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1. 发明授权

US09097470B2 Internal liquid separating hood-type condensation heat exchange tube 有权
标题翻译：内部液体分离罩型冷凝热交换管
公开(公告)号：US09097470B2
公开(公告)日：2015-08-04
申请号：US13984659
申请日：2012-03-05
申请人： Hongxia Chen , Jinliang Xu , Wei Wang
发明人： Hongxia Chen , Jinliang Xu , Wei Wang
IPC分类号： B01F3/04 , F28F1/10 , F28F13/04 , F28F9/013 , F28D15/04 , F28F1/42 , F28F1/16 , F28D15/02
CPC分类号： F28F1/10 , F28D15/025 , F28D15/046 , F28F1/16 , F28F1/426 , F28F9/013 , F28F13/04
摘要： An internal liquid separating hood-type condensation head exchange tube, comprising an external heat exchange tube and an internal liquid separating hood disposed in the cavity of the external heat exchange tube and coaxial with the external heat exchange tube. The internal liquid separating hood is a hollow tube with a plurality of micropores or gaps distributed on a wall surface. The condensate formed during the heat exchange is pumped to the internal liquid separating hood in time under the effect of surface tension of the liquid via the micropores or gaps, and then is discharged from the heat exchange tube by the internal liquid separating hood. Vapor is retained to flow in the annular region between the external heat exchange tube and the internal liquid separating hood, so the inner wall of the external heat exchange tube comes into contact with the vapor to the greatest extent.
摘要翻译：内部液体分离罩型冷凝水头更换管，包括设置在外部热交换管的空腔中并与外部热交换管同轴的外部热交换管和内部分液罩。内部液体分离罩是具有分布在壁表面上的多个微孔或间隙的中空管。在热交换期间形成的冷凝物在液体的表面张力经由微孔或间隙的作用下及时被泵送到内部液体分离罩中，然后通过内部分液罩从换热管排出。蒸汽保持在外部热交换管和内部分液罩之间的环形区域中流动，因此外部热交换管的内壁最大程度地与蒸气接触。

2. 发明申请

US20140138861A1 INTERNAL LIQUID SEPARATING HOOD-TYPE CONDENSATION HEAT EXCHANGE TUBE 有权
标题翻译：内部液体分离式冷凝热交换管
公开(公告)号：US20140138861A1
公开(公告)日：2014-05-22
申请号：US13984659
申请日：2012-03-05
申请人： Hongxia Chen , Jianling Xu , Wei Wang
发明人： Hongxia Chen , Jianling Xu , Wei Wang
IPC分类号： F28F1/10
CPC分类号： F28F1/10 , F28D15/025 , F28D15/046 , F28F1/16 , F28F1/426 , F28F9/013 , F28F13/04
摘要： An internal liquid separating hood-type condensation head exchange tube, comprising an external heat exchange tube and an internal liquid separating hood disposed in the cavity of the external heat exchange tube and coaxial with the external heat exchange tube. The internal liquid separating hood is a hollow tube with a plurality of micropores or gaps distributed on a wall surface. The condensate formed during the heat exchange is pumped to the internal liquid separating hood in time under the effect of surface tension of the liquid via the micropores or gaps, and then is discharged from the heat exchange tube by the internal liquid separating hood. Vapor is retained to flow in the annular region between the external heat exchange tube and the internal liquid separating hood, so the inner wall of the external heat exchange tube comes into contact with the vapor to the greatest extent.
摘要翻译：内部液体分离罩型冷凝水头更换管，包括设置在外部热交换管的空腔中并与外部热交换管同轴的外部热交换管和内部分液罩。内部液体分离罩是具有分布在壁表面上的多个微孔或间隙的中空管。在热交换期间形成的冷凝物在液体的表面张力经由微孔或间隙的作用下及时被泵送到内部液体分离罩中，然后通过内部分液罩从换热管排出。蒸汽保持在外部热交换管和内部分液罩之间的环形区域中流动，因此外部热交换管的内壁最大程度地与蒸气接触。

3. 发明申请

US20130231369A1 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US20130231369A1
公开(公告)日：2013-09-05
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

