5,1-ij]-quinolin-6-one-6-oxime-O-sulfonic acid compounds at 2-position, namely 2-(2-penten-3-yl)-, 2-cyclohexyl-, 2-naphthyl-, 2-thienyl-, etc.The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effects as well as an activity of removing ascites. The compounds of the present invention are extremely useful for treatment of diseases and disorders mentioned above.

8. 发明申请

US20060004028A1 Novel PARP inhibitor 审中-公开
标题翻译：新型PARP抑制剂
公开(公告)号：US20060004028A1
公开(公告)日：2006-01-05
申请号：US11125259
申请日：2005-05-10
申请人： Ikuya Shiromizu , Kazuo Kato , Ichiro Yamamoto , Hajime Hamamoto
发明人： Ikuya Shiromizu , Kazuo Kato , Ichiro Yamamoto , Hajime Hamamoto
IPC分类号： C07D487/04 , A61K31/519 , C12N9/22
CPC分类号： C07D471/06 , A61K31/519 , A61K31/551
摘要： A compound represented by: or a salt thereof, and a pharmaceutical composition containing the compound or the salt, the compound having a poly (ADP-ribose)polymerase inhibitory effect, and is safe and advantageous for drug formulation.
摘要翻译：由其表示的化合物或其盐，以及含有该化合物或其盐的药物组合物，具有聚（ADP-核糖）聚合酶抑制作用的化合物，对药物制剂而言是安全有利的。

9. 发明授权

US08440521B2 Method of manufacturing a semiconductor device 有权
标题翻译：制造半导体器件的方法
公开(公告)号：US08440521B2
公开(公告)日：2013-05-14
申请号：US13067788
申请日：2011-06-27
申请人： Naomi Fukumaki , Eiji Hasegawa , Toshihiro Iizuka , Ichiro Yamamoto
发明人： Naomi Fukumaki , Eiji Hasegawa , Toshihiro Iizuka , Ichiro Yamamoto
IPC分类号： H01L21/3105
CPC分类号： H01L21/823857 , H01L21/823842
摘要： A method of manufacturing a semiconductor device having a p-type field effect transistor and an n-type field effect transistor includes the steps of: forming an interface insulating layer and a high-permittivity layer on a substrate in the stated order; forming a pattern of a sacrifice layer on the high-permittivity layer; forming a metal-containing film containing metal elements therein on the high-permittivity layer in a first region where the sacrifice layer is formed and a second region where no sacrifice layer is formed; introducing the metal elements into an interface between the interface insulating layer and the high-permittivity layer in the second region by conducting a heat treatment; and removing the sacrifice layer by wet etching, wherein in the removing step, the sacrifice layer is etched easily more than the high-permittivity layer. With this configuration, the semiconductor device excellent in reliability is obtained.
摘要翻译：制造具有p型场效应晶体管和n型场效应晶体管的半导体器件的方法包括以下步骤：按照所述顺序在衬底上形成界面绝缘层和高电容率层; 在高电介质层上形成牺牲层的图案; 在形成有牺牲层的第一区域和形成牺牲层的第二区域的高介电常数层上形成含有金属元素的含金属膜; 通过进行热处理，将金属元素引入第二区域中的界面绝缘层与高电容率层之间的界面; 并且通过湿法蚀刻去除牺牲层，其中在去除步骤中，牺牲层比高介电常数层容易蚀刻。由此，能够获得可靠性优异的半导体装置。

10. 发明授权

US08132572B2 Permanent wave treatment method and apparatus thereof 有权
标题翻译：永久性波浪处理方法及其装置
公开(公告)号：US08132572B2
公开(公告)日：2012-03-13
申请号：US12063357
申请日：2007-07-25
申请人： Hideyuki Kawabata , Koji Okamoto , Takashi Hoshina , Ryuhei Nagata , Yasuaki Nakatani , Terumi Shibano , Tomoaki Takada , Ryouji Kitamura , Toshiki Yajima , Daisuke Mouri , Kazuya Yamanaka , Ichiro Yamamoto , Shinji Katsura
发明人： Hideyuki Kawabata , Koji Okamoto , Takashi Hoshina , Ryuhei Nagata , Yasuaki Nakatani , Terumi Shibano , Tomoaki Takada , Ryouji Kitamura , Toshiki Yajima , Daisuke Mouri , Kazuya Yamanaka , Ichiro Yamamoto , Shinji Katsura
IPC分类号： A45D6/06
CPC分类号： A45D7/06 , A45D44/02
摘要： A permanent wave treatment apparatus comprises: a housing 3; a blower 1 which is installed within the housing to suck air and blow air; a steam separator 2 which is provided on the blower to remove water content from air sucked by suction force of the blower; an outlet hole formed in the housing through which air is spouted from the blower; hoods F mounted on the housing such that they are capable of being opened/closed freely; a plurality of rods R on which the hair of an object person is to be wound and in which air vent holes are formed; tubes 4 connected to the rods so as to keep the interior of the rods in a negative pressure by the suction force of the blower; and extraction member 5 which holds a plurality of the tubes such that they are capable of being extracted freely.
摘要翻译：永久波处理装置包括：壳体3; 鼓风机1，其安装在壳体内以吸入空气并吹送空气; 蒸汽分离器2，其设置在鼓风机上，以通过鼓风机的吸力吸入的空气去除水分; 出口孔，形成在壳体中，空气从鼓风机喷出; 罩F安装在壳体上，使得它们能够自由地打开/关闭; 多个杆R，其上要形成有人的头发，其中形成有通气孔; 管4连接到杆上，以通过鼓风机的吸力将棒的内部保持在负压; 以及提取构件5，其保持多个管，使得它们能够自由地提取。

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