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1. 发明授权

US4965266A Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same 失效
标题翻译：杂芳基甲酰胺衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4965266A
公开(公告)日：1990-10-23
申请号：US296083
申请日：1988-10-18
申请人： Hitoshi Uno , Tatsuya Kon , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
发明人： Hitoshi Uno , Tatsuya Kon , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
IPC分类号： C07D233/54 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/495 , A61K31/496 , A61P11/00 , A61P27/16 , A61P37/08 , A61P43/00 , C07D207/337 , C07D213/64 , C07D213/82 , C07D215/14 , C07D215/48 , C07D215/54 , C07D215/56 , C07D217/02 , C07D217/16 , C07D217/26 , C07D235/06 , C07D235/26 , C07D237/08 , C07D239/26 , C07D241/12 , C07D241/24 , C07D241/44 , C07D261/06 , C07D261/20 , C07D263/30 , C07D263/54 , C07D307/54 , C07D401/06 , C07D401/12 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D495/04
CPC分类号： C07D213/82 , C07D215/54 , C07D471/04
摘要： Heteroarylcarboxamide derivatives of the formula I: ##STR1## wherein A means an alkylene group, X means

2. 发明授权

US4778796A .omega.-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same 失效
标题翻译： ω-（3-吡啶基）烯酰胺衍生物和含有其的抗过敏药物组合物
公开(公告)号：US4778796A
公开(公告)日：1988-10-18
申请号：US884717
申请日：1986-07-11
申请人： Hitoshi Uno , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
发明人： Hitoshi Uno , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/455 , A61K31/495 , A61P7/02 , A61P37/08 , A61P43/00 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/59 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/70 , C07D213/72 , C07D213/74 , C07D213/80 , C07D213/84 , C07D213/87 , C07D213/89 , C07D215/14 , C07D215/38 , C07D215/60 , C07D243/00 , C07D401/12 , C07D403/06 , C12N9/99 , C07D401/14
CPC分类号： C07D213/64 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/643 , C07D213/65 , C07D213/70 , C07D213/72 , C07D213/80 , C07D213/89 , C07D401/12
摘要： Compounds of the formula: ##STR1## wherein X is alkylene or --(CR.sub.6 .dbd.CR.sub.7).sub.r -- wherein R.sub.6 is H, alkyl or phenyl, R.sub.7 is H, alkyl, cyano or phenyl, and r is 1 or 2; A is alkylene or alkylene interrupted by at least one double bond; R.sub.1 is H, halogen, alkyl, alkoxy, alkylthio, cycloalkyloxy, cycloalkylthio, alkoxycarbonyl, carboxy, phenyl, phenoxy, phenylthio, 3-pyridyloxy or 3-pyridylthio; R.sub.2 is H, hydroxy, alkanoyloxy or alkoxycarbonyloxy, or adjacent R.sub.1 and R.sub.2 may combine to form tetramethylene or --CH.sub.2 OCR.sub.8 R.sub.9 O-- (R.sub.8 and R.sub.9 are alkyl); R.sub.3 is H, alkyl or hydroxyalkyl; R.sub.4 is H or alkyl; R.sub.5 is phenyl, heteroaryl or --(CH.sub.2).sub.m --CHR.sub.10 R.sub.11 (R.sub.10 is H or phenyl, R.sub.11 is phenyl or pyridyl and m is 0 to 2); p is 0 or 1; and q is 2 or 3; the phenyl group or moiety being optionally substituted, and a salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. Said compounds and salts thereof show excellent antiallergic activity mainly through 5-lipoxygenase inhibiting activity, antihistamine activity and/or inhibitory activity against chemical mediator release and useful for treatment of allergic diseases.
摘要翻译：其中X为亚烷基或 - （CR 6 = CR 7）r - ，其中R 6为H，烷基或苯基，R 7为H，烷基，氰基或苯基，且r为1或2; A是被至少一个双键中断的亚烷基或亚烷基; R 1是H，卤素，烷基，烷氧基，烷硫基，环烷氧基，环烷硫基，烷氧基羰基，羧基，苯基，苯氧基，苯硫基，3-吡啶基氧基或3-吡啶硫基。 R2是H，羟基，烷酰氧基或烷氧基羰基氧基，或相邻的R1和R2可以结合形成四亚甲基或-CH 2 OCR 8 R 9 O-（R 8和R 9是烷基）; R3是H，烷基或羟烷基; R4是H或烷基; R5是苯基，杂芳基或 - （CH2）m-CHR10R11（R10是H或苯基，R11是苯基或吡啶基，m是0-2）; p为0或1; q为2或3; 任选取代的苯基或部分，及其盐，其制备方法和含有该方法的药物组合物。所述化合物及其盐主要通过5-脂氧合酶抑制活性，抗组织胺活性和/或对化学介质释放的抑制活性显示出优异的抗过敏活性，并且可用于治疗过敏性疾病。

