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1. 发明授权

US06297904B1 Inverted confocal microscope 失效
标题翻译：倒置共聚焦显微镜
公开(公告)号：US06297904B1
公开(公告)日：2001-10-02
申请号：US09400410
申请日：1999-09-21
申请人： Hisao Kitagawa , Yasushi Aono , Kazuhiko Osa , Yosuke Kishi , Yoshihiro Shimada
发明人： Hisao Kitagawa , Yasushi Aono , Kazuhiko Osa , Yosuke Kishi , Yoshihiro Shimada
IPC分类号： G02B2100
CPC分类号： G02B21/0052 , G02B21/0048 , G02B21/0076 , G02B21/0088
摘要： An inverted microscope is provided that reflects an observation light passing through an image-formation optical system upward using at least one reflection optical system and that leads the observation light to an observation path. The inverted microscope includes a confocal scanner arranged at an image surface position of the image-formation optical system, a light source for applying light onto a sample through the confocal scanner and the image-formation optical system, and a confocal image formation optical system that leads the light passing through the confocal scanner to the sample through the image-formation optical system, returns a return light from the sample to the confocal scanner along a route opposite to that for leading the light to the sample, and obtains a confocal image. A confocal observation optical system is also provided for leading the return light from the sample passing through the optical scanner to the observation optical path.
摘要翻译：提供一种倒置显微镜，其使用至少一个反射光学系统向上反射通过图像形成光学系统的观察光，并将观察光引导到观察路径。倒置显微镜包括布置在图像形成光学系统的图像表面位置处的共焦扫描器，用于通过共焦扫描器和图像形成光学系统将光施加到样本上的光源，以及共焦图像形成光学系统，其中将通过共聚焦扫描器的光引导到通过图像形成光学系统的样品，沿着与将光导向样品的路线相反的路线从样品返回到共聚焦扫描器，并获得共聚焦图像。还提供了共焦观察光学系统，用于将来自通过光学扫描器的样品的返回光引导到观察光路。

2. 发明授权

US4629862A Sample heater for use in microscopes 失效
标题翻译：用于显微镜的样品加热器
公开(公告)号：US4629862A
公开(公告)日：1986-12-16
申请号：US671732
申请日：1984-11-15
申请人： Hisao Kitagawa , Yasuo Inoue , Tadafumi Fujihara , Itaru Endo , Yoshihiro Shimada
发明人： Hisao Kitagawa , Yasuo Inoue , Tadafumi Fujihara , Itaru Endo , Yoshihiro Shimada
IPC分类号： G02B21/30 , H05B3/22
CPC分类号： G02B21/30 , C12M41/12 , C12M41/36
摘要： A heater for microscopes for heating a sample and maintaining the sample, which is mounted on a platform of the microscope, at a preset temperature during observation of the sample. The heater includes a platform for supporting thereon a sample container and a heater for heating at least part of the platform. A first heater box is fitted, open end down, over the platform and is connected thereto to form a first space which surrounds the sample container. A second heater box is then fitted over the first heater box in such a manner that a second space which surrounds the first heater box is formed. Heater means are provided for heating the second space. Accordingly, the temperatures in the first space and in the second space can be controlled independently to achieve better control over the temperature of the sample which is to be observed and to control condensation which may otherwise form in the sample holding container.
摘要翻译：用于在样品观察期间加热样品并将安装在显微镜的平台上的样品保持在预设温度的显微镜加热器。加热器包括用于在其上支撑样品容器的平台和用于加热至少部分平台的加热器。第一加热箱被安装在平台上并向下开口，并与之相连，形成围绕样品容器的第一空间。然后将第二加热器盒以这样的方式装配在第一加热器盒上，使得形成围绕第一加热箱的第二空间。提供加热装置用于加热第二空间。因此，可以独立地控制第一空间和第二空间中的温度，以便更好地控制待观察的样品的温度并控制另外可能在样品保持容器中形成的冷凝。

