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1. 发明授权

US08795632B2 Disease animal model for chronic pain 有权
标题翻译：慢性疼痛疾病动物模型
公开(公告)号：US08795632B2
公开(公告)日：2014-08-05
申请号：US13001743
申请日：2009-10-07
申请人： Yukinori Nagakura , Tomoya Oe
发明人： Yukinori Nagakura , Tomoya Oe
IPC分类号： A01K67/00 , A61K49/00 , A61P43/00
CPC分类号： G01N33/5088 , A01K67/027 , A01K2227/105 , A01K2267/035 , G01N2800/2842
摘要： A disease animal model, characterized in that a chronic pain is induced by applying a treatment for reducing the biogenic amine level to a mammal, and a method for screening for a therapeutic agent for a chronic pain, characterized in that a test substance is administered to said disease animal model.
摘要翻译：一种疾病动物模型，其特征在于，通过对哺乳动物施用降低生物胺水平的治疗来诱导慢性疼痛，以及用于筛选慢性疼痛治疗剂的方法，其特征在于，将测试物质施用于说疾病动物模型。

2. 发明申请

US20120253036A1 AGENT FOR TREATING FIBROMYALGIA 审中-公开
标题翻译：代理治疗纤维瘤
公开(公告)号：US20120253036A1
公开(公告)日：2012-10-04
申请号：US13514870
申请日：2010-12-10
申请人： Yukinori Nagakura , Mina Tsukamoto , Tomonari Watabiki
发明人： Yukinori Nagakura , Mina Tsukamoto , Tomonari Watabiki
IPC分类号： C07D487/04 , C07D223/16 , C07D513/06 , C07D495/04 , C07D307/81 , C07D491/048 , C07D487/06
CPC分类号： C07D491/04 , A61K31/00 , A61K31/137 , A61K31/335 , A61K31/343 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/415 , A61K31/416 , A61K31/4162 , A61K31/437 , A61K31/4525 , A61K31/4535 , A61K31/473 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5365 , A61K31/5375 , A61K31/55 , A61K31/551 , C07D209/14 , C07D209/52 , C07D213/74 , C07D223/04 , C07D231/56 , C07D239/70 , C07D307/81 , C07D311/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/06 , C07D495/04 , C07D513/06
摘要： An agent for treating fibromyalgia containing a 5-HT2C receptor agonist as an active ingredient
摘要翻译：用于治疗含有5-HT 2C受体激动剂的纤维肌痛作为活性成分的药剂

3. 发明申请

US20110110862A1 DISEASE ANIMAL MODEL FOR CHRONIC PAIN 有权
标题翻译：慢性疼痛的疾病动物模型
公开(公告)号：US20110110862A1
公开(公告)日：2011-05-12
申请号：US13001743
申请日：2009-10-07
申请人： Yukinori Nagakura , Tomoya Oe
发明人： Yukinori Nagakura , Tomoya Oe
IPC分类号： A01K67/00 , A61K49/00 , A61P43/00
CPC分类号： G01N33/5088 , A01K67/027 , A01K2227/105 , A01K2267/035 , G01N2800/2842
摘要： A disease animal model, characterized in that a chronic pain is induced by applying a treatment for reducing the biogenic amine level to a mammal, and a method for screening for a therapeutic agent for a chronic pain, characterized in that a test substance is administered to said disease animal model.
摘要翻译：一种疾病动物模型，其特征在于，通过对哺乳动物施用降低生物胺水平的治疗来诱导慢性疼痛，以及用于筛选慢性疼痛治疗剂的方法，其特征在于，将测试物质施用于说疾病动物模型。

4. 发明申请

US20070191311A1 P2x receptor inhibitor 审中-公开
标题翻译： P2x受体抑制剂
公开(公告)号：US20070191311A1
公开(公告)日：2007-08-16
申请号：US10587866
申请日：2005-01-27
申请人： Shuichiro Kakimoto , Seiji Tamura , Yukinori Nagakura
发明人： Shuichiro Kakimoto , Seiji Tamura , Yukinori Nagakura
IPC分类号： A61K31/675 , A61P19/08 , A61P25/04 , A61P35/04 , C07F9/38
CPC分类号： A61K31/663 , C07F9/6561
摘要： The present inventors have carried out intensive screening of a new type compound which inhibits the P2X2/3,3 receptor and found as a result that minodronic acid as a bisphosphonate having bone resorption inhibitory action shows excellent P2X2/3,3 receptor inhibitory action and can be used as a preventive or therapeutic agent for various pains, thus accomplishing the invention. That is, the invention relates to a P2X2/3,3 receptor inhibitor, particularly an analgesic, which comprises minodronic acid or a salt thereof as the active ingredient. Since the “P2X2/3 and/or P2X3 receptor inhibitor” of the invention inhibits the function of P2X2/3,3 receptor known as a molecule which is concerned in various pains consisting of nociceptive pain, inflammatory pain and neurogenic pain, it is useful for the prevention or treatment of various pains in which the P2X2/3,3 receptor is concerned in the pain transduction.
摘要翻译：本发明人对抑制P2X 2/3,3受体的新型化合物进行了深入筛选，结果发现作为具有骨吸收抑制作用的二膦酸盐的米诺膦酸表现出优异的P2X < 可以用作各种疼痛的预防或治疗剂，从而完成本发明。也就是说，本发明涉及包含米诺膦酸或其盐作为活性成分的P2X 2 / 3,3受体抑制剂，特别是止痛剂。由于本发明的“P2X 3/3”和/或“P2X 3”受体抑制剂“抑制P2X 2 / 3,3”受体的功能被称为分子，其涉及由伤害性疼痛，炎性疼痛和神经源性疼痛组成的各种疼痛，其可用于预防或治疗P2X 2 / 3,3受体是各种疼痛关注疼痛转导。

