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1. 发明授权

US09234005B2 Products useful for the treatment of malignant neoplasms of the human nervous system 有权
标题翻译：可用于治疗人类神经系统恶性肿瘤的产品
公开(公告)号：US09234005B2
公开(公告)日：2016-01-12
申请号：US14350005
申请日：2012-10-11
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , Universite Pierre Et Marie Curie (Paris 6)
发明人： Nicolas Wolff , Monique Lafon , Nicolas Babault
IPC分类号： A61K38/00 , A61P35/00 , C07K7/08 , C07K14/705 , C07K14/005 , A61K9/127 , A61K38/10 , A61K45/06
CPC分类号： C07K7/08 , A61K9/127 , A61K38/10 , A61K45/06 , C07K14/005 , C07K14/705 , C12N2760/20122 , C12N2760/20133
摘要： The application provides products, which may trigger pro-apoptotic or pro-death effects on neoplastic cells and/or tissues of the human nervous system, more particularly on neoplastic cells and/or tissues of the human CNS. The products of the application can be used as anti-proliferative or tumoricid agents in the treatment and/or palliation and/or prevention of neoplasms of the human nervous system, more particularly of glioblastoma or brain stem glioma. Therefore, the application also relates to compositions, such as pharmaceutical compositions or drugs, which comprise at least one of said products, as well as to the biotechnological and medical applications of said products and compositions.
摘要翻译：该应用提供的产品可以触发对人类神经系统的肿瘤细胞和/或组织的促凋亡或死亡作用，更特别地涉及人CNS的肿瘤细胞和/或组织。该应用的产品可用作抗增殖剂或肿瘤剂，用于治疗和/或缓解和/或预防人类神经系统肿瘤，尤其是胶质母细胞瘤或脑干胶质瘤。因此，本申请还涉及包含至少一种所述产品的组合物，例如药物组合物或药物，以及所述产品和组合物的生物技术和医学应用。

2. 发明申请

US20170022567A1 HIGH MAST2-AFFINITY POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：高MAST2-AFFINITY多聚体及其用途
公开(公告)号：US20170022567A1
公开(公告)日：2017-01-26
申请号：US15265172
申请日：2016-09-14
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
发明人： Christophe Prehaud , Monique Lafon , Nicolas Wolff , Zakir Khan , Elouan Terrien , Sandrine Vitry
IPC分类号： C12Q1/68 , C12N7/00 , C12Q1/70 , G01N33/50
CPC分类号： C12Q1/6883 , C07K14/005 , C07K14/435 , C07K2319/02 , C07K2319/05 , C07K2319/70 , C12N7/00 , C12N2799/027 , C12Q1/70 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/5038 , G01N33/5058 , G01N2333/705
摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
摘要翻译：本发明涉及含有以MAST-2结合域结束的胞质结构域的多肽，11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L ，对人MAST2蛋白的PDZ结构域具有高亲和力的多肽。本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及含有它们的组合物。本发明还涉及多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物在治疗和/或预防疾病，病症或病症中的用途，其改变中枢神经系统（CNS）和/或外周神经系统（PNS）。本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。

3. 发明申请

US20140302123A1 PRODUCTS USEFUL FOR THE TREATMENT OF MALIGNANT NEOPLASMS OF THE HUMAN NERVOUS SYSTEM 有权
标题翻译：用于治疗人神经系统恶性肿瘤的产品
公开(公告)号：US20140302123A1
公开(公告)日：2014-10-09
申请号：US14350005
申请日：2012-10-11
申请人： Institut Pasteur , Universite Pierre Et Marie Curie (Paris 6) , Centre National de la Recherche Scientifique
发明人： Nicolas Wolfe , Monique Lafon , Nicolas Babault
IPC分类号： C07K7/08 , A61K9/127 , A61K45/06 , A61K38/10
CPC分类号： C07K7/08 , A61K9/127 , A61K38/10 , A61K45/06 , C07K14/005 , C07K14/705 , C12N2760/20122 , C12N2760/20133
摘要： The application provides products, which may trigger pro-apoptotic or pro-death effects on neoplastic cells and/or tissues of the human nervous system, more particularly on neoplastic cells and/or tissues of the human CNS. The products of the application can be used as anti-proliferative or tumoricid agents in the treatment and/or palliation and/or prevention of neoplasms of the human nervous system, more particularly of glioblastoma or brain stem glioma. Therefore, the application also relates to compositions, such as pharmaceutical compositions or drugs, which comprise at least one of said products, as well as to the biotechnological and medical applications of said products and compositions.
摘要翻译：该应用提供的产品可以触发对人类神经系统的肿瘤细胞和/或组织的促凋亡或死亡作用，更特别地涉及人CNS的肿瘤细胞和/或组织。该应用的产品可用作抗增殖剂或肿瘤剂，用于治疗和/或缓解和/或预防人类神经系统肿瘤，尤其是胶质母细胞瘤或脑干胶质瘤。因此，本申请还涉及包含至少一种所述产品的组合物，例如药物组合物或药物，以及所述产品和组合物的生物技术和医学应用。

4. 发明授权

US10227653B2 High MAST2-affinity polypeptides and uses thereof 有权
公开(公告)号：US10227653B2
公开(公告)日：2019-03-12
申请号：US15265172
申请日：2016-09-14
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
发明人： Christophe Prehaud , Monique Lafon , Nicolas Wolff , Zakir Khan , Elouan Terrien , Sandrine Vitry
IPC分类号： G01N33/50 , C12N7/00 , C12Q1/6883 , C07K14/435 , C07K14/005 , C12Q1/70
摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.