3. 发明授权

US4356186A Acetic acid derivatives and composition containing the same 失效
标题翻译：乙酸衍生物及含有其的组合物
公开(公告)号：US4356186A
公开(公告)日：1982-10-26
申请号：US246114
申请日：1981-03-20
申请人： Hitoshi Uno , Mikio Kurokawa , Hideo Nakamura
发明人： Hitoshi Uno , Mikio Kurokawa , Hideo Nakamura
IPC分类号： A61K31/34 , A61K31/38 , A61P29/00 , C07D313/12 , C07D337/12 , C07D337/14 , C07D405/06 , C07D409/06 , A61K31/335
CPC分类号： C07C323/00 , C07D313/12 , C07D337/12 , Y10S514/825 , Y10S514/916
摘要： Novel acetic acid derivatives of the formula: ##STR1## wherein X is oxygen or sulfur; R.sub.1 is hydrogen or a lower alkyl; R.sub.2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a substituted aryloxy, an aryl-lower alkoxy, a substituted aryl-lower alkoxy, an aryl-lower alkenyloxy, a substituted aryl-lower alkenyloxy, an .omega.-disubstituted amino-lower alkoxy, a lower alkoxycrbonyl-lower alkoxy, a lower alkoxy-lower alkoxy, a hydroxy-lower alkoxy-lower alkoxy, an acyl-lower alkoxy, or a group ##STR2## wherein R.sub.3 is hydrogen, hydroxy, a lower alkyl, an aryl-lower alkyl, a hydroxy-lower alkyl, or a carboxy-lower alkyl, R.sub.4 is hydrogen, a lower alkyl or a hydroxy-lower alkyl, or the R.sub.3 and R.sub.4 may combine together with the nitrogen atom to which they are joined to form a heterocyclic group; and the group --CH(R.sub.1)COR.sub.2 is joined to the carbon atom at 2- or 3-position, and pharmaceutically acceptable salts thereof, processes for their preparation, and pharmaceutical compositions containing these compounds. They have excellent anti-inflammatory, analgesic and antipyretic activities with weak ulcerogenicity in the gastrointestinal tract and toxicity.
摘要翻译：下式的新型乙酸衍生物：其中X是氧或硫; R1是氢或低级烷基; R2是羟基，烷氧基，烯氧基，环烷氧基，芳氧基，取代的芳氧基，芳基 - 低级烷氧基，取代的芳基 - 低级烷氧基，芳基 - 低级烯氧基，取代的芳基 - 低级烯氧基，ω-二取代氨基 - 低级烷氧基，低级烷氧基羰基 - 低级烷氧基，低级烷氧基 - 低级烷氧基，羟基 - 低级烷氧基 - 低级烷氧基，酰基 - 低级烷氧基或基团，其中R3是氢，羟基，低级烷基，芳基 - 低级烷基，羟基 - 低级烷基或羧基 - 低级烷基，R 4是氢，低级烷基或羟基 - 低级烷基，或者R 3和R 4可以与它们所在的氮原子结合在一起连接形成杂环基; 并且基团-CH（R 1）COR 2与2-或3-位的碳原子及其药学上可接受的盐连接，其制备方法和含有这些化合物的药物组合物。它们具有优良的抗炎，止痛和解热活性，肠胃道溃疡性弱，毒性低。

