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1. 发明申请

US20100255069A1 COMPOSITIONS AND METHODS FOR TREATING ANGIOGENESIS-RELATED DISEASES, WOUNDS AND COSMETIC USE OF COMPONENTS OF ANGELICA SINENSIS, AND METHODS OF PREPARATION THEREOF 有权
标题翻译：用于治疗血管发生相关疾病的组合物和方法，天然成分组分的成分和化妆品用途及其制备方法
公开(公告)号：US20100255069A1
公开(公告)日：2010-10-07
申请号：US12758863
申请日：2010-04-13
申请人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
发明人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
IPC分类号： A61K9/70 , A61K36/232 , A61K8/97 , A61P17/02 , A61Q19/00 , A61K38/43 , A61K31/79 , A61P31/00 , A61P29/00
CPC分类号： A61K36/232 , A61K9/0014 , A61K9/06 , A61K38/18 , A61K47/38 , A61K2300/00
摘要： Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from Angelica sinensis, or a fraction or a lyophilizate thereof, or one or more active component contained in said extract.
摘要翻译：公开了用于治疗哺乳动物血管生成相关疾病和皮肤护理的组合物和方法，其包括作为活性药剂的有效量的当归纯化提取物或其一部分或冻干物，或一种或多种活性成分包含在所述提取物中。

2. 发明申请

US20100291185A1 THERITOL PHOSPHATES, SALTS THEREOF AND METHODS OF USE 有权
标题翻译： THERITOL磷酸盐，其盐及其使用方法
公开(公告)号：US20100291185A1
公开(公告)日：2010-11-18
申请号：US12620138
申请日：2009-11-17
申请人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
发明人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
IPC分类号： A61K31/661 , C07F9/09 , A61K8/55 , A61K31/6615 , A61K9/00 , A61K9/50 , A61K9/70 , A61Q17/04 , A61P17/02 , A61P19/00 , A61Q19/00
CPC分类号： C07F9/098 , A61K8/55 , A61K31/661 , A61K31/6615 , A61L15/20 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07F9/091
摘要： This application discloses compositions containing synthetic threitol phosphates, in particular threitol monophosphate, threitol-bis-phosphate, threitol diphosphate, and/or threitol triphosphate. The threitol phosphates are useful in treating wounds, for cosmetic applications, and for bone and periodontal regeneration.
摘要翻译：本申请公开了含有合成的苏糖醇磷酸盐，特别是苏糖醇单磷酸盐，苏糖醇 - 双磷酸盐，苏糖醇二磷酸盐和/或苏糖醇三磷酸盐的组合物。磷酸铁铵可用于治疗伤口，用于化妆品应用，以及用于骨骼和牙周再生。

3. 发明申请

US20060068032A1 Compositions and methods for treating angiogenesis-related diseases, wounds and cosmetic use of components of Angelica sinensis, and methods of preparation thereof 审中-公开
标题翻译：用于治疗血管新生相关疾病的组合物和方法，当归的组分的伤口和美容使用及其制备方法
公开(公告)号：US20060068032A1
公开(公告)日：2006-03-30
申请号：US10948590
申请日：2004-09-24
申请人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
发明人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
IPC分类号： A61K36/232 , A61K38/18
CPC分类号： A61K36/232 , A61K9/0014 , A61K9/06 , A61K38/18 , A61K47/38 , A61K2300/00
摘要： Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from Angelica sinensis, or a fraction or a lyophilizate thereof, or one or more active component contained in said extract.
摘要翻译：公开了用于治疗哺乳动物血管生成相关疾病和皮肤护理的组合物和方法，其包括作为活性药剂的有效量的当归纯化提取物或其一部分或冻干物，或一种或多种活性成分包含在所述提取物中。

