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1. 发明授权

US06495675B1 Pharmaceutical composition for treating or preventing influenza, and novel capped oligonucleotide 失效
标题翻译：用于治疗或预防流感的药物组合物和新型封端寡核苷酸
公开(公告)号：US06495675B1
公开(公告)日：2002-12-17
申请号：US09603378
申请日：2000-06-26
申请人： Hiroshi Takaku , Kin-ichiro Miura , Toshifumi Hatta , Kazuyuki Takai , Masahide Ishikawa
发明人： Hiroshi Takaku , Kin-ichiro Miura , Toshifumi Hatta , Kazuyuki Takai , Masahide Ishikawa
IPC分类号： C07H2104
CPC分类号： A61K31/7105 , A61K38/00 , C07H21/00 , C12N15/1131 , C12N2310/317 , C12N2310/321 , C12N2310/3521
摘要： A pharmaceutical composition comprising a capped oligonucleotide capable of binding to a PB2 protein of an influenza virus RNA polymerase, and a pharmaceutically acceptable carrier or dilute, said capped oligonucleotide having a structure of the formula (I): m7GpppXpY (I) wherein ppp is a triphosphate bridge, p is a monophosphate bridge, m7G is 7-methylguanosine group binding at 5′ end thereof to said ppp, X is a 2′-O-methyl guanosine group or guanosine group, said 2′-O-methyl guanosine group or guanosine group binds at a 5′ end thereof to said ppp, and at a 3′ end thereof to said p, and Y is an oligoribonucleotide moiety binding at 5′ end thereof to said p, and having 5 to 11 bases is disclosed. The pharmaceutical composition can inhibit a protein expression of an influenza virus.
摘要翻译：一种药物组合物，其包含能够结合流感病毒RNA聚合酶的PB2蛋白的封端寡核苷酸和药学上可接受的载体或稀释的具有式（I）结构的所述封端寡核苷酸：其中ppp是三磷酸桥，p 是单磷酸桥，m7G是在5'末端与所述ppp结合的7-甲基鸟苷类，X是2'-O-甲基鸟苷或鸟苷酸，所述2'-O-甲基鸟苷或鸟苷基结合于其5'端至所述ppp，并且在其3'末端与所述p结合，Y是在其5'末端与所述p结合并且具有5至11个碱基的寡核糖核苷酸部分。药物组合物可以抑制流感病毒的蛋白质表达。

2. 发明授权

US07696380B2 Amide-based compound, polyolefin resin composition and molded product 有权
标题翻译：酰胺类化合物，聚烯烃树脂组合物和成型品
公开(公告)号：US07696380B2
公开(公告)日：2010-04-13
申请号：US10574832
申请日：2004-10-08
申请人： Hiroshi Kitagawa , Masahide Ishikawa , Chiaki Ueoka , Sukehiro Niga , Yohei Uchiyama
发明人： Hiroshi Kitagawa , Masahide Ishikawa , Chiaki Ueoka , Sukehiro Niga , Yohei Uchiyama
IPC分类号： C07C233/05
CPC分类号： C08K5/20 , C07C233/06 , C08K2201/014 , C08L23/02 , C08L2666/18 , C08K5/098 , C08L23/10 , C08K5/49
摘要： Disclosed are a mixture of at least two amide-based compounds represented by General Formula (1): wherein a represents an integer of 2 to 6, R1 represents a C2-30 saturated or unsaturated aliphatic polycarboxylic acid residue, and the aliphatic polycarboxylic acid has a valency of 2 to 6, and two to six R2 groups are the same or different, and each represent a trans-2-alkylcyclohexylamine residue or a cis-2-alkylcyclohexylamine residue, the mixture having a content of a trans-2-alkylcyclohexylamine residue of at least 70 mole % but less than 100 mole % of the total 2-alkylcyclohexylamine residues in the mixture, or an all-trans amide-based compound wherein all of the 2 to 6 R2 groups represent a trans-2-alkylcyclohexylamine residue; a polyolefin resin nucleating agent comprising the mixture or the all-trans amide-based compound; a polyolefin resin composition containing the amide-based compound or the mixture; a molded article obtainable by molding the composition.
摘要翻译：公开了由通式（1）表示的至少两种酰胺类化合物的混合物：其中a表示2〜6的整数，R1表示C2-30饱和或不饱和脂肪族多元羧酸残基，脂族多元羧酸具有 2〜6的化合价和2〜6个R 2相同或不同，各自表示反式-2-烷基环己胺残基或顺式-2-烷基环己胺残基，该混合物的反式-2-烷基环己胺混合物中的2-烷基环己胺残基总数至少为70摩尔％但小于100摩尔％的残基，或全反式酰胺类化合物，其中所有2至6个R 2基团代表反式-2-烷基环己胺残基 ; 包含该混合物或全酰胺类化合物的聚烯烃树脂成核剂; 含有该酰胺类化合物或该混合物的聚烯烃树脂组合物; 可通过模塑该组合物获得的模制品。

