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1. 发明授权

US07250429B2 Aminomethyl-substituted thiazolobenzimidazole compounds 失效
标题翻译：氨基甲基取代的噻唑并噻唑化合物
公开(公告)号：US07250429B2
公开(公告)日：2007-07-31
申请号：US10508329
申请日：2003-03-19
申请人： Hirotsune Itahana , Jiro Fujiyasu , Satoshi Hayashibe , Toshihiro Watanabe , Masamichi Okada , Takashi Toya
发明人： Hirotsune Itahana , Jiro Fujiyasu , Satoshi Hayashibe , Toshihiro Watanabe , Masamichi Okada , Takashi Toya
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： A61K31/429 , A61K31/5377 , C07D513/04
摘要： This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof.The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.)
摘要翻译：本发明涉及提供由以下通式（I）表示的新型氨基甲基取代的噻唑并苯并咪唑衍生物或其盐。上述衍生物或其盐具有代谢型谷氨酸受体作用和优异的口服活性，因此可用作药物。（式中，R 1：含氧饱和杂环等，Alk 1：低级亚烷基，m：0或1，Alk， 2：可以被氧代基取代的低级亚烷基，n：0或1，X：键，O，S或NR 5，R 3 O >：H等，R 2，R 4，R 5，R 6和R 6，其中R 3彼此相同或不同，并且各自表示H等，条件是R 3不表示低级烷基或卤代低级烷基，当X为键，n为1.另外，当m为1时，R 4表示除Me以外的基团，R 1是OH或OMe，Alk 1 是C 1-3亚烷基，进一步1）当X为键时，n为1且R 3为H，或2）当X为键时，n为0，R 3为环己烷）

2. 发明申请

US20050148642A1 Aminomethyl-substituted thiazolobenzimidazole derivative 失效
标题翻译：氨基甲基取代的噻唑并噻唑衍生物
公开(公告)号：US20050148642A1
公开(公告)日：2005-07-07
申请号：US10508329
申请日：2003-03-19
申请人： Hirotsune Itahana , Jiro Fujiyasu , Satoshi Hayashibe , Toshihiro Watanabe , Masamichi Okada , Takashi Toya
发明人： Hirotsune Itahana , Jiro Fujiyasu , Satoshi Hayashibe , Toshihiro Watanabe , Masamichi Okada , Takashi Toya
IPC分类号： A61K31/429 , A61K31/5377 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P43/00 , C07D513/04 , A61K31/43 , C07D498/04
CPC分类号： A61K31/429 , A61K31/5377 , C07D513/04
摘要： This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.)
摘要翻译：本发明涉及提供由以下通式（I）表示的新型氨基甲基取代的噻唑并苯并咪唑衍生物或其盐。上述衍生物或其盐具有代谢型谷氨酸受体作用和优异的口服活性，因此可用作药物。（式中，R 1：含氧饱和杂环等，Alk 1：低级亚烷基，m：0或1，Alk， 2：可以被氧代基取代的低级亚烷基，n：0或1，X：键，O，S或NR 5，R 3 O >：H等，R 2，R 4，R 5，R 6和R 6，其中R 3彼此相同或不同，并且各自表示H等，条件是R 3不表示低级烷基或卤代低级烷基，当X为键，n为1.另外，当m为1时，R 4表示除Me以外的基团，R 1是OH或OMe，Alk 1 是C 1-3亚烷基，进一步1）当X为键时，n为1且R 3为H，或2）当X为键时，n为0，R 3为环己烷）

3. 发明申请

US20080200551A1 Flourene Derivative 审中-公开
标题翻译： Flourene衍生物
公开(公告)号：US20080200551A1
公开(公告)日：2008-08-21
申请号：US10568684
申请日：2005-02-17
申请人： Hiroyoshi Yamada , Hirotsune Itahana , Ayako Moritomo , Takaho Matsuzawa , Koichiro Harada , Jiro Fujiyasu , Yuji Koga , Makoto Oku , Toshio Okazaki , Shinobu Akuzawa , Toshihiro Watanabe
发明人： Hiroyoshi Yamada , Hirotsune Itahana , Ayako Moritomo , Takaho Matsuzawa , Koichiro Harada , Jiro Fujiyasu , Yuji Koga , Makoto Oku , Toshio Okazaki , Shinobu Akuzawa , Toshihiro Watanabe
IPC分类号： A61K31/166 , C07C233/78 , A61P25/06
CPC分类号： C07D311/96 , A61K31/166 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/385 , A61K31/41 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/438 , C07C279/22 , C07D207/20 , C07D209/54 , C07D209/96 , C07D211/70 , C07D221/20 , C07D233/50 , C07D249/14 , C07D257/06 , C07D263/28 , C07D277/18 , C07D303/06 , C07D305/14 , C07D307/94 , C07D309/06 , C07D309/20 , C07D317/12 , C07D319/14 , C07D327/04 , C07D335/04 , C07D339/06
摘要： This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof.The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT2B receptor and 5-HT7 receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT2B receptor and 5-HT7 receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.
摘要翻译：本发明涉及具有胍基等官能团通过羰基与芴结构连接的特征结构的新型芴衍生物或其盐。本发明的化合物具有的优点在于其对5-羟色胺受体亚型具有高亲和力，特别是对于5-HT 2B受体和5-HT 7受体，并且显示出优异的与仅具有5-HT 2B受体和5-HT 7受体的拮抗活性的常规化合物相比，药理作用可用作预防性抗偏头痛药剂安全性高，效果好。

