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1. 发明申请

US20200149578A9 MICRO FLOW FILTRATION SYSTEM AND INTEGRATED MICROFLUIDIC ELEMENT 审中-公开
公开(公告)号：US20200149578A9
公开(公告)日：2020-05-14
申请号：US15962700
申请日：2018-04-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： F16B33/00 , F16B35/00 , B29C45/14 , B29C70/72 , B29L31/00 , B29K105/08
摘要： A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1). An integrated microfluidic element (20) of the circuitry (1) contains the functionality of at least two elements of the group of elements of the circuitry (1).

2. 发明申请

US20150041395A1 MICRO FLOW FILTRATION SYSTEM AND FLOW FILTRATION METHOD 审中-公开
标题翻译：微流量过滤系统和流量过滤方法
公开(公告)号：US20150041395A1
公开(公告)日：2015-02-12
申请号：US14386097
申请日：2013-03-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D61/22 , B01D61/18 , B01D61/14
CPC分类号： B01D61/22 , B01D61/147 , B01D61/18 , B01D61/20 , B01D2311/14 , B01D2313/10 , B01D2313/14 , B01D2313/243 , B01D2313/28 , B01D2313/50 , B01D2315/10 , B01D2315/12
摘要： A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present). The volume of the first reservoir (1) outside the circuitry (3) is significantly larger than the volume of the second reservoir (2). The first reservoir (1) outside the fluid circuitry (3) is connected to the circuitry (3) via a connection conduit (31) such that the fluid flows unidirectionally into the circuitry (3) until the first reservoir (1) is empty so that a continuous fluid flow from the first reservoir (1) to the circuitry (3) is established.
摘要翻译：微流过滤系统包括流体回路（3）和适于容纳流体的电路（3）外部的第一储存器（1）。流体回路（3）包括切向流过滤模块（10），该切向流过滤模块（10）能够通过入口进料（18）将流体样品分离成切向流过滤模块（10），该流动过滤模块能够将流体样品分离成滞留物流和渗透物流）。流体回路（3）还包括集成在流体回路（3）中的第二贮存器（2），用于创建和驱动流体流的泵（5），可选地至少一个压力传感器（6,7或8）获取和检测关于流体样本的数据，可选地用于调节流体回路（3）中的流动的压力调节器（9）和与第二储存器（2）一起形成流体回路（3）的多个管道（22），TFF模块（10），泵（5），压力传感器（6,7或8）（如果存在）和压力调节器（9）（如果存在）。电路（3）外部的第一储存器（1）的体积显着大于第二储存器（2）的体积。流体回路（3）外部的第一储存器（1）经由连接导管（31）连接到电路（3），使得流体单向流入电路（3），直到第一储存器（1）为空建立从第一储存器（1）到电路（3）的连续流体流动。

3. 发明申请

US20150041375A1 MICRO FLOW FILTRATION SYSTEM AND INTEGRATED MICROFLUIDIC ELEMENT 审中-公开
标题翻译：微流过滤系统和集成微流体元件
公开(公告)号：US20150041375A1
公开(公告)日：2015-02-12
申请号：US14386085
申请日：2013-03-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D63/00 , B01D61/22 , B01D61/14
CPC分类号： B01D63/005 , B01D61/147 , B01D61/22 , B01D63/087 , B01D63/088 , B01D2311/14 , B01D2311/246 , B01D2311/25 , B01D2313/90 , B01D2315/10 , B01L3/502715 , B01L3/502753 , B01L2200/146 , B01L2300/0681 , B01L2300/0816 , B01L2300/088 , B01L2400/0478 , B01L2400/0487 , G01N2001/4088
摘要： A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1). An integrated microfluidic element (20) of the circuitry (1) contains the functionality of at least two elements of the group of elements of the circuitry (1).
摘要翻译：微流体过滤系统（100）优选地用于增加包含在流体样品中的组分的浓度具有流体回路（1）。流体回路（1）包括以下元件：切向流过滤元件（7），其能够在流体通过时将流体样品分离为滞留物流和渗透物流，用于泵送的元件（3）用于产生和驱动通过流体电路（1）的流体流和至少一个元件，用于获得关于电路内的流体样品的属性的信息。电路还包括连接流体回路（1）的元件的多个导管（24），流体样品的流体流通过该导管传导。电路（1）具有至多5ml的最小工作体积，其是保留在电路（1）的元件和导管（24）中的最小流体体积，使得流体可以在电路（1）中再循环）而不通过电路（1）抽空。电路（1）的集成微流体元件（20）包含电路（1）的元件组中的至少两个元件的功能。

