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1. 发明申请

US20080091005A1 MODIFIED NUCLEOTIDES, METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：改性核子，制备和使用方法
公开(公告)号：US20080091005A1
公开(公告)日：2008-04-17
申请号：US11781160
申请日：2007-07-20
申请人： Hongyi Wang , Xiaolian Gao , Peilin Yu , Mitsu Reddy , Susan Hardin , Tommie Lincecum , Amy Williams , Norha Deluge , Yuri Belosludtsev , Steven Menchen , Joe Lam , Jer-Kang Chen
发明人： Hongyi Wang , Xiaolian Gao , Peilin Yu , Mitsu Reddy , Susan Hardin , Tommie Lincecum , Amy Williams , Norha Deluge , Yuri Belosludtsev , Steven Menchen , Joe Lam , Jer-Kang Chen
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.
摘要翻译：公开了用于单分子测序的修饰的核苷酸，用于制备修饰的核苷酸的方法和使用修饰的核苷酸的方法。还公开了用于制备修饰的核苷酸的接头。

2. 发明申请

US20090186343A1 METHODS FOR PREPARING MODIFIED BIOMOLECULES, MODIFIED BIOMOLECULES AND METHODS FOR USING SAME 审中-公开
标题翻译：制备改性生物分子的方法，改良生物分子及其使用方法
公开(公告)号：US20090186343A1
公开(公告)日：2009-07-23
申请号：US12035352
申请日：2008-02-21
申请人： Hongyi Wang , Norha Deluge , Kristi Kincaid , Yuri Belosludtsev , Tommie Lincecum, JR. , Amy Williams , Amy Bryant , Ming Fa , Benjamin Stevens , Susan H. Hardin
发明人： Hongyi Wang , Norha Deluge , Kristi Kincaid , Yuri Belosludtsev , Tommie Lincecum, JR. , Amy Williams , Amy Bryant , Ming Fa , Benjamin Stevens , Susan H. Hardin
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07H1/00 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2565/101 , C12Q2525/117 , C12Q2521/101
摘要： A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs having non-persistent or persistent and non-persistent modifications. Novel biomolecular reactions are also disclosed using the novel modified biomolecules disclosed herein.
摘要翻译：公开了一种用于制备修饰的核苷酸，核苷酸类似物，核苷酸多磷酸酯和核苷酸多磷酸酯类似物的新型和有效的单锅合成方案。该新方法用于制备具有非持久性或持久性和非持久性修饰的核苷酸，核苷酸类似物，核苷酸多磷酸酯和核苷酸多磷酸酯类似物。使用本文公开的新的改性生物分子也公开了新的生物分子反应。

3. 发明申请

US20080076189A1 MODIFIED SURFACES FOR THE DETECTION OF BIOMOLECULES AT THE SINGLE MOLECULE LEVEL 审中-公开
标题翻译：在单分子水平上检测生物分子的改性表面
公开(公告)号：US20080076189A1
公开(公告)日：2008-03-27
申请号：US11694605
申请日：2007-03-30
申请人： Yuri Belosludtsev , Nasanshargal Battulga , Mistu Reddy , Anelia Kraltcheva , Susan Hardin , Tommie Lincecum , Hongyi Wang , Norha Deluge , Uma Nagaswamy , Benjamin Stevens , Kristi Kincaid
发明人： Yuri Belosludtsev , Nasanshargal Battulga , Mistu Reddy , Anelia Kraltcheva , Susan Hardin , Tommie Lincecum , Hongyi Wang , Norha Deluge , Uma Nagaswamy , Benjamin Stevens , Kristi Kincaid
IPC分类号： G01N21/64
CPC分类号： G01N21/6428
摘要： Support surfaces are disclosed that are designed to support molecules or molecular assemblies immobilized thereon so that the molecules or molecular assemblies can be observed in single molecule detections systems, where the support surfaces have reduced background and the fluorescent labels associated with the immobilized molecules or molecular assemblies have longer active lifetimes prior to permanent photo-bleaching or deactivation and have improve fluorescence properties and where the surfaces have more uniform fluorescent properties.
摘要翻译：公开了支撑表面，其被设计成支持固定在其上的分子或分子组件，使得可以在单分子检测系统中观察分子或分子组件，其中支持表面具有降低的背景，并且与固定化分子或分子组装相关联的荧光标记在永久性光漂白或去活化之前具有更长的活性寿命，并且具有改善的荧光性能以及其表面具有更均匀的荧光性质。