4. 发明授权

US08044206B2 Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl 失效
标题翻译：含2,6-二取代苯乙烯基的含氮杂环衍生物
公开(公告)号：US08044206B2
公开(公告)日：2011-10-25
申请号：US10548197
申请日：2004-03-05
申请人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
发明人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
IPC分类号： C07D211/08 , A61K31/47
CPC分类号： C07D211/12
摘要： The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.
摘要翻译：本发明提供了具有2,6-二取代苯乙烯基的新型含氮杂环衍生物及其药学上可接受的盐，以及包含含氮杂环衍生物及其药学上可接受的盐的药物组合物，特别是作为钠通道抑制剂，具有优异的镇痛作用，特别是对神经性疼痛具有最小的副作用。

5. 发明申请

US20080070898A1 Piperidine Derivative or Pharmaceutically Acceptable Salt Thereof 审中-公开
标题翻译：哌啶衍生物或其药学上可接受的盐
公开(公告)号：US20080070898A1
公开(公告)日：2008-03-20
申请号：US11661446
申请日：2005-08-31
申请人： Kazumi Kikuchi , Jiro Fujiyasu , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
发明人： Kazumi Kikuchi , Jiro Fujiyasu , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/553 , A61P25/04 , C07D273/01 , C07D401/06 , C07D413/06
CPC分类号： C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/12 , C07D487/08 , C07D491/10
摘要： The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (—R1) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [—C(═O)—R4], or a pharmaceutically acceptable salt thereof has an excellent sodium channel inhibition action and an excellent analgesic action and shows a high analgesic effect particularly to neurogenic pain. The present compound is useful as a sodium channel inhibitor of low side effect
摘要翻译：其中哌啶环的4位通过亚乙烯基键合到单取代的（-R 1）或未取代的苯环上的本发明的哌啶衍生物和1-取代的哌啶环具有酰基[-C（-O）-R 4]，或其药学上可接受的盐具有优异的钠通道抑制作用和优异的镇痛作用，并显示出高镇痛作用特别是神经源性疼痛。本发明化合物可用作低副作用的钠通道抑制剂

6. 发明申请

US20160132815A1 SKILL ESTIMATION METHOD IN MACHINE-HUMAN HYBRID CROWDSOURCING 有权
标题翻译：机器人混合运动中的技巧估计方法
公开(公告)号：US20160132815A1
公开(公告)日：2016-05-12
申请号：US14869308
申请日：2015-09-29
申请人： Toshinari Itoko , Masatomo Kobayashi , Shin Saito , Toshihiro Watanabe
发明人： Toshinari Itoko , Masatomo Kobayashi , Shin Saito , Toshihiro Watanabe
IPC分类号： G06Q10/06 , G06Q50/00
CPC分类号： G06Q10/06398 , G06Q10/0639 , G06Q50/01
摘要： In one embodiment, a computer-implemented method for estimating an ability of a worker in a process for integrating work results of multiple workers for the same task includes acquiring, for each of one or more tasks, a work result of a preceding-stage worker and a work result of a succeeding-stage worker that works based on the work result of the preceding-stage worker. The method also includes estimating multiple parameters of a probability model in which an ability of the succeeding-stage worker conditioned by a quality of the work result of the preceding-stage worker is introduced as a conditioned ability parameter, based on the multiple work results obtained for each of the one or more tasks.
摘要翻译：在一个实施例中，用于估计工作人员在用于为同一任务整合多个工人的工作结果的过程中的能力的计算机实现的方法包括为一个或多个任务中的每一个获取前一阶段工作者的工作结果以及根据前期工作人员的工作成果开展工作的后期工作者的工作成果。该方法还包括基于获得的多个工作结果来估计其中引入了由前级工作人员的工作结果的质量调节的后级工作人员的能力作为条件能力参数的概率模型的多个参数对于每个一个或多个任务。

