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1. 发明申请

US20170021352A1 Reconfigurable microfluidic systems: Microwell plate interface 有权
标题翻译：可重构微流体系统：微孔板接口
公开(公告)号：US20170021352A1
公开(公告)日：2017-01-26
申请号：US14808933
申请日：2015-07-24
申请人： Hong Jiao , Erik C Jensen , Homayun Mehrabani , Liran Yosef Haller
发明人： Hong Jiao , Erik C Jensen , Homayun Mehrabani , Liran Yosef Haller
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/0293 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/14 , B01L2300/165 , B01L2400/0487 , B01L2400/049 , B01L2400/088
摘要： Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Such systems are suitable for automated microwell plate interfaces.
摘要翻译：可重构微流体系统基于通过疏水微流体通道连接的微流体腔的网络。每个空腔被分类为储存器或节点，并且包括可以施加气体压力的压力端口。根据流体转移规则施加到储层和节点的气体压力序列使得流体能够从任何储存器移动到系统中的任何其它储存器。这种系统适用于自动化微孔板界面。

2. 发明授权

US09733239B2 Reconfigurable microfluidic systems: scalable, multiplexed immunoassays 有权
公开(公告)号：US09733239B2
公开(公告)日：2017-08-15
申请号：US14808939
申请日：2015-07-24
申请人： Hong Jiao , Erik C Jensen , Homayun Mehrabani , Liran Yosef Haller
发明人： Hong Jiao , Erik C Jensen , Homayun Mehrabani , Liran Yosef Haller
IPC分类号： B01L3/00 , G01N33/53 , G01N33/536
CPC分类号： G01N33/5302 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2300/165 , B01L2400/0487 , B01L2400/088 , G01N33/536 , G01N33/54366
摘要： Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Systems may be configured with multiple switched interaction regions connected in series for scalable, multiplexed immunoassays. Multiple, switched interaction regions may also be implemented with microvalves.

3. 发明申请

US20170021351A1 Reconfigurable microfluidic systems: Homogeneous assays 有权
标题翻译：可重构微流体系统：均相试验
公开(公告)号：US20170021351A1
公开(公告)日：2017-01-26
申请号：US14808929
申请日：2015-07-24
申请人： Hong Jiao , Erik C. Jensen , Homayun Mehrabani , Liran Yosef Haller
发明人： Hong Jiao , Erik C. Jensen , Homayun Mehrabani , Liran Yosef Haller
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/14 , B01L2300/165 , B01L2400/0487 , B01L2400/0655 , B01L2400/088
摘要： Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Such systems are suitable for automated, multi-input, multi-output homogeneous assays.
摘要翻译：可重构微流体系统基于通过疏水微流体通道连接的微流体腔的网络。每个空腔被分类为储存器或节点，并且包括可以施加气体压力的压力端口。根据流体转移规则施加到储层和节点的气体压力序列使得流体能够从任何储存器移动到系统中的任何其它储存器。这样的系统适用于自动化，多输入，多输出均相测定。

4. 发明申请

US20170021353A1 Reconfigurable microfluidic systems: Scalable, multiplexed immunoassays 有权
标题翻译：可重构微流体系统：可扩展的多重免疫测定
公开(公告)号：US20170021353A1
公开(公告)日：2017-01-26
申请号：US14808939
申请日：2015-07-24
申请人： Hong Jiao , Erik C. Jensen , Homayun Mehrabani , Liran Yosef Haller
发明人： Hong Jiao , Erik C. Jensen , Homayun Mehrabani , Liran Yosef Haller
IPC分类号： B01L3/00 , G01N33/53 , G01N33/536
CPC分类号： G01N33/5302 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2300/165 , B01L2400/0487 , B01L2400/088 , G01N33/536 , G01N33/54366
摘要： Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Systems may be configured with multiple switched interaction regions connected in series for scalable, multiplexed immunoassays. Multiple, switched interaction regions may also be implemented with microvalves.
摘要翻译：可重构微流体系统基于通过疏水微流体通道连接的微流体腔的网络。每个空腔被分类为储存器或节点，并且包括可以施加气体压力的压力端口。根据流体转移规则施加到储层和节点的气体压力序列使得流体能够从任何储存器移动到系统中的任何其它储存器。系统可以配置有串联连接的多个交换交互区域，用于可扩展的多路复用的免疫测定。多个切换交互区域也可以用微型阀实现。