4. 发明申请

US20110165652A1 COMPOSITIONS, METHODS AND SYSTEMS FOR SINGLE MOLECULE SEQUENCING 审中-公开
标题翻译：单分子测序的组成，方法和系统
公开(公告)号：US20110165652A1
公开(公告)日：2011-07-07
申请号：US12812952
申请日：2009-01-14
申请人： Susan H. Hardin , Tommie Lloyd Lincecum, JR. , Norha Deluge , Hongyi Wang , Yuri Belosludtsev , Kristi Kincaid , Anelia Kraltcheva , Benjamin Stevens , Ming Fa , Amy Bryant , Amy Castillo , Hye Eun Kim , Uma Nagaswamy , Mitsu Sreedhar Reddy , Alok N. Bandekar , Ivan Pan , Andrei Volkov
发明人： Susan H. Hardin , Tommie Lloyd Lincecum, JR. , Norha Deluge , Hongyi Wang , Yuri Belosludtsev , Kristi Kincaid , Anelia Kraltcheva , Benjamin Stevens , Ming Fa , Amy Bryant , Amy Castillo , Hye Eun Kim , Uma Nagaswamy , Mitsu Sreedhar Reddy , Alok N. Bandekar , Ivan Pan , Andrei Volkov
IPC分类号： C12N9/12
CPC分类号： C07H19/207 , C07H19/10 , C12N9/1252 , C12Q1/6869
摘要： Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.
摘要翻译：公开了组合物，系统和测序方法，其中组合物和系统包括经遗传修饰以更有效地掺入核苷酸的聚合酶，包括在掺入期间释放的具有可检测性质的标记，以增加标记的核苷酸掺入率，增加焦磷酸盐释放的速率，或增加这些性质和速率中的两种或更多种。还公开了末端标记和双重标记的核苷酸，以及基于点击化学的合成方法。

5. 发明授权

US08632975B2 Nucleotide transient binding for sequencing methods 有权
标题翻译：测序方法的核苷酸瞬变结合
公开(公告)号：US08632975B2
公开(公告)日：2014-01-21
申请号：US12790760
申请日：2010-05-28
申请人： Peter B. Vander Horn , Cheng-Yao Chen , Guobin Luo , Michael Previte , Jamshid Temirov , Theo Nikiforov , Zhaohui Zhou , Hongye Sun , Yufang Wang , Stefanie Yukiko Nishimura , Hongyi Wang , Marian Peris , Barnett B. Rosenblum , Michael Phelan
发明人： Peter B. Vander Horn , Cheng-Yao Chen , Guobin Luo , Michael Previte , Jamshid Temirov , Theo Nikiforov , Zhaohui Zhou , Hongye Sun , Yufang Wang , Stefanie Yukiko Nishimura , Hongyi Wang , Marian Peris , Barnett B. Rosenblum , Michael Phelan
IPC分类号： C12Q1/68
CPC分类号： C12N9/1252 , C12Q1/68 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C12Q1/6869 , C12Q1/6872 , C12Y207/07007 , G01N2500/00 , C12Q2565/632 , C12Q2563/137 , C12Q2563/107 , C12Q2565/30 , C12Q2537/157
摘要： Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.
摘要翻译：本文提供了用于聚合酶依赖性核苷酸瞬变结合方法的组合物和系统。该方法可用于推导模板核酸分子和单核苷酸多态性（SNP）分析的序列。该方法依赖于与非互补核苷酸相比，互补核苷酸的聚合酶瞬时结合时间更长的事实。标记的核苷酸以模板依赖的方式瞬时结合聚合酶，但不包括在内。所述方法在允许互补或非互补核苷酸与聚合酶短暂结合并且抑制核苷酸掺入的任何反应条件下进行。

6. 发明授权

US06711224B1 Timing acquisition algorithm for an adaptive antenna array 有权
标题翻译：自适应天线阵列的定时采集算法
公开(公告)号：US06711224B1
公开(公告)日：2004-03-23
申请号：US09535710
申请日：2000-03-27
申请人： Roger David Benning , Hongyi Wang
发明人： Roger David Benning , Hongyi Wang
IPC分类号： H04L706
CPC分类号： H04L7/10 , H04B7/0854 , H04L7/042
摘要： A timing acquisition algorithm for locating the sync timing position of a sync word embedded in a received signal for achieving synchronization between the received signal and a base station, e.g., a base station receiving the received signal, within a wireless telecommunications system. The timing acquisition algorithm is preferably a set of programmable instructions incorporated within a software package and processed by a processor at the within the wireless telecommunications system, such as at the base station. The timing acquisition algorithm gets rid of the unlikely sync timing position for each branch of an adaptive antenna array in the first step; gets rid of the unlikely sync timing position for all branches in the second step; and uses optimal diversity combining for the remaining timing position and uses the conventional correlation or mean-square-error (MSE) approach on the combined data in the third step to finally locate the timing position of the sync word. The first two steps limit the computational load of the third step to a reasonable level. For example, if only two sync timing positions remain after the first two steps, then during the third step, weight calculations need only be performed twice, i.e., one for each sync timing position that still remains.
摘要翻译：一种定时获取算法，用于定位嵌入在接收信号中的同步字的同步定时位置，以实现在无线电信系统内的接收信号与基站（例如接收接收信号的基站）之间的同步。定时获取算法优选地是并入软件包内并由无线电信系统内的处理器（例如在基站处理）处理的一组可编程指令。在第一步中，定时获取算法消除了自适应天线阵列的每个分支的可能的同步定时位置; 在第二步中摆脱所有分支的不太可能的同步时序位置; 并且对于剩余的定时位置使用最佳分集组合，并且在第三步骤中对组合数据使用传统的相关或均方误差（MSE）方法，以最终定位同步字的定时位置。前两个步骤将第三步的计算负载限制在合理的水平。例如，如果在前两个步骤之后仅剩下两个同步定时位置，则在第三步骤期间，仅需执行两次加权计算，即仍然保留的每个同步定时位置中的一个。