4. 发明授权

US08236784B2 Composition comprising threitol phosphate and salts thereof 有权
标题翻译：含有苏糖醇磷酸盐及其盐的组合物
公开(公告)号：US08236784B2
公开(公告)日：2012-08-07
申请号：US12620138
申请日：2009-11-17
申请人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
发明人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
IPC分类号： A61K31/66 , A61K31/6615 , A61K8/55 , C07F9/09 , A61P17/00 , A61P19/00 , A61Q11/00 , A61Q19/00 , A61Q19/08
CPC分类号： C07F9/098 , A61K8/55 , A61K31/661 , A61K31/6615 , A61L15/20 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07F9/091
摘要： This application discloses compositions containing synthetic threitol phosphates, in particular threitol monophosphate, threitol-bis-phosphate, threitol diphosphate, and/or threitol triphosphate. The threitol phosphates are useful in treating wounds, for cosmetic applications, and for bone and periodontal regeneration.
摘要翻译：本申请公开了含有合成的苏糖醇磷酸盐，特别是苏糖醇单磷酸盐，苏糖醇 - 双磷酸盐，苏糖醇二磷酸盐和/或苏糖醇三磷酸盐的组合物。磷酸铁铵可用于治疗伤口，用于化妆品应用，以及用于骨骼和牙周再生。

5. 发明授权

US07927634B2 Compositions and methods for treating angiogenesis-related diseases, wounds and cosmetic use of components of Angelica sinensis, and methods of preparation thereof 有权
标题翻译：用于治疗血管新生相关疾病的组合物和方法，当归的组分的伤口和美容使用及其制备方法
公开(公告)号：US07927634B2
公开(公告)日：2011-04-19
申请号：US12758863
申请日：2010-04-13
申请人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
发明人： Hui Zhao , Krzysztof Bojanowski , Fariba Aria , Reza Mortezaei
IPC分类号： A61K36/00 , A61L15/16
CPC分类号： A61K36/232 , A61K9/0014 , A61K9/06 , A61K38/18 , A61K47/38 , A61K2300/00
摘要： Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from Angelica sinensis, or a fraction or a lyophilizate thereof, or one or more active component contained in said extract.
摘要翻译：公开了用于治疗哺乳动物血管生成相关疾病和皮肤护理的组合物和方法，其包括作为活性药剂的有效量的当归纯化提取物或其一部分或冻干物，或一种或多种活性成分包含在所述提取物中。

6. 发明授权

US5430196A Preparation of 19-nor vitamin D compounds 失效
标题翻译： 19-维生素D化合物的制备
公开(公告)号：US5430196A
公开(公告)日：1995-07-04
申请号：US302399
申请日：1994-09-08
申请人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
发明人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
IPC分类号： C07C29/17 , C07C35/17 , C07C35/27 , C07C401/00 , C07F7/18 , C07C43/02 , C07C35/24
CPC分类号： C07F7/1856 , C07C401/00 , Y02P20/55
摘要： A synthesis of 1.alpha.-hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring potions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.
摘要翻译： 1α-羟基-19-去甲维生素D化合物的合成包括（a）通过将期望的最终产物的环A和环-C / D部分连接而构建5,8-二醇-6-中间体通过含有所需最终产物的C / D环部分的炔属衍生物与代表期望最终产物的A环的环状二羟基酮缩合; （b）部分还原A和C / D环部分之间的6,7炔基三键键，得到5,8-二醇-6-烯中间体; 或（c）还原去除5,8-氧官能团以产生所需的5,7-二烯最终产物，从其中直接纯化所需的7-反式（7E） - 异构体，或在任选的双键异构化使用新的苯硫酚促进异构化步骤的7-顺式（7Z） - 异构体。

7. 发明授权

US5616744A 19-Nor-vitamin D compounds 失效
标题翻译： 19-维生素D化合物
公开(公告)号：US5616744A
公开(公告)日：1997-04-01
申请号：US447795
申请日：1995-05-23
申请人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
发明人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
IPC分类号： C07C29/17 , C07C35/17 , C07C35/27 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , Y02P20/55
摘要： A 19-nor intermediate compound of the formula ##STR1## where R is the sidechain of a vitamin D derivative and where X.sub.1 and X.sub.2 are hydrogen or a hydroxy protecting group. The compounds are used in the preparation of 19-nor-vitamin D end products.
摘要翻译：其中R是维生素D衍生物的侧链，并且其中X 1和X 2是氢或羟基保护基团的19-中间体式的化合物。该化合物用于制备19-维生素D终产物。