4. 发明授权

US4256753A 4-(2-Pyridylamino)phenylacetic acid derivatives 失效
标题翻译： 4-（2-吡啶基氨基）苯乙酸衍生物
公开(公告)号：US4256753A
公开(公告)日：1981-03-17
申请号：US95572
申请日：1979-11-19
申请人： Hitoshi Uno , Yasutaka Nagai , Katsuhiko Hino , Hideo Nakamura
发明人： Hitoshi Uno , Yasutaka Nagai , Katsuhiko Hino , Hideo Nakamura
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P25/04 , A61P29/00 , C07D213/74
CPC分类号： C07D213/74
摘要： Novel 4-(2'-pyridylamino)phenylacetic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, a halogen, a lower alkyl having 1 to 3 carbon atoms, or nitro, R.sub.2 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.3 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.4 is hydrogen or a lower alkyl having 1 to 3 carbon atoms, R.sub.5 is hydrogen or --CH.sub.2 CH.sub.2 OR.sub.6 wherein R.sub.6 is a lower alkyl having 2 or 3 carbon atoms and being substituted with 1 or 2 hydroxy groups, provided that R.sub.1 or R.sub.2 is not 4-halogen, or pharmaceutically acceptable salts thereof, and a process for the preparation thereof, pharmaceutical composition of said compounds, and a method of using said compounds as anti-inflammatory and analgesic agents. They have excellent anti-inflammatory and analgesic activities with an extremely weak ulcerogenicity in the gastrointestinal tract. Some of the compounds have superior inhibitory activity against chronic inflammation mediated by cellular immunity.
摘要翻译：下式的新型4-（2'-吡啶基氨基）苯乙酸衍生物：其中R 1是氢，卤素，具有1至3个碳原子的低级烷基或硝基，R 2是氢，卤素或低级具有1至3个碳原子的烷基，R 3是氢，卤素或具有1至3个碳原子的低级烷基，R 4是氢或具有1至3个碳原子的低级烷基，R 5是氢或-CH 2 CH 2 OR 6，其中R 6是具有2或3个碳原子并且被1或2个羟基取代的低级烷基，条件是R1或R2不是4-卤素，或其药学上可接受的盐，及其制备方法，所述化合物的药物组合物和使用所述化合物作为抗炎和止痛剂的方法。它们具有优异的抗炎和止痛活性，在胃肠道中具有非常弱的溃疡形成能力。一些化合物对由细胞免疫介导的慢性炎症具有优异的抑制活性。

5. 发明授权

US4238620A Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process for preparation thereof, method of using the same, and compositions thereof 失效
标题翻译：二苯并[b，f]氧杂七环素和二苯并[b，f]硫蛋白衍生物，其制备方法，使用该方法及其组合物
公开(公告)号：US4238620A
公开(公告)日：1980-12-09
申请号：US13477
申请日：1979-02-21
申请人： Hitoshi Uno , Yasutaka Nagai , Hideo Nakamura
发明人： Hitoshi Uno , Yasutaka Nagai , Hideo Nakamura
IPC分类号： A61K31/335 , A61P25/04 , A61P29/00 , C07C41/26 , C07C43/295 , C07C59/68 , C07C65/34 , C07D295/194 , C07D313/14 , C07D337/14
CPC分类号： C07D295/194 , C07C323/00 , C07C41/22 , C07C41/26 , C07C59/68 , C07C65/34 , C07D313/14 , C07D337/14 , Y10S514/916
摘要： Novel dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives of the formula ##STR1## wherein X is an oxygen or sulfur atom, each of R.sub.1 and R.sub.2 is a hydrogen atom or a methyl group, and R.sub.3 is a hydrogen atom or a 2-(2-hydroxyethoxy)ethyl group; provided that when R.sub.1 is a hydrogen atom, the group ##STR2## is a group other than a 1-carboxyethyl group; and when X is a sulfur atom, both R.sub.1 and R.sub.2 are methyl groups;and pharmaceutically acceptable salts of said compounds in which R.sub.3 is a hydrogen atom. Compositions of said compounds, processes for the preparation of said compounds, and a method of using said compounds are also provided. These novel compounds have excellent anti-inflammatory, analgesic and antipyretic activities.
摘要翻译：新颖的二苯并[b，f]氧杂七环和二苯并[b，f]硫酮衍生物，其中X是氧或硫原子，R1和R2各自为氢原子或甲基，R3为氢原子或2-（2-羟基乙氧基）乙基; 条件是当R1是氢原子时，基团是除1-羧乙基以外的基团; 当X为硫原子时，R1和R2均为甲基; 和所述化合物的药学上可接受的盐，其中R 3是氢原子。还提供了所述化合物的组合物，所述化合物的制备方法和使用所述化合物的方法。这些新化合物具有优异的抗炎，止痛和解热活性。

6. 发明授权

US4080453A 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same 失效
标题翻译： 1-取代的4-（1,2-二苯基乙基）哌嗪衍生物和含有它们的组合物
公开(公告)号：US4080453A
公开(公告)日：1978-03-21
申请号：US663158
申请日：1976-03-02
申请人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
发明人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
IPC分类号： C07D295/02 , C07D295/03 , C07D295/096 , C07D295/14 , A61K31/495
CPC分类号： C07D295/03 , C07D295/096
摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.
摘要翻译： 1-取代的4-（1,2-二苯基乙基）哌嗪衍生物，其结构式如下：其中X是2-或3-羟基，2-甲氧基，3-甲基，具有1至4个碳原子的3-烷氧基，或具有2至5个碳原子的2-或3-烷酰氧基; R是烯丙基，3-羟基异戊基，3-甲基-2-丁烯基，3-甲基-3-丁烯基，丙基，未取代的具有5-8个碳原子的单环烷基，2-氯苯基或被羟基或甲氧基取代的苯基; 条件是当X是位置2的取代基时，R是环己基，当X是3-甲基时，R是2-甲氧基苯基或未取代的具有6-8个碳原子的单环烷基及其药学上可接受的盐及其制备方法，以及含有与基本上活性成分相同的镇痛或镇咳药物。