3. 发明授权

US06563634B2 Microscope with aberration correcting function 有权
标题翻译：具有像差校正功能的显微镜
公开(公告)号：US06563634B2
公开(公告)日：2003-05-13
申请号：US09951871
申请日：2001-09-13
申请人： Masakazu Shimada , Yoshihiro Shimada , Hisao Kitagawa
发明人： Masakazu Shimada , Yoshihiro Shimada , Hisao Kitagawa
IPC分类号： G02B2100
CPC分类号： G02B21/241
摘要： A microscope according to the invention comprises an aberration correcting objective lens facing a specimen and having an aberration correcting lens correcting an aberration due to an error in the thickness of a cover, a Petri dish or a slide glass; a moving amount detector detecting moving amount of the aberration correcting lens; a focusing unit moving the specimen; a driver unit driving the focusing unit; and an arithmetic unit obtaining a defocus amount based on a moving amount detected by the moving amount detector. When the aberration correcting lens is moved, the specimen is put out of focus. On the basis of a defocus amount obtained by the arithmetic unit, the driver unit drives the focusing unit so that the lens may focus on the specimen.
摘要翻译：根据本发明的显微镜包括面向样本的像差校正物镜，并且具有校正由盖，培养皿或载玻片的厚度误差引起的像差的像差校正透镜; 移动量检测器，检测像差校正透镜的移动量; 移动样本的聚焦单元; 驱动聚焦单元的驱动单元; 以及算术单元，基于由移动量检测器检测到的移动量获得散焦量。当像差校正透镜移动时，样本失焦。基于由运算单元获得的散焦量，驱动单元驱动聚焦单元，使得透镜可以聚焦在样本上。

4. 发明授权

US08210728B2 LED illumination apparatus with feedback control means 有权
标题翻译：具有反馈控制装置的LED照明装置
公开(公告)号：US08210728B2
公开(公告)日：2012-07-03
申请号：US12335954
申请日：2008-12-16
申请人： Ryo Tsutsui , Yuichiro Matsuo , Yoshihiro Shimada , Mitsuo Harada
发明人： Ryo Tsutsui , Yuichiro Matsuo , Yoshihiro Shimada , Mitsuo Harada
IPC分类号： F21V7/04 , F21V9/10 , G05D25/02
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6458 , G01N2021/6419 , G01N2021/6484 , G01N2201/0624 , G01N2201/0627 , G02B21/06
摘要： An illumination apparatus that includes a plurality of LEDs of different center emission wavelengths, a photodetector, a path sharing device for introducing light emitted from the plurality of LEDs into the common optical path, a light-introducing device located on the common optical path to introduce part of the light emitted from the plurality of LEDs passing through the common optical path into the photodetector, a feedback controller controlling turning-on states of the LEDs over preset states in accordance with the amount of light emitted from the plurality of LEDs detected by the photodetector, and an illumination light supplying device located on the common optical path to supply light which is emitted from the plurality of LEDs to pass through the common optical path and is not introduced into the photodetector through the light-introducing device, as illumination light for a cellular analysis.
摘要翻译：一种照明装置，包括具有不同中心发射波长的多个LED，光电检测器，用于将从多个LED发射的光引入公共光路的路径共享装置，位于公共光路上的光导入装置，从通过公共光路的多个LED发射的光的一部分光进入光电检测器，反馈控制器根据由多个LED检测到的多个LED发射的光量，控制LED在预设状态下的导通状态光电检测器和位于公共光路上的照明光供应装置，用于提供从多个LED发射的光，以通过公共光路，并且不通过光导入装置引入到光电检测器中，作为照明光，细胞分析。

5. 发明授权

US08175370B2 Automatic cell analyzer and automatic cell analyzing method 有权
标题翻译：自动细胞分析仪和自动细胞分析方法
公开(公告)号：US08175370B2
公开(公告)日：2012-05-08
申请号：US12377324
申请日：2007-08-10
申请人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
发明人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
IPC分类号： G06K9/60
CPC分类号： G01N21/6486 , G01N21/6458 , G01N2021/6482
摘要： A sharp image showing a thin projecting part is acquired without using a complex dyeing method, and the analysis accuracy is improved. An automatic cell analyzer (1) comprises: an imaging unit (4) for capturing fluorescence emitted from a cell (S) and acquiring a cell image; an exposure changing section (5) for changing the exposure condition when the imaging unit (4) captures cell images; and a processing section (5) for analyzing the cell (S) on the basis of a plurality of cell images respectively captured under the changed exposure conditions.
摘要翻译：在不使用复杂染色方法的情况下获取显示薄的突出部分的清晰图像，并且提高分析精度。一种自动细胞分析仪（1）包括：用于捕获从细胞（S）发射的荧光并获取细胞图像的成像单元（4）用于当所述成像单元（4）捕获细胞图像时改变所述曝光条件的曝光改变部分（5）; 以及用于基于在改变的曝光条件下分别捕获的多个单元图像来分析单元（S）的处理部分（5）。

