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1. 发明授权

US08623855B2 Azetidinone compounds and medical use thereof 有权
标题翻译：氮杂环丁酮化合物及其医疗用途
公开(公告)号：US08623855B2
公开(公告)日：2014-01-07
申请号：US13389932
申请日：2010-08-09
申请人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
发明人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
IPC分类号： A01N43/00 , C07D205/00
CPC分类号： A61K31/397 , C07D205/08 , C07D263/26
摘要： Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.
摘要翻译：氮杂环丁酮化合物的制备及其医疗用途由本发明提供。更具体地，式（I）所示的氮杂环丁烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在描述中定义，其制备方法由本发明提供。本发明化合物可以降低血浆中总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，可用作降低血液中胆固醇的药物。因此，本发明的化合物可用于治疗或预防动脉粥样硬化，血管紧张素，心力衰竭，冠状动脉疾病，心血管病，心肌，心绞痛，高脂血症和高胆固醇血症等疾病。式（I）化合物和中间体化合物的制备方法也由本发明提供。

2. 发明申请

US20120208994A1 AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF 有权
标题翻译： AZETIDINONE化合物及其医疗用途
公开(公告)号：US20120208994A1
公开(公告)日：2012-08-16
申请号：US13389932
申请日：2010-08-09
申请人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
发明人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
IPC分类号： C07D205/08 , C07D263/26
CPC分类号： A61K31/397 , C07D205/08 , C07D263/26
摘要： Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.
摘要翻译：氮杂环丁酮化合物的制备及其医疗用途由本发明提供。更具体地，式（I）所示的氮杂环丁烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在描述中定义，其制备方法由本发明提供。本发明化合物可以降低血浆中总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，可用作降低血液中胆固醇的药物。因此，本发明的化合物可用于治疗或预防动脉粥样硬化，血管紧张素，心力衰竭，冠状动脉疾病，心血管病，心肌，心绞痛，高脂血症和高胆固醇血症等疾病。式（I）化合物和中间体化合物的制备方法也由本发明提供。

3. 发明授权

US09350454B2 Multi-laser transmitter optical subassembly 有权
标题翻译：多激光发射机光学组件
公开(公告)号：US09350454B2
公开(公告)日：2016-05-24
申请号：US13011741
申请日：2011-01-21
申请人： Xiaojie Xu , Bernd Huebner
发明人： Xiaojie Xu , Bernd Huebner
IPC分类号： H04B10/00 , G02B27/10 , H04B10/50 , G02B6/42 , G02B6/293 , H01S5/40
CPC分类号： H04B10/506 , G02B6/29367 , G02B6/4215 , H01S5/4012
摘要： Multi-laser transmitter optical subassembly (TOSA). In one example embodiment, a method of fabricating a multi-laser TOSA includes various acts. First, first and second optical signals are transmitted from first and second lasers, respectively. Next, the angle of a first collimating lens is actively adjusted to cause the second optical signal to be aligned with the first optical signal as the first optical signal passes through a first filter and as the second optical signal is reflected by the first filter such that the first and second optical signals are aligned and combined.
摘要翻译：多激光发射机光学组件（TOSA）。在一个示例性实施例中，制造多激光TOSA的方法包括各种动作。首先，第一和第二光信号分别从第一和第二激光器发射。接下来，当第一光信号通过第一滤光器时，主动调整第一准直透镜的角度，使得第二光信号与第一光信号对准，并且由于第二光信号被第一滤光器反射，使得第一和第二光信号被对准并组合。

4. 发明授权

US07801442B2 Redundant channel implementation to extend optical transceiver lifetime and reliability 有权
标题翻译：冗余通道实现，延长光收发器的使用寿命和可靠性
公开(公告)号：US07801442B2
公开(公告)日：2010-09-21
申请号：US11648491
申请日：2006-12-28
申请人： Frank Wang , Darren Crews , Lee Xu , Graham Flower , Miaobin Gao , Chien-Chang Liu , Jesse Chin , Brian Kim , William Wang , Guobin Liu , Xiaojie Xu , Thiri Lwin , Yousheng Wu , Simon Lee, II
发明人： Frank Wang , Darren Crews , Lee Xu , Graham Flower , Miaobin Gao , Chien-Chang Liu , Jesse Chin , Brian Kim , William Wang , Guobin Liu , Xiaojie Xu , Thiri Lwin , Yousheng Wu , Simon Lee, II
IPC分类号： G02F1/00
CPC分类号： H04B10/40 , H04B10/032
摘要： Embodiments introduce redundant optical channels to significantly extend the lifetime of parallel optical transceivers. A plurality of transmitters, N, transmit on a plurality of optical channels, where N is an integer number of optical channels greater than 1. One or more redundant channels, M, are also provided. N+M multiple input shift registers provide multiple paths for signals from each of the transmitters to connect to N+M laser diodes. In the event up to M of the N+M laser diodes fail, the multiple input shift registers connect the N transmitters to functioning ones of the N+M laser diodes thus extending the life of the device. A corresponding scheme is also described for the receiver side.
摘要翻译：实施例引入冗余光通道以显着延长并行光收发器的寿命。多个发射机N在多个光信道上发射，其中N是大于1的整数个光信道。还提供了一个或多个冗余信道M。 N + M多输入移位寄存器为来自每个发射器的信号提供多个路径，以连接到N + M个激光二极管。在N + M个激光二极管的M个失效的情况下，多个输入移位寄存器将N个发射器连接到N + M个激光二极管的功能，从而延长了器件的使用寿命。还针对接收机侧描述了相应的方案。

