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1. 发明授权

US08871779B2 Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds 有权
标题翻译：制备具有低水平的α，β-不饱和酮化合物的吗啡喃-6-酮产物的方法
公开(公告)号：US08871779B2
公开(公告)日：2014-10-28
申请号：US11915606
申请日：2007-03-02
申请人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
发明人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
IPC分类号： A61K31/485 , C07D489/04 , C07D489/08
CPC分类号： A61K31/485 , C07D489/08
摘要： The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A)
摘要翻译：本发明一般涉及制备高纯度吗啡喃-6-酮产品的方法。该方法涉及通过用含硫化合物处理降低吗啡喃6一种产物或包含吗啡喃6一种化合物的反应混合物中作为杂质存在的α，bgr-不饱和酮化合物的浓度。（一个）

2. 发明授权

US08748611B2 Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds 有权
标题翻译：制备低水平αβ-不饱和化合物的吗啡喃-6-酮产物的方法
公开(公告)号：US08748611B2
公开(公告)日：2014-06-10
申请号：US13294546
申请日：2011-11-11
申请人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
发明人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
IPC分类号： C07D489/08 , C07D489/02
CPC分类号： A61K31/485 , C07D489/08
摘要： The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
摘要翻译：本发明一般涉及制备高纯度吗啡喃-6-酮产物的方法。该方法涉及通过用含硫化合物处理降低吗啡喃6一种产物或包含吗啡喃6一种化合物的反应混合物中作为杂质存在的α，bgr-不饱和酮化合物的浓度。

3. 发明申请

US20060012143A1 Vehicle wheel axle centrifugal adjusting arrangement 失效
标题翻译：车轮轴离心调节装置
公开(公告)号：US20060012143A1
公开(公告)日：2006-01-19
申请号：US10876411
申请日：2004-06-25
申请人： Hong Gu
发明人： Hong Gu
IPC分类号： B60G3/00
CPC分类号： B60G3/01 , B60G2200/10 , B60G2204/4192 , B60G2204/423 , B60G2300/12 , B62K9/02 , B62K25/02 , Y10T74/2114
摘要： A vehicle wheel includes a wheel body having an elongated guiding slot radially extended from a center of the wheel body; and an axle centrifugal adjusting arrangement, which includes a sliding member slidably mounted along the guiding slot for mounting the wheel body to the wheel axle; and a gear adjustment device including a first gear unit mounted at the guiding slot of the wheel body, and a second gear unit mounted at the sliding member to substantially engage with the first gear unit so as to selectively adjust the sliding member to slide along the guiding slot.
摘要翻译：车轮包括具有从轮体的中心径向延伸的细长引导槽的轮体; 以及轴离心调节装置，其包括沿着所述引导槽可滑动地安装的滑动构件，用于将所述车轮主体安装到所述车轮轴; 以及齿轮调节装置，包括安装在所述车轮主体的引导槽处的第一齿轮单元和安装在所述滑动构件处以与所述第一齿轮单元基本接合的第二齿轮单元，以便选择性地调节所述滑动构件沿着所述滑动构件滑动导槽

4. 发明授权

US08846365B2 Nucleic acids encoding phosphate fluorescent indicators and methods of using the same 有权
标题翻译：编码磷酸荧光指示剂的核酸及其使用方法
公开(公告)号：US08846365B2
公开(公告)日：2014-09-30
申请号：US12083267
申请日：2005-10-14
申请人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
发明人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
IPC分类号： C12N9/30 , C07K14/195
CPC分类号： C07K14/195
摘要： Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells.
摘要翻译：公开了磷酸盐生物传感器，其包含与供体和荧光部分缀合的磷酸盐结合结构域，其允许在磷酸盐结合时检测和测量荧光共振能量转移。这种生物传感器可用于实时监测活细胞中的磷酸盐代谢。

