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1. 发明申请

US20070161808A1 Process for the preparation of aq4n 审中-公开
标题翻译：制备aq4n的方法
公开(公告)号：US20070161808A1
公开(公告)日：2007-07-12
申请号：US10597865
申请日：2005-02-11
申请人： Ian Matthews , Ronald Scott , John Barry , Stephen Hughes , Ann Heslip
发明人： Ian Matthews , Ronald Scott , John Barry , Stephen Hughes , Ann Heslip
IPC分类号： C07C225/26
CPC分类号： C07C221/00 , C07C291/04 , C07C2603/24 , C07C225/36
摘要： A process for the preparation of compound AQ4N of formula (2) or a salt or solvate thereof wherein the said process includes the reaction step: Formula (1), Formula (2), where compound AQ4 of formula (1) is oxidised to compound AQ4N of formula (2) with an oxidising agent at a reaction temperature not exceeding 10° C.
摘要翻译：制备式（2）化合物AQ4N或其盐或溶剂合物的方法，其中所述方法包括反应步骤：将式（1）的化合物AQ4氧化成化合物的式（1），式（2）式（2）的AQ4N与氧化剂在不超过10℃的反应温度下反应

2. 发明授权

US07560117B2 Foamy virus mutant reverse transcriptase 失效
标题翻译：泡沫病毒突变逆转录酶
公开(公告)号：US07560117B2
公开(公告)日：2009-07-14
申请号：US10478442
申请日：2002-05-22
申请人： Stephen Hughes , Paul Boyer , Maxine Linial , Carolyn Stenbak , Patrick Clark
发明人： Stephen Hughes , Paul Boyer , Maxine Linial , Carolyn Stenbak , Patrick Clark
IPC分类号： A61K39/12 , A61K39/21
CPC分类号： C07K14/005 , C12N9/1247 , C12N9/1276 , C12N2740/17022 , C12Y207/07049
摘要： The present invention relates to a highly processive reverse transcriptase having DNA polymerase activity and substantially reduced protease activity. More specifically, the invention relates to an isolated reverse transcriptase from foamy virus comprising a substantially inactivated protease. The invention also relates to vectors containing the gene and hosts transformed with the vector of the invention. Further, the invention relates to a method for producing reverse transcriptase having DNA polymerase activity and substantially reduced protease activity by expressing the reverse transcriptase genes of the present invention in a recombinant host. Methods are also provided for producing cDNA from polynucleotides using the highly processive reverse transcriptase of the invention. Kits for the preparation of cDNA from RNA comprising the highly processive reverse transcriptase of the invention are also provided.
摘要翻译：本发明涉及具有DNA聚合酶活性和显着降低的蛋白酶活性的高度进展的逆转录酶。更具体地，本发明涉及由泡沫病毒分离的逆转录酶，其包含基本上灭活的蛋白酶。本发明还涉及含有用本发明的载体转化的基因和宿主的载体。此外，本发明涉及通过在本发明的重组宿主中表达本发明的逆转录酶基因来生产具有DNA聚合酶活性的反转录酶的方法和基本上减少的蛋白酶活性的方法。还提供了使用本发明的高度进行性逆转录酶从多核苷酸产生cDNA的方法。还提供了用于从包含本发明的高度进行性逆转录酶的RNA制备cDNA的试剂盒。