5. 发明申请

US20070099956A1 Nitrogen-containing heterocyclic derivatives having 2, 6-disubstituted styryl 失效
标题翻译：含2,6-二取代苯乙烯基的含氮杂环衍生物
公开(公告)号：US20070099956A1
公开(公告)日：2007-05-03
申请号：US10548197
申请日：2004-03-05
申请人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watana , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
发明人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watana , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
IPC分类号： A61K31/47 , A61K31/44 , C07D215/12 , C07D213/81
CPC分类号： C07D211/12
摘要： The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.
摘要翻译：本发明提供了具有2,6-二取代苯乙烯基的新型含氮杂环衍生物及其药学上可接受的盐，以及包含含氮杂环衍生物及其药学上可接受的盐的药物组合物，特别是作为钠通道抑制剂，具有优异的镇痛作用，特别是对神经性疼痛具有最小的副作用。

6. 发明授权

US08044206B2 Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl 失效
标题翻译：含2,6-二取代苯乙烯基的含氮杂环衍生物
公开(公告)号：US08044206B2
公开(公告)日：2011-10-25
申请号：US10548197
申请日：2004-03-05
申请人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
发明人： Kazumi Kikuchi , Makoto Oku , Jiro Fujiyasu , Norio Asai , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
IPC分类号： C07D211/08 , A61K31/47
CPC分类号： C07D211/12
摘要： The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.
摘要翻译：本发明提供了具有2,6-二取代苯乙烯基的新型含氮杂环衍生物及其药学上可接受的盐，以及包含含氮杂环衍生物及其药学上可接受的盐的药物组合物，特别是作为钠通道抑制剂，具有优异的镇痛作用，特别是对神经性疼痛具有最小的副作用。

7. 发明申请

US20080070898A1 Piperidine Derivative or Pharmaceutically Acceptable Salt Thereof 审中-公开
标题翻译：哌啶衍生物或其药学上可接受的盐
公开(公告)号：US20080070898A1
公开(公告)日：2008-03-20
申请号：US11661446
申请日：2005-08-31
申请人： Kazumi Kikuchi , Jiro Fujiyasu , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
发明人： Kazumi Kikuchi , Jiro Fujiyasu , Toshihiro Watanabe , Yukinori Nagakura , Hiroshi Tomiyama , Motoharu Sonegawa , Kazuo Tokuzaki , Yoshinori Iwai
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/553 , A61P25/04 , C07D273/01 , C07D401/06 , C07D413/06
CPC分类号： C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/12 , C07D487/08 , C07D491/10
摘要： The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (—R1) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [—C(═O)—R4], or a pharmaceutically acceptable salt thereof has an excellent sodium channel inhibition action and an excellent analgesic action and shows a high analgesic effect particularly to neurogenic pain. The present compound is useful as a sodium channel inhibitor of low side effect
摘要翻译：其中哌啶环的4位通过亚乙烯基键合到单取代的（-R 1）或未取代的苯环上的本发明的哌啶衍生物和1-取代的哌啶环具有酰基[-C（-O）-R 4]，或其药学上可接受的盐具有优异的钠通道抑制作用和优异的镇痛作用，并显示出高镇痛作用特别是神经源性疼痛。本发明化合物可用作低副作用的钠通道抑制剂

8. 发明授权

US06664283B1 Pharmaceuticals for neurogenic pain 失效
标题翻译：药物用于神经源性疼痛
公开(公告)号：US06664283B1
公开(公告)日：2003-12-16
申请号：US10031404
申请日：2002-05-15
申请人： Masamichi Okada , Yukinori Nagakura , Tetsuo Kiso , Takashi Toya , Satoshi Hayashibe
发明人： Masamichi Okada , Yukinori Nagakura , Tetsuo Kiso , Takashi Toya , Satoshi Hayashibe
IPC分类号： A61K31415
CPC分类号： A61K31/429 , A61K31/00
摘要： This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.
摘要翻译：本发明涉及用于神经性疼痛的药物，其包含用于全身给药的mGluR1受体拮抗剂。可以通过本发明提供治疗各种神经性疼痛的药物。

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