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1. 发明授权

US4305935A Bone formation stimulant 失效
标题翻译：骨形成兴奋剂
公开(公告)号：US4305935A
公开(公告)日：1981-12-15
申请号：US196223
申请日：1980-04-09
申请人： Hiroyuki Kawashima , Minoru Hayashi , Seiji Kurozumi , Yoshiki Suzuki , Yoshinobu Hashimoto
发明人： Hiroyuki Kawashima , Minoru Hayashi , Seiji Kurozumi , Yoshiki Suzuki , Yoshinobu Hashimoto
IPC分类号： A61K31/59 , A61K31/60 , A61P3/02 , A61P3/14 , A61K31/605
CPC分类号： A61K31/60
摘要： This is a bone formation stimulant containing vitamin D.sub.3 or its derivative and acetylsalicylic acid or its formaceutically permissible salt. The present bone formation stimulant is used to cure or prevent the diseases caused by the deficiency of vitamin D or related diseases by dosing human beings or animals with it.
摘要翻译：这是含有维生素D3或其衍生物和乙酰水杨酸或其营养允许的盐的骨形成兴奋剂。目前的骨形成兴奋剂用于通过给予人或动物来治疗或预防由维生素D缺乏引起的疾病或相关疾病。

2. 发明授权

US4022891A Novel 1.alpha.,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them 失效
标题翻译：新型1 {60,24-二羟基胆钙化甾醇组合物，其新型前体及其制备方法
公开(公告)号：US4022891A
公开(公告)日：1977-05-10
申请号：US583115
申请日：1975-06-02
申请人： Toru Takeshita , Yoshinobu Hashimoto , Hiroyuki Kawashima , Sachio Ishimoto , Nobuo Ikekawa , Masuo Morisaki
发明人： Toru Takeshita , Yoshinobu Hashimoto , Hiroyuki Kawashima , Sachio Ishimoto , Nobuo Ikekawa , Masuo Morisaki
IPC分类号： A23K1/16 , C07J9/00 , C07J71/00 , A61K31/59
CPC分类号： C07J9/00 , A23K20/174 , C07J71/001 , Y02P20/55
摘要： Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treatment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha., 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha., 24-dihydroxycholesterol prepared by reacting 1.alpha., 2.alpha.-epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha., 24-dihydroxycholesterol with an allylic brominating agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha.,3.beta., 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultraviolet irradiation in a organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha., 24-dihydroxycholesterol into an (S)-epimer and an (R)-epimer, and also for separating at least one of 1.alpha., 3.beta., 24(S)-and 1.alpha., 3.beta., 24(R)-trihydroxycholesta-5,7-dienes from trihydroxycholesta-4,6-diene.
摘要翻译：用于治疗由肝衰竭，肾衰竭，胃肠道衰竭和甲状旁腺功能衰竭引起的钙和磷的异常代谢的副作用的新型1α，24-二羟基胆钙化甾醇及其衍生物以及相关的骨疾病。 1α，24-二羟基胆钙化甾醇及其衍生物的制备从1α，24-二羟基胆固醇开始，其通过使1α，2α-环氧-24-酮 - 胆甾烯-4,6-二烯-3-酮与碱金属和质子供体在液态氨或液态胺存在下进行。 1α，24-二羟基胆固醇与烯丙基溴化剂的反应，然后与脱氢溴化剂接触，得到1α，3β，24-三羟基胆甾-5,7-二烯衍生物，然后将其转化为1α，通过紫外线照射在有机溶剂中进行异构化，得到24-二羟基胆钙化甾醇。还提供了用于将1α，24-二羟基胆固醇分离成（S） - 对映体和（R） - 对映体的方法，还用于分离1α，3β，24（S） - 和1α， 3β，24（R） - 三羟基胆甾-5,7-二烯的三羟基胆甾-4,6-二烯。