8. 发明授权

US5856536A Preparation of 19-Nor-vitamin D compounds 失效
标题翻译： 19-维生素D化合物的制备
公开(公告)号：US5856536A
公开(公告)日：1999-01-05
申请号：US797001
申请日：1997-02-07
申请人： Hector F. Deluca , Heinrich K. Schnoes , Fariba Aria
发明人： Hector F. Deluca , Heinrich K. Schnoes , Fariba Aria
IPC分类号： C07C29/17 , C07C35/17 , C07C35/27 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , Y02P20/55
摘要： Disclosed are 20-epi-19-nor-vitamin D compounds having the structure: ##STR1## where each of X.sub.1 and X.sub.2 independently represents hydrogen or a hydroxy-protecting group, and Z represents various known side chains.
摘要翻译：公开了具有以下结构的20-epi-19-维生素D化合物：其中X 1和X 2各自独立地表示氢或羟基保护基，Z表示各种已知的侧链。

9. 发明授权

US5599958A Preparation of 19-nor vitamin D compounds 失效
标题翻译： 19-维生素D化合物的制备
公开(公告)号：US5599958A
公开(公告)日：1997-02-04
申请号：US448115
申请日：1995-05-23
申请人： Hector F. Deluca , Heinrich K. Schnoes , Fariba Aria
发明人： Hector F. Deluca , Heinrich K. Schnoes , Fariba Aria
IPC分类号： C07C29/17 , C07C35/17 , C07C35/27 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , Y02P20/55
摘要： A synthesis of 1.alpha.-hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring portions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.
摘要翻译： 1α-羟基-19-去甲维生素D化合物的合成包括（a）通过将期望的最终产物的环A和环-C / D部分连接而构建5,8-二醇-6-中间体通过含有所需最终产物的C / D环部分的炔属衍生物与代表期望最终产物的A环的环状二羟基酮缩合; （b）部分还原A和C / D环部分之间的6,7炔基三键键，得到5,8-二醇-6-烯中间体; 或（c）还原去除5,8-氧官能团以产生所需的5,7-二烯最终产物，从其中直接纯化所需的7-反式（7E） - 异构体，或在任选的双键异构化使用新的苯硫酚促进异构化步骤的7-顺式（7Z） - 异构体。

10. 发明授权

US5525745A Intermediates in the preparation of 19-nor vitamin D compounds 失效
标题翻译：中间体制备19-维生素D化合物
公开(公告)号：US5525745A
公开(公告)日：1996-06-11
申请号：US410858
申请日：1995-03-27
申请人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
发明人： Hector F. DeLuca , Heinrich K. Schnoes , Fariba Aria
IPC分类号： C07C29/17 , C07C35/17 , C07C35/27 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , Y02P20/55
摘要： The invention describes intermediates for use in the synthesis of 1.alpha.-hydroxy-19-nor-vitamin D compounds. The intermediates have the following formula: ##STR1## The disclosed process includes (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring portions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.
摘要翻译：本发明描述了用于合成1α-羟基-19-去甲维生素D化合物的中间体。中间体具有以下分子式：所公开的方法包括（a）通过将期望的最终产物的环A和环-C / D部分连接到所述中间体上来构建5,8-二醇-6-中间体含有所需最终产物的C / D环部分的炔属衍生物与表示所需最终产物的A环的环状二羟基酮缩合; （b）部分还原A和C / D环部分之间的6,7炔基三键键，得到5,8-二醇-6-烯中间体; 或（c）还原去除5,8-氧官能团以产生所需的5,7-二烯最终产物，从其中直接纯化所需的7-反式（7E） - 异构体，或在任选的双键异构化使用新的苯硫酚促进异构化步骤的7-顺式（7Z） - 异构体。

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