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1. 发明授权

US5292758A Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US5292758A
公开(公告)日：1994-03-08
申请号：US923345
申请日：1992-07-31
申请人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , A61K31/44
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R.sup.1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R.sup.2 and R.sup.3 which are each a hydrogen atom, A and B which are each .dbd.CH-- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded, or pharmacologically acceptance salts of them, have an excellent antitumor activity.
摘要翻译：通式（I）的磺酰胺衍生物：其中优选R 1表示低级烷氧基，R 2，R 3，R 4，R 5，R 6和R 7可以彼此相同或不同，并且各自表示氢原子，卤原子或低级烷基，A和B可以相同或不同，并且各自表示= N-或= CH-，E表示可具有1或2个氮原子的芳族6元环基并且被1〜3个可以相同或不同的取代基取代，条件是可以被保护的是氢原子，低级烷基，硝基或氨基的R 1的组合， R 2和R 3各自为氢原子，A和B各自为CH-，E为可被1至3个彼此可相同或不同的取代基G所取代的苯基，不包括或它们的药理学接受盐具有优异的抗肿瘤活性。

2. 发明授权

US5610304A Pyrimidinyl or pyridinyl sulfonamide substituted compounds 失效
标题翻译：嘧啶基或吡啶基磺酰胺取代的化合物
公开(公告)号：US5610304A
公开(公告)日：1997-03-11
申请号：US453058
申请日：1995-05-26
申请人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , C07D239/02 , C07D213/02
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide compounds of formula (I) or a pharmacologically acceptable salt thereof: ##STR1## exhibit excellent antitumor activity and low toxicity.
摘要翻译：式（I）的磺酰胺化合物或其药理学上可接受的盐：表现出优异的抗肿瘤活性和低毒性。

3. 发明授权

US5434172A Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US5434172A
公开(公告)日：1995-07-18
申请号：US231272
申请日：1994-04-22
申请人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , A61K31/44 , C07D213/02
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R.sup.1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R.sup.2 and R.sup.3 which are each a hydrogen atom, A and B which are each .dbd.CH-- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded,or pharmacologically acceptance salts of them, have an excellent antitumo-activity.
摘要翻译：通式（I）的磺酰胺衍生物：其中优选R 1表示低级烷氧基，R 2，R 3，R 4，R 5，R 6和R 7可以彼此相同或不同，并且各自表示氢原子，卤原子或低级烷基，A和B可以相同或不同，并且各自表示= N-或= CH-，E表示可具有1或2个氮原子的芳族6元环基并且被1〜3个可以相同或不同的取代基取代，条件是可以被保护的是氢原子，低级烷基，硝基或氨基的R 1的组合， R 2和R 3各自为氢原子，A和B各自为CH-，E为可被1至3个彼此可相同或不同的取代基G所取代的苯基，不包括或它们的药理学接受盐具有优异的防虫活性。

4. 发明授权

US5332751A Pyridine carboxamide compounds which have useful as pharmaceutical utility 失效
标题翻译：可用作药物效用的吡啶甲酰胺化合物
公开(公告)号：US5332751A
公开(公告)日：1994-07-26
申请号：US85962
申请日：1993-06-30
申请人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , C07D213/02 , A61K31/44
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R.sup.1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R.sup.2 and R.sup.3 which are each a hydrogen atom, A and B which are each .dbd.CH-- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded,or pharmacologically acceptable salts of them, have an excellent antitumor activity.
摘要翻译：通式（I）的磺酰胺衍生物：其中优选R 1表示低级烷氧基，R 2，R 3，R 4，R 5，R 6和R 7可以彼此相同或不同，并且各自表示氢原子，卤原子或低级烷基，A和B可以相同或不同，并且各自表示= N-或= CH-，E表示可具有1或2个氮原子的芳族6元环基并且被1〜3个可以相同或不同的取代基取代，条件是可以被保护的是氢原子，低级烷基，硝基或氨基的R 1的组合， R 2和R 3各自为氢原子，A和B各自为CH-，E为可被1至3个彼此可相同或不同的取代基G所取代的苯基，不包括或其药理学上可接受的盐具有优异的抗肿瘤活性。

5. 发明授权

US5250549A Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US5250549A
公开(公告)日：1993-10-05
申请号：US742618
申请日：1991-08-08
申请人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hiroyuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , C07D213/75 , A61K31/44
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in the specification, A and B may be the same or different from each other and each represents .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and may be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R.sup.1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R.sup.2 and R.sup.3 which are each a hydrogen atom, A and B which are each .dbd.CH-- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded, or pharmacologically acceptance salts of them.