6. 发明授权

US07852552B2 Observation apparatus provided with immersion objective lens 有权
标题翻译：配有浸没物镜的观察装置
公开(公告)号：US07852552B2
公开(公告)日：2010-12-14
申请号：US11970210
申请日：2008-01-07
申请人： Mitsuo Harada , Yoshihiro Shimada
发明人： Mitsuo Harada , Yoshihiro Shimada
IPC分类号： G02B21/00
CPC分类号： G02B21/33 , G02B21/248 , G02B21/367
摘要： An observation apparatus for observing an observation object mounted at an observation position on a stage through an immersion objective lens placed below the observation object. The observation apparatus has a liquid pouring device, constructed to be relatively movable with respect to the immersion objective lens, pouring a liquid on a top lens surface of the immersion objective lens from the upper side of the immersion objective lens at a distance from the observation position on the stage; and a position control device automatically adjusting relative positions of a liquid pouring position of the liquid pouring device and the immersion objective lens and automatically adjusting relative positions of the immersion objective lens on which the liquid is poured by the liquid pouring device and a desired observation position on the stage.
摘要翻译：一种用于通过放置在观察对象下方的浸没物镜观察安装在舞台上的观察位置的观察对象的观察装置。观察装置具有液体注入装置，其被构造成相对于浸没物镜相对移动，从浸没物镜的上侧距离观察距离处将液体浸入浸没物镜的上侧透镜表面舞台上的位置以及位置控制装置，自动调整所述液体注入装置的液体倾倒位置和所述浸没物镜的相对位置，并且自动调节由所述液体注入装置注入所述液体的所述浸没物镜的相对位置和期望的观察位置在舞台上。

7. 发明授权

US07649686B2 Box-type microscope apparatus 有权
标题翻译：盒式显微镜装置
公开(公告)号：US07649686B2
公开(公告)日：2010-01-19
申请号：US12141371
申请日：2008-06-18
申请人： Mitsuo Harada , Yoshihiro Shimada
发明人： Mitsuo Harada , Yoshihiro Shimada
IPC分类号： G02B21/26
CPC分类号： G01N21/6458 , G02B21/0088 , G02B21/24 , G02B21/362
摘要： A box-type microscope apparatus includes a stage, a microscope, and a housing, which has a fixed housing and a moving housing provided to be openable, closable, and movable with respect to the fixed housing. The box-type microscope apparatus further includes a specimen vessel positioning device for fixing the specimen vessel placed on the stage at a constant position. of the stage and a positioning release device for actuating the specimen vessel positioning means when the moving housing is moved toward a position of a closed state to release a positioning of the specimen vessel performed by the specimen vessel positioning device with respect to the stage when the moving housing is opened.
摘要翻译：盒式显微镜装置包括台架，显微镜和壳体，其具有设置成可相对于固定壳体可开启，关闭和移动的固定壳体和移动壳体。盒型显微镜装置还包括用于将放置在台架上的标本容器固定在恒定位置的检体容器定位装置。以及定位释放装置，用于当移动壳体朝向关闭状态的位置移动时致动样本容器定位装置，以释放由样本容器定位装置执行的样本容器相对于该阶段的定位移动房屋开放。