5. 发明授权

US06891994B2 Micro optical design for DWDM interleavers with narrow channel spacing 失效
标题翻译：具有窄通道间隔的DWDM交织器的微光学设计
公开(公告)号：US06891994B2
公开(公告)日：2005-05-10
申请号：US10274728
申请日：2002-10-21
申请人： Xiaojie Xu , Kenneth A. Fesler , Kaine Mildenberger
发明人： Xiaojie Xu , Kenneth A. Fesler , Kaine Mildenberger
IPC分类号： G02B6/28 , G02B6/34 , G02B27/14
CPC分类号： G02B6/29386 , G02B6/2817 , G02B6/2935 , G02B6/29398 , G02B27/144 , G02B27/145
摘要： A device includes a first fiber collimator, a second fiber collimator, a third fiber collimator, a first beam splitting prism, a second beam splitting prism, a spacer, a resonator cube, and a dielectric beam splitting coating. The dielectric beam splitting coating separates the second beam splitting prism from the resonator cube. The spacer and the first fiber collimator straddle the first beam splitting prism. The first beam splitting prism and the second beam splitting prism straddle the spacer. The second fiber collimator and the spacer straddle the second beam splitting prism. The third fiber collimator and the spacer straddle the second beam splitting prism.
摘要翻译：一种器件包括第一光纤准直器，第二光纤准直器，第三光纤准直器，第一分束棱镜，第二分束棱镜，间隔物，谐振器立方体和介质光束分裂涂层。介质分束涂层将第二分束棱镜与共振器立方体分开。间隔件和第一光纤准直器跨越第一分束棱镜。第一分束棱镜和第二分束棱镜跨越间隔件。第二光纤准直仪和间隔物跨越第二分束棱镜。第三光纤准直器和间隔物跨越第二分束棱镜。

6. 发明授权

US06871022B2 Cascaded optical multiplexer 失效
标题翻译：级联光复用器
公开(公告)号：US06871022B2
公开(公告)日：2005-03-22
申请号：US09952286
申请日：2001-09-14
申请人： Xiaojie Xu
发明人： Xiaojie Xu
IPC分类号： G02B6/28 , G02B6/34 , H04J14/00
CPC分类号： G02B6/29386 , G02B6/2861 , G02B6/2935
摘要： Methods and apparatus for multiplexing and demultiplexing optical signals. An interleaver having a modified Mach-Zehnder interferometer as a first stage is used as a wavelength division multiplexer. This first stage is combined with one or more cascaded stages, each having a beam splitter and an optical delay element. A light beam including a number of signals at different wavelengths is received. The beam is split such that approximately half of each signal is contained in one of two sub-beams. One of the two sub-beams passes through a delay element, which provides a phase shift. The two sub-beams are recombined and split again. Each wavelength adds constructively or destructively in the new sub-beams such that the signals are separated—some wavelengths are in one of the new sub-beams, some are in the other. One of these sub-beams is delayed, and the two are combined and split again, improving the separation.
摘要翻译：用于复用和解复用光信号的方法和装置。具有作为第一级的修正的马赫 - 曾德干涉仪的交织器被用作波分复用器。该第一级与一个或多个级联级组合，每级具有分束器和光学延迟元件。接收包括不同波长的多个信号的光束。光束被分离，使得每个信号的大约一半被包含在两个子光束之一中。两个子光束中的一个通过延迟元件，其提供相移。这两个子光束再次重合并分裂。每个波长在新的子光束中建设性地或相消地增加，使得信号被分离 - 一些波长在新的子光束之一中，一些在另一个中。这些子光束中的一个被延迟，并且两个被再次组合和分离，从而改善了分离。

