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1. 发明申请

US20070243180A1 Composition Containing Reduced Coenzyme Q 审中-公开
标题翻译：含有还原型辅酶Q的组合物
公开(公告)号：US20070243180A1
公开(公告)日：2007-10-18
申请号：US10577211
申请日：2004-10-22
申请人： Hozumi Tanaka , Kenji Fujii , Taizo Kawabe
发明人： Hozumi Tanaka , Kenji Fujii , Taizo Kawabe
IPC分类号： A61K31/047 , C07C39/04 , C08B37/16
CPC分类号： A61K9/1652 , A23V2002/00 , A61K31/09 , A23V2250/314
摘要： It is an object of the present invention to provide a reduced coenzyme Q, as a composition capable of being stably stored and, at the same time, soluble in water, which has not been used for industrial application because of its auto oxidation and lipophilic property. A reduced coenzyme Q-containing composition capable of being stored in a refrigerator or at room temperature for a prolonged period of time and of being soluble in water can be prepared by contacting or mixing the reduced coenzyme Q and a cyclodextrin to obtain a clathrated compound or by mixing an antioxidant, the reduced coenzyme Q and the cyclodextrin under an appropriate condition.
摘要翻译：本发明的目的是提供还原型辅酶Q作为能够稳定储存的组合物，并且同时可溶于水，因为其自身氧化和亲油性没有被用于工业应用。可以通过使还原型辅酶Q和环糊精接触或混合来制备能够在冰箱或室温下长时间储存并且可溶于水的还原型辅酶Q组合物，以获得包合的化合物或通过在适当的条件下混合抗氧化剂，还原型辅酶Q和环糊精。

2. 发明授权

US5294643A Cinnamamide derivative 失效
标题翻译：肉桂酰胺衍生物
公开(公告)号：US5294643A
公开(公告)日：1994-03-15
申请号：US548121
申请日：1990-07-05
申请人： Yoshihide Fuse , Kenji Fujii , Keiji Kameyama , Taizo Kawabe , Toshiaki Miwa , Ikuo Katsumi
发明人： Yoshihide Fuse , Kenji Fujii , Keiji Kameyama , Taizo Kawabe , Toshiaki Miwa , Ikuo Katsumi
IPC分类号： C07C235/34 , C07C235/36 , C07C235/88 , C07C237/22 , C07C243/34 , C07C255/29 , C07C255/44 , C07C271/12 , C07C323/41 , C07C323/52 , C07D207/09 , C07D209/14 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/74 , C07D213/79 , C07D213/81 , C07D233/84 , C07D235/28 , C07D239/38 , C07D277/46 , C07D295/135 , C07D295/185 , C07D307/33 , C07D333/20 , C07D521/00 , A61K31/165 , C07C233/11
CPC分类号： C07D213/40 , C07C235/34 , C07C235/36 , C07C235/88 , C07C237/22 , C07C243/34 , C07C255/29 , C07C255/44 , C07C271/12 , C07C323/41 , C07C323/52 , C07D207/09 , C07D209/14 , C07D211/60 , C07D211/62 , C07D213/70 , C07D213/74 , C07D213/79 , C07D213/81 , C07D231/12 , C07D233/56 , C07D233/84 , C07D235/28 , C07D239/38 , C07D249/08 , C07D277/46 , C07D295/135 , C07D295/185 , C07D307/33 , C07D333/20 , C07C2102/08 , C07C2102/10
摘要： Novel cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.
摘要翻译：提供了新颖的肉桂酰胺衍生物及其盐。还提供了抗高脂血症组合物。该组合物包含选自上述肉桂酰胺衍生物和其药学上可接受的盐中的至少一种的活性成分。

