专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08623855B2 Azetidinone compounds and medical use thereof 有权
标题翻译：氮杂环丁酮化合物及其医疗用途
公开(公告)号：US08623855B2
公开(公告)日：2014-01-07
申请号：US13389932
申请日：2010-08-09
申请人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
发明人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
IPC分类号： A01N43/00 , C07D205/00
CPC分类号： A61K31/397 , C07D205/08 , C07D263/26
摘要： Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.
摘要翻译：氮杂环丁酮化合物的制备及其医疗用途由本发明提供。更具体地，式（I）所示的氮杂环丁烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在描述中定义，其制备方法由本发明提供。本发明化合物可以降低血浆中总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，可用作降低血液中胆固醇的药物。因此，本发明的化合物可用于治疗或预防动脉粥样硬化，血管紧张素，心力衰竭，冠状动脉疾病，心血管病，心肌，心绞痛，高脂血症和高胆固醇血症等疾病。式（I）化合物和中间体化合物的制备方法也由本发明提供。

2. 发明申请

US20120208994A1 AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF 有权
标题翻译： AZETIDINONE化合物及其医疗用途
公开(公告)号：US20120208994A1
公开(公告)日：2012-08-16
申请号：US13389932
申请日：2010-08-09
申请人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
发明人： Hua Bai , Xuyang Zhao , Xiaojie Xu , Xiaoyu Liu , Yuncai Zhang , Ying Chen , Xiaohe Zheng , Maojian Gu , Qifeng Zhu , Yong Zhang , Hairong Luo
IPC分类号： C07D205/08 , C07D263/26
CPC分类号： A61K31/397 , C07D205/08 , C07D263/26
摘要： Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.
摘要翻译：氮杂环丁酮化合物的制备及其医疗用途由本发明提供。更具体地，式（I）所示的氮杂环丁烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在描述中定义，其制备方法由本发明提供。本发明化合物可以降低血浆中总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，可用作降低血液中胆固醇的药物。因此，本发明的化合物可用于治疗或预防动脉粥样硬化，血管紧张素，心力衰竭，冠状动脉疾病，心血管病，心肌，心绞痛，高脂血症和高胆固醇血症等疾病。式（I）化合物和中间体化合物的制备方法也由本发明提供。

3. 发明申请

US20130225810A1 BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF 有权
标题翻译：用杀虫剂活性衍生的苯扎明和制备方法及其用途
公开(公告)号：US20130225810A1
公开(公告)日：2013-08-29
申请号：US13883520
申请日：2011-11-03
申请人： Hua Bai , Xuyang Zhao , Yongxiang Gong , Jinqing Zhong , Qifeng Zhu , Xiaoyu Liu , Lifei Liu , Qixian Zhou
发明人： Hua Bai , Xuyang Zhao , Yongxiang Gong , Jinqing Zhong , Qifeng Zhu , Xiaoyu Liu , Lifei Liu , Qixian Zhou
IPC分类号： C07C255/60 , C07D295/192 , C07C233/65
CPC分类号： C07C255/60 , C07C231/02 , C07C233/65 , C07C233/92 , C07C253/30 , C07C255/57 , C07C271/64 , C07D295/192
摘要： Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
摘要翻译：提供式（I）所示的苯甲酰胺衍生物或其药学上可接受的盐及其制备用于治疗癌症的药物的制备方法和用途，其中式（I）的基团定义如说明书所述。

4. 发明授权

US08946478B2 Benzamide derivative with anticancer activity and preparation method and use thereof 有权
标题翻译：具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途
公开(公告)号：US08946478B2
公开(公告)日：2015-02-03
申请号：US13883520
申请日：2011-11-03
申请人： Hua Bai , Xuyang Zhao , Yongxiang Gong , Jinqing Zhong , Qifeng Zhu , Xiaoyu Liu , Lifei Liu , Qixian Zhou
发明人： Hua Bai , Xuyang Zhao , Yongxiang Gong , Jinqing Zhong , Qifeng Zhu , Xiaoyu Liu , Lifei Liu , Qixian Zhou
IPC分类号： C07C255/60 , C07C233/65 , C07D295/192 , C07C231/02 , C07C233/92 , C07C253/30 , C07C255/57 , C07C271/64
CPC分类号： C07C255/60 , C07C231/02 , C07C233/65 , C07C233/92 , C07C253/30 , C07C255/57 , C07C271/64 , C07D295/192
摘要： Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.
摘要翻译：提供式（I）所示的苯甲酰胺衍生物或其药学上可接受的盐及其制备用于治疗癌症的药物的制备方法和用途，其中式（I）的基团定义如说明书所述。