3. 发明申请

US20060061545A1 Motion-activated control with haptic feedback 审中-公开
标题翻译：运动激活控制与触觉反馈
公开(公告)号：US20060061545A1
公开(公告)日：2006-03-23
申请号：US11122631
申请日：2005-05-05
申请人： Stephen Hughes , Ian Oakley , Jussi Angesleva , Maure O'Modhrain
发明人： Stephen Hughes , Ian Oakley , Jussi Angesleva , Maure O'Modhrain
IPC分类号： G09G5/00
CPC分类号： G06F3/016 , G06F3/0346
摘要： A mechanism for sensing the changing positional and orientation of a hand held device as it is moved by the device user to control the state or operation of the hand held device and one or more vibrotactile transducers positioned on the body of the hand held device to provide haptic feedback stimuli to the user indicative of the state of the device. The mechanism employs the combination of accelerometers for obtaining inertial data in three degrees of freedom, gyro sensor for obtaining roll, pitch and yaw angular motion data, a GPS system for providing position data, and magnetometers for providing directional data. This sensor data may be used to control the functioning of the hand held device; for example to control display scrolling, and the vibratory stimuli fed back to the user provides an indication of the effects of the gestural movements the user imparts to the device.
摘要翻译：一种用于感测手持装置在由装置用户移动以控制手持装置的状态或操作以及定位在手持装置的主体上的一个或多个振动脉动换能器的位置和取向的机构，以提供触觉反馈刺激给用户指示设备的状态。该机构采用加速度计的组合来获得三自由度的惯性数据，用于获得滚动，俯仰和横摆角运动数据的陀螺仪传感器，用于提供位置数据的GPS系统和用于提供方向数据的磁力计。该传感器数据可用于控制手持设备的功能; 例如以控制显示滚动，并且反馈给用户的振动刺激提供用户对设备施加的姿势运动的影响的指示。

4. 发明申请

US20070175299A1 Process for copper converting 有权
标题翻译：铜转化工艺
公开(公告)号：US20070175299A1
公开(公告)日：2007-08-02
申请号：US10599570
申请日：2005-04-06
申请人： Stephen Hughes , Robert Matusewicz , Ross McClelland , Antony Acquadro , BriaN Baldock
发明人： Stephen Hughes , Robert Matusewicz , Ross McClelland , Antony Acquadro , BriaN Baldock
IPC分类号： C22B15/00
CPC分类号： C22B15/0054 , C22B15/0041
摘要： The process for converting a copper sulphide matte to blister copper, is achieved by adding the copper sulphide matte and flux to a suitable agitated slag phase; and injecting, from a discharge tip at the lower end of a top-submerged lance, an oxidizing gas suitable for reacting with the matte to produce blister copper which forms or adds to a continuous blister copper phase below the slag phase. The lance tip is located within the slag phase at a depth enabling the injected gas to agitate the slag phase, and to react with copper sulphide matte dispersed therein, while precluding a substantial proportion of the gas from contacting the continuous blister copper phase.
摘要翻译：通过将硫化铜锍和助熔剂加入到合适的搅拌的渣相中来实现将硫化铜锍转化为吸塑铜的方法; 并且从顶部浸入式喷枪的下端的排出尖端喷射适于与无光泽反应的氧化气体，以产生形成或添加到渣相下方的连续泡状铜相的泡罩铜。喷枪尖端位于炉渣相内，使得喷射的气体能够搅拌渣相，并与其中分散的硫化亚铜反应，同时排除大部分气体与连续的泡罩铜相接触。

5. 发明申请

US20060039993A1 Retinal cell grafts and instrument for implanting 审中-公开
标题翻译：视网膜细胞移植物和植入器械
公开(公告)号：US20060039993A1
公开(公告)日：2006-02-23
申请号：US11171876
申请日：2005-06-29
申请人： Stephen Hughes
发明人： Stephen Hughes
IPC分类号： A61K35/44 , A61M31/00
CPC分类号： A61L27/3683 , A61B90/00 , A61B2017/00969 , A61F2/14 , A61F9/0017 , A61F9/007 , A61K35/44 , A61L27/3604 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/383 , A61L27/3839 , A61L27/3891 , A61L2430/16 , A61M2025/0042
摘要： Surgical instruments, surgical techniques, retinal cell grafts, retinal cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, and/or retinal pigment epithelium, with the cells in the isolated tissue having their normal cell to cell configuration are disclosed.
摘要翻译：手术器械，外科技术，视网膜细胞移植物，视网膜细胞和组织分离技术以及用于将分离的组织中具有正常细胞与细胞构型的细胞移植视网膜细胞（包括光感受器和/或视网膜色素上皮）的方法，披露

