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1. 发明授权

US3843687A Method for the preparation of derivatives of 5-hydro xy-2-carboxychromone 失效
标题翻译： 5-羟基XY-2-羧基酮衍生物的制备方法
公开(公告)号：US3843687A
公开(公告)日：1974-10-22
申请号：US26027372
申请日：1972-06-06
申请人： ISF SPA
发明人： PIFFERI G
IPC分类号： C07D311/24
CPC分类号： C07D311/24
摘要： WHEREIN X is an aliphatic alkyl having from C3 to C7 with its chain possibly interrupted by an oxygen atom and preferably containing a secondary alcoholic grouping, by alkaline hydrolysis of the corresponding lower alkyl ester, the latter being prepared starting from the corresponding bis-phenoxy derivative (a) by double Claisen reaction with an alkyl oxalate in the presence of an alkali metal alcoholate as the catalyst, and (b) by cyclizing the intermediate thus obtained in an acidic environment, the improvement consisting in that the reaction with the alkyl oxalate is carried out in an alcoholic protic solvent in the presence of stoichiometric amounts of the alkali metal alcoholate at a temperature not above 50*C and for a time not longer than 3 hours, the cyclization being carried out by adding an anhydrous mineral acid to the reaction mass. By so doing, the preparation of the expected compounds is cheaper, quicker and gives virtually quantitative yields.

A method for the preparation of derivatives of the 5-hydroxy-2carboxychromone is disclosed, said derivatives having the general formula

2. 发明授权

US3775464A Process for preparing 2-dialkylaminoethyl 4-alkoxy-3-aminobenzoates 失效
标题翻译：制备2-二烷基氨基乙基4-烷氧基-3-氨基苯甲酸酯的方法
公开(公告)号：US3775464A
公开(公告)日：1973-11-27
申请号：US3775464D
申请日：1970-08-10
申请人： ISF SPA
发明人： PIFFERI G
IPC分类号： C07C205/59 , C07C213/00 , C07C213/06 , C07C219/14 , C07C227/04 , C07C229/64 , C07C101/54
CPC分类号： C07C213/06 , C07C201/12 , C07C205/59 , C07C213/00 , C07C227/04 , C07C229/64 , C07C219/14
摘要： 2-DIALKYLAMINOETHYL 4-ALKOXY-3-AMINOBENZOATES, OF THE GENERAL FORMULA:

(4-(R-O-),3-(H2N-)PHENYL)-COO-(CH2)2-N(-R'')2

ARE PREPARED BY A NEW AND SIMPLER PROCESS WHICH COMPRISES ALKOXYLATING A 4-HALO-3-NITROBENZOIC ACID WITH AN ALKALI METAL ALKOXIDE IN AN APROTIC SOLVENT, ESTERIFYING AND REDUCING THE ESTER BY CONVENTIONAL MEANS.

3. 发明授权

US3769278A Antihypertensive 6-substituted 3-hydrazino-pyridazines and their preparation 失效
标题翻译：抗坏血酸6-取代的3-羟基吡啶并吡啶的制备
公开(公告)号：US3769278A
公开(公告)日：1973-10-30
申请号：US3769278D
申请日：1971-08-04
申请人： ISF SPA
发明人： PIFFERI G
IPC分类号： C07D237/20 , C07D51/02
CPC分类号： C07D237/20
摘要： ANTIHYPERTENSIVE COMPOUNDS COMPRISE 3-HYDRAZINOPYRIDAZINE DERIVATIVES SUBSTITUTED IN THE 6-POSITION WITH AN N-(2-HYDROXYPROPYL) AMINO GROUP. A NEW METHOD FOR THE PREPARATION OF THESE COMPOUNDS INVOLVES THE INTERMEDIATE ISOLATION OF THEIR HYDRAZONES AND SUBSEQUENT DECOMPOSITION OF THE HYDRAZONES WITH AN ACID TO FORM THE DESIRED HYDRAZINO DERIVATIVES.

4. 发明授权

US3755317A Thioamides of 4-substituted syringic acid and their preparation 失效
标题翻译： 4-取代的水杨酸的制备及其制备
公开(公告)号：US3755317A
公开(公告)日：1973-08-28
申请号：US3755317D
申请日：1970-11-27
申请人： ISF SPA
发明人： PIFFERI G
IPC分类号： C07D295/10 , C07D261/02 , C07D263/06 , C07D277/04 , C07D295/18 , C07D295/194 , C07D87/46
CPC分类号： C07D261/02 , C07D277/04 , C07D295/194
摘要： New thioamides of 4-substituted zyringic acid are provided, which are characterized with respect to the corresponding amides in that they have a more prolonged effect. The new thioamides herein provided can be used in therapy showing a prolonged ataraxic or tranquilizing action upon the central nervous system without comprising the reflexes and the motorial coordination; furthermore, they show a very low toxicity, a favourable therapeutic coefficient and the absence of collateral effects on the circle.
摘要翻译：提供了4-取代的丁酸的新的硫代酰胺，其相对于相应的酰胺被表征，因为它们具有更长的效果。本文提供的新型硫代酰胺可用于治疗，显示对中枢神经系统长时间的无痛或镇静作用，不包括反射和运动协调; 此外，它们显示出非常低的毒性，良好的治疗系数和在圆圈上没有附带效应。

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