4. 发明申请

US20070232481A1 Catalyst composition for ethylene oligomerization and the use thereof 有权
标题翻译：用于乙烯低聚的催化剂组合物及其用途
公开(公告)号：US20070232481A1
公开(公告)日：2007-10-04
申请号：US11716540
申请日：2007-03-09
申请人： Baojun Zhang , Tao Jiang , Jianzhong Li , Lihua Xing , Yingnan Ning , Shukun Sun , Dongting Kuang , Yongcheng Sun , Yunguang Han , Qian Chen , Hongxia Chen , Deshun Zhang , Yulong Li , Yongjun Zhang , Huimin Yuan , Sihan Wang , Guizhi Wang , Jingyuan Zhang
发明人： Baojun Zhang , Tao Jiang , Jianzhong Li , Lihua Xing , Yingnan Ning , Shukun Sun , Dongting Kuang , Yongcheng Sun , Yunguang Han , Qian Chen , Hongxia Chen , Deshun Zhang , Yulong Li , Yongjun Zhang , Huimin Yuan , Sihan Wang , Guizhi Wang , Jingyuan Zhang
IPC分类号： C08F4/00
CPC分类号： C07C2/32 , B01J31/0201 , B01J31/0204 , B01J31/0231 , B01J31/188 , B01J2231/20 , B01J2531/62 , C07C2531/14 , C07C2531/22 , C08F110/02 , Y02P20/52 , C08F2500/02
摘要： The present invention relates to a catalyst composition for ethylene oligomerization and the use thereof. Such catalyst composition includes chromium compound, ligand containing P and N, activator and accelerator; wherein the chromium compound is selected from the group consisting of acetyl acetone chromium, THF-chromium chloride and/or Cr(2-ethylhecanoate)3; general formula of the ligand containing P and N is shown as: in which R1, R2, R3 and R4 are phenyl, benzyl, or naphthyl. R5 is isopropyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl or fluorenyl; the activatior is methyl aluminoxane, ethyl aluminoxane, propyl aluminoxane and/or butyl aluminoxane; general formula of the accelerator is X1R6X2, in which X1 and X2 are F, Cl, Br, I or alkoxyl, R6 is alkyl or aryl; the molar ratio of a, b, c and d is 1:0.5˜10:50˜3000:0.5˜10. After mixing the four components mentioned previously under nitrogen atmosphere for 10 minutes, they are incorporated to the reactor, or these four components are incorporated directly into the reactor. Then ethylene is introduced for oligomerization. Such catalyst can be used in producing 1-octene through ethylene oligomerization. It is advantageous in high catalysing activity, high 1-octene selectivity, etc. The catalytic activity is more than 1.0×106 g product·mol−1 Cr ·h−1, the fraction of C8 linear α-olefin is more than 70% by mass.
摘要翻译：本发明涉及一种用于乙烯低聚的催化剂组合物及其用途。这种催化剂组合物包括铬化合物，含有P和N的配体，活化剂和促进剂; 其中所述铬化合物选自乙酰丙酮铬，THF-氯化铬和/或Cr（2-乙基庚酸酯）3。含有P和N的配体的通式示于：其中R 1，R 2，R 3和R 4 苯基，苄基或萘基。 R 5是异丙基，丁基，环丙基，环戊基，环己基或芴基; 活性物质是甲基铝氧烷，乙基铝氧烷，丙基铝氧烷和/或丁基铝氧烷; 加速剂的通式是X 1，X 6，X 2，其中X 1和X 2， 2是F，Cl，Br，I或烷氧基，R 6是烷基或芳基; a，b，c和d的摩尔比为1：0.5〜10：50〜3000：0.5〜10。在氮气氛下将上述四种组分混合10分钟后，将它们并入反应器中，或将这四种组分直接并入反应器中。然后引入乙烯用于低聚。这种催化剂可用于通过乙烯低聚制备1-辛烯。在高催化活性，高1-辛烯选择性等方面是有利的。催化活性大于1.0×10 -6 g产物。 > -1，C 8直链α-烯烃的分数大于70质量％。

5. 发明授权

US08318772B2 Amine compounds and medical uses thereof 有权
标题翻译：胺化合物及其医疗用途
公开(公告)号：US08318772B2
公开(公告)日：2012-11-27
申请号：US13001379
申请日：2009-06-23
申请人： Bohua Zhong , Youzhi Zhang , Yanping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Meiying Li
发明人： Bohua Zhong , Youzhi Zhang , Yanping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Meiying Li
IPC分类号： A61K31/4535 , A61K31/4025 , A61K31/381 , A61K31/357 , A61K31/36 , C07D407/12 , C07D409/14 , C07D409/12
CPC分类号： C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14
摘要： The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.
摘要翻译：本发明涉及一种新的胺化合物或其药学上可接受的盐，其中X，R 1，R 2和n的定义在说明书中给出含有该化合物作为活性成分的药物组合物，以及使用该胺化合物或其药学上可接受的盐，用于制造抗抑郁药物。

6. 发明授权

US08921563B2 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US08921563B2
公开(公告)日：2014-12-30
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： A61K31/445 , A61K31/505 , C07D211/68 , C07D239/02 , C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

7. 发明申请

US20110178127A1 AMINE COMPOUNDS AND MEDICAL USES THEREOF 有权
标题翻译：胺化合物及其医疗用途
公开(公告)号：US20110178127A1
公开(公告)日：2011-07-21
申请号：US13001379
申请日：2009-06-23
申请人： Bohua Zhong , Youzhi Zhang , Yangping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Melying Li
发明人： Bohua Zhong , Youzhi Zhang , Yangping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Melying Li
IPC分类号： A61K31/381 , C07D409/12 , C07D409/14 , C07D407/12 , A61K31/4025 , A61K31/4535 , A61K31/36 , A61K31/357 , A61P25/24
CPC分类号： C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14
摘要： The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.
摘要翻译：本发明涉及一种新的胺化合物或其药学上可接受的盐，其中X，R 1，R 2和n的定义在说明书中给出含有该化合物作为活性成分的药物组合物，以及使用该胺化合物或其药学上可接受的盐，用于制造抗抑郁药物。