6. 发明申请

US20060037436A1 Smelting process for the production of iron 有权
标题翻译：冶炼生产铁的过程
公开(公告)号：US20060037436A1
公开(公告)日：2006-02-23
申请号：US10542721
申请日：2004-01-01
申请人： Colette Ng , Brian Baldock , Giuseppe Sofra , Stephen Hughes , Robert Matusewicz , Ross McCelland , David Sherrington
发明人： Colette Ng , Brian Baldock , Giuseppe Sofra , Stephen Hughes , Robert Matusewicz , Ross McCelland , David Sherrington
IPC分类号： C21C5/30
CPC分类号： C22B5/10 , C21B3/06 , C21B13/0013 , C21B2400/022 , C21C5/562 , C22B7/04 , Y02P10/136 , Y02P10/216 , Y02W30/543
摘要： A process for producing iron metal and slag by smelting iron-containing source material, having iron present as oxide and/or a partially metallised state, in a reactor containing a molten bath comprising or having a slag phase, utilises injection of fuel/reductant and oxygen-containing gas into the slag, by at least one top-submerged lance, to generate heating and reducing conditions in at least one reducing region in the bath. The source material is fed to the reactor, together with additional reductant and with flux, at or adjacent to the at least one reducing region, to subject the source material to smelting reduction which generates combustion gases comprising CO and H2. The rates of injection of the oxygen-containing gas and fuel/reductant by said at least one lance are controlled to achieve required, sufficient reducing conditions; and, in the reactor above the bath, the combustion gases generated by the smelting are post-combusted. The controlling of step (c) is conducted to result in the injected oxygen-containing gas having an oxygen content of from about 40 volume % to about 100 volume % and sufficient for a degree of combustion in excess of 60 wt % of the fuel/reductant injected by the at least one lance.
摘要翻译：通过熔炼含铁源材料（在含有或具有渣相的熔池的反应器中）以含氧化物和/或部分金属化状态存在的铁来生产铁金属和炉渣的方法利用燃料/还原剂的注入和通过至少一个顶部浸没的喷枪将含氧气体进入炉渣，以在浴中的至少一个还原区域中产生加热和还原条件。源材料与附加的还原剂和助熔剂一起在至少一个还原区域或邻近的至少一个还原区域内进料到反应器中，以使源材料进行熔炼还原，其产生包含CO和H 2的燃烧气体， SUB>。控制由所述至少一根喷枪喷射含氧气体和燃料/还原剂的速率以达到所需的足够的还原条件; 并且在浴池上方的反应器中，由熔炼产生的燃烧气体后燃烧。进行步骤（c）的控制以产生氧含量为约40体积％至约100体积％并且足以使燃烧程度超过燃料/燃料的60重量％还原剂由至少一根喷枪注射。

7. 发明授权

US10783584B1 Recommendation of insurance products based on an inventory analysis 有权
公开(公告)号：US10783584B1
公开(公告)日：2020-09-22
申请号：US13608752
申请日：2012-09-10
申请人： William Loo , Stephen Hughes , James Gillespie , Jennifer A. Brandmaier , Daniel Koza
发明人： William Loo , Stephen Hughes , James Gillespie , Jennifer A. Brandmaier , Daniel Koza
IPC分类号： G06Q40/08
摘要： Apparatuses and methods may provide for generating, maintaining, and using an inventory for insurance purposes. An optimized inventory analysis server may generate and maintain user profile information for determining a demographic classification of each user associated with an inventory. A demographic classification for a given user may be used along with data related to items owned by other users to determine one or more items for recommendation to the given user. Details associated with existing insurance coverage levels may also be used to recommend new insurance products to the user. In addition, the optimized inventory analysis server may determine a depreciated value of each item within an inventory. These values may be used to assess loss and settle an insurance claim for damage to one or more of the items in the inventory.

8. 发明授权

US10332208B1 Total cost of vehicle ownership 有权
公开(公告)号：US10332208B1
公开(公告)日：2019-06-25
申请号：US13592413
申请日：2012-08-23
申请人： William Loo , Stephen Hughes , James Gillespie , Jennifer A. Brandmaier , Daniel Koza
发明人： William Loo , Stephen Hughes , James Gillespie , Jennifer A. Brandmaier , Daniel Koza
IPC分类号： G06Q40/08 , G06Q30/06 , G06Q40/06
摘要： A total cost of ownership (TCO) of a vehicle may be calculated based on received information identifying a vehicle, and retrieved vehicle data corresponding to the vehicle, such as vehicle insurance records, maintenance records, and vehicle operation sensor data. Additional information may be received identifying one or more entities associated with the vehicle, for example, a potential buyer and a potential seller of the vehicle Data may be retrieved corresponding to the entities associated with the vehicle, and a TCO calculation for a vehicle may be based on the vehicle data and additional information retrieved corresponding to the entities associated with the vehicle.