3. 发明申请

US20080270744A1 BUFFER MEMORY SHARING APPARATUS 审中-公开
标题翻译：缓冲存储器共享设备
公开(公告)号：US20080270744A1
公开(公告)日：2008-10-30
申请号：US12108840
申请日：2008-04-24
申请人： Yoshinobu Hashimoto
发明人： Yoshinobu Hashimoto
IPC分类号： G06F12/02
CPC分类号： G06F13/1673
摘要： The present invention allows a buffer memory to be shared for data streams, while maintaining space efficiency of the buffer memory. A buffer memory sharing apparatus allowing the buffer memory to be shared includes: a flag managing circuit which manages flags each indicating an occupancy status of a region; and, for the each data stream, an address generating circuit. The address generating circuit includes: an occupancy managing circuit which manages exclusive allocation of regions based on the flags; a FIFO memory which stores a bit sequence indicating an allocated region; a write counter; and a read counter. The address generating circuit generates a write address by combining a bit sequence stored at an end of the FIFO memory and a value of the write counter, and generates a read address by combining a bit sequence stored at a start of the FIFO memory and a value of the read counter.
摘要翻译：本发明允许为数据流共享缓冲存储器，同时保持缓冲存储器的空间效率。允许缓冲存储器共享的缓冲存储器共享装置包括：标志管理电路，其管理各自指示区域的占用状态的标志; 并且对于每个数据流，地址产生电路。地址发生电路包括：占用管理电路，其管理基于该标志的区域的独占分配; 存储指示分配区域的比特序列的FIFO存储器; 写计数器和一个读取计数器。地址生成电路通过组合存储在FIFO存储器的末端的位序列和写入计数器的值来生成写入地址，并且通过组合存储在FIFO存储器的开始处的位序列和值的读取计数器。

4. 发明授权

US4169150A Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives 失效
标题翻译：苯并二氮杂衍生物和含有所述衍生物的药物组合物
公开(公告)号：US4169150A
公开(公告)日：1979-09-25
申请号：US737985
申请日：1976-11-02
申请人： Takeshi Hara , Yasutaka Kayama , Kazuhiko Itoh , Toshiro Mori , Hitoshi Fujimori , Tamiko Sunami , Yoshinobu Hashimoto , Sachio Ishimoto
发明人： Takeshi Hara , Yasutaka Kayama , Kazuhiko Itoh , Toshiro Mori , Hitoshi Fujimori , Tamiko Sunami , Yoshinobu Hashimoto , Sachio Ishimoto
IPC分类号： C07D209/48 , C07D487/04 , A61K31/55
CPC分类号： C07D209/48 , C07D487/04 , Y02P20/55
摘要： Novel 4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives of the formula ##STR1## wherein at least one of R.sub.1, R.sub.2 and R.sub.3 represent lower alkyl and the remainder hydrogen, R.sub.4 represents hydrogen or lower alkyl, ring A optionally contains at least one substituent selected from halogen, nitro and trifluoromethyl, and ring B optionally contains at least one substituent selected from halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy; and novel intermediates thereof expressed by the formula ##STR2## wherein Z represents protected amino. Compounds of formula (I) are prepared by subjecting compounds of formula (II) to protective group-elimination and cyclization. The compounds of formula (I) and acid addition salts thereof have useful anti-anxietic, sedative, anti-convulsant, muscle relaxant and hypnotic, and their toxicity is low.
摘要翻译：式（I）的新的4H-吡咯并[1,2-a] [1,4]苯并二氮杂衍生物其中R 1，R 2和R 3中的至少一个表示低级烷基，其余为氢，R 4表示氢或低级烷基，环A任选地含有至少一个选自卤素，硝基和三氟甲基的取代基，环B任选含有至少一个选自卤素，硝基，三氟甲基，低级烷基和低级烷氧基的取代基; 和由式（II）表示的新的中间体，其中Z表示被保护的氨基。通过使式（II）的化合物进行保护基团消除和环化来制备式（I）化合物。式（I）化合物及其酸加成盐具有有用的抗神经，镇静，抗惊厥，肌肉松弛剂和催眠药，其毒性低。

