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1. 发明授权

US06764654B2 Flat cell and an analyzer using the same 失效
公开(公告)号：US06764654B2
公开(公告)日：2004-07-20
申请号：US10101424
申请日：2002-03-20
申请人： Hiroshi Sasaki , Yutaka Ito , Katsuhiro Kambara
发明人： Hiroshi Sasaki , Yutaka Ito , Katsuhiro Kambara
IPC分类号： B01I300
CPC分类号： B01L3/5088 , B01L3/5085 , B01L2300/161 , B01L2300/168 , G01N21/03 , G02B21/34
摘要： A measurement cell for analyzer for carrying out qualitative and/or quantitative analysis for one or more substances by an optical means, which is planar and has sample-holding portions, the contact angle between said sample-holding portion and water being 30° or less, and the contact angle between the other portion of said plane and water being 100° or more, permits a plurality of measurements with a single cell for the same one sample, repeated use and reduction of the amount of sample than before.

2. 发明授权

US06835350B2 Flat cell and an analyzer using the same 失效
标题翻译：扁平电池和使用其的分析仪
公开(公告)号：US06835350B2
公开(公告)日：2004-12-28
申请号：US10207172
申请日：2002-07-30
申请人： Hiroshi Sasaki , Yutaka Ito , Katsuhiro Kambara
发明人： Hiroshi Sasaki , Yutaka Ito , Katsuhiro Kambara
IPC分类号： B01L300
CPC分类号： B01L3/5088 , B01L3/5085 , B01L2300/161 , B01L2300/168 , G01N21/03 , G02B21/34
摘要： A measurement cell for analyzer for carrying out qualitative and/or quantitative analysis for one or more substances by an optical means, which is planar and has sample-holding portions, the contact angle between said sample-holding portion and water being 30° or less, and the contact angle between the other portion of said plane and water being 100° or more, permits a plurality of measurements with a single cell for the same one sample, repeated use and reduction of the amount of sample than before.
摘要翻译：一种用于通过平面且具有样品保持部分的光学装置对一种或多种物质进行定性和/或定量分析的测量单元，所述样品保持部分和水之间的接触角为30°或更小，并且所述平面和水的另一部分之间的接触角为100°以上，允许对于相同的一个样品，单个电池进行多次测量，重复使用和减少样品量。

3. 发明授权

US08278108B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08278108B2
公开(公告)日：2012-10-02
申请号：US13145801
申请日：2010-01-22
申请人： Kentaro Wada , Katsuhiro Kambara , Tetsuji Kawahara , Hidenobu Komatsu
发明人： Kentaro Wada , Katsuhiro Kambara , Tetsuji Kawahara , Hidenobu Komatsu
IPC分类号： G01N1/00 , G01N1/10 , G01N35/10 , B01L3/02
CPC分类号： G01N35/0092 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/113332 , Y10T436/2575
摘要： An automatic analyzer of the type equipped with a sample preprocessing function pretreats a desired sample in a pretreating unit before pipetting the sample into an analyzing unit for analysis. When all samples are carried to the analyzing unit via the pretreating unit, irrespective of whether the sample is to be pretreated, this causes loss in terms of both costs and installation space requirements. In the case where the preprocessing is required, a minimal quantity of the sample is also necessary in order to make the sample react to the preprocessing liquid. In addition, the possible presence of a residual sample left in the pretreating unit could affect analytical results. The automatic analyzer which includes an analyzing unit and a pretreating unit further includes a sample-pipetting mechanism constructed to have a function that allows the mechanism to access a plurality of pipetting positions without a sample sucking/discharging position being fixed.
摘要翻译：具有样品预处理功能的自动分析仪在将样品移入分析单元进行分析之前，预处理单元中预期所需的样品。当所有样品都通过预处理单元运送到分析单元时，无论样品是否被预处理，都会导致成本和安装空间要求方面的损失。在需要预处理的情况下，为了使样品与预处理液反应，也需要最小量的样品。此外，留在预处理单元中残留样品的可能存在会影响分析结果。包括分析单元和预处理单元的自动分析器还包括样品移液机构，其被构造成具有允许机构在没有固定样品吸取/排出位置的情况下进入多个移液位置的功能。

4. 发明申请

US20070009387A1 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US20070009387A1
公开(公告)日：2007-01-11
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N33/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

