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    • 1. 发明授权
    • Apparatus and method for inspecting pipelines
    • 管道检查装置及方法
    • US09404773B2
    • 2016-08-02
    • US14131584
    • 2012-07-13
    • Hyun Young ChangDong Wook KimHeung Bae ParkSang Heon Lee
    • Hyun Young ChangDong Wook KimHeung Bae ParkSang Heon Lee
    • G01D11/30G21C17/017G01N21/952F17D5/00
    • G01D11/30F17D5/00G01N21/952G21C17/017
    • Apparatus and method for inspecting pipeline are provided. The pipeline inspecting apparatus moving along an external circumferential surface of a pipeline to inspect the pipeline, includes: a main frame having an arc shape having an opened portion to surround the pipeline; a main movement unit that is movably installed on the main frame, wherein the main movement unit is movably installed along a length direction of the pipeline while being in contact with the external circumferential surface of the pipeline; an auxiliary frame that has an arc shape having an opened portion to surround the pipeline and is separated from the main frame to face the main frame; an auxiliary frame adjusting unit that movably connects the auxiliary frame to the main movement unit in a circumferential direction of the pipeline; and a sensor adjusting unit that is fixed to the auxiliary frame, wherein a sensor for inspecting a state of the pipeline is installed.
    • 提供了检查管道的设备和方法。 管道检查装置沿着管道的外周表面移动以检查管道,包括:具有弧形的主框架,其具有围绕管道的开口部分; 主移动单元,可移动地安装在主框架上,其中主移动单元沿着管道的长度方向可移动地安装在与管道的外周面接触的同时; 辅助框架,其具有圆弧形状,具有围绕所述管道的开口部分,并且与所述主框架分离以面对所述主框架; 辅助框架调节单元,其沿着管道的圆周方向将辅助框架可移动地连接到主移动单元; 以及传感器调节单元,其固定到所述辅助框架,其中安装有用于检查所述管道的状态的传感器。
    • 9. 发明申请
    • OXALIPLATIN NANOPARTICLES AND METHOD FOR PREPARING SAME
    • OXALIPLATIN纳米颗粒及其制备方法
    • US20120177728A1
    • 2012-07-12
    • US13497208
    • 2010-09-20
    • Sung Jae LeeYoung Hoon KimSang Heon LeeKab Sig Kim
    • Sung Jae LeeYoung Hoon KimSang Heon LeeKab Sig Kim
    • A61K31/282A61K9/48B32B5/16A61K9/00A61P35/00B82Y40/00B82Y5/00
    • A61K9/146A61K9/0095A61K9/10A61K9/2027A61K9/4866A61K31/555A61K47/38Y10T428/2982
    • The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost. Since the oxaliplatin nanoparticle can be prepared economically using a relatively inexpensive supercritical fluid producing facility, it can be prepared via a simple process with high yield in commercial scale.
    • 本发明涉及奥沙利铂的纳米粒子,其为水溶性活性物质,含有该纳米粒子的药物组合物,以及通过乳化脂质混合溶液制备口服奥沙利铂纳米粒子的方法,其中固体脂质和表面活性剂为 在其中混合奥沙利铂和特定共溶剂的混合物水溶液中混合,然后使用超临界流体气体除去固体脂质和助溶剂。 通过提供目前仅以注射用于肠胃外给药的奥沙利铂作为纳米颗粒的形式,本发明允许开发对胃酸稳定的可口服奥沙利铂,并且具有改善的生物利用度,从而通过 避免注射带来的不便,大大降低医疗成本。 由于奥沙利铂纳米颗粒可以使用相对便宜的超临界流体生产设备经济地制备,所以可以通过工业规模的高产率的简单方法制备。