5. 发明申请

US20090201106A1 HARMONIC SUPPRESSION RESONATOR, HARMONIC PROPAGATION BLOCKING FILTER, AND RADAR APPARATUS 有权
标题翻译：谐波抑制谐振器，谐波传播阻塞滤波器和雷达设备
公开(公告)号：US20090201106A1
公开(公告)日：2009-08-13
申请号：US12343267
申请日：2008-12-23
申请人： Ken'ichi Iio , Mitsuru Makihara , Hiroshi Nagata , Yoshinobu Hashimoto
发明人： Ken'ichi Iio , Mitsuru Makihara , Hiroshi Nagata , Yoshinobu Hashimoto
IPC分类号： H01P1/20 , H01P7/00 , G01S13/00
CPC分类号： H01P1/208
摘要： A harmonic suppression resonator comprises a plurality of waveguide resonators that resonate in TE mode, in which harmonic suppression resonator, adjoining resonators are coupled via a plurality of coupling windows. Four coupling windows 33bc1, 33bc2, 33bc3 and 33bc4 are provided between a resonant region 51b and a resonant region adjoining the resonant region 51b. These coupling windows allow fundamental wave modes of the adjoining resonators to be coupled mainly by magnetically coupling. The coupling windows 33bc3 and 33bc4 allow second harmonic modes of the adjoining resonators to be electrically coupled, and the coupling windows 33bc1 and 33bc2 allow the second harmonic modes of the adjoining resonators to be magnetically coupled. By causing the amount of the electrically coupling and the amount of the magnetically coupling to be substantially equal, the coupling of the second harmonic modes is negated, whereby propagation of the second harmonic is blocked.
摘要翻译：谐波抑制谐振器包括在TE模式下谐振的多个波导谐振器，其中谐波抑制谐振器，邻接的谐振器经由多个耦合窗口耦合。四个耦合窗口33bc1,33bc2,33bc3和33bc4设置在谐振区域51b和与谐振区域51b相邻的谐振区域之间。这些耦合窗口允许相邻谐振器的基波模式主要通过磁耦合耦合。耦合窗口33bc3和33bc4允许相邻谐振器的二次谐波模式电耦合，并且耦合窗口33bc1和33bc2允许相邻谐振器的二次谐波模式被磁耦合。通过使电耦合的量和磁耦合量基本上相等，二次谐波模式的耦合被否定，从而阻止了二次谐波的传播。

6. 发明授权

US4613505A Ester of flurbiprofen and emulsion containing the same 失效
标题翻译：氟比洛芬酯和含有相同的乳液
公开(公告)号：US4613505A
公开(公告)日：1986-09-23
申请号：US622244
申请日：1984-06-19
申请人： Yutaka Mizushima , Katsuhiro Uchida , Shozoh Masumoto , Masao Tohno , Yoshinobu Hashimoto , Kazumasa Yokoyama , Hiroyuki Okamoto , Kiichiro Nabeta , Tadakazu Suyama
发明人： Yutaka Mizushima , Katsuhiro Uchida , Shozoh Masumoto , Masao Tohno , Yoshinobu Hashimoto , Kazumasa Yokoyama , Hiroyuki Okamoto , Kiichiro Nabeta , Tadakazu Suyama
IPC分类号： A61K9/107 , A61K31/215 , A61K31/365 , A61P25/04 , A61P29/00 , C07D307/33 , A61K31/235 , A61K31/685
CPC分类号： A61K31/365 , A61K31/215 , A61K9/1075
摘要： There is provided a fat emulsion of an ester of flurbiprofen having the formula ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sub.2 is a C.sub.1 -C.sub.15 alkyl group or a C.sub.2 -C.sub.8 alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula ##STR3## wherein R.sub.3 and R.sub.4 are same as or different from each other and are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and n is an integer of 1 or 2.The emulsion containing particles of a vegetable oil dissolving the ester can be orally or parenterally administered to human or animal for analgesia, antiphlogosis and antipyresis in various diseases and exhibits a high activity with small amounts in terms of flurbiprofen as compared with flurbiprofen itself.
摘要翻译：提供了一种氟比洛芬的酯的脂肪乳剂，其具有式“IMAGE”，其中R是下式的基团：其中R 1是氢原子或C 1 -C 3烷基，R 2是C 1 -C 15烷基或C 2 -C 8烯基，m为0或1的整数; 或式“IMAGE”的内酯基团，其中R 3和R 4彼此相同或不同，为氢原子或C 1 -C 3烷基，n为1或2的整数。溶解酯的植物油可以口服或肠胃外给予人或动物用于各种疾病的镇痛，消炎和除血，并且与氟比洛芬本身相比，在氟比洛芬方面表现出较低的活性。