8. 发明授权

US07786336B2 Catalyst composition for ethylene oligomerization and the use thereof 有权
标题翻译：用于乙烯低聚的催化剂组合物及其用途
公开(公告)号：US07786336B2
公开(公告)日：2010-08-31
申请号：US11716540
申请日：2007-03-09
申请人： Baojun Zhang , Tao Jiang , Jianzhong Li , Lihua Xing , Yingnan Ning , Shukun Sun , Dongting Kuang , Yongcheng Sun , Yunguang Han , Qian Chen , Hongxia Chen , Deshun Zhang , Yulong Li , Yongjun Zhang , Huimin Yuan , Sihan Wang , Guizhi Wang , Jingyuan Zhang
发明人： Baojun Zhang , Tao Jiang , Jianzhong Li , Lihua Xing , Yingnan Ning , Shukun Sun , Dongting Kuang , Yongcheng Sun , Yunguang Han , Qian Chen , Hongxia Chen , Deshun Zhang , Yulong Li , Yongjun Zhang , Huimin Yuan , Sihan Wang , Guizhi Wang , Jingyuan Zhang
IPC分类号： C07C2/26 , C07C2/32 , B01J31/14 , B01J31/18 , B01J31/22
CPC分类号： C07C2/32 , B01J31/0201 , B01J31/0204 , B01J31/0231 , B01J31/188 , B01J2231/20 , B01J2531/62 , C07C2531/14 , C07C2531/22 , C08F110/02 , Y02P20/52 , C08F2500/02
摘要： The present invention relates to a catalyst composition for ethylene oligomerization and the use thereof. Such catalyst composition includes chromium compound, ligand containing P and N, activator and accelerator; wherein the chromium compound is selected from the group consisting of acetyl acetone chromium, THF-chromium chloride and Cr(2-ethylhecanoate)3; general formula of the ligand containing P and N is shown as: in which R1, R2, R3 and R4 are phenyl, benzyl, or naphthyl. R5 is isopropyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl or fluorenyl; the activatior is methyl aluminoxane, ethyl aluminoxane, propyl aluminoxane and/or butyl aluminoxane; the accelerator is selected from the group consisting of 1,1,2,2,-tetrachloroethane, 1,1,2,2-tetrabromoethane, 1,1,2,2-tetrafluoroethane, and compounds having a formula of X1R6X2, in which X1 and X2 are F, Cl, Br, I or alkoxyl, R6 is alkylene or arylene group; the molar ratio of chromium compound, ligand containing P and N, activator and accelerator is 1:0.5˜10:50˜3000:0.5˜10. After mixing the four components mentioned previously under nitrogen atmosphere for 10 minutes, they are incorporated to the reactor, or these four components are incorporated directly into the reactor. Then ethylene is introduced for oligomerization. Such catalyst can be used in producing 1-octene through ethylene oligomerization. It is advantageous in high catalysing activity, high 1-octene selectivity, etc. The catalytic activity is more than 1.0×106 g product·ma−1 Cr·h−1, the fraction of C8 linear α-olefin is more than 70% by mass.
摘要翻译：本发明涉及一种用于乙烯低聚的催化剂组合物及其用途。这种催化剂组合物包括铬化合物，含有P和N的配体，活化剂和促进剂; 其中铬化合物选自乙酰丙酮铬，THF-氯化铬和Cr（2-乙基庚酸酯）3; 含有P和N的配体的通式为：其中R 1，R 2，R 3和R 4为苯基，苄基或萘基。 R5是异丙基，丁基，环丙基，环戊基，环己基或芴基; 活性物质是甲基铝氧烷，乙基铝氧烷，丙基铝氧烷和/或丁基铝氧烷; 促进剂选自1,1,2,2-四氯乙烷，1,1,2,2-四溴乙烷，1,1,2,2-四氟乙烷和具有式X1R6X2的化合物，其中 X 1和X 2是F，Cl，Br，I或烷氧基，R 6是亚烷基或亚芳基; 铬化合物，含P和N的配体，活化剂和促进剂的摩尔比为1:0.5〜10:50〜3000:0.5〜10。在氮气氛下将上述四种组分混合10分钟后，将它们并入反应器中，或将这四种组分直接并入反应器中。然后引入乙烯用于低聚。这种催化剂可用于通过乙烯低聚制备1-辛烯。高催化活性，1-辛烯选择性高等优点。催化活性大于1.0×106 g产物·ma-1 Cr·h-1，C8线性α-烯烃的分数大于70％的质量。

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