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1. 发明申请

US20160136543A1 SEPARATION DEVICE AND SEPARATION METHOD 审中-公开
标题翻译：分离装置和分离方法
公开(公告)号：US20160136543A1
公开(公告)日：2016-05-19
申请号：US14897844
申请日：2014-06-19
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Yasuhiko TADA , Takeyuki KONDO , Sei MURAKAMI
IPC分类号： B01D15/22 , B01D15/18
CPC分类号： B01D15/22 , B01D15/08 , B01D15/1821 , B01D15/1885 , B01D15/20 , C07K1/22 , G01N2030/8813
摘要： An object of the present invention is to separate a material to be separated at a low cost and constant accuracy when the material to be separated is separated from a mobile phase containing the material to be separated through the passing of the mobile phase through a stationary phase, even if the mobile phase has a large volume. A separation device characterized in that a separation column provided with a stationary phase having a volume capable of processing the entire volume of a mobile phase containing a material to be separated is provided, the separation column is replaceable, and the usage count of the stationary phase reaches a lifetime count through the processing of one batch.
摘要翻译：本发明的目的是当待分离的材料通过流动相通过固定相与含有待分离材料的流动相分离时，以低成本和恒定的精度将待分离的材料分离，即使流动相具有较大的体积。一种分离装置，其特征在于，设置有具有能够处理含有待分离材料的流动相的整个体积的体积的固定相的分离塔，所述分离塔是可更换的，并且所述固定相的使用计数通过一批处理达到终身计数。

2. 发明申请

US20140178996A1 CULTURE CONTROL METHOD, CELL CULTURE APPARATUS, AND APPARATUS FOR EVALUATION OF CELLULAR CHARACTERISTICS 有权
标题翻译：文化控制方法，细胞培养装置和细胞特性评价装置
公开(公告)号：US20140178996A1
公开(公告)日：2014-06-26
申请号：US14108409
申请日：2013-12-17
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Ryoichi HAGA , Masaru NAMBA , Kenichiro OKA , Ken AMANO
IPC分类号： C12M1/34
CPC分类号： C12M41/42 , C12M25/02 , C12M27/02 , C12M35/04 , C12M41/32 , C12M41/48
摘要： This invention provides a culture control method and a cell culture apparatus that enable stable cell culture by regulating shear stress to be applied to cells within an adequate range. With the application of such culture control method and cell culture apparatus, cell culture is performed under agitation culture conditions in which the shear stress distribution is 0.5 Pa to 20 Pa in 80% or more of the culture vessel by volume.
摘要翻译：本发明提供一种培养控制方法和细胞培养装置，其通过调节施加到适当范围内的细胞的剪切应力来实现稳定的细胞培养。通过这样的培养控制方法和细胞培养装置的应用，在培养容器的体积的80％以上的剪切应力分布为0.5Pa〜20Pa的搅拌条件下进行细胞培养。

3. 发明申请

US20200063106A1 CELL CULTURE MEDIUM, AND CELL CULTURE APPARATUS AND CELL CULTURE METHOD EACH USING SAME 审中-公开
公开(公告)号：US20200063106A1
公开(公告)日：2020-02-27
申请号：US16462954
申请日：2017-10-31
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Masashi MARUYAMA , Takeyuki KONDOU
IPC分类号： C12N5/071 , C12M1/06 , C12M1/00 , C12M1/34
摘要： A cell culture apparatus (1) of the present invention comprises: a culture vessel (2) in which a cell culture medium comprising at least one of culture components composed of a conjugate with a stimuli-responsive polymer is stored and cells are cultured in the medium; a stimulus-applying mechanism (4) that applies a predetermined stimulus to the conjugate so as to induce a predetermined change of the stimuli-responsive polymer in response to the stimulus; and, a separation mechanism (5) that separates at least a part of the medium components except for the conjugate from the cell culture medium, while leaving the conjugate in the cell culture medium, on the basis of a property change of the stimuli-responsive polymer.

