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    • 3. 发明授权
    • Tocopherol derivatives
    • 生育酚衍生物
    • US5606080A
    • 1997-02-25
    • US438971
    • 1995-05-11
    • Kazumi OgataHidetoshi Nakao
    • Kazumi OgataHidetoshi Nakao
    • C07D311/72C07D405/10
    • C07D311/72
    • Tocopherol derivatives of the following formula (I) or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.l and R.sub.2 are the same or different and each represents hydrogen or methyl; R.sub.3 represents an .alpha.-amino acid, .omega.-amino acid, or peptide bonding via the N terminus thereof, except that in the case of cysteine or glutathione which has a thiol group, bonding via the thiol group, are water-soluble and can be expected to be of use as a cerebral function-improving drug and an anticataract drug. Moreover, these compounds are of value as an UV-absorber, a skin care ingredient, or a stabilizer for other cosmetic ingredients.
    • 下式(I)的生育酚衍生物或其药学上可接受的盐相同或不同,各自表示氢或甲基; R3表示通过其N末端键合的α-氨基酸,ω-氨基酸或肽键,除了在具有硫醇基的半胱氨酸或谷胱甘肽的情况下,经由硫醇基团的键合是水溶性的并且可以是 预计将用作大脑功能改善药物和抗atar药。 此外,这些化合物对于其他化妆品成分具有紫外线吸收剂,护肤成分或稳定剂的价值。