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1. 发明授权

US5238938A Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US5238938A
公开(公告)日：1993-08-24
申请号：US857726
申请日：1992-03-26
申请人： Hitoshi Tone , Seiji Sato , Hideaki Sato , Katsumi Tamura , Shigeharu Tamada , Kazumi Kondo , Tomoyuki Kawaguchi , Yoshimasa Nakano , Yasuyuki Kita , Shuji Akai , Hiromichi Fujioka , Yasumitsu Tamura , Katsuhide Matoba , Youichi Taniguchi , Shinji Nishitani , Satoshi Hayakawa , Toshinori Kaneyasu , Yoshihiko Ito , Masahiro Murakami
发明人： Hitoshi Tone , Seiji Sato , Hideaki Sato , Katsumi Tamura , Shigeharu Tamada , Kazumi Kondo , Tomoyuki Kawaguchi , Yoshimasa Nakano , Yasuyuki Kita , Shuji Akai , Hiromichi Fujioka , Yasumitsu Tamura , Katsuhide Matoba , Youichi Taniguchi , Shinji Nishitani , Satoshi Hayakawa , Toshinori Kaneyasu , Yoshihiko Ito , Masahiro Murakami
IPC分类号： C07D403/04 , C07D403/06
CPC分类号： C07D403/04 , C07D403/06
摘要： The novel indole derivatives and salts thereof represented by the general formula (1) ##STR1## possess, for example, an inhibitory effect against superoxide (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation and an anti-albuminuria activity against Masugi nephritis, and are useful in various clinical fields as an agent for preventing and treating diseases and cases associated with the above superoxide radical, for example, autoimmune diseases (e.g. rheumatism), arteriosclerosis, ischemic disease, ischemic encephalopathia, hepatic insufficiency and renal insufficiency, and also as an agent for preventing and treating nephritis.
摘要翻译：由通式（1）表示的新的吲哚衍生物及其盐具有例如通过刺激和抗白蛋白尿对豚鼠巨噬细胞释放的对超氧化物（O 2 - ）的抑制作用针对Masugi肾炎的活性，并且在各种临床领域中用作预防和治疗与上述超氧化物基团相关的疾病和病例的药剂，例如自身免疫性疾病（例如风湿病），动脉硬化，缺血性疾病，缺血性脑病，肝功能不全和肾功能不全，还可用作预防和治疗肾炎的药剂。

2. 发明申请

US20110190461A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER 审中-公开
标题翻译：新型杂环芳族化合物和聚合物
公开(公告)号：US20110190461A1
公开(公告)日：2011-08-04
申请号：US13054425
申请日：2008-09-10
申请人： Yasuyuki Kita , Toshifumi Dohi , Koji Morimoto , Yoshiyuki Morita , Tetsuya Hosomi , Setsuko Ishioka
发明人： Yasuyuki Kita , Toshifumi Dohi , Koji Morimoto , Yoshiyuki Morita , Tetsuya Hosomi , Setsuko Ishioka
IPC分类号： C08F34/04 , C07D495/04 , C07D491/056
CPC分类号： C08F28/06 , C07D495/04 , C08G61/123 , C08L65/00 , C09D5/24 , C09D201/00 , H01B1/127 , Y02P20/582
摘要： A heterocycle-containing aromatic compound represented by the formula: A-B, and an electrically conductive polymer obtained by oxidative polymerization of the heterocycle-containing aromatic compound as a monomer are provided. In the above formula, A represents a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; B represents a substituted or unsubstituted hydrocarbon aromatic ring group, a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; the ring represented by A and the ring represented by B are directly linked; however, A and B represent structures that are different from each other. The compound can be produced by a coupling reaction using a hypervalent iodine reactant.
摘要翻译：提供由式-A-B表示的含杂环芳族化合物和通过含杂环芳香族化合物作为单体进行氧化聚合而得到的导电性聚合物。在上式中，A表示取代或未取代的噻吩环基或取代或未取代的吡咯环基; B表示取代或未取代的烃芳族环基团，取代或未取代的噻吩环基团，或取代或未取代的吡咯环基团; 由A表示的环和由B表示的环直接连接; 然而，A和B表示彼此不同的结构。该化合物可以通过使用高价碘反应物的偶联反应来制备。