5. 发明申请

US20140315822A1 HIGH MAST2-AFFINITY POLYPEPTIDES AND USES THEREOF 有权
标题翻译：高MAST2-AFFINITY多聚体及其用途
公开(公告)号：US20140315822A1
公开(公告)日：2014-10-23
申请号：US14356543
申请日：2012-11-07
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNVERSITE PIERRE ET MARIE CURIE
发明人： Christophe Prehaud , Monique Lafon , Nicolas Wolff , Zakir Khan , Elouan Terrien , Sandrine Vitry
IPC分类号： C07K14/435 , G01N33/50
CPC分类号： C12Q1/6883 , C07K14/005 , C07K14/435 , C07K2319/02 , C07K2319/05 , C07K2319/70 , C12N7/00 , C12N2799/027 , C12Q1/70 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/5038 , G01N33/5058 , G01N2333/705
摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
摘要翻译：本发明涉及含有以MAST-2结合域结束的胞质结构域的多肽，11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L 所述多肽对人MAST2蛋白的PDZ结构域具有高亲和力。本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及包含其的组合物。本发明还涉及使用所述多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物来治疗和/或预防疾病，病症或病症，其改变中枢神经系统（CNS）和/或外周神经系统（PNS）。本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。

6. 发明授权

US11339211B2 Nanobodies suitable for neuron regeneration therapy 有权
公开(公告)号：US11339211B2
公开(公告)日：2022-05-24
申请号：US16839009
申请日：2020-04-02
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Christophe Prehaud , Monique Lafon , Pierre Lafaye
IPC分类号： C07K16/18 , A61K39/395 , A61K47/68 , A61K39/00
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).

7. 发明授权

US09475851B2 High MAST2-affinity polypeptides and uses thereof 有权
标题翻译：高MAST2亲和力多肽及其用途
公开(公告)号：US09475851B2
公开(公告)日：2016-10-25
申请号：US14356543
申请日：2012-11-07
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNVERSITE PIERRE ET MARIE CURIE (PARIS 6)
发明人： Christophe Prehaud , Monique Lafon , Nicolas Wolff , Zakir Khan , Elouan Terrien , Sandrine Vitry
IPC分类号： C07K14/435 , C12Q1/68 , G01N33/50 , C07K14/005
CPC分类号： C12Q1/6883 , C07K14/005 , C07K14/435 , C07K2319/02 , C07K2319/05 , C07K2319/70 , C12N7/00 , C12N2799/027 , C12Q1/70 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/5038 , G01N33/5058 , G01N2333/705
摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
摘要翻译：本发明涉及含有以MAST-2结合域结束的胞质结构域的多肽，11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L ，对人MAST2蛋白的PDZ结构域具有高亲和力的多肽。本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及含有它们的组合物。本发明还涉及多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物在治疗和/或预防疾病，病症或病症中的用途，其改变中枢神经系统（CNS）和/或外周神经系统（PNS）。本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。

8. 发明授权

US10640552B2 Nanobodies suitable for neuron regeneration therapy 有权
公开(公告)号：US10640552B2
公开(公告)日：2020-05-05
申请号：US15508486
申请日：2015-09-09
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Christophe Prehaud , Monique Lafon , Pierre Lafaye
IPC分类号： C07K16/18 , A61K39/395 , A61K47/68 , A61K39/00
CPC分类号： C07K16/18 , A61K39/0007 , A61K47/6843 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/22 , C07K2319/33 , C12N2760/20122
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e.g. neurons, astrocytes and microglial cells).

9. 发明授权

US09249194B2 Neuron generation, regeneration and protection 有权
标题翻译：神经元生成，再生和保护
公开(公告)号：US09249194B2
公开(公告)日：2016-02-02
申请号：US14312048
申请日：2014-06-23
申请人： INSTITUT PASTEUR , THOMAS JEFFERSON UNIVERSITY
发明人： Christophe Prehaud , Monique Lafon , Matthias Johannes Schnell
IPC分类号： A61K38/16 , C07K14/005 , A61K35/766 , A61K35/13 , A61K38/00
CPC分类号： C07K14/005 , A61K35/13 , A61K35/766 , A61K38/00 , A61K38/162 , C12N2760/20122 , Y02A50/465
摘要： The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of the non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides methods for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.
摘要翻译：本发明证明，与凋亡性狂犬病病毒G蛋白相反，某些非凋亡性狂犬病病毒G蛋白，如CVS-NIV菌株的G蛋白具有神经突增生促进作用。本发明进一步表明，这种神经突增生促进作用是由于非凋亡性狂犬病病毒G蛋白的细胞质尾部，更特别是其与PDZ-BS的细胞质尾部相比，其与凋亡性狂犬病病毒G 蛋白质。本发明提供了用于诱导和/或刺激神经突生长的方法，其可用于诱导神经元分化，例如用于治疗神经系统的肿瘤，以及再生受损的神经元，例如用于治疗神经变性疾病，病症或状况，或治疗微生物感染，或保护神经元免受神经毒性物质或氧化应激。

10. 发明授权

US10591466B2 In vitro blood-brain barrier model 有权
公开(公告)号：US10591466B2
公开(公告)日：2020-03-17
申请号：US15508488
申请日：2015-09-09
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
发明人： Christophe Prehaud , Monique Lafon , Pierre-Emmanuel Ceccaldi , Philippe Afonso , Pierre Lafaye
IPC分类号： G01N33/50 , C12N5/079 , C12M1/00 , C12M1/12 , C12N5/071 , C12M3/00
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).

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