5. 发明授权

US08392187B2 Dynamic pruning for automatic speech recognition 有权
标题翻译：动态修剪自动语音识别
公开(公告)号：US08392187B2
公开(公告)日：2013-03-05
申请号：US12362668
申请日：2009-01-30
申请人： Qifeng Zhu
发明人： Qifeng Zhu
IPC分类号： G10L19/04
CPC分类号： G10L15/083
摘要： Methods, speech recognition systems, and computer readable media are provided that recognize speech using dynamic pruning techniques. A search network is expanded based on a frame from a speech signal, a best hypothesis is determined in the search network, a default beam threshold is modified, and the search network is pruned using the modified beam threshold. The search network may be further pruned based on the search depth of the best hypothesis and/or the average number of frames per state for a search path.
摘要翻译：提供了使用动态修剪技术来识别语音的方法，语音识别系统和计算机可读介质。基于来自语音信号的帧扩展搜索网络，在搜索网络中确定最佳假设，修改默认波束阈值，并且使用修改的波束阈值修剪搜索网络。可以基于搜索路径的最佳假设的搜索深度和/或每个状态的平均帧数来进一步修剪搜索网络。

6. 发明申请

US20070299667A1 SYSTEM AND METHOD FOR REDUCING STORAGE REQUIREMENTS FOR A MODEL CONTAINING MIXED WEIGHTED DISTRIBUTIONS AND AUTOMATIC SPEECH RECOGNITION MODEL INCORPORATING THE SAME 审中-公开
标题翻译：用于减少包含混合加权分布的模型的存储要求的系统和方法以及与之相关的自动语音识别模型
公开(公告)号：US20070299667A1
公开(公告)日：2007-12-27
申请号：US11425746
申请日：2006-06-22
申请人： Lorin P. Netsch , Qifeng Zhu
发明人： Lorin P. Netsch , Qifeng Zhu
IPC分类号： G10L15/06
CPC分类号： G10L15/06 , G10L15/285
摘要： A system for, and method of, generating an acoustic model and a mobile communication device that includes an acoustic model having at least one mixture weight vector generated by the method. In one embodiment, the method includes: (1) generating at least one mixture weight vector, (2) re-ordering elements of the at least one mixture weight vector to yield at least one re-ordered mixture weight vector and (3) vector quantizing the at least one re-ordered mixture weight vector to yield at least one quantized re-ordered mixture weight vector.
摘要翻译：用于生成声学模型和移动通信设备的系统和方法，其包括具有通过该方法生成的至少一个混合权重向量的声学模型。在一个实施例中，该方法包括：（1）产生至少一个混合权重向量，（2）重新排序该至少一个混合权重向量的元素以产生至少一个重新排列的混合权重向量;（3）向量量化所述至少一个重排混合权重向量以产生至少一个量化的重排混合权重向量。

7. 发明申请

US20070260459A1 SYSTEM AND METHOD FOR GENERATING HETEROGENEOUSLY TIED GAUSSIAN MIXTURE MODELS FOR AUTOMATIC SPEECH RECOGNITION ACOUSTIC MODELS 审中-公开
标题翻译：用于生成自动语音识别语音模型的异构高斯混合模型的系统和方法
公开(公告)号：US20070260459A1
公开(公告)日：2007-11-08
申请号：US11381576
申请日：2006-05-04
申请人： Qifeng Zhu
发明人： Qifeng Zhu
IPC分类号： G10L15/04
CPC分类号： G10L15/146
摘要： A system for, and method of, generating an acoustic model and a heterogeneously tied mixture (HTM) acoustic model generated by means of the system and the method. In one embodiment, the system includes: (1) a first tyer configured to employ a first tying structure to tie weighted Gaussian distributions in a first pool to a first group of phones and (2) a second tyer associated with the first tyer and configured to employ a second tying structure to tie weighted Gaussian distributions in a second pool to a second group of phones, the first tying structure differing from the second tying structure, the weighted Gaussian distributions in the first pool being mutually exclusive of the weighted Gaussian distributions in the second pool, at least a criterion distinguishing the first group of phones from the second group of phones. Within each pool, different numbers of Gaussian may be assigned to different phones.
摘要翻译：一种用于生成声学模型和通过系统和方法产生的非均匀混合（HTM）声学模型的系统和方法。在一个实施例中，系统包括：（1）第一倾斜器，其被配置为采用第一捆扎结构将第一池中的加权高斯分布与第一组电话相关联;以及（2）与所述第一倾斜器相关联的第二倾斜器并且被配置使用第二绑定结构将第二池中的加权高斯分布与第二组电话相关联，所述第一绑定结构与第二绑定结构不同，第一池中的加权高斯分布与第一组中的加权高斯分布相互排斥第二池，至少将第一组电话与第二组电话区分开来的标准。在每个池中，可以将不同数量的高斯分配给不同的电话。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式