3. 发明授权

US07667031B2 Nucleic acid base pair 失效
标题翻译：核酸碱基对
公开(公告)号：US07667031B2
公开(公告)日：2010-02-23
申请号：US11078607
申请日：2005-03-10
申请人： Ichiro Hirao , Masahide Ishikawa , Tsuyoshi Fujihara , Shigeyuki Yokoyama
发明人： Ichiro Hirao , Masahide Ishikawa , Tsuyoshi Fujihara , Shigeyuki Yokoyama
IPC分类号： C07H21/00 , C07H21/04 , C07H19/06 , C07H19/048
CPC分类号： C07H11/04 , C07H19/207 , C07H21/00 , C12N15/11 , C12P21/02
摘要： A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase such as DNA polymerase; a novel artificial gene; and a method of designing nucleic acid bases so as to form a selective base pair with the use of steric hindrance, static repulsion and stacking effect at the base moiety of the nucleic acid. An artificial nucleic acid comprising these bases; a process for producing the same; a codon containing the same; a nucleic acid molecule containing the same; a process for producing a non-natural gene by using the same; a process for producing a novel protein by using the above nucleic acid molecule or non-natural gene, and the like.
摘要翻译：通过引入具有空间位阻的基团（优选具有空间位阻和静电排斥和堆叠效应的基团）形成选择性碱基对而获得的新型人造核酸碱基对，可以通过聚合酶如DNA聚合酶识别; 一种新型人工基因; 以及设计核酸碱基以在核酸的碱基部分上使用空间位阻，静电排斥和堆叠效应形成选择性碱基对的方法。包含这些碱的人造核酸; 其制造方法; 含有相同的密码子; 含有该核酸分子的核酸分子; 通过使用该方法生产非天然基因的方法; 通过使用上述核酸分子或非天然基因来生产新型蛋白质的方法等。

4. 发明授权

US08475337B2 Vehicle heat management device 有权
标题翻译：车辆热管理装置
公开(公告)号：US08475337B2
公开(公告)日：2013-07-02
申请号：US13258252
申请日：2009-05-07
申请人： Masahide Ishikawa , Kaname Uzuki , Atsushi Morita , Keiko Tanaka , Yuki Miyamoto , Satoru Shiga , Masaki Morita , Miyuki Matsuda , Manabu Orihashi , Yoshihiro Saeki , Keiichi Uno , Hiroki Nishimura , Takayuki Kumamoto
发明人： Masahide Ishikawa , Kaname Uzuki , Atsushi Morita , Keiko Tanaka , Yuki Miyamoto , Satoru Shiga , Masaki Morita , Miyuki Matsuda , Manabu Orihashi , Yoshihiro Saeki , Keiichi Uno , Hiroki Nishimura , Takayuki Kumamoto
IPC分类号： F16H59/00
CPC分类号： B60H1/08 , B60H1/00314 , F01P2060/16 , F02B29/0493 , F02M26/33 , F02N19/04 , F16H57/0413 , Y02T10/146 , Y02T10/16 , Y10T477/653
摘要： When there is an extremely low ambient temperature, an electronic control unit controls operation of a circulation path for coolant water in such a manner that, after starting of an engine, the coolant water is supplied from the engine first to a throttle valve and an EGR valve and then to an oil warmer for a transmission. This solves a failure problem in the throttle valve and the EGR valve caused by frost formation at an early stage. As a result, desired operating performance of the vehicle is quickly ensured and heat management in the vehicle is carried out in a desired manner when there is an extremely low ambient temperature.
摘要翻译：当环境温度非常低时，电子控制单元控制冷却水循环路径的操作，使得在发动机启动之后，冷却水从发动机首先供应到节流阀和EGR 阀门，然后到油加热器进行传动。这解决了在早期阶段由于霜冻形成引起的节流阀和EGR阀的故障问题。结果，当环境温度极低时，能够快速确保车辆的期望的操作性能，并且以期望的方式进行车辆的热管理。