8. 发明授权

US09234845B2 Microscope with reflecting fluorescence illumination optical system 有权
标题翻译：具有反射荧光照明光学系统的显微镜
公开(公告)号：US09234845B2
公开(公告)日：2016-01-12
申请号：US12090763
申请日：2007-10-19
申请人： Kenji Kawasaki , Yoshihiro Shimada
发明人： Kenji Kawasaki , Yoshihiro Shimada
IPC分类号： G02B21/06 , G01N21/64 , G02B13/00 , G02B21/16 , G02B21/00 , G02B21/36
CPC分类号： G01N21/6458 , G02B13/0095 , G02B21/0032 , G02B21/0076 , G02B21/082 , G02B21/16 , G02B21/361 , G02B21/367
摘要： A microscope includes an objective lens, an imaging lens projecting light passing through the objective lens to form an image of a specimen, an image sensor located at an imaging position where the image of the specimen is formed, an illumination light source, and a reflecting fluorescence illumination optical system including a dichroic mirror introducing light from the illumination light source into an optical to illuminate the specimen with the light. The microscope further includes a relay optical system forming an intermediate image of the specimen between the objective lens and the imaging lens to relay it to the imaging lens. The dichroic mirror of the reflecting fluorescence illumination optical system is located between the relay optical system and a pupil conjugate position that is conjugate with a pupil position of the objective lens, formed between the relay optical system and the imaging lens.
摘要翻译：显微镜包括物镜，投影透过物镜的光以成像样本的成像透镜，位于形成有检体的图像的摄像位置的图像传感器，照明光源和反射镜荧光照明光学系统，包括将来自照明光源的光引入光学的二向色镜，以用光照射样本。显微镜还包括中继光学系统，其形成物镜和成像透镜之间的样本的中间图像，以将其中继到成像透镜。反射荧光照明光学系统的分色镜位于中继光学系统和与中继光学系统和成像透镜之间形成的物镜的光瞳位置共轭的光瞳共轭位置之间。

9. 发明授权

US08146340B2 Link chain 有权
标题翻译：链接链
公开(公告)号：US08146340B2
公开(公告)日：2012-04-03
申请号：US12680397
申请日：2007-09-27
申请人： Yoshihiro Shimada , Nobuyuki Matsui
发明人： Yoshihiro Shimada , Nobuyuki Matsui
IPC分类号： F16G13/08 , F16H7/06 , B21L9/04
CPC分类号： F16G13/06 , F16G13/04
摘要： A bush is pressed into a link plate in a turning link rank that turns relatively with a pin. The bush is molded into a seamless cylindrical shape by cold-forging and is coated with a metal carbide layer formed by cementation of chrome, vanadium and other metals and having Vickers hardness of 1300 Hv or more similarly to the pin. Afterwards, the bush is treated by a quenching, tempering or isothermal transformation process. Thereby, wear resistance of the pins and the link plates of a silent (link) chain is improved, productivity is improved and associated costs are reduced.
摘要翻译：衬套被压入连接板，转向链中的销与针相对转动。衬套通过冷锻成型为无定形的圆柱形，并且涂覆有通过铬，钒和其它金属的粘结而形成的金属碳化物层，其维氏硬度与销的类似度为1300Hv或更高。然后，通过淬火，回火或等温转化过程处理衬套。因此，提高了静音（连杆）链的销和链板的耐磨性，提高了生产率并降低了相关成本。

10. 发明申请

US20100307128A1 LINK CHAIN 有权
标题翻译：链链
公开(公告)号：US20100307128A1
公开(公告)日：2010-12-09
申请号：US12680397
申请日：2007-09-27
申请人： Yoshihiro Shimada , Nobuyuki Matsui
发明人： Yoshihiro Shimada , Nobuyuki Matsui
IPC分类号： F16G13/08
CPC分类号： F16G13/06 , F16G13/04
摘要： A bush is pressed into a link plate in a turning link rank that turns relatively with a pin. The bush is molded into a seamless cylindrical shape by cold-forging and is coated with a metal carbide layer formed by cementation of chrome, vanadium and others and having Vickers hardness of 1300 Hv or more similarly to the pin. After that, the bush is treated by a quenching, tempering or isothermal transformation process. Thereby, wear resistance of the pins and the link plates of a silent (link) chain is improved, productivity is improved and the cost is cut.
摘要翻译：衬套被压入连接板，转向链中的销与针相对转动。衬套通过冷锻成型为无定形圆柱形，并且涂覆有通过铬，钒等的粘结形成的金属碳化物层，并且与销相似的维氏硬度为1300Hv或更高。之后，通过淬火，回火或等温转化过程处理衬套。因此，提高了无声（链）链的销和链板的耐磨性，提高了生产率并降低了成本。

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