3. 发明申请

US20060073131A1 Coenzyme Q compositions persisting in blood 有权
标题翻译：辅酶Q组合物持续存在血液
公开(公告)号：US20060073131A1
公开(公告)日：2006-04-06
申请号：US11085181
申请日：2005-03-22
申请人： Kenji Fujii , Taizo Kawabe , Hiroshi Kubo
发明人： Kenji Fujii , Taizo Kawabe , Hiroshi Kubo
IPC分类号： A61K38/43 , A61K31/12
CPC分类号： A61K31/122 , Y10S514/824 , Y10S514/878 , Y10S514/879
摘要： The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals. By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.
摘要翻译：本发明的目的是提供一种维持血液辅酶Q浓度在血液中长时间保持的组合物，以确保达到辅酶Q的效果，其可以预期表现出优异的效果维持人类和动物的健康。通过使用包含还原型辅酶Q和还原型辅酶Q的还原型辅酶Q与整个辅酶Q的比例大于95重量％的辅酶Q的混合物的组合物，本发明可以达到高辅酶Q的最大血液浓度以及血液中长时间维持高浓度辅酶Q长时间，血液浓度曲线下面积（AUC）可以扩大。

4. 发明授权

US06939897B2 Method and composition for inhibiting arteriosclerosis 有权
标题翻译：抑制动脉硬化的方法和组合物
公开(公告)号：US06939897B2
公开(公告)日：2005-09-06
申请号：US10892164
申请日：2004-07-16
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/05 , A61K45/00 , A61K45/06 , A61P9/10 , A61P43/00 , A61K31/12 , A61K31/35 , A61K31/405
CPC分类号： A61K45/06 , A61K31/09 , A61K31/22 , A61K2300/00
摘要： The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.
摘要翻译：本发明的目的是提供一种方法和组合物，其通过使用抗高脂血症或降胆固醇药物抑制血浆LDL的抗氧化活性或甚至增加，从而更有效地回收确保增强的抗动脉硬化功效。一种抑制动脉硬化的方法，其包括使用降胆固醇剂和由下式（1）表示的还原型辅酶Q 10的组合，以及抑制动脉硬化的组合物，其含有胆固醇 - 降低剂和所述还原型辅酶Q 10。

5. 发明申请

US20050070481A1 Stabilized compositions of aqueous reduced coenzyme q solution 有权
标题翻译：水性还原型辅酶Q溶液的稳定组合物
公开(公告)号：US20050070481A1
公开(公告)日：2005-03-31
申请号：US10492167
申请日：2002-10-10
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K9/08 , A61K9/127 , A61K31/05 , A61K31/085 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/46 , A61P3/02 , A61P9/00 , A61P43/00 , C07C43/23 , A61K38/05 , A61K31/075 , A61K31/198 , A61K31/375
CPC分类号： A61K47/18 , A61K9/127 , A61K31/085 , A61K47/183 , A61K47/22 , C07C43/23
摘要： The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
摘要翻译：本发明提供一种还原型辅酶Q溶液，其能够通过使用疏水性并易受氧化并因此不稳定的还原型辅酶Q而更加稳定地保持抗氧化。含有本发明得到的还原型辅酶Q的水溶液是含有还原型辅酶Q和抗氧化剂如维生素C和/或螯合剂如乙二胺四乙酸的溶液。

6. 发明授权

US07708990B2 Coenzyme Q compositions persisting in blood 有权
标题翻译：辅酶Q组合物持续存在血液
公开(公告)号：US07708990B2
公开(公告)日：2010-05-04
申请号：US11085181
申请日：2005-03-22
申请人： Kenji Fujii , Taizo Kawabe , Hiroshi Kubo
发明人： Kenji Fujii , Taizo Kawabe , Hiroshi Kubo
IPC分类号： A61K38/43 , A01N31/14
CPC分类号： A61K31/122 , Y10S514/824 , Y10S514/878 , Y10S514/879
摘要： The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals.By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.
摘要翻译：本发明的目的是提供一种维持血液辅酶Q浓度在血液中长时间保持的组合物，以确保达到辅酶Q的效果，其可以预期表现出优异的效果维持人类和动物的健康。通过使用包含还原型辅酶Q和还原型辅酶Q的还原型辅酶Q与整个辅酶Q的比例大于95重量％的辅酶Q的混合物的组合物，本发明可以达到高辅酶Q的最大血液浓度以及血液中长时间维持高浓度辅酶Q长时间，血液浓度曲线下面积（AUC）可以扩大。