5. 发明申请

US20130040393A1 FLUORESCENCE DYE TAGGING SCHEME FOR MERCURY QUANTIFICATION AND SPECIATION 有权
标题翻译：荧光染料标记方法用于汞的量化和指标
公开(公告)号：US20130040393A1
公开(公告)日：2013-02-14
申请号：US13570548
申请日：2012-08-09
申请人： Hong Jiao , Hannah Catterall
发明人： Hong Jiao , Hannah Catterall
IPC分类号： C07D311/16 , G01N21/64
CPC分类号： C07D311/18 , C07D405/12
摘要： A fluorescent dye or fluorophore capable of forming complexes with mercury comprises 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate amide, wherein the amide is formed by reacting the succinimidyl ester (Pacific Blue™) with an amino acid containing a thiol group, such as cysteine or glutathione. Mercury complexes of the fluorophore fluoresce when excited by a UV or violet laser diode, and the detected intensity can be calibrated to quantify the concentration of mercury in a sample reacted with the fluorophore.
摘要翻译：能够与汞形成络合物的荧光染料或荧光团包含6,8-二氟-7-羟基-2-氧代-2H-色烯-3-羧酸酯酰胺，其中酰胺是通过使琥珀酰亚胺酯（Pacific Blue TM）含有硫醇基的氨基酸，如半胱氨酸或谷胱甘肽。荧光团的汞络合物在被紫外或紫外激光二极管激发时发出荧光，并且可以校准检测到的强度以量化与荧光团反应的样品中的汞浓度。

6. 发明授权

US09839605B2 Borojo skin care product and use thereof for natural moisturizing, anti-ageing, anti-UV, anti-anaphylaxis and whitening 有权
公开(公告)号：US09839605B2
公开(公告)日：2017-12-12
申请号：US15164864
申请日：2016-05-25
申请人： GUANGZHOU YIJIAN BIOMEDICAL TECHNOLOGY DEVELOPMENT CO.LTD , Hong Jiao
发明人： Hong Jiao
IPC分类号： A61K8/9789 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K8/97 , A61K8/37 , A61K8/58 , A61Q17/04
CPC分类号： A61K8/97 , A61K8/375 , A61K8/585 , A61K8/9789 , A61K2800/782 , A61K2800/85 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08
摘要： A Borojo skin care product and a preparation method thereof are disclosed. The skin care product comprises a matrix and Borojo powder, and the preparation method thereof comprises the steps: mixing and homogeneously stirring the Borojo powder in the matrix to obtain the Borojo skin care product.

7. 发明授权

US09139550B2 Fluorescence dye tagging scheme for mercury quantification and speciation 有权
标题翻译：用于汞定量和形态的荧光染料标记方案
公开(公告)号：US09139550B2
公开(公告)日：2015-09-22
申请号：US13570548
申请日：2012-08-09
申请人： Hong Jiao , Hannah Catterall
发明人： Hong Jiao , Hannah Catterall
IPC分类号： G01N21/64 , G01N33/84 , C07D311/18 , C07D405/12
CPC分类号： C07D311/18 , C07D405/12
摘要： A fluorescent dye or fluorophore capable of forming complexes with mercury comprises 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate amide, wherein the amide is formed by reacting the succinimidyl ester (Pacific Blue™) with an amino acid containing a thiol group, such as cysteine or glutathione. Mercury complexes of the fluorophore fluoresce when excited by a UV or violet laser diode, and the detected intensity can be calibrated to quantify the concentration of mercury in a sample reacted with the fluorophore.
摘要翻译：能够与汞形成络合物的荧光染料或荧光团包含6,8-二氟-7-羟基-2-氧代-2H-色烯-3-羧酸酯酰胺，其中酰胺是通过使琥珀酰亚胺酯（Pacific Blue TM）含有硫醇基的氨基酸，如半胱氨酸或谷胱甘肽。荧光团的汞络合物在被紫外或紫外激光二极管激发时发出荧光，并且可以校准检测到的强度以量化与荧光团反应的样品中的汞浓度。