7. 发明授权

US5630857A Process for manufacturing GRIN lenses by melting a series of layers of frits 失效
标题翻译：通过熔化一系列玻璃料来制造GRIN镜片的工艺
公开(公告)号：US5630857A
公开(公告)日：1997-05-20
申请号：US441275
申请日：1995-05-15
申请人： Xiaojie Xu , Michael E. Savard
发明人： Xiaojie Xu , Michael E. Savard
IPC分类号： C03B19/02 , C03B19/09 , G02B3/00 , C03B19/06
CPC分类号： C03B19/02 , C03B19/09 , G02B3/0087
摘要： A method of manufacturing an optical device having a profile of refractive indices along its optical axis. A desired volume of each of a plurality of types of optical material are dispensed into a mold of known plan area in the form of a frit or a melt and the mold is heated to cause the materials to melt and fuse together to define a contiguous body of optical material having a desired profile. As the optical materials melt, the different types of material separate out so that they are arranged with the most dense material closest to the bottom of the mold and the least dense material closest to the top of the mold. To enhance this effect, the optical materials are layered in the mold in decreasing order of density of the materials from the bottom to the top so that the layers of optical material with the greater densities are closer to the bottom of the mold than the layers of materials with lesser densities.
摘要翻译：具有沿其光轴的折射率分布的光学器件的制造方法。将多种类型的光学材料中的每一种的期望体积分散到玻璃料或熔体形式的已知平面区域的模具中，并且加热模具以使材料熔化并熔合在一起以限定连续体的光学材料具有所需的轮廓。当光学材料熔化时，不同类型的材料分离出来，使得它们布置成最接近模具底部的最致密的材料和最靠近模具顶部的最不致密的材料。为了提高这种效果，光学材料在模具中以从底部到顶部的材料的密度的降低的顺序分层，使得具有更大密度的光学材料层比模具的层更接近模具的底部密度较小的材料

8. 发明授权

US5459613A Lead glass composition series for gradient glasses 失效
标题翻译：铅玻璃组合系列渐变眼镜
公开(公告)号：US5459613A
公开(公告)日：1995-10-17
申请号：US195581
申请日：1993-11-24
申请人： Xiaojie Xu
发明人： Xiaojie Xu
IPC分类号： G02B3/00 , G02B13/20
CPC分类号： G02B3/0087
摘要： A fused glass block having an axial gradient index of refraction profile between two opposed parallel surfaces, with a change in refractive index from one of the surfaces to the other ranging from about 0.04 to 0.47, is provided. The fused glass block has a change in thermal expansion coefficient from one of the surfaces to the other of less than about 3.times.10.sup.-7 .degree.C..sup.-1, has essentially no strain or birefringence therein, and has a smoothly varying refractive index profile from one of the surfaces to the other. The fused glass block is prepared from at least two pre-selected compositions of a lead-silicate glass series that has been discovered to provide the requisite properties.
摘要翻译：提供了一种熔融玻璃块，其具有在两个相对的平行表面之间的折射率分布的轴向梯度折射率，其中从一个表面到另一个表面的折射率的变化范围为约0.04至0.47。熔融玻璃块具有从小于约3×10 -7℃-1的表面之一到另一个的热膨胀系数的变化，其中基本上没有应变或双折射，并且具有从一个的平滑变化的折射率分布的表面到另一个。熔融玻璃块由至少两种预先选择的已被发现提供所需性质的硅酸铅玻璃系列组合物制备。

9. 发明授权

US06277777B1 Boron-free glass composition and filtration media 有权
标题翻译：无硼玻璃组成和过滤介质
公开(公告)号：US06277777B1
公开(公告)日：2001-08-21
申请号：US09366389
申请日：1999-08-03
申请人： Xiaojie Xu , Foster Laverne Harding , Jon Frederick Bauer
发明人： Xiaojie Xu , Foster Laverne Harding , Jon Frederick Bauer
IPC分类号： C03C1300
CPC分类号： B01D39/2017 , C03C3/087 , C03C13/00 , Y10T428/29 , Y10T442/2992
摘要： Novel boron-free glass compositions are described which are particularly suited for making fine diameter glass fibers for HEPA electronic clean-room filtration media using flame-attenuation or rotary glass processing.
摘要翻译：描述了新型无硼玻璃组合物，其特别适用于使用阻燃或旋转玻璃加工制造用于HEPA电子净化室过滤介质的细直径玻璃纤维。

10. 发明授权

US6060644A Isolation and use of cuticular lipid genes 失效
标题翻译：分离和使用角质脂质基因
公开(公告)号：US6060644A
公开(公告)日：2000-05-09
申请号：US581148
申请日：1995-12-29
申请人： Patrick S. Schnable , Donald S. Robertson , Joel D. Hansen , Basil J. Nikolau , Xiaojie Xu , Yiji Xia
发明人： Patrick S. Schnable , Donald S. Robertson , Joel D. Hansen , Basil J. Nikolau , Xiaojie Xu , Yiji Xia
IPC分类号： C07K14/415 , C12N9/00 , C12N9/10 , C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C07K14/415 , C12N15/8247 , C12N15/8279 , C12N9/00 , C12N9/1029
摘要： The present invention relates to cuticular lipid genes, their gene products, and methods of use thereof, for the generation of new plant varieties having novel environmental, disease and pest resistance. In particular, certain isolated or enriched nucleic acids specifying cuticular lipid genes, or portions thereof, are disclosed.
摘要翻译：本发明涉及角质层脂质基因，其基因产物及其使用方法，用于产生具有新型环境，疾病和害虫抗性的新植物品种。特别地，公开了指定角质层脂质基因的某些分离或富集的核酸或其部分。

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