7. 发明申请

US20100330570A1 NUCLEOTIDE TRANSIENT BINDING FOR SEQUENCING METHODS 有权
标题翻译：用于测序方法的核心瞬态绑定
公开(公告)号：US20100330570A1
公开(公告)日：2010-12-30
申请号：US12790760
申请日：2010-05-28
申请人： Peter B. VANDER HORN , Cheng-Yao Chen , Guobin Luo , Michael Previte , Jamshid Temirov , Theo Nikiforov , Zhaohui Zhou , Hongye Sun , Yufang Wang , Stefanie Yukiko Nishimura , Hongyi Wang , Marian Peris , Barnett B. Rosenblum , Michael Phelan
发明人： Peter B. VANDER HORN , Cheng-Yao Chen , Guobin Luo , Michael Previte , Jamshid Temirov , Theo Nikiforov , Zhaohui Zhou , Hongye Sun , Yufang Wang , Stefanie Yukiko Nishimura , Hongyi Wang , Marian Peris , Barnett B. Rosenblum , Michael Phelan
IPC分类号： C12Q1/68 , C12N9/96
CPC分类号： C12N9/1252 , C12Q1/68 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C12Q1/6869 , C12Q1/6872 , C12Y207/07007 , G01N2500/00 , C12Q2565/632 , C12Q2563/137 , C12Q2563/107 , C12Q2565/30 , C12Q2537/157
摘要： Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer compared to that of a non-complementary nucleotide. The labeled nucleotides transiently-binds the polymerase in a template-dependent manner, but does not incorporate. The methods are conducted under any reaction condition that permits transient binding of a complementary or non-complementary nucleotide to a polymerase, and inhibits nucleotide incorporation.
摘要翻译：本文提供了用于聚合酶依赖性核苷酸瞬变结合方法的组合物和系统。该方法可用于推导模板核酸分子和单核苷酸多态性（SNP）分析的序列。该方法依赖于与非互补核苷酸相比，互补核苷酸的聚合酶瞬时结合时间更长的事实。标记的核苷酸以模板依赖的方式瞬时结合聚合酶，但不包括在内。所述方法在允许互补或非互补核苷酸与聚合酶短暂结合并且抑制核苷酸掺入的任何反应条件下进行。

8. 发明申请

US20050288119A1 Real-time measurements for establishing database of sporting apparatus motion and impact parameters 审中-公开
标题翻译：建立运动器材运动和影响参数数据库的实时测量
公开(公告)号：US20050288119A1
公开(公告)日：2005-12-29
申请号：US11051087
申请日：2005-02-04
申请人： Hongchuan Wang , Jeffrey Yao , Damon Lim , Hongyi Wang
发明人： Hongchuan Wang , Jeffrey Yao , Damon Lim , Hongyi Wang
IPC分类号： A63B24/00 , A63B57/00 , A63B69/00 , A63B69/36 , A63B71/06
CPC分类号： A63B69/36 , A63B69/0024 , A63B69/3632 , A63B71/06 , A63B2069/362 , A63B2209/08 , A63B2220/40 , A63B2220/80 , A63B2220/833 , A63B2225/50
摘要： A sporting apparatus used by a person for engaging in a sporting activity. The sporting apparatus includes a single or multiple embedded MR sensors for measuring magnetic vectors of the earth magnetic field for dynamically recording a path of motion of the sporting apparatus in real time. In a preferred embodiment, the sporting apparatus further includes one or multiple MEMS accelerometer sensors for sensing acceleration of a designated portion of the sporting apparatus for measuring impact velocity as the designated portion impacting a ball. In a specific embodiment, the sporting apparatus is a golf club wherein the accelerometer sensors are disposed adjacent to the grip side of the shaft for sensing the impact of the club head against a golf ball. In another specific embodiment, the golf club further includes a magnetic field sensor disposed near the grip end of the golf club for measuring a motion path of the golf club.
摘要翻译：一个人从事体育活动所使用的运动器材。运动装置包括用于测量地球磁场的磁矢量的单个或多个嵌入式MR传感器，用于实时地动态地记录运动装置的运动路径。在优选实施例中，运动装置还包括一个或多个MEMS加速计传感器，用于感测用于测量冲击速度的运动装置的指定部分的加速度，作为影响球的指定部分。在具体实施例中，运动装置是高尔夫球杆，其中加速度计传感器被布置成与轴的抓握侧相邻，用于感测球杆头抵靠高尔夫球的冲击。在另一个具体实施例中，高尔夫球杆还包括设置在高尔夫球杆的手柄端附近的用于测量高尔夫球杆的运动路径的磁场传感器。