5. 发明授权

US07745661B2 Process for producing tricarboxylic acid tris (alkyl-substituted cyclohexylamide) 失效
标题翻译：制备三羧酸三（烷基取代的环己基酰胺）的方法
公开(公告)号：US07745661B2
公开(公告)日：2010-06-29
申请号：US11911054
申请日：2006-04-05
申请人： Sachio Kitagawa , Masahide Ishikawa , Yoshihiro Ishibashi , Taiichiro Iwamura , Yoshihiro Kihara
发明人： Sachio Kitagawa , Masahide Ishikawa , Yoshihiro Ishibashi , Taiichiro Iwamura , Yoshihiro Kihara
IPC分类号： C07C231/02
CPC分类号： C07D207/40 , C07C231/02 , C07C2601/14 , C07C233/06
摘要： Disclosed are, for example, a process for producing a tricarboxylic acid tris(alkyl-substituted cyclohexylamide), the process comprising subjecting a tricarboxylic acid and an alkyl-substituted cyclohexylamine to an amidation reaction, either (a) in the presence of a boric acid compound and a phenol compound or (b) in the presence of a boric acid ester obtained by the dehydration condensation of a boric acid compound and a phenol compound, and optionally purifying the resulting crude reaction product.
摘要翻译：公开了例如三羧酸三（烷基取代的环己基酰胺）的制备方法，该方法包括使三羧酸和烷基取代的环己胺进行酰胺化反应，（a）在硼酸存在下化合物和酚化合物，或（b）在通过硼酸化合物和酚化合物的脱水缩合得到的硼酸酯的存在下，并任选地纯化所得粗反应产物。

6. 发明申请

US20100016491A1 NOVEL POLYOLEFIN RESIN COMPOSITION AND MOLDED RESIN OBTAINED THEREFROM 审中-公开
标题翻译：新型聚烯烃树脂组合物和获得的模塑树脂
公开(公告)号：US20100016491A1
公开(公告)日：2010-01-21
申请号：US12513199
申请日：2006-12-19
申请人： Sukehiro Niga , Masahide Ishikawa
发明人： Sukehiro Niga , Masahide Ishikawa
IPC分类号： C08K3/26 , C08K3/34 , C08K3/22 , C08K3/10 , C08K3/18 , C09K3/00
CPC分类号： C08L23/02 , C08K3/22 , C08K3/26 , C08K5/20 , C08L53/00 , C08L2666/02 , C08L23/10
摘要： The present invention provides a polyolefin-based resin composition comprising 100 weight parts of a polyolefin-based resin, 0.01 to 1 weight part of a specific amide-based component (A), 0.005 to 1 weight part of at least one inorganic compound (B) selected from the group consisting of hydrotalcite, calcined hydrotalcite, talc, alkali aluminum double hydroxides, magnesium hydroxide, magnesium oxide, calcium carbonate and calcium oxide. The present invention also provides polyolefin-based rein molded articles with excellent crystallinity, rigidity and transparency; etc.
摘要翻译：本发明提供一种聚烯烃类树脂组合物，其包含100重量份的聚烯烃类树脂，0.01〜1重量份的特定酰胺类成分（A），0.005〜1重量份的至少一种无机化合物（B ）选自水滑石，煅烧水滑石，滑石，碱金属铝双氢氧化物，氢氧化镁，氧化镁，碳酸钙和氧化钙。本发明还提供了具有优异的结晶度，刚性和透明度的聚烯烃类树脂成型体; 等等