5. 发明授权

US07027935B2 Sample dispensing apparatus and automatic analyzer using the same 有权
标题翻译：样品分配装置和使用其的自动分析仪
公开(公告)号：US07027935B2
公开(公告)日：2006-04-11
申请号：US10634775
申请日：2003-08-06
申请人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
发明人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
IPC分类号： G01F1/00 , G01F7/00
CPC分类号： G01N35/1016 , G01N35/1004
摘要： A sample dispensing apparatus is realized which can detect a dispensing abnormality occurred during the sample dispensing operation regardless of the type and the extent of the abnormality. A pressure sensor is connected to a dispensing flow passage system, including a sample probe and a dispensing syringe, and a plurality of output values of the pressure sensor during the sample dispensing operation are taken in. A multi-item analysis (based on the Mahalanobis distance) is carried out by using, as items, the plurality of taken-in output values of the pressure sensor. Whether the dispensing is normally performed or not is determined by comparing an analysis result with a threshold. A highly reliable determination result is obtained in spite of variations of sensitivity of the pressure sensor.
摘要翻译：实现了一种样品分配装置，其可以检测在样品分配操作期间发生的分配异常，而不管异常的类型和程度如何。压力传感器连接到分配流路系统，包括样品探针和分注注射器，并且在样品分配操作期间采用压力传感器的多个输出值。多项目分析（基于马哈拉诺比斯距离）通过使用压力传感器的多个取入输出值作为项目进行。通过将分析结果与阈值进行比较来确定分配是否正常执行。尽管压力传感器的灵敏度变化，但获得了高度可靠的测定结果。

6. 发明授权

US08658102B2 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US08658102B2
公开(公告)日：2014-02-25
申请号：US12785835
申请日：2010-05-24
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： B06B1/06
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus comprising reaction containers containing therein a substance to be analyzed; an agitating mechanism spaced from the substance to be analyzed and agitating said substance to be analyzed with a liquid in said reaction container; and, a measuring portion for measuring physical properties of the substance to be analyzed, said agitating mechanism having a sound supply portion supplying sound waves to the substance to be analyzed, wherein said sound supply portion comprises a mechanism changing, in time, intensity of ultrasonic waves to be irradiated so as to apply pulsation to a swirl flow in the reaction container.
摘要翻译：一种化学分析装置，包括含有待分析物质的反应容器; 与待分析物质间隔开的搅拌机构，并在所述反应容器中用液体搅拌待分析物质; 以及用于测量被分析物质的物理性质的测量部分，所述搅拌机构具有向待分析物质供应声波的声音供给部分，其中所述声音供应部分包括时间上改变超声波强度的机构要被照射的波浪以便对反应容器中的涡流施加脉动。

7. 发明申请

US20110283779A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20110283779A1
公开(公告)日：2011-11-24
申请号：US13145801
申请日：2010-01-22
申请人： Kentaro Wada , Katsuhiro Kambara , Tetsuji Kawahara , Hidenobu Komatsu
发明人： Kentaro Wada , Katsuhiro Kambara , Tetsuji Kawahara , Hidenobu Komatsu
IPC分类号： G01N1/10
CPC分类号： G01N35/0092 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/113332 , Y10T436/2575
摘要： An automatic analyzer of the type equipped with a sample preprocessing function pretreats a desired sample in a pretreating unit before pipetting the sample into an analyzing unit for analysis. When all samples are carried to the analyzing unit via the pretreating unit, irrespective of whether the sample is to be pretreated, this causes loss in terms of both costs and installation space requirements. In the case where the preprocessing is required, a minimal quantity of the sample is also necessary in order to make the sample react to the preprocessing liquid. In addition, the possible presence of a residual sample left in the pretreating unit could affect analytical results. The automatic analyzer which includes an analyzing unit and a pretreating unit further includes a sample-pipetting mechanism constructed to have a function that allows the mechanism to access a plurality of pipetting positions without a sample sucking/discharging position being fixed.
摘要翻译：具有样品预处理功能的自动分析仪在将样品移入分析单元进行分析之前，预处理单元中预期所需的样品。当所有样品都通过预处理单元运送到分析单元时，无论样品是否被预处理，都会导致成本和安装空间要求方面的损失。在需要预处理的情况下，为了使样品与预处理液反应，也需要最小量的样品。此外，留在预处理单元中残留样品的可能存在会影响分析结果。包括分析单元和预处理单元的自动分析器还包括样品移液机构，其被构造成具有允许机构在没有固定样品吸取/排出位置的情况下进入多个移液位置的功能。