5. 发明申请

US20080167332A1 Novel Compounds 243 审中-公开
标题翻译：新型化合物243
公开(公告)号：US20080167332A1
公开(公告)日：2008-07-10
申请号：US11779700
申请日：2007-07-18
申请人： Scott Gibson , Barry Elkins , Mike Rogers , Ian Hassall , Hong Gu , Zhenyu Wang , Vinod Kumar , Synthana Suresh Kumar , Santosh Kavitake , Sidda Lingesha , Eric Merifield , David Ennis , John Pavey , Austen Pimm , James Reuberson , Bo-Goran Josefsson , Martin Hemmerling , Svetlana Ivanova , Marguerite Mensonides-Harsema , Hakan Schulz , John Mo , Tomas Eriksson , Per Strandberg
发明人： Scott Gibson , Barry Elkins , Mike Rogers , Ian Hassall , Hong Gu , Zhenyu Wang , Vinod Kumar , Synthana Suresh Kumar , Santosh Kavitake , Sidda Lingesha , Eric Merifield , David Ennis , John Pavey , Austen Pimm , James Reuberson , Bo-Goran Josefsson , Martin Hemmerling , Svetlana Ivanova , Marguerite Mensonides-Harsema , Hakan Schulz , John Mo , Tomas Eriksson , Per Strandberg
IPC分类号： A61K31/438 , A61P11/00 , C07D491/107 , C07C275/32 , C07D211/52 , C07C69/76 , C07C69/52 , C07C233/81 , C07C233/00 , C07D303/46 , A61P29/00
CPC分类号： C07C233/25 , C07C69/92 , C07C235/60 , C07D211/48 , C07D303/23 , C07D491/107
摘要： Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
摘要翻译：式（I）的化合物，其中R 1，R 3，R 4，R 5，R SUP > 6 ，R＆lt; 7＆gt;和＆lt; 10＆gt;如说明书中所定义。本发明还涉及包含所述化合物的药物组合物和所述化合物在治疗中的用途。本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。除此之外，本发明涉及新化合物的盐和多晶型物及其制备。

6. 发明申请

US20060194761A1 Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol 审中-公开
标题翻译：橄榄油 - 环糊精复合物和制备δ9-四氢大麻酚的区域选择性方法
公开(公告)号：US20060194761A1
公开(公告)日：2006-08-31
申请号：US10550042
申请日：2004-04-02
申请人： Hong Gu
发明人： Hong Gu
IPC分类号： A61K31/724 , C07D311/80 , C08B37/16
CPC分类号： A61K31/724 , A61K45/06 , C07C37/16 , C07C2601/16 , C07D311/80 , C08B37/0015 , A61K2300/00 , C07C39/17
摘要： A cyclodextrin-olivetol derivative complex is provided. The complex effectively blocks reaction at specific carbons to prevent unwanted reactions. A process for preparing a cannabinoid compound is further provided. The process comprises reacting at least one terpenoid with cyclodextrin-olivetol derivative complex to produce the cannabinoid compound.
摘要翻译：提供了环糊精 - 橄榄油衍生物复合物。该配合物有效阻止了特定碳原子的反应，以防止不必要的反应。还提供了制备大麻素化合物的方法。该方法包括使至少一种萜类化合物与环糊精 - 橄榄油衍生物复合物反应以产生大麻素化合物。