3. 发明申请

US20060058379A1 Connexin 26 inhibitor and cancer metastasis inhibitors 审中-公开
标题翻译：连接蛋白26抑制剂和癌症转移抑制剂
公开(公告)号：US20060058379A1
公开(公告)日：2006-03-16
申请号：US10536805
申请日：2003-11-28
申请人： Yasuyuki Kita , Hiroshi Nojima , Akihiko Ito
发明人： Yasuyuki Kita , Hiroshi Nojima , Akihiko Ito
IPC分类号： A61K31/336
CPC分类号： A61K31/336 , A61K31/16
摘要： A connexin 26 inhibitor and a cancer metastasis inhibitor have a cis-oxirane structure and a terminal amide structure as represented by the following general formula (1): where R is a hydrogen atom or a hydrocarbon group, X is one of a hydrogen atom, a methansulfonyl group, an ethansulfonyl group, an acetyl group, a trifluoroacetyl group, a hydroxyl group, an alkoxy group and an amino group; m is an integer of from 4 to 10; and n is an integer of from 4 to 7. This compound is a novel cancer metastasis inhibitor which specifically inhibits the function of connexin 26.
摘要翻译：连接蛋白26抑制剂和癌症转移抑制剂具有如以下通式（1）所示的顺式 - 环氧乙烷结构和末端酰胺结构：

4. 发明授权

US07677121B2 Apparatus and methods for measuring shape of both sides of a plate 有权
标题翻译：用于测量板的两侧形状的装置和方法
公开(公告)号：US07677121B2
公开(公告)日：2010-03-16
申请号：US11462737
申请日：2006-08-07
申请人： Shigetaka Akiyama , Shinichi Tanaka , Takanobu Akiyama , Katsunobu Ueda , Yasuyuki Kita
发明人： Shigetaka Akiyama , Shinichi Tanaka , Takanobu Akiyama , Katsunobu Ueda , Yasuyuki Kita
IPC分类号： G01M19/00 , B23Q17/09
CPC分类号： G03F7/70791 , G01B11/306 , G03F1/60 , G03F1/84 , G03F7/70783
摘要： In an apparatus for measuring shapes of both sides of a plate, a measuring apparatus body includes a reference plane of a longitudinal surface plate disposed in an almost vertical state at one end on a metallic bed, a holding mechanism for holding a plate to be measured in almost parallel therewith, and a displacement gauge scanning column. The displacement gauge scanning column includes a first air slide for mounting a first (second) displacement gauge and a second air slide for mounting a third displacement gauge, and is moved in a horizontal axis direction along a pair of V grooves. Moreover, the first (second) air slide is moved in a vertical axis direction. A shape of one of plate surfaces of the plate to be measured is measured by the scan of the first (second) displacement gauge, and at the same time, a shape of the other surface of the plate surface is measured by the scan of the third displacement gauge.
摘要翻译：在用于测量板的两侧的形状的装置中，测量装置主体包括在金属床的一端处于几乎垂直状态的纵向表面板的基准面，用于保持被测量板的保持机构几乎与其平行，以及位移计扫描柱。位移计扫描柱包括用于安装第一（第二）位移计的第一空气滑块和用于安装第三位移量规的第二空气滑块，并沿着一对V形槽在水平轴线方向上移动。此外，第一（第二）空气滑块沿垂直轴方向移动。通过第一（第二）位移计的扫描来测量要测量的板的一个板表面的形状，同时通过扫描板的表面来测量板表面的另一个表面的形状第三排量规。