9. 发明授权

US06966985B2 Self-diluting feedwell including a vertical education mechanism 失效
标题翻译：自我稀释的饲养场包括垂直教育机制
公开(公告)号：US06966985B2
公开(公告)日：2005-11-22
申请号：US10382096
申请日：2003-03-05
申请人： Frederick R. Schoenbrunn , Stephen Hughes , Kurt R. Dahl
发明人： Frederick R. Schoenbrunn , Stephen Hughes , Kurt R. Dahl
IPC分类号： B01D20060101 , B01D21/02 , B03D1/14 , B01D21/01
CPC分类号： B01D21/2444 , B01D21/0042 , B01D21/01 , B01D21/02 , B01D21/08 , B01D21/18 , B01D21/2405 , B01D21/2427 , B01D21/2488
摘要： An apparatus and method of diluting a solid particle-containing slurry in conjunction with a sedimentation process. A slurry is introduced into the launder portion of a feedwell and flowed vertically downward through an eductor nozzle having its exit location placed below the liquid level of a volume of clarified liquor. The eductor nozzle is positioned adjacent a diluent inlet such that discharge of the slurry through the eductor nozzle creates a low pressure zone, drawing clarified liquor through the diluent inlet for mixing and dilution of the slurry. A flocculating reagent may additionally be introduced into the diluted slurry for producing a floc and expediting settling of the solid particles.
摘要翻译：一种与沉淀过程一起稀释含固体颗粒的浆料的装置和方法。将浆料引入进料井的洗涤部分并垂直向下流动通过其出口位置放置在一定体积的澄清液体的液面以下的喷射喷嘴。喷射器喷嘴定位在稀释剂入口附近，使得浆料通过喷射器喷嘴的排出产生低压区，将澄清的液体通过稀释剂入口抽出以混合和稀释浆料。另外可以将絮凝试剂引入稀浆中以产生絮凝物并加速固体颗粒的沉降。

10. 发明授权

US5965857A Flotation cell row 失效
标题翻译：浮选槽排
公开(公告)号：US5965857A
公开(公告)日：1999-10-12
申请号：US818976
申请日：1997-03-14
申请人： Stephen Hughes
发明人： Stephen Hughes
IPC分类号： B03B11/00 , B03D1/14 , B03D1/16 , F16K1/20 , F16K31/122
CPC分类号： B03D1/16 , B03B11/00 , B03D1/028 , B03D1/1406 , F16K1/2007 , F16K1/2021 , F16K1/2028 , F16K1/2057 , F16K31/122
摘要： A flotation cell row including a row of cells through which, in use, a process liquid flows in turn, including a first bank of cells having a last cell 4 being the most downstream cell and a second bank of cells having a first cell 5 being the most upstream cell, the second bank being the bank immediately downstream of the first bank, in which one or both of the last cell 4 and the first cell 5 are structured to define a port 37 having a rim through which, in use, the process liquid flows from the last cell 4 to the first cell 5, and a valve member 10 mounted for movement between a closed position abutting the rim 44 and an open position spaced from rim 44, to control flow of process liquid through the port 37.
摘要翻译：一种浮选槽行，包括一排单元，在使用中，处理液依次流过该单元格，其中包括具有最下游单元的最后单元4的第一组单元，以及具有第一单元5的第二单元组最上游单元，第二组是紧邻第一组下游的组，其中最后单元4和第一单元5中的一个或两个构造成限定具有边沿的端口37，在使用中，处理液体从最后一个单元4流到第一单元5;以及阀构件10，安装用于在邻接边缘44的关闭位置和与边框44间隔开的打开位置之间移动，以控制处理液体通过端口37的流动。

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