6. 发明授权

US5610320A Sulfonamide phenyl substituted compounds 失效
标题翻译：磺酰胺苯基取代的化合物
公开(公告)号：US5610320A
公开(公告)日：1997-03-11
申请号：US450138
申请日：1995-05-26
申请人： Hiroshi Yoshino , Norihiro Ueda , Hirovuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
发明人： Hiroshi Yoshino , Norihiro Ueda , Hirovuki Sugumi , Jun Niijima , Yoshihiko Kotake , Toshimi Okada , Nozomu Koyanagi , Tatsuo Watanabe , Makoto Asada , Kentaro Yoshimatsu , Atsumi Iijima , Takeshi Nagasu , Kappei Tsukahara , Kyosuke Kitoh
IPC分类号： C07C311/48 , A61K31/18 , A61P35/00 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/74 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D239/69 , C07D307/68 , C07D333/38 , C07F9/58 , C07H15/203 , C07H15/26 , C07D307/02 , C07D333/02 , C07C311/15
CPC分类号： C07D213/74 , C07C311/21 , C07C311/29 , C07C311/44 , C07D213/76 , C07D213/81 , C07D213/82 , C07D239/42 , C07D239/48 , C07D239/50 , C07D307/68 , C07D333/38 , C07F9/588 , C07H15/203 , C07H15/26
摘要： Sulfonamide compounds of the formula or pharmacologically acceptable salts thereof: ##STR1## wherein: R.sup.1 is a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, nitro group, phenoxy group, cyano group, acetyl group, amino group or a protected amino group; R.sup.2 and R.sup.3 may be the same or different from each other and each is a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group; R.sup.4 and R.sup.7 may be the same or different from each other and each is a hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 may be the same or different from each other and each is a hydrogen atom, halogen atom, lower alkoxy group, amino group or amino group substituted with a lower alkyl or a phenyl group; A is .dbd.CH--; B is .dbd.CH--; and E is selected from the group consisting of ##STR2## in which Q is an oxygen atom or a sulfur atom; and R.sup.11 is a hydrogen atom, a lower alkyl group, an amino group which may be substituted with a lower alkyl group, a lower alkoxy group, a 2-thienyl group, a 2-furyl group, phenyl group or a phenyl group having from 1 to 3 substituents, said substituents being the same or different from one another and selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, carboxyl group, esterified carboxyl group, amidated carboxyl group, lower alkylthio group and phenoxy group; and (b) a phenyl group or a phenyl group having from 1 to 3 substituents.
摘要翻译：下式的磺酰胺化合物或其药理学上可接受的盐：其中：R1是氢原子，卤素原子，低级烷基，低级烷氧基，羟基，硝基，苯氧基，氰基，乙酰基，氨基或被保护的氨基; R2和R3可以相同或不同，各自为氢原子，卤素原子，低级烷基或低级烷氧基; R 4和R 7可以相同或不同，各自为氢原子或低级烷基; R5和R6可以相同或不同，分别为氢原子，卤素原子，低级烷氧基，氨基或被低级烷基或苯基取代的氨基; A = CH-; B为= CH-; 并且E选自其中Q是氧原子或硫原子的组; R 11为氢原子，低级烷基，可被低级烷基，低级烷氧基，2-噻吩基，2-呋喃基，苯基或苯基取代的氨基， 1至3个取代基，所述取代基彼此相同或不同，并且选自卤素原子，低级烷基，低级烷氧基，羟基，羧基，酯化羧基，酰胺化羧基，低级烷硫基组和苯氧基; 和（b）苯基或具有1至3个取代基的苯基。