4. 发明申请

US20170193190A1 MEDICINE PRODUCTION SUPPORT SYSTEM AND MEDICINE PRODUCTION SUPPORT METHOD 审中-公开
公开(公告)号：US20170193190A1
公开(公告)日：2017-07-06
申请号：US15314633
申请日：2014-05-30
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Toshiaki MATSUO
IPC分类号： G06F19/00 , G06Q50/22 , C12N5/07 , A61J3/00 , A61K9/00
CPC分类号： G06F19/3462 , A61J3/00 , A61K9/00 , A61M2205/52 , A61M2205/6009 , C12N5/06 , G06F19/00 , G06F19/3456 , G06Q50/22 , G06Q50/24
摘要： In order to improve variety of medicines producible, a central control device that controls a plant control device for controlling a cell culture environment of a cell strain for producing a medicine is installed in a pharmaceutical manufacturing plant for manufacturing a medicine. The central control device controls the plant control device on the basis of analysis data relevant to an inspection result of a patient. The central control device transmits traffic information to a navigation device, and the navigation device searches for a delivery route of a delivery vehicle for delivering a medicine on the basis of the transmitted traffic information.

5. 发明申请

US20160017059A1 ADSORBENT 审中-公开
标题翻译：吸引力
公开(公告)号：US20160017059A1
公开(公告)日：2016-01-21
申请号：US14798608
申请日：2015-07-14
申请人： HITACHI, LTD.
发明人： Masashi MARUYAMA , Yasuhiko TADA , Keisuke SHIBUYA
IPC分类号： C07K17/06 , C07K1/22
CPC分类号： C07K17/06 , B01D15/3809 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3225 , B01J20/3274 , B01J20/3278 , B01J20/3285 , B01J2220/58 , C07K1/22
摘要： An adsorbent of the present invention includes a support; and a protein having an adsorption site for adsorbing a target substance, in which the protein includes a reversible binding site and a covalent binding site, the support includes an orientation-controlling site forming a reversible bond with the reversible binding site, and an immobilization site forming a covalent bond with the covalent binding site, the covalent binding site includes a nucleophilic functional group, and the immobilization site includes a functional group capable of reacting with the nucleophilic functional group by a nucleophilic substitution or a nucleophilic addition. Thus, it is possible to provide an adsorbent in which the utilization efficiency of the adsorption site of the protein is improved. As a result, the protein amount can be reduced, and the step for storing a culture solution can be simplified due to the faster purification step.
摘要翻译：本发明的吸附剂包括载体; 以及具有吸附目标物质的吸附部位的蛋白质，其中所述蛋白质包含可逆结合位点和共价结合位点，所述载体包括与可逆结合位点形成可逆键的取向控制位点和固定位点与共价结合位点形成共价键，共价结合位点包括亲核官能团，并且固定位点包括能够通过亲核取代或亲核加成与亲核官能团反应的官能团。因此，可以提供蛋白质的吸附部位的利用效率提高的吸附剂。结果，可以降低蛋白质量，并且由于更快的纯化步骤，可以简化用于储存培养溶液的步骤。

6. 发明申请

US20210189452A1 METHOD AND APPARATUS FOR SCREENING OF CELL STRAINS AND CULTURE CONDITIONS 有权
公开(公告)号：US20210189452A1
公开(公告)日：2021-06-24
申请号：US16771837
申请日：2018-11-01
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Kenichirou OKA , Takeyuki KONDOU
IPC分类号： C12Q1/02 , C12M1/34
摘要： A method and apparatus for screening of cell lines and culture conditions includes a target value setting step that sets a target value relating to a metabolic reaction of a culture cell; a first culturing step; an analysis step; an analysis value calculation step that performs a metabolism analysis based on an analysis result from the analysis step and calculates an analysis value; a culture condition computation step that computes, using a correlation model, a culture condition giving an analysis value most close to the target value, and modifies the culture condition set in the first culturing step to the computed culture condition; a second culturing step that cultures a cell under the modified culture condition; and a screening step.

