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1. 发明申请

US20090203120A1 Thermal Cycling Apparatus and Method for Providing Thermal Uniformity 审中-公开
标题翻译：热循环装置和提供热均匀性的方法
公开(公告)号：US20090203120A1
公开(公告)日：2009-08-13
申请号：US12421568
申请日：2009-04-09
申请人： Hon Siu Shin , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
发明人： Hon Siu Shin , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
IPC分类号： C12M1/00
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
摘要翻译：一种用于快速热循环的装置和方法，包括热扩散板。热扩散板可以通过热电模块的热循环期间在整个热块组件中提供显着的温度均匀性。边缘加热器可以在热循环期间在整个热块组件中提供显着的温度均匀性。

2. 发明授权

US08859271B2 Thermal cycling apparatus and method for providing thermal uniformity 有权
标题翻译：热循环装置和提供热均匀性的方法
公开(公告)号：US08859271B2
公开(公告)日：2014-10-14
申请号：US13029085
申请日：2011-02-16
申请人： Hon Siu Shin , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
发明人： Hon Siu Shin , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
IPC分类号： C12M1/00 , C12M3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
摘要翻译：一种用于快速热循环的装置和方法，包括热扩散板。热扩散板可以通过热电模块的热循环期间在整个热块组件中提供显着的温度均匀性。边缘加热器可以在热循环期间在整个热块组件中提供显着的温度均匀性。

3. 发明申请

US20110136219A1 THERMAL CYCLING APPARATUS AND METHOD FOR PROVIDING THERMAL UNIFORMITY 有权
标题翻译：热循环装置和提供热均匀性的方法
公开(公告)号：US20110136219A1
公开(公告)日：2011-06-09
申请号：US13029085
申请日：2011-02-16
申请人： Hon Siu SHIN , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
发明人： Hon Siu SHIN , Jew Kwee Ngui , Chee Kiong Lim , Ching Ong Lau , Lim Hi Tan , Yang Hooi Kee
IPC分类号： C12M1/00
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
摘要翻译：一种用于快速热循环的装置和方法，包括热扩散板。热扩散板可以通过热电模块的热循环期间在整个热块组件中提供显着的温度均匀性。边缘加热器可以在热循环期间在整个热块组件中提供显着的温度均匀性。

4. 发明授权

US08871470B2 Adaptive thermal block temperature control method and system 有权
标题翻译：自适应热块温度控制方法和系统
公开(公告)号：US08871470B2
公开(公告)日：2014-10-28
申请号：US12053416
申请日：2008-03-21
申请人： Chee Kiong Lim , Chee Wee Ching
发明人： Chee Kiong Lim , Chee Wee Ching
IPC分类号： C12P19/34 , G05D23/32 , B01L7/00
CPC分类号： B01J19/0046 , B01L7/52 , B01L2200/147 , B01L2300/1827 , C12P19/34 , G05D23/32
摘要： Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature enters a sample window region between a preliminary setpoint temperature and a target setpoint temperature for the sample. Based on thermodynamic behavior of the sample and the predetermined phase of PCR, predicting a time period measured subsequent to the preliminary setpoint temperature when the sample will reach the target setpoint suitable for the predetermined phase of PCR. During this time period, varying the block temperature ramp rate with a series of cooling and heating changes to ensure the block temperature reaches the target setpoint temperature at approximately the same time as the sample reaches the same. Synchronizing the block temperature and sample temperature to the target setpoint temperature reduces undershooting and overshooting of the sample temperature and increases the speed and efficiency of the overall PCR process as it relates to the thermal cycling operations.
摘要翻译：本教导的方面描述了用于自动控制块温度以减少包含在块中并参与聚合酶链式反应（PCR）的样品的低温和过冲的方法和装置。当样品温度进入样品的初步设定点温度和目标设定点温度之间的采样窗口区域时，自适应热块温度控制开始。基于样品的热力学行为和PCR的预定阶段，预测当样品将达到适合于预定阶段的PCR的目标设定点时初始设定点温度之后测量的时间段。在此期间，通过一系列冷却和加热变化来改变块温度升高速率，以确保块体温度在与样品达到相同时间大致相同的时间达到目标设定点温度。将块温度和样品温度同步到目标设定点温度可降低样品温度的下冲和过冲，并提高整个PCR过程的速度和效率，因为它与热循环操作有关。