7. 发明申请

US20080161419A1 Prophylactic Antimigraine Agents 审中-公开
标题翻译：预防性抗偏头痛药
公开(公告)号：US20080161419A1
公开(公告)日：2008-07-03
申请号：US10589892
申请日：2005-02-17
申请人： Shinobu Akuzawa , Toshihiro Watanabe
发明人： Shinobu Akuzawa , Toshihiro Watanabe
IPC分类号： A61K45/00 , A61P25/06
CPC分类号： A61K31/166 , A61K31/454 , A61K31/505 , C07D339/06
摘要： The present invention relates to prophylactic antimigraine agents comprising as an active ingredient a dual antagonist for the 5-HT2B and 5-HT7 receptors, the antagonist having a binding affinity selective for the 5-HT2B and 5-HT7 receptors.Since these prophylactic antimigraine agents show an excellent pharmacological effect in comparison with the cases in which a 5-HT2B receptor antagonist having a selective binding affinity to the 5-HT2B receptor or a 5-HT7 receptor antagonist having a selective binding affinity to the 5-HT7 receptor is used alone, they are useful as drugs which are excellent in prophylaxis of migraine and in which the side effects found in the existing prophylactic antimigraine agents are reduced.
摘要翻译：本发明涉及含有5-HT 2B和5-HT 7受体的双重拮抗剂作为活性成分的预防性抗偏头痛药，所述拮抗剂具有结合亲和选择性对于5-HT 2B和5-HT 7受体。由于与对5-HT 2B受体具有选择性结合亲和力的5-HT 2B受体拮抗剂相比，这些预防性抗偏头痛药物显示出优异的药理作用或对5-HT 7受体具有选择性结合亲和力的5-HT 7受体拮抗剂单独使用，它们可用作预防偏头痛的药物并且其中在现有的预防性抗偏头痛药中发现的副作用减少。

8. 发明申请

US20070167444A1 Benzamide derivative or salt thereof 有权
标题翻译：苯甲酰胺衍生物或其盐
公开(公告)号：US20070167444A1
公开(公告)日：2007-07-19
申请号：US10560282
申请日：2004-06-10
申请人： Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
发明人： Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
IPC分类号： A61K31/538 , A61K31/404 , C07D413/02 , C07D403/02
CPC分类号： C07C237/40 , A61K31/167 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D209/08 , C07D209/34 , C07D213/75 , C07D215/38 , C07D217/04 , C07D223/16 , C07D231/56 , C07D235/06 , C07D241/42 , C07D249/18 , C07D263/58 , C07D265/36 , C07D277/64 , C07D277/82 , C07D279/16 , C07D295/155 , C07D307/79 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).
摘要翻译：提供了具有辣椒素受体VR1抑制活性的化合物，并且可用作各种疼痛的治疗剂，包括炎性疼痛和神经源性疼痛，偏头痛，丛集性头痛，包括膀胱活动过度的膀胱疾病等。一种苯甲酰胺衍生物或其盐，其中苯环通过酰胺键连接到D环（单环或双环烃环或单环或双环杂芳族环），苯环直接键合到E环（单环或双环烃环或单环或双环杂芳族环），并且苯环通过L（低级亚烷基）进一步与A（氨基部分，单环或双环杂环）键合。

9. 发明授权

US07035901B1 SMTP server, POP server, mail server, mail processing system and web server 有权
标题翻译： SMTP服务器，POP服务器，邮件服务器，邮件处理系统和Web服务器
公开(公告)号：US07035901B1
公开(公告)日：2006-04-25
申请号：US09466813
申请日：1999-12-20
申请人： Masatoshi Kumagai , Toshihiro Watanabe , Kenichiro Osada , Nobuhiro Miyatake
发明人： Masatoshi Kumagai , Toshihiro Watanabe , Kenichiro Osada , Nobuhiro Miyatake
IPC分类号： G06F15/16
CPC分类号： G06Q30/0277 , G06Q10/107 , G06Q30/02 , G06Q30/0256 , G06Q30/0271 , H04L51/063
摘要： According to the present invention, an SMTP server sending a mail having a predetermined mail address as a recipient to a server that receives and manages the mail having the predetermined mail address, includes: an advertisement information memory operable to store advertisement information to be added to the mail; an advertisement information detector operable to detect the advertisement information to be added to the mail from the advertisement information memory based on at least one of user information about a user having the mail address of the recipient of the mail, user information about a user having a mail address of a sender of the mail and a sentence included in the mail; an advertisement information adding portion operable to add the advertisement information to the mail; and a sending portion operable to send the mail to the server.
摘要翻译：根据本发明，向接收和管理具有预定邮件地址的邮件的服务器发送具有预定邮件地址的邮件作为收件人的SMTP服务器包括：广告信息存储器，用于存储要添加到的广告信息邮件; 广告信息检测器，用于基于关于具有所述邮件的接收者的邮件地址的用户的用户信息中的至少一个来检测从所述广告信息存储器添加到所述邮件的广告信息，所述用户信息关于具有所述邮件的用户的用户信息邮件的发件人的邮件地址和邮件中包含的句子; 广告信息添加部分，用于将广告信息添加到邮件中; 以及可操作以将邮件发送到服务器的发送部分。

10. 发明授权

US06617519B2 Flexible printed circuit board and manufacturing method 有权
公开(公告)号：US06617519B2
公开(公告)日：2003-09-09
申请号：US10075379
申请日：2002-02-15
申请人： Yuji Wakimoto , Toshihiro Watanabe , Ryuji Moriya
发明人： Yuji Wakimoto , Toshihiro Watanabe , Ryuji Moriya
IPC分类号： H05K100
CPC分类号： H05K3/4691 , H05K3/28 , H05K3/386 , H05K2203/063 , Y10T29/49155
摘要： A flexible printed circuit board including a component mount section, which an electronic component is mounted on, and a cable section, which connects to the component mount section; circuit patterns being provided on the cable section, and covered by a soft laminated adhesive.

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