7. 发明申请

US20160144294A1 PURIFICATION DEVICE, AND PURIFICATION METHOD 有权
标题翻译：净化装置和净化方法
公开(公告)号：US20160144294A1
公开(公告)日：2016-05-26
申请号：US14787428
申请日：2014-05-07
申请人： HITACHI, LTD.
发明人： Keisuke SHIBUYA , Yui SUGITA , Ryouichi HAGA , Masaru NANBA
IPC分类号： B01D15/38 , B01J20/286 , B01J20/24
CPC分类号： B01D15/3809 , B01D15/3876 , B01J20/24 , B01J20/286 , B01J20/3272 , B01J20/3425 , B01J20/3475 , B01J20/3483 , B01J2220/58 , C07K1/22
摘要： Provided is a purification device for purifying a useful substance (i.e., target substance) without using an acidic eluent. The purification device purifying the target substance comprises a column and a filler packed in the column. The filler contains a carrier, a temperature responsive polyamino acid bonded to the carrier, and a binding substance bonded to the temperature responsive polyamino acid and specifically bonding to the target substance.
摘要翻译：提供一种不使用酸性洗脱液来纯化有用物质（即目标物质）的净化装置。纯化目标物质的净化装置包括柱和填充在柱中的填料。填料含有载体，与载体结合的温度响应性聚氨基酸，以及与温度响应性聚氨基酸键合并特异性结合目标物质的结合物质。

8. 发明申请

US20150344831A1 STIMULATION-RESPONSIVE MATERIAL AND CELL CULTURE CONTAINER MADE THEREOF 审中-公开
标题翻译：刺激性物质和细胞培养容器
公开(公告)号：US20150344831A1
公开(公告)日：2015-12-03
申请号：US14690755
申请日：2015-04-20
申请人： Hitachi, Ltd.
发明人： Keisuke SHIBUYA , Masashi MARUYAMA , Yasuhiko TADA
IPC分类号： C12M1/12 , C08L41/00 , C08L33/26 , C08L35/00 , C08L33/10 , C08L79/02 , C08L33/00
CPC分类号： C12M25/14 , C08L33/00 , C08L33/10 , C08L33/26 , C08L35/00 , C08L41/00 , C08L79/02 , C08L2203/02 , C12M23/20 , C12M25/06 , C12M33/00
摘要： A stimulation-responsive material comprises regions of pH-responsive polymer and regions of temperature-responsive polymer, the regions existing at different locations.
摘要翻译：刺激响应材料包含pH响应聚合物区域和温度响应性聚合物区域，该区域存在于不同位置。

9. 发明申请

US20200299744A1 MODIFIED PROTEIN AND METHOD FOR USING SAME 审中-公开
公开(公告)号：US20200299744A1
公开(公告)日：2020-09-24
申请号：US16765658
申请日：2019-01-30
申请人： HITACHI, LTD.
发明人： Masashi MARUYAMA , Keisuke SHIBUYA
IPC分类号： C12P21/00 , C07K14/62 , C08F8/30 , C08F20/56
摘要： The present invention pertains to a means and method for, from a mixture (cell culture) of cells, a medium component, and a useful substance, recovering the first two using a single process. Specifically, the present invention pertains to a polypeptide modified with a stimulus-responsive polymer, characterized in that the stimulus-responsive polymer responds to a stimulus to induce a change in the physical properties of the modified polypeptide overall, and the change is reversible or pseudo-reversible.

10. 发明申请

US20190039046A1 ADSORBENT MATERIAL AND PURIFICATION METHOD 审中-公开
公开(公告)号：US20190039046A1
公开(公告)日：2019-02-07
申请号：US16077577
申请日：2017-01-13
申请人： HITACHI, LTD.
发明人： Masashi MARUYAMA , Nanae YAMASHITA , Hiroshi YOSHIDA , Keisuke SHIBUYA
IPC分类号： B01J20/281 , B01J20/32 , B01D15/38 , C07K1/22
摘要： The present invention has a subject of desorbing a target substance under mild elusion conditions in affinity purification using a low molecular weight ligand. In the present invention, a polar auxiliary group is introduced to a site adjacent to the low molecular weight ligand to perturb a pKa value of a functional group in the low-molecular-weight ligand, thereby ionizing the low molecular weight ligand under mild pH conditions.

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