8. 发明授权

US06737021B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US06737021B2
公开(公告)日：2004-05-18
申请号：US09789625
申请日：2001-02-22
申请人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
发明人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
IPC分类号： B32B500
CPC分类号： G01N35/025 , B01F11/0283 , G01N2035/00554 , Y10T436/11
摘要： Multiple piezoelectric elements 35 are arranged in a row along the top of liquid level in a reaction vessel 11. An ultrasonic reflecting material 38 is installed on the bottom of the portion of the heat insulating bath 12 where heat insulating medium 13 is stored. A lateral ultrasonic wave 9b is generated on the lower side by actuation of the piezoelectric element 35. Wave 9b is reflected by the ultrasonic reflecting material 38. As lower ultrasonic wave 8 advances along the wall surface of the reaction vessel, it collides with the specimen liquid, thereby causing a portion of the liquid level closer to the piezoelectric element 35 to be raised. When lateral ultrasonic wave 9a is applied to this portion, it reaches the inclined portion of the raised liquid level of the specimen. Swirling flow by agitation 36 is produced by acoustic radiation pressure of the ultrasonic wave. The specimen and reagent are mixed and agitated by this swirling flow.
摘要翻译：多个压电元件35沿着反应容器11中的液面顶部排列成一排。超声波反射材料38安装在绝热槽12的存储绝热介质13的部分的底部。通过压电元件35的驱动，在下侧产生横向超声波9b。波形9b被超声波反射材料38反射。随着低超声波8沿着反应容器的壁表面前进，它与样品液体，从而使更靠近压电元件35的液面的一部分升高。当横向超声波9a被施加到该部分时，其到达样本的升高的液面的倾斜部分。通过搅拌36产生的旋流由超声波的声辐射压力产生。样品和试剂通过这种旋流混合和搅拌。

9. 发明授权

US08997589B2 Automatic analysis apparatus and automatic analysis method 有权
标题翻译：自动分析仪器及自动分析方法
公开(公告)号：US08997589B2
公开(公告)日：2015-04-07
申请号：US13145804
申请日：2010-01-25
申请人： Hidenobu Komatsu , Katsuhiro Kambara , Tetsuji Kawahara , Kentaro Wada
发明人： Hidenobu Komatsu , Katsuhiro Kambara , Tetsuji Kawahara , Kentaro Wada
IPC分类号： G01N1/00 , G01N35/02 , G01N35/00
CPC分类号： G01N35/025 , G01N35/0092 , G01N35/0095 , G01N35/026 , G01N2035/00326
摘要： A rack buffer unit 8 serving as a sample-container switching unit is provided between a rack conveying module 4 and a rack conveying module 5 which convey racks 2 on which the sample containers 1 are mounted, and an urgent-sample loading module 7 installing a rack 2 on which a sample container 1 storing a sample desired to be preferentially analyzed is mounted is provided. The rack 2 which is in the process of sample dispensing and the rack 2 desired to be preferentially analyzed are switched from each other by the rack buffer unit 8, and the sample container 1 mounted on the rack 2 desired to be preferentially analyzed is moved to a sample dispensing position in a short period of time.
摘要翻译：作为样本容器切换单元的架子缓冲单元8设置在架子输送模块4和输送安装有样本容器1的架子2的架子输送模块5之间，紧急样品装载模块7安装提供了容纳有希望被优先分析的样品的样品容器1的支架2。在样品分配过程中的架子2和希望被优先分析的架子2通过齿条缓冲单元8彼此切换，并且安装在希望被优先分析的架子2上的样品容器1移动到样品分配位置在短时间内。

10. 发明授权

US07820114B2 Reaction container for chemical analysis with the controlled surface property 有权
标题翻译：具有受控表面性质的化学分析反应容器
公开(公告)号：US07820114B2
公开(公告)日：2010-10-26
申请号：US10927046
申请日：2004-08-27
申请人： Mina Amo , Takayuki Nakakawaji , Taku Sakazume , Katsuhiro Kambara
发明人： Mina Amo , Takayuki Nakakawaji , Taku Sakazume , Katsuhiro Kambara
IPC分类号： B01L3/00
CPC分类号： B01L3/5082 , B01L2200/0684 , B01L2300/12 , B01L2300/165
摘要： A highly reliable reaction container capable of restraining an initial detection failure (bubble attachment), and a biochemical and/or immunological automatic analyzer loaded with the reaction container. In a reaction container made of a synthetic resin and used for receiving a biological sample and a reagent, developing a biochemical and/or immunological reaction between the biological sample and the reagent, and measuring proceedings of the reaction and/or the state at a predetermined point in time by optical means, an inner wall surface of the reaction container in contact with the biological sample