5. 外观设计

USD691164S1 Display screen with graphical user interface 有权
公开(公告)号：USD691164S1
公开(公告)日：2013-10-08
申请号：US29403049
申请日：2011-09-30
申请人： Chee Kiong Lim , Kok Siong Teo , Gary Chappell
设计人： Chee Kiong Lim , Kok Siong Teo , Gary Chappell

6. 发明授权

US09566583B2 Thermal uniformity for thermal cycler instrumentation using dynamic control 有权
标题翻译：热循环仪器的热均匀性采用动态控制
公开(公告)号：US09566583B2
公开(公告)日：2017-02-14
申请号：US13082888
申请日：2011-04-08
申请人： Thomas Conner , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
发明人： Thomas Conner , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
IPC分类号： C12Q3/00 , C12M1/40 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1894
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.
摘要翻译：提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并通过第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度样品块部门。该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度更多热电冷却器。一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

7. 发明申请

US20110275055A1 THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 有权
标题翻译：使用动态控制的热循环仪器的热均匀性
公开(公告)号：US20110275055A1
公开(公告)日：2011-11-10
申请号：US13082888
申请日：2011-04-08
申请人： Thomas CONNER , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
发明人： Thomas CONNER , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
IPC分类号： C12Q3/00 , C12M1/40
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1894
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.
摘要翻译：提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并通过第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度样品块部门。该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度更多热电冷却器。一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

8. 发明申请

US20080248534A1 Adaptive Thermal Block Temperature Control Method and System 有权
标题翻译：自适应热块温度控制方法和系统
公开(公告)号：US20080248534A1
公开(公告)日：2008-10-09
申请号：US12053416
申请日：2008-03-21
申请人： Chee Kiong Lim , Chee Wee Ching
发明人： Chee Kiong Lim , Chee Wee Ching
IPC分类号： C12P19/34 , C12M1/02
CPC分类号： B01J19/0046 , B01L7/52 , B01L2200/147 , B01L2300/1827 , C12P19/34 , G05D23/32
摘要： Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature enters a sample window region between a preliminary setpoint temperature and a target setpoint temperature for the sample. Based on thermodynamic behavior of the sample and the predetermined phase of PCR, predicting a time period measured subsequent to the preliminary setpoint temperature when the sample will reach the target setpoint suitable for the predetermined phase of PCR. During this time period, varying the block temperature ramp rate with a series of cooling and heating changes to ensure the block temperature reaches the target setpoint temperature at approximately the same time as the sample reaches the same. Synchronizing the block temperature and sample temperature to the target setpoint temperature reduces undershooting and overshooting of the sample temperature and increases the speed and efficiency of the overall PCR process as it relates to the thermal cycling operations.
摘要翻译：本教导的方面描述了用于自动控制块温度以减少包含在块中并参与聚合酶链式反应（PCR）的样品的低温和过冲的方法和装置。当样品温度进入样品的初步设定点温度和目标设定点温度之间的采样窗口区域时，自适应热块温度控制开始。基于样品的热力学行为和PCR的预定阶段，预测当样品将达到适合于预定阶段的PCR的目标设定点时初始设定点温度之后测量的时间段。在此期间，通过一系列冷却和加热变化来改变块温度升高速率，以确保块体温度在与样品达到相同时间大致相同的时间达到目标设定点温度。将块温度和样品温度同步到目标设定点温度可降低样品温度的下冲和过冲，并提高整个PCR过程的速度和效率，因为它与热循环操作有关。

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