7. 发明授权

US5075296A Azacyclooctadiene compound and pharmaceutical use 失效
标题翻译：氨基胆碱化合物和药物使用
公开(公告)号：US5075296A
公开(公告)日：1991-12-24
申请号：US484101
申请日：1990-02-23
申请人： Kenji Koga , Kiyoshi Tomioka , Yoshihiro Kubota , Makoto Asada , Kyosuke Kitoh
发明人： Kenji Koga , Kiyoshi Tomioka , Yoshihiro Kubota , Makoto Asada , Kyosuke Kitoh
IPC分类号： C07D317/58 , C07D317/60 , C07D405/06 , C07D413/06 , C07D491/04 , C07D491/056 , C07D491/14 , C07D491/147 , C07D498/14 , C07D499/14
CPC分类号： C07D405/06 , C07D317/58 , C07D317/60 , C07D413/06 , C07D491/04 , C07D491/14
摘要： An azacyclooctadiene compound having the formula (1) or a pharmacologically acceptable salt thereof is novel and useful as an anti-tumor agent. ##STR1## in which R1 is --CH2R, R being hydrogen, --COCH3, --OH, --NH2, --COOH or --OCOCH3, or may form --CH2--X--Y-- together with R2; R2 is hydrogen, an alkyl having 1 to 4 carbon atoms or --COR10, R10 being hydrogen, an alkyl having 1 to 4 carbon atoms, --OR11 or --NHR11, R11 being an alkyl having 1 to 4 carbon atoms, or may form --CH2--X--Y-- together with R1; R3, R4 and R5 each are hydrogen or methyl; R6 and R7 each are hydrogen or may form the direct bond to each other; R8 is hydrogen or may form the direct bond to R7; and R9 is hydrogen, --N3, --NH2, --OCH3 or .dbd.0; X being oxygen or --NZ--, Z being hydrogen, methyl, --COCH3, --CH2COOH, --CO--CH.dbd.CH2, --CO--CH.dbd.CH--CH3, --CH2C6H5, --CH2OH, --CH2OCOCH3 or --CH2--COOC(CH3)3, Y being --SC--, --CO-- or --CH2--.

8. 发明授权

US07994441B2 Compound operation input device 有权
标题翻译：复合操作输入装置
公开(公告)号：US07994441B2
公开(公告)日：2011-08-09
申请号：US12081813
申请日：2008-04-22
申请人： Makoto Asada
发明人： Makoto Asada
IPC分类号： H01H9/00
CPC分类号： H01H25/008 , H01H19/003
摘要： A compound operation input device includes a casing; an operating lever accommodatable in the casing in such a manner that the lever is depressingly operable from a neutral position in a pressing-movement direction and swingingly operable from the neutral position in two opposite swinging directions intersecting the pressing-movement direction; a position detector accommodatable in the casing and adapted to output a signal in accordance with a swing of the lever; a pressing member facing an end surface of the lever on the pressing-movement direction side; and a press switch facing the pressing member with a depressible portion of the switch facing a direction substantially orthogonal to the pressing-movement direction and the swinging directions of the lever. The pressing member is adapted to move toward the switch when pressed by the end surface of the lever so as to depress the depressible portion of the switch.
摘要翻译：复合操作输入装置包括壳体; 操作杆可以容纳在所述壳体中，使得所述杆能够在按压移动方向上从中立位置按压操作，并且可在与所述按压移动方向相交的两个相反的摆动方向上从所述中立位置摆动操作; 位置检测器，可容纳在壳体中并且适于根据杆的摆动输出信号; 面向所述杠杆在所述按压移动方向侧的端面的按压构件; 以及面向所述按压构件的按压开关，所述开关的可按压部分面向与所述按压移动方向和所述杠杆的摆动方向大致正交的方向。按压构件适于在由杆的端面按压时朝向开关移动，以便按压开关的可按压部分。

9. 发明授权

US07964815B2 Push-button switch 有权
标题翻译：按钮开关
公开(公告)号：US07964815B2
公开(公告)日：2011-06-21
申请号：US12216976
申请日：2008-07-14
申请人： Makoto Asada
发明人： Makoto Asada
IPC分类号： H01H3/20
CPC分类号： H01H13/20 , H01H13/48 , H01H13/64 , H01H15/102 , H01H2013/525
摘要： In a lateral pushing type push-button switch, a pair of guiding portions against which an actuating portion that is projected from a pressing portion of an operating member into a housing is buttable are disposed in a cover which is attached to an upper portion of the housing. The switch has a second actuating member which is formed in continuously with a peripheral portion that is accommodated in a peripheral side portion of the housing, and which is projected into the housing to be opposed to the actuating portion. When the operating member is pressed in a lateral direction, the actuating portion and the second actuating member are downward displaced to depress movable contacts to be contacted with stationary contacts.
摘要翻译：在侧推式按钮开关中，一对引导部分，其中从操作构件的按压部分突出到壳体中的致动部分可靠地布置在盖子中，盖子附接到操作构件的上部住房。开关具有第二致动构件，该第二致动构件与容纳在壳体的周边部分中的周边部分连续地形成，并且突出到壳体中以与致动部分相对。当操作构件沿横向按压时，致动部分和第二致动构件向下移位以压下可动触头以与固定触点接触。

10. 外观设计

USD627745S1 Switch 有权
公开(公告)号：USD627745S1
公开(公告)日：2010-11-23
申请号：US29354567
申请日：2010-01-26
申请人： Makoto Asada
设计人： Makoto Asada

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