9. 发明申请

US20100317005A1 Modified Nucleotides and Methods for Making and Use Same 审中-公开
标题翻译：修饰的核苷酸和制造和使用相同的方法
公开(公告)号：US20100317005A1
公开(公告)日：2010-12-16
申请号：US12724392
申请日：2010-03-15
申请人： Susan H. Hardin , Hongyi Wang , Brent A. Mulder , Nathan K. Agnew , Tommie L. Lincecum, JR.
发明人： Susan H. Hardin , Hongyi Wang , Brent A. Mulder , Nathan K. Agnew , Tommie L. Lincecum, JR.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： Labeled nucleotide triphosphates are disclosed having a label bonded to the gamma phosphate of the nucleotide triphosphate. Methods for using the gamma phosphate labeled nucleotide are also disclosed where the gamma phosphate labeled nucleotide are used to attach the labeled gamma phosphate in a catalyzed (enzyme or man-made catalyst) reaction to a target biomolecule or to exchange a phosphate on a target biomolecule with a labeled gamme phosphate. Preferred target biomolecules are DNAs, RNAs, DNA/RNAs, PNA, polypeptide (e.g., proteins enzymes, protein, assemblages, etc.), sugars and polysaccharides or mixed biomolecules having two or more of DNAs, RNAs, DNA/RNAs, polypeptide, sugars and polysaccharides moieties.
摘要翻译：公开了标记的核苷酸三磷酸，其具有与三磷酸核苷酸的γ磷酸盐结合的标记。还公开了使用γ-磷酸酯标记的核苷酸的方法，其中使用γ磷酸酯标记的核苷酸将标记的γ磷酸酯在催化的（酶或人造催化剂）反应中附着到靶生物分子上或在目标生物分子上交换磷酸盐带有标记的磷酸甘油。优选的目标生物分子是DNA，RNA，DNA / RNA，PNA，多肽（例如蛋白质酶，蛋白质，组合物等），糖和多糖或具有两个或多个DNA，RNA / RNA，多肽等的混合生物分子，糖和多糖部分。

10. 发明授权

US06766164B1 System and method for providing radio frequency conditions for testing wireless communications equipment 有权
标题翻译：提供用于测试无线通信设备的射频条件的系统和方法
公开(公告)号：US06766164B1
公开(公告)日：2004-07-20
申请号：US09233175
申请日：1999-01-19
申请人： Robert B. Funk , Martin H. Meyers , Hongyi Wang , Ron Lessnick
发明人： Robert B. Funk , Martin H. Meyers , Hongyi Wang , Ron Lessnick
IPC分类号： H04Q732
CPC分类号： H04W16/18 , H04B17/0085 , H04B17/391
摘要： An apparatus and a method for recreating radio frequency (RF) conditions of a cellular network extracts significant RF effects from field test data, and recreates variable RF attenuation using a multi-channel attenuator. A field data processor converts the field test data to time-varying attenuator control values for each channel of the multi-channel attenuator. Accordingly, a mobile in the lab which is connected to the multi-channel attenuator sees the same carrier and interference levels that were observed in the field environment, allowing cellular communication equipment testing without repeated field testing.
摘要翻译：用于重建蜂窝网络的射频（RF）条件的装置和方法从现场测试数据中提取显着的RF效应，并且使用多信道衰减器重新创建可变的RF衰减。场数据处理器将场测试数据转换为多通道衰减器的每个通道的时变衰减器控制值。因此，连接到多通道衰减器的实验室中的移动体看到在现场环境中观察到的相同的载波和干扰电平，允许蜂窝通信设备测试而不经过重复的现场测试。

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