7. 发明授权

US4364941A Method for regulating bone metabolism of warm-blooded animals, and pharmaceutical compositions thereof 失效
标题翻译：调节温血动物骨代谢的方法及其药物组合物
公开(公告)号：US4364941A
公开(公告)日：1982-12-21
申请号：US297975
申请日：1981-08-31
申请人： Mamoru Kiyoki , Hiroyoshi Endo , Tatsuyuki Naruchi , Yoshinobu Hashimoto
发明人： Mamoru Kiyoki , Hiroyoshi Endo , Tatsuyuki Naruchi , Yoshinobu Hashimoto
IPC分类号： A61K31/59 , A61P3/00 , A61P3/02
CPC分类号： A61K31/59
摘要： A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha., 24-dihydroxycholecalciferol (1.alpha., 24-DHCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) to said warm-blooded animal, and a pharmaceutical composition comprising 1.alpha.,24-DHCC, 24,25-DHCC and a pharmaceutically acceptable carrier.According to the invention, a condition of abnormal bone metabolism requiring long-term therapy, such as osteoporosis, can be safely treated by administering 1.alpha., 24-DHCC and 24,25-DHCC over a long period of time because no substantial adverse effect of 1.alpha., 24-DHCC on the metabolis of 24,25-DHCC is observed.
摘要翻译：一种用于调节温血动物的骨代谢的方法，其包括将药学有效量的1α，24-二羟基胆钙化甾醇（1α，24-DHCC）和24,25-二羟基胆钙化甾醇（24,25-DHCC）施用于所述温血动物，以及包含1α，24-DHCC，24,25-DHCC和药学上可接受的载体的药物组合物。根据本发明，通过长期施用1α，24-DHCC和24,25-DHCC可以安全地治疗需要长期治疗的骨质疏松症如骨质疏松症的病症，因为没有实质的不利影响的1α，24-DHCC对24,25-DHCC的代谢。

8. 发明授权

US08354898B2 Harmonic suppression resonator, harmonic propagation blocking filter, and radar apparatus 有权
标题翻译：谐波抑制谐振器，谐波传播阻塞滤波器和雷达装置
公开(公告)号：US08354898B2
公开(公告)日：2013-01-15
申请号：US12343267
申请日：2008-12-23
申请人： Ken'ichi Iio , Mitsuru Makihara , Hiroshi Nagata , Yoshinobu Hashimoto
发明人： Ken'ichi Iio , Mitsuru Makihara , Hiroshi Nagata , Yoshinobu Hashimoto
IPC分类号： H01P7/06
CPC分类号： H01P1/208
摘要： A harmonic suppression resonator comprises a plurality of waveguide resonators that resonate in TE mode, in which harmonic suppression resonator, adjoining resonators are coupled via a plurality of coupling windows. Four coupling windows 33bc1, 33bc2, 33bc3 and 33bc4 are provided between a resonant region 51b and a resonant region adjoining the resonant region 51b. These coupling windows allow fundamental wave modes of the adjoining resonators to be coupled mainly by magnetically coupling. The coupling windows 33bc3 and 33bc4 allow second harmonic modes of the adjoining resonators to be electrically coupled, and the coupling windows 33bc1 and 33bc2 allow the second harmonic modes of the adjoining resonators to be magnetically coupled. By causing the amount of the electrically coupling and the amount of the magnetically coupling to be substantially equal, the coupling of the second harmonic modes is negated, whereby propagation of the second harmonic is blocked.
摘要翻译：谐波抑制谐振器包括在TE模式下谐振的多个波导谐振器，其中谐波抑制谐振器，邻接的谐振器经由多个耦合窗口耦合。四个耦合窗口33bc1,33bc2,33bc3和33bc4设置在谐振区域51b和与谐振区域51b相邻的谐振区域之间。这些耦合窗口允许相邻谐振器的基波模式主要通过磁耦合耦合。耦合窗口33bc3和33bc4允许相邻谐振器的二次谐波模式电耦合，并且耦合窗口33bc1和33bc2允许相邻谐振器的二次谐波模式被磁耦合。通过使电耦合的量和磁耦合量基本上相等，二次谐波模式的耦合被否定，从而阻止了二次谐波的传播。