7. 发明申请

US20130008165A1 RANKINE CYCLE SYSTEM 审中-公开
标题翻译： RANKINE CYCLE系统
公开(公告)号：US20130008165A1
公开(公告)日：2013-01-10
申请号：US13636246
申请日：2010-03-25
申请人： Kenichi Yamada , Hideo Kobayashi , Masahide Ishikawa , Toshihisa Sugiyama
发明人： Kenichi Yamada , Hideo Kobayashi , Masahide Ishikawa , Toshihisa Sugiyama
IPC分类号： F01K13/00
CPC分类号： F01K25/10 , F01K9/00 , F01K23/065
摘要： A Rankine cycle system includes: a superheater, an expander including a first outlet discharging steam and a second outlet discharging liquid refrigerant produced therein; a first discharge path discharging the steam from the expander; a condenser condensing the steam introduced through the first discharge path into liquid refrigerant, a condensed water tank reserving the liquid refrigerant produced in the condenser; and a second discharge path discharging the liquid refrigerant from the expander to the condensed water tank, wherein a liquid level in the condensed water tank satisfies a following relation: Δh>ΔPto/ρg, when Δh means a height difference between the liquid level and a lowest liquid level in the second discharge path, ΔPto means a pressure loss when the steam flows into the condenser from the expander through the first discharge path, ρ means a density of the liquid refrigerant, and g means a gravitational acceleration.
摘要翻译：兰金循环系统包括：过热器，膨胀器，包括排出蒸汽的第一出口和排出其中产生的液体制冷剂的第二出口; 从膨胀机排出蒸汽的第一排放路径; 冷凝器，其将通过第一排出路径导入的蒸汽冷凝成液体制冷剂;冷凝水箱，储存在冷凝器中产生的液体制冷剂; 以及将液体制冷剂从膨胀机排出到冷凝水箱的第二排出路径，其中冷凝水箱中的液面满足以下关系：＆Dgr; h>＆Dgr; Pto /＆rgr; g，当＆Dgr; h表示液面与第二排出路径中的最低液面之间的高度差，Dgr表示当蒸汽通过第一排出路径从膨胀器流入冷凝器时的压力损失; 表示液体制冷剂的密度，g表示重力加速度。

8. 发明申请

US20120037336A1 VEHICLE HEAT MANAGEMENT DEVICE 有权
标题翻译：车辆热管理装置
公开(公告)号：US20120037336A1
公开(公告)日：2012-02-16
申请号：US13258252
申请日：2009-05-07
申请人： Masahide Ishikawa , Kaname Uzuki , Atsushi Morita , Keiko Tanaka , Yuki Miyamoto , Satoru Shiga , Masaki Morita , Miyuki Matsuda , Manabu Orihashi , Yoshihiro Saeki , Keiichi Uno , Hiroki Nishimura , Takayuki Kumamoto
发明人： Masahide Ishikawa , Kaname Uzuki , Atsushi Morita , Keiko Tanaka , Yuki Miyamoto , Satoru Shiga , Masaki Morita , Miyuki Matsuda , Manabu Orihashi , Yoshihiro Saeki , Keiichi Uno , Hiroki Nishimura , Takayuki Kumamoto
IPC分类号： F01P9/00
CPC分类号： B60H1/08 , B60H1/00314 , F01P2060/16 , F02B29/0493 , F02M26/33 , F02N19/04 , F16H57/0413 , Y02T10/146 , Y02T10/16 , Y10T477/653
摘要： When there is an extremely low ambient temperature, an electronic control unit controls operation of a circulation path for coolant water in such a manner that, after starting of an engine, the coolant water is supplied from the engine first to a throttle valve and an EGR valve and then to an oil warmer for a transmission. This solves a failure problem in the throttle valve and the EGR valve caused by frost formation at an early stage. As a result, desired operating performance of the vehicle is quickly ensured and heat management in the vehicle is carried out in a desired manner when there is an extremely low ambient temperature.
摘要翻译：当环境温度非常低时，电子控制单元控制冷却水循环路径的操作，使得在发动机启动之后，冷却水从发动机首先供应到节流阀和EGR 阀门，然后到油加热器进行传动。这解决了在早期阶段由于霜冻形成引起的节流阀和EGR阀的故障问题。结果，当环境温度极低时，能够快速确保车辆的期望的操作性能，并且以期望的方式进行车辆的热管理。