7. 发明申请

US20060027995A1 Foldable bicycle 有权
标题翻译：可折叠自行车
公开(公告)号：US20060027995A1
公开(公告)日：2006-02-09
申请号：US10911250
申请日：2004-08-03
申请人： Hong Gu
发明人： Hong Gu
IPC分类号： B62K1/00
CPC分类号： B62K15/006
摘要： A foldable bicycle includes a foldable bicycle frame which comprises a main frame and an enclosing frame foldably to define a receiving cavity; a front and a rear wheel assembly rotatably supported by the bicycle frame; a bicycle driving unit operatively mounted on the bicycle frame and connected to the two wheel assemblies for driving at least one of the wheel assemblies rotating; a steering unit longitudinally extended from the front wheel assembly for steering a moving direction of the front wheel assembly; and a folding arrangement. The folding arrangement includes a folding link connecting the front and the rear wheel assembly, the bicycle driving unit, the steering unit, the enclosing frame, and the main frame in a foldable manner; and a folding actuator operatively connected with the folding link in such a manner that the foldable bicycle is adapted to move between a folded position and an unfolded position.
摘要翻译：可折叠自行车包括可折叠自行车车架，其包括主框架和可折叠地限定接收腔的封闭框架; 由所述自行车车架可旋转地支撑的前轮和后轮组件; 自行车驱动单元，其可操作地安装在所述自行车车架上并连接到所述两个车轮组件，用于驱动所述车轮组件中的至少一个旋转; 从所述前轮组件纵向延伸的用于转向所述前轮组件的移动方向的转向单元; 和折叠装置。折叠装置包括以可折叠的方式连接前轮组件和后轮组件，自行车驱动单元，转向单元，包围框架和主框架的折叠连接件; 以及折叠致动器，其以可折叠自行车适于在折叠位置和展开位置之间移动的方式与折叠连杆操作地连接。

8. 发明申请

US20120059167A1 PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF ALPHA BETA-UNSATURATED COMPOUNDS 有权
标题翻译：制备具有低水平的不饱和化合物的莫利尼6-ONE产品的方法
公开(公告)号：US20120059167A1
公开(公告)日：2012-03-08
申请号：US13294546
申请日：2011-11-11
申请人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
发明人： Henry J. Buehler , William E. Dummitt , Anthony Mannino , Dennis C. Aubuchon , Hong Gu
IPC分类号： C07D489/00
CPC分类号： A61K31/485 , C07D489/08
摘要： The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A)
摘要翻译：本发明一般涉及制备高纯度吗啡喃-6-酮产品的方法。该方法涉及通过用含硫化合物处理降低吗啡喃6一种产物或包含吗啡喃6一种化合物的反应混合物中作为杂质存在的α，bgr-不饱和酮化合物的浓度。（一个）

9. 发明申请

US20090311674A1 Phosphate Biosensors and Methods of Using the Same 有权
标题翻译：磷酸盐生物传感器及其使用方法
公开(公告)号：US20090311674A1
公开(公告)日：2009-12-17
申请号：US12083267
申请日：2005-10-14
申请人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
发明人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/19 , C12N5/10 , C12N15/63 , A01K67/00 , C07K14/435
CPC分类号： C07K14/195
摘要： Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells.
摘要翻译：公开了磷酸盐生物传感器，其包含与供体和荧光部分缀合的磷酸盐结合结构域，其允许在磷酸盐结合时检测和测量荧光共振能量转移。这种生物传感器可用于实时监测活细胞中的磷酸盐代谢。

10. 发明申请

US20060084828A1 Process for preparation of (+)-p-mentha-2,8-diene-1-ol 有权
标题翻译：制备（+） - 对 - 薄荷-2,8-二烯-1-醇的方法
公开(公告)号：US20060084828A1
公开(公告)日：2006-04-20
申请号：US10549976
申请日：2004-04-14
申请人： Hong Gu , J. Killgore , John Duchek
发明人： Hong Gu , J. Killgore , John Duchek
IPC分类号： C07C35/08
CPC分类号： C07D295/096 , C07C29/00 , C07C213/04 , C07C291/04 , C07C2601/14 , C07C2601/16 , C07C215/44 , C07C35/18
摘要： A process for preparing (+)-p-mentha-2,8-diene-1-ol comprising reacting (+)-limonene oxide with at least one amine in the presence of at least one Lewis acid to form amine adduct intermediates. The amine adduct is then oxidized to form an N-oxide that is pyrolized to form (+)-p-mentha-2,8-diene-1-ol.
摘要翻译：制备（+） - 对 - 薄荷-2,8-二烯-1-醇的方法包括在至少一种路易斯酸存在下使（+） - 柠檬烯氧化物与至少一种胺反应形成胺加合物中间体。然后将胺加合物氧化形成N-氧化物，其被热解形成（+） - 对 - 薄荷-2,8-二烯-1-醇。

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