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    • 3. 发明授权
    • 1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for
preparing same
    • 1-苯基-1H-吡唑并[3,4-b]吡嗪衍生物及其制备方法
    • US4460773A
    • 1984-07-17
    • US428016
    • 1982-09-29
    • Shinichi SuzukiKunitomo SuzukiHiromitsu Honda
    • Shinichi SuzukiKunitomo SuzukiHiromitsu Honda
    • C07D407/04C07D487/04A61K31/495
    • C07D407/04
    • Novel 1-phenyl-1H-pyrazolo[3,4-b]pyrazine derivatives are provided which are represented by the formula: ##STR1## wherein A is (i) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or an alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl or amino group, or a divalent radical forming a nitrogen-containing saturated heterocyclic ring together with the nitrogen atom, (ii) ##STR3## wherein R.sub.3 is a phenyl group which is unsubstituted or substituted by halogen or a lower alkyl, lower alokoxy, carboxyl or nitro group, and R.sub.4 is halogen or a methyl or ethyl group, (iii)--OR.sub.5 in which R.sub.5 is a phenyl group which is unsubstituted or substituted by halogen or a hydroxyl, lower alkyl, lower alkoxy, amino or lower alkylamide group, or (iv)--OR.sub.6 is an alkyl group which is unsubstituted or substituted by halogen or a phenyl, furanyl, tetrahydrofuranyl or alkylamino group. These derivatives have antitumor or antiviral activity.
    • 提供新的1-苯基-1H-吡唑并[3,4-b]吡嗪衍生物,其由下式表示:其中A是(i)其中R 1和R 2是氢或烷基,被取代的 烷基,环烷基,取代的环烷基或氨基,或与氮原子一起形成含氮饱和杂环的二价基团,(ii)其中R3是未被取代或被卤素或低级 烷基,低级甲氧基,羧基或硝基,R4为卤素或甲基或乙基,(ⅲ)-OR5,其中R5为未取代的或被卤素或羟基取代的苯基,低级烷基,低级烷氧基, 氨基或低级烷基酰胺基,或(iv)-OR 6是未被取代或被卤素或苯基,呋喃基,四氢呋喃基或烷基氨基取代的烷基。 这些衍生物具有抗肿瘤或抗病毒活性。