9. 发明申请

US20090069599A1 PROCESS FOR PRODUCING TRICARBOXYLIC ACID TRIS (ALKYL-SUBSTITUTED CYCLOHEXYLAMIDE) 失效
标题翻译：生产三羧酸三氯乙酸（烷基取代的环己基甲酰胺）的方法
公开(公告)号：US20090069599A1
公开(公告)日：2009-03-12
申请号：US11911054
申请日：2006-04-05
申请人： Sachio Kitagawa , Masahide Ishikawa , Yoshihiro Ishibashi , Taiichiro Iwamura , Yoshihiro Kihara
发明人： Sachio Kitagawa , Masahide Ishikawa , Yoshihiro Ishibashi , Taiichiro Iwamura , Yoshihiro Kihara
IPC分类号： C07C231/02
CPC分类号： C07D207/40 , C07C231/02 , C07C2601/14 , C07C233/06
摘要： Disclosed are, for example, a process for producing a tricarboxylic acid tris(alkyl-substituted cyclohexylamide), the process comprising subjecting a tricarboxylic acid and an alkyl-substituted cyclohexylamine to an amidation reaction, either (a) in the presence of a boric acid compound and a phenol compound or (b) in the presence of a boric acid ester obtained by the dehydration condensation of a boric acid compound and a phenol compound, and optionally purifying the resulting crude reaction product.
摘要翻译：公开了例如三羧酸三（烷基取代的环己基酰胺）的制备方法，该方法包括使三羧酸和烷基取代的环己胺进行酰胺化反应，（a）在硼酸存在下化合物和酚化合物，或（b）在通过硼酸化合物和酚化合物的脱水缩合得到的硼酸酯的存在下，并任选地纯化所得粗反应产物。

10. 发明授权

US06245843B1 Diacetal composition, process for the preparation of the same, nucleating agent for polyolefins containing the same, polyolefin resin compositions, and moldings 有权
标题翻译：二缩醛组合物，其制备方法，含有它们的聚烯烃成核剂，聚烯烃树脂组合物和模制品
公开(公告)号：US06245843B1
公开(公告)日：2001-06-12
申请号：US09319187
申请日：1999-06-02
申请人： Toshiaki Kobayashi , Masahide Ishikawa , Harutomo Nomoto , Toshihiro Mizutani
发明人： Toshiaki Kobayashi , Masahide Ishikawa , Harutomo Nomoto , Toshihiro Mizutani
IPC分类号： C08K515
CPC分类号： C07D493/04 , C08K5/0008 , C08K5/0083 , C08K5/09 , C08K5/1575 , C08K5/42 , C08L23/02
摘要： This invention provides a granular or powdery diacetal composition comprising: (a) at least one diacetal such as 1,3:2,4-O-dibenzylidene-D-sorbitol or a nucleus-substituted derivative thereof, and (b) at least one binder selected from the group consisting of neutral or weakly acidic monovalent organic acids, neutral or weakly acidic polyvalent organic acids, partial salts of neutral or weakly acidic polyvalent organic acids, salts of sulfuric acid ester, sulfonic acid salts, salts of phosphoric acid ester, phosphoric acid esters, phosphorous acid esters and aluminum salts of a neutral or weakly acidic monovalent organic acid, the binder being uniformly dispersed on the surface and in the interior of the particles of the granular or powdery diacetal composition; a process for preparing the composition; a polyolefin resin nucleating agent comprising the composition; a resin composition containing the nucleating agent and a polyolefin resin; and a polyolefin resin molded article.
摘要翻译：本发明提供了一种颗粒状或粉状二缩醛组合物，其包含：（a）至少一种二缩醛，例如1,3：2,4-O-二亚苄基-D-山梨醇或其核取代衍生物，和（b）至少一种选自中性或弱酸性单价有机酸，中性或弱酸性多价有机酸，中性或弱酸性多价有机酸的部分盐，硫酸酯的盐，磺酸盐，磷酸酯的盐，磷酸酯，亚磷酸酯和中性或弱酸性单价有机酸的铝盐，粘合剂均匀地分散在颗粒状或粉状二缩醛组合物颗粒的表面和内部; 制备组合物的方法; 包含该组合物的聚烯烃树脂成核剂; 含有成核剂和聚烯烃树脂的树脂组合物; 和聚烯烃树脂成型品。

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