专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09820986B2 Glycopeptide compositions 有权
公开(公告)号：US09820986B2
公开(公告)日：2017-11-21
申请号：US11071975
申请日：2005-03-04
申请人： I-Chien Wei , David J. Yang , Dong-Fang Yu
发明人： I-Chien Wei , David J. Yang , Dong-Fang Yu
IPC分类号： A61K31/505 , A61K31/66 , A61K51/02
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.

2. 发明申请

US20110087003A1 GLYCOPEPTIDE COMPOSITIONS 审中-公开
标题翻译：糖精组合物
公开(公告)号：US20110087003A1
公开(公告)日：2011-04-14
申请号：US12970026
申请日：2010-12-16
申请人： I-Chien Wei , David J. Yang , Dong-Fang Yu
发明人： I-Chien Wei , David J. Yang , Dong-Fang Yu
IPC分类号： C07K2/00 , C07K1/113
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译：本发明包括具有糖苷和通过酰胺键共价键合的肽的糖肽。糖肽还可以包括与糖肽结合的诊断或治疗剂。诸如放射性核素的金属也可以与糖肽螯合。本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的壳聚糖制成的糖肽。与糖肽缀合的诊断剂可以促进成像。可以与糖肽结合的特异性治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。一些药剂如放射性核素可能具有诊断和治疗作用。糖肽可以通过在碳二亚胺和酸基活化剂的存在下组合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。

3. 发明申请

US20080300389A1 Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy 审中-公开
标题翻译：金属 - 多糖共轭物：用于癌症治疗的组合物，合成和方法
公开(公告)号：US20080300389A1
公开(公告)日：2008-12-04
申请号：US12009421
申请日：2008-01-18
申请人： David J. Yang , Dong-Fang Yu , I-Chien Wei
发明人： David J. Yang , Dong-Fang Yu , I-Chien Wei
IPC分类号： C07H15/00
CPC分类号： A61K33/24 , A61K31/282 , A61K47/61
摘要： The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid.
摘要翻译：在一个实施方案中，本公开内容包括多糖缀合物。该缀合物具有多糖和至少一个与多糖共价结合的具有O-基团的单体氨基酸。缀合物还具有至少一种由氨基酸的O-基缀合的金属。根据另一个实施方案，本公开提供了通过将具有O-基团的单体氨基酸与多糖共价键合并通过将金属与O基团缀合以形成多糖缀合物来合成多糖缀合物的方法。根据第三实施方案，本公开涉及通过向细胞施用有效量的多糖缀合物来杀死癌细胞的方法。该缀合物具有多糖和至少一个与多糖共价结合的具有O-基团的单体氨基酸。缀合物还具有至少一种由氨基酸的O-基缀合的金属。

4. 发明申请

US20060198786A1 Glycopeptide compositions 有权
标题翻译：糖肽组合物
公开(公告)号：US20060198786A1
公开(公告)日：2006-09-07
申请号：US11071975
申请日：2005-03-04
申请人： I-Chien Wei , David Yang , Dong-Fang Yu
发明人： I-Chien Wei , David Yang , Dong-Fang Yu
IPC分类号： A61K51/00 , C07K9/00
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译：本发明包括具有糖苷和通过酰胺键共价结合的肽的糖肽。糖肽还可以包括与糖肽结合的诊断或治疗剂。诸如放射性核素的金属也可以与糖肽螯合。本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的壳聚糖制成的糖肽。与糖肽缀合的诊断剂可以促进成像。可以与糖肽结合的特异性治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。一些药剂如放射性核素可能具有诊断和治疗作用。糖肽可以通过在碳二亚胺和酸基活化剂的存在下组合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。

5. 发明授权

US07611693B2 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US07611693B2
公开(公告)日：2009-11-03
申请号：US10942615
申请日：2004-09-16
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K49/00
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

6. 发明授权

US06884817B2 Water soluble paclitaxel derivatives 有权
标题翻译：水溶性紫杉醇衍生物
公开(公告)号：US06884817B2
公开(公告)日：2005-04-26
申请号：US10146809
申请日：2002-05-17
申请人： Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
发明人： Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号： A61K31/337 , A61K41/00 , A61K47/48 , A61K51/04 , A61K51/08 , A61L31/10 , A61L31/16 , C08G73/10 , A61N43/02 , A61K31/30 , A61K33/24 , A61N37/00 , A61N55/02
CPC分类号： A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要： Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
摘要翻译：公开了通过将紫杉醇或多西他赛与水溶性聚合物如聚谷氨酸，聚天冬氨酸或聚赖氨酸缀合而形成的紫杉醇和多西他赛的水溶性组合物。还公开了使用组合物治疗肿瘤，自身免疫疾病如类风湿性关节炎的方法。其他实施方案包括用于预防再狭窄的可植入支架的涂层。

7. 发明授权

US08758723B2 Compositions and methods for cellular imaging and therapy 有权
标题翻译：细胞成像和治疗的组合和方法
公开(公告)号：US08758723B2
公开(公告)日：2014-06-24
申请号：US11737694
申请日：2007-04-19
申请人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
发明人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
IPC分类号： A61K51/00 , A61B5/055
CPC分类号： C07F13/005 , A61K47/547 , A61K51/0474 , A61K51/0491
摘要： The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
摘要翻译：本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N4化合物和衍生物的成像，试剂盒和成像和治疗方法。

8. 发明申请

US20130165631A1 BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS 审中-公开
标题翻译：双嘧磺隆对齐配体结合物和组合物
公开(公告)号：US20130165631A1
公开(公告)日：2013-06-27
申请号：US13552414
申请日：2012-07-18
申请人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
发明人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
IPC分类号： A61K51/04 , A61K51/08
CPC分类号： A61K51/0497 , A61K51/0453 , A61K51/0459 , A61K51/0491 , A61K51/087 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
摘要翻译：本发明在一般意义上提供了采用与乙二酸半胱氨酸（EC）螯合的99mTc的新标记策略。 EC与多种配体缀合并螯合至99mTc，用作组织特异性疾病的显像剂。本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。还提供了用于组织特异性疾病成像的试剂盒。

9. 发明授权

US08236279B2 Bisaminoethanethiol-targeting ligand conjugates and compositions 有权
标题翻译：双氨基乙硫醇靶向配体缀合物和组合物
公开(公告)号：US08236279B2
公开(公告)日：2012-08-07
申请号：US12563724
申请日：2009-09-21
申请人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
发明人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0497 , A61K51/0453 , A61K51/0459 , A61K51/0491 , A61K51/087 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
摘要翻译：本发明在一般意义上提供了采用与乙二酸半胱氨酸（EC）螯合的99mTc的新标记策略。 EC与多种配体缀合并螯合至99mTc，用作组织特异性疾病的显像剂。本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。还提供了用于组织特异性疾病成像的试剂盒。

10. 发明授权

US07067111B1 Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging 有权
标题翻译：亚乙基半胱氨酸（EC） - 药物共轭物，组织特异性疾病成像的组合物和方法
公开(公告)号：US07067111B1
公开(公告)日：2006-06-27
申请号：US09599152
申请日：2000-06-21
申请人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
发明人： David J. Yang , Chun W. Liu , Dong-Fang Yu , E. Edmund Kim
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , A61K51/04 , A61K51/0478 , A61K51/0491 , A61K51/0497 , A61K51/087
摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
摘要翻译：本发明在一般意义上提供了采用与乙二
氨酸（EC）螯合的99m Tc的新标记策略。 EC与各种配体缀合并螯合至99m Tc以用作组织特异性疾病的显像剂。本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。还提供了用于组织特异性疾病成像的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式