4. 发明申请

US20150083665A1 MICRO FLOW FILTRATION SYSTEM AND FLOW FILTRATION METHOD FOR A FLUID SAMPLE 有权
标题翻译：一种流体样品的微流量过滤系统和流量过滤方法
公开(公告)号：US20150083665A1
公开(公告)日：2015-03-26
申请号：US14386092
申请日：2013-03-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D61/20 , B01D61/18
CPC分类号： B01D61/20 , B01D61/145 , B01D61/18 , B01D61/22 , B01D63/088 , B01D2313/243 , B01D2313/90 , B01D2315/10
摘要： A flow filtration system (1) for concentration of components contained in a fluid sample comprises a fluid channel (2) being formed by two conduits (4, 5) allowing a bidirectional flow of the fluid sample through the fluid channel (2), a tangential flow filtration module (3) and at least two pairs (8, 9) of piston pumps (6) each having two piston pumps (6), wherein the piston pumps (6) having a piston swept volume forming a reservoir being able to contain the fluid for volumes of up to 100 ml. The tangential flow filtration module (3) is located in the fluid channel (2) so that a fluid flowing through the channel (2) passes through the filtration module (3). At each end (10, 11) of the channel (2) one piston pump (6) of each pair (8, 9) of piston pumps (6) is located in such a manner that the piston pumps are fluidically connected in parallel. The system (1) is arranged and adapted such that during the concentration process at least for a predetermined period of time only one of the pairs (8, 9) of piston pumps (6) is used to drive the fluid through the tangential flow filtration module (3).
摘要翻译：用于浓缩包含在流体样品中的组分的流过滤系统（1）包括由允许流体样品通过流体通道（2）的双向流动的两个管道（4,5）形成的流体通道（2），切向流过滤模块（3）和具有两个活塞泵（6）的活塞泵（6）的至少两对（8,9），其中具有形成储存器的活塞扫掠体积的活塞泵（6）能够含有高达100ml体积的流体。切向流过滤模块（3）位于流体通道（2）中，使得流过通道（2）的流体通过过滤模块（3）。在通道（2）的每个端部（10,11）处，活塞泵（6）的每对（8,9）的一个活塞泵（6）以这样的方式定位，使得活塞泵流体地并联连接。系统（1）被布置和适配成使得在浓缩过程期间至少在预定时间段内，活塞泵（6）的对（8,9）中的仅一个用于驱动流体通过切向流过滤模块（3）。

5. 发明授权

US11045767B2 Micro flow filtration system and integrated microfluidic element 有权
公开(公告)号：US11045767B2
公开(公告)日：2021-06-29
申请号：US15962700
申请日：2018-04-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D63/00 , B01D63/08 , B01L3/00 , B29C45/14 , B29C70/72 , F16B33/00 , F16B35/00 , B01D61/14 , B01D61/22 , G01N1/40 , B29K105/08 , B29L31/00
摘要： A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1). An integrated microfluidic element (20) of the circuitry (1) contains the functionality of at least two elements of the group of elements of the circuitry (1).

6. 发明申请

US20180245619A1 MICRO FLOW FILTRATION SYSTEM AND INTEGRATED MICROFLUIDIC ELEMENT 审中-公开
公开(公告)号：US20180245619A1
公开(公告)日：2018-08-30
申请号：US15962700
申请日：2018-04-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： F16B33/00 , F16B35/00 , B29C45/14 , B29C70/72 , B29L31/00 , B29K105/08
CPC分类号： F16B33/006 , B01L3/502715 , B01L3/502753 , B01L2200/0647 , B01L2300/0627 , B01L2300/0681 , B01L2300/0864 , B29C45/14 , B29C70/72 , B29K2105/08 , B29L2031/727 , F16B33/004 , F16B35/00 , Y10T403/473 , Y10T403/56
摘要： A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1). An integrated microfluidic element (20) of the circuitry (1) contains the functionality of at least two elements of the group of elements of the circuitry (1).

7. 发明授权

US09700845B2 Micro flow filtration system and flow filtration method for a fluid sample 有权
公开(公告)号：US09700845B2
公开(公告)日：2017-07-11
申请号：US14386092
申请日：2013-03-25
申请人： Hoffmann-La Roche Inc.
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D61/14 , B01D61/20 , B01D63/08 , B01D61/18 , B01D61/22
CPC分类号： B01D61/20 , B01D61/145 , B01D61/18 , B01D61/22 , B01D63/088 , B01D2313/243 , B01D2313/90 , B01D2315/10
摘要： A flow filtration system (1) for concentration of components contained in a fluid sample comprises a fluid channel (2) being formed by two conduits (4, 5) allowing a bidirectional flow of the fluid sample through the fluid channel (2), a tangential flow filtration module (3) and at least two pairs (8, 9) of piston pumps (6) each having two piston pumps (6), wherein the piston pumps (6) having a piston swept volume forming a reservoir being able to contain the fluid for volumes of up to 100 ml. The tangential flow filtration module (3) is located in the fluid channel (2) so that a fluid flowing through the channel (2) passes through the filtration module (3). At each end (10, 11) of the channel (2) one piston pump (6) of each pair (8, 9) of piston pumps (6) is located in such a manner that the piston pumps are fluidically connected in parallel. The system (1) is arranged and adapted such that during the concentration process at least for a predetermined period of time only one of the pairs (8, 9) of piston pumps (6) is used to drive the fluid through the tangential flow filtration module (3).

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