8. 发明申请

US20090059209A1 LOCK-IN DEMODULATION TECHNIQUE FOR OPTICAL INTERROGATION OF A GRATING SENSOR 审中-公开
标题翻译：用于光栅传感器的光学插值的锁定解调技术
公开(公告)号：US20090059209A1
公开(公告)日：2009-03-05
申请号：US12201256
申请日：2008-08-29
申请人： An-Dien Nguyen , Hong Jiao
发明人： An-Dien Nguyen , Hong Jiao
IPC分类号： G01N21/01
CPC分类号： G01L1/246 , G01D5/38 , G01K11/3206
摘要： A grating sensor and method for optical interrogation of that sensor uses a lock-in technique to achieve simultaneous measurements of strain (and related temperature) and ultrasonic stress wave signals, as well as other environmental conditions that affect a reflection spectrum of the grating sensor. It achieves this by using a lock-in amplifier or a software demodulator to detect slight shifts in the grating reflection spectrum with high sensitivity and accuracy. A dynamic feedback loop based on the lock-in error signal output retunes the light wavelength of the light source (e.g., a tunable laser) or of a wavelength filter in the reflection path to maintain it relative to a specified reflection point of the grating reflector. The lock-in error signal serves as a measure of temperature/strain changes and of ultrasonic vibrations.
摘要翻译：该传感器的光栅传感器和光学询问方法使用锁定技术来实现应变（和相关温度）和超声波应力波信号的同时测量以及影响光栅传感器反射光谱的其它环境条件。它通过使用锁定放大器或软件解调器来以高灵敏度和精确度检测光栅反射光谱的轻微偏移来实现。基于锁定误差信号输出的动态反馈回路重新调节反射路径中光源的光波长（例如，可调谐激光）或波长滤波器，以使其相对于光栅反射器的指定反射点。锁定误差信号用作温度/应变变化和超声波振动的量度。

9. 发明申请

US20160346194A1 BOROJO SKIN CARE PRODUCT AND USE THEREOF FOR NATURAL MOISTURIZING, ANTI-AGEING, ANTI-UV, ANTI-ANAPHYLAXIS AND WHITENING 审中-公开
标题翻译： BOROJO皮肤护理产品及其用于天然滋润，抗衰老，抗紫外线，抗脱落和白化
公开(公告)号：US20160346194A1
公开(公告)日：2016-12-01
申请号：US15164864
申请日：2016-05-25
申请人： Hong Jiao , GUANGZHOU YIJIAN BIOMEDICAL TECHNOLOGY DEVELOPMENT CO.LTD
发明人： Hong Jiao
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/08 , A61Q19/00
CPC分类号： A61K8/97 , A61K8/375 , A61K8/585 , A61K8/9789 , A61K2800/782 , A61K2800/85 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08
摘要： A Borojo skin care product and a preparation method thereof are disclosed. The skin care product comprises a matrix and Borojo powder, and the preparation method thereof comprises the steps: mixing and homogeneously stirring the Borojo powder in the matrix to obtain the Borojo skin care product.
摘要翻译：公开了一种Borojo护肤品及其制备方法。皮肤护理产品包括基质和Borojo粉末，其制备方法包括以下步骤：混合并均匀搅拌基质中的Borojo粉末，得到Borojo护肤品。

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