7. 发明授权

US5352677A Cinnamamide derivative 失效
标题翻译：肉桂酰胺衍生物
公开(公告)号：US5352677A
公开(公告)日：1994-10-04
申请号：US914753
申请日：1992-07-15
申请人： Yoshihide Fuse , Kenji Fujii , Keiji Kameyama , Taizo Kawabe , Toshiaki Miwa , Ikuo Katsumi
发明人： Yoshihide Fuse , Kenji Fujii , Keiji Kameyama , Taizo Kawabe , Toshiaki Miwa , Ikuo Katsumi
IPC分类号： A61K31/495 , C07D295/104 , C07D401/04
CPC分类号： A61K31/495 , C07D295/104 , C07D401/04
摘要： Cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.
摘要翻译：提供肉桂酰胺衍生物及其盐。还提供了抗高脂血症组合物。该组合物包含选自上述肉桂酰胺衍生物和其药学上可接受的盐中的至少一种的活性成分。

8. 发明授权

US08946303B2 Fatigue reducing agent 有权
标题翻译：减疲劳剂
公开(公告)号：US08946303B2
公开(公告)日：2015-02-03
申请号：US10541020
申请日：2004-01-19
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/122 , A61K38/43 , A61K38/44 , A61K31/09
CPC分类号： A61K31/09 , A61K31/122
摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.
摘要翻译：为了保持生活在老龄化社会门槛的中老年人的身体健康和健康，本发明提供了一种对预防和减轻疲劳高度有效的疲劳减轻剂，其中药剂由物质组成这是非常安全的，以便长期管理是可能的。发现含有还原型辅酶Q的组合物可有效预防和减少疲劳，包括肌肉疲劳。由于本发明的组合物的疲劳降低效果不仅在年轻大鼠中被观察到，而且在老年大鼠中也更加显着，本发明可以提供非常有用的疲劳减轻剂，特别是对于中老年人以及年轻人。

9. 发明授权

US07364751B2 Stabilized compositions of aqueous reduced coenzyme Q solution 有权
标题翻译：水性还原型辅酶Q溶液的稳定组合物
公开(公告)号：US07364751B2
公开(公告)日：2008-04-29
申请号：US10492167
申请日：2002-10-10
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K9/127 , A61K31/19 , A61K31/13 , A61K31/05 , A01N37/00 , A01N33/08 , A01N31/08
CPC分类号： A61K47/18 , A61K9/127 , A61K31/085 , A61K47/183 , A61K47/22 , C07C43/23
摘要： The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable.The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
摘要翻译：本发明提供一种还原型辅酶Q溶液，其能够通过使用疏水性并易受氧化并因此不稳定的还原型辅酶Q而更加稳定地保持抗氧化。含有本发明得到的还原型辅酶Q的水溶液是含有还原型辅酶Q和抗氧化剂如维生素C和/或螯合剂如乙二胺四乙酸的溶液。

10. 发明申请

US20060106116A1 Composition for lessening oxidative stress 审中-公开
标题翻译：用于减轻氧化应激的组合物
公开(公告)号：US20060106116A1
公开(公告)日：2006-05-18
申请号：US11315201
申请日：2005-12-23
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/12 , A61K31/075
CPC分类号： A61K31/085 , A61K31/122
摘要： A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q and an oxidized coenzyme of Q.
摘要翻译：一种用于减轻有需要的受试者体内氧化应激的方法，包括向所述受试者施用含有还原型辅酶Q和Q的氧化型辅酶的组合物。

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