7. 发明授权

US4162316A 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same 失效
公开(公告)号：US4162316A
公开(公告)日：1979-07-24
申请号：US821918
申请日：1977-08-04
申请人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
发明人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
IPC分类号： C07D295/02 , C07D295/03 , C07D295/096 , C07D241/04 , A61K31/495
CPC分类号： C07D295/03 , C07D295/096
摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

8. 发明授权

US3988456A 1,2-Diphenylethanolamine derivatives and their salts and the preparation thereof 失效
标题翻译： 1,2-二苯乙醇胺衍生物及其盐及其制备方法
公开(公告)号：US3988456A
公开(公告)日：1976-10-26
申请号：US561336
申请日：1975-03-24
申请人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
发明人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
IPC分类号： C07D295/08 , A61K31/495 , A61P9/12 , A61P11/14 , A61P25/00 , A61P25/04 , C07D213/74 , C07D295/084 , C07D295/10
CPC分类号： C07D295/092 , Y10S514/849
摘要： 1,2-Diphenylethanolamine derivatives of the formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are each hydrogen, a halogen, nitro, hydroxy, an alkyl or methoxy; R.sub.3 is a group of the formula: ##SPC2##Wherein R.sub.4, R.sub.5 and R.sub.6 are each hydrogen, a halogen or methoxy and n is an integer of 0 to 3, or a pyridyl; and Z is hydroxy or an acyloxy; with proviso that when R.sub.1 and/or R.sub.2 are hydroxy, Z is hydroxy, and their pharmaceutically acceptable salts, which have excellent analgesic and anti-tussive activities, and a process for the preparation thereof.
摘要翻译：下式的1,2-二苯乙醇胺衍生物：

9. 发明授权

US3957788A 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof 失效
标题翻译： 1-取代-4-（1,2-二苯基乙基）哌嗪衍生物及其盐及其制备方法
公开(公告)号：US3957788A
公开(公告)日：1976-05-18
申请号：US541351
申请日：1975-01-15
申请人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
发明人： Haruki Nishimura , Hitoshi Uno , Kagayaki Natsuka , Noriaki Shimokawa , Masanao Shimizu , Hideo Nakamura
IPC分类号： C07D295/02 , C07D295/03 , C07D295/096 , C07D295/145 , C07D295/08
CPC分类号： C07D295/03 , C07D295/096 , C07D295/145 , Y10S514/849
摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##SPC1##Wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl,And their pharmaceutically acceptable salts, which have excellent analgesic, anti-tussive and anti-inflammatory activities, without undesirable side effect such as narcotic activity, and a process for the preparation thereof.

10. 发明申请

US20150158119A1 WELDING METHOD, WELDING DEVICE, AND METHOD FOR MANUFACTURING BATTERY 有权
标题翻译：焊接方法，焊接装置以及制造电池的方法
公开(公告)号：US20150158119A1
公开(公告)日：2015-06-11
申请号：US14401189
申请日：2012-05-15
申请人： Hideo Nakamura , Tooru Sugiyama , Seiichi Matsumoto , Noriaki Yamamoto , Yoshinori Shibata
发明人： Hideo Nakamura , Tooru Sugiyama , Seiichi Matsumoto , Noriaki Yamamoto , Yoshinori Shibata
IPC分类号： B23K26/03 , H01M2/02 , B23K26/20
CPC分类号： B23K26/034 , B23K26/032 , B23K26/0622 , B23K26/21 , B23K26/32 , B23K31/125 , B23K2101/36 , B23K2103/08 , B23K2103/10 , H01M2/02 , H01M2/0439
摘要： Disclosed is a technique for quickly detecting a defect of a portion welded by laser beam welding. Specifically disclosed is a welding step in which a welding device is used, the welding device welding an object to be welded with a pulsed laser. In the welding step, a first photodetector receives only infrared rays having a wavelength allowing detection of a keyhole formed in a molten pool from among infrared rays radiating from a welded portion during the welding of the object, and an analyzer determines quality of the welded portion on the basis of intensity of the infrared rays received by the first photodetector.
摘要翻译：公开了一种用于快速检测通过激光束焊接焊接的部分的缺陷的技术。具体公开了一种焊接步骤，其中使用焊接装置，焊接装置用脉冲激光焊接待焊接的物体。在焊接工序中，第一光电检测器仅在物体焊接期间从仅从焊接部分发射的红外线中仅接收具有波长的红外线，该波长允许检测在熔池中形成的锁孔，并且分析器确定焊接部分的质量基于由第一光电检测器接收的红外线的强度。

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