5. 发明申请

US20080089924A1 Multimeric Oleamide Derivative Having Connexin-26 Inhibiting Potency and Use Thereof in Cancer Therapy, etc. 有权
标题翻译：具有连接蛋白-26抑制效力及其在癌症治疗中的用途的多聚Oleamide衍生物等
公开(公告)号：US20080089924A1
公开(公告)日：2008-04-17
申请号：US11718361
申请日：2005-11-01
申请人： Hiroshi Nojima , Yasuyuki Kita
发明人： Hiroshi Nojima , Yasuyuki Kita
IPC分类号： A61K47/00 , A61K31/16 , A61P35/00
CPC分类号： C07C233/09 , A23L33/12 , A23V2002/00 , C07C233/38 , C07D303/36 , C07D303/46 , A23V2200/308 , A23V2250/188
摘要： The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.
摘要翻译：本发明涉及具有连接蛋白26抑制活性的多聚体油酰胺衍生物，并且包括由下式（1）表示的二聚油酰胺衍生物或其药理学上可接受的盐：其中n表示3,5或8的整数。新的油酰胺本发明的衍生物不仅可以用作研究试剂，还可用于广泛的工业领域，因为它们表现出有用的生物活性，例如癌症转移/生长抑制。因此，除了癌症预防和癌症治疗药物之外，它们具有各种应用，例如药物，补充剂和功能性食品。

6. 发明授权

US07846972B2 Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc 有权
标题翻译：具有连接蛋白-26抑制效力的多聚油酰胺衍生物及其在癌症治疗中的应用等
公开(公告)号：US07846972B2
公开(公告)日：2010-12-07
申请号：US11718361
申请日：2005-11-01
申请人： Hiroshi Nojima , Yasuyuki Kita
发明人： Hiroshi Nojima , Yasuyuki Kita
IPC分类号： A01N37/18 , A61K31/195 , A61K47/00 , C07C233/00
CPC分类号： C07C233/09 , A23L33/12 , A23V2002/00 , C07C233/38 , C07D303/36 , C07D303/46 , A23V2200/308 , A23V2250/188
摘要： The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.
摘要翻译：本发明涉及具有连接蛋白26抑制活性的多聚体油酰胺衍生物，并且包括由下式（1）表示的二聚油酰胺衍生物或其药理学上可接受的盐：其中n表示3,5或8的整数。新的油酰胺本发明的衍生物不仅可以用作研究试剂，还可用于广泛的工业领域，因为它们表现出有用的生物活性，例如癌症转移/生长抑制。因此，除了癌症预防和癌症治疗药物之外，它们具有各种应用，例如药物，补充剂和功能性食品。

7. 发明授权

US6013826A Method formation of a carbon-carbon bond 失效
标题翻译：方法形成碳 - 碳键
公开(公告)号：US6013826A
公开(公告)日：2000-01-11
申请号：US63825
申请日：1998-04-22
申请人： Yasuyuki Kita , Atsunori Sano , Takahiro Yamaguchi , Masahisa Oka , Masato Matsugi , Kentoku Gotanda
发明人： Yasuyuki Kita , Atsunori Sano , Takahiro Yamaguchi , Masahisa Oka , Masato Matsugi , Kentoku Gotanda
IPC分类号： B01J31/02 , C07B37/02 , C07B39/00 , C07C253/30 , C07C255/00
CPC分类号： C07B39/00 , B01J31/0235 , C07B37/02 , C07C253/30 , B01J2231/323
摘要： A method for an addition reaction with the formation of an additional carbon--carbon bond comprising reacting an .alpha.-halogeno carboxylic acid derivative with an alkene in the presence of a catalyst shown by the general formula (1): ##STR1## wherein R.sub.1 is a lower alkyl group.
摘要翻译：一种形成另外的碳 - 碳键的加成反应的方法，包括在由通式（1）表示的催化剂存在下使α-卤代羧酸衍生物与烯烃反应：其中R1是低级烷基。

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