9. 发明授权

US07311919B2 Agents for treating osteoporosis and inhibiting osteoclast formation 有权
标题翻译：用于治疗骨质疏松症和抑制破骨细胞形成的药剂
公开(公告)号：US07311919B2
公开(公告)日：2007-12-25
申请号：US11533665
申请日：2006-09-20
申请人： Shigetoshi Kadota , Yoshinobu Hashimoto , Chia-Chin Sheu
发明人： Shigetoshi Kadota , Yoshinobu Hashimoto , Chia-Chin Sheu
IPC分类号： A61K36/068 , A61P19/10 , A61P3/14
CPC分类号： A61K36/068
摘要： Compositions and methods for treating osteoporosis, the formation of osteoeclasts, and/or for the suppression of decreasing spongy bone density. Example methods include administering Cordyceps sinensis or its processed product.
摘要翻译：用于治疗骨质疏松症，成骨细胞形成和/或抑制海绵骨密度降低的组合物和方法。示例方法包括施用冬虫夏草或其加工产品。

10. 发明授权

US4873208A Holder for sealing member 失效
标题翻译：密封件支架
公开(公告)号：US4873208A
公开(公告)日：1989-10-10
申请号：US109399
申请日：1987-10-19
申请人： Mitsuhiro Nagata , Tadashi Hayashi , Yoshinobu Hashimoto , Kiyoshi Nakamura
发明人： Mitsuhiro Nagata , Tadashi Hayashi , Yoshinobu Hashimoto , Kiyoshi Nakamura
IPC分类号： C03C29/00 , B25B11/00 , C03C27/02 , C04B35/565 , C04B35/58 , C04B35/584 , C04B35/599 , H01J9/24
CPC分类号： C04B35/584 , C04B35/565 , C04B35/581 , C04B35/597 , Y10S269/908
摘要： Disclosed is a holder for sealing member, in which at least a portion of the holder which comes into contact with the member comprises a sintered body comprising as a main component a non-oxide ceramic of silicon nitride, aluminum nitride, sialon or silicon carbide.By the use of the holder according to this invention, in the hermetic sealing process which is carried out continuously and automatically, an exchange frequency of the holder can be decreased remarkably, and thus a working efficiency on a manufacturing line can be increased. In consequence, the holder according to this invention is industrially very useful, and in particular, it is suitable for the hermetic sealing of the panel pins for cathode ray tubes.
摘要翻译：公开了一种用于密封构件的保持器，其中与构件接触的保持器的至少一部分包括烧结体，该烧结体包括氮化硅，氮化铝，赛隆或碳化硅的非氧化物陶瓷作为主要成分。通过使用本发明的保持器，在连续自动进行的气密密封处理中，可以显着地降低保持器的交换频率，从而可以提高生产线上的工作效率。因此，根据本发明的保持器在工业上非常有用，特别是适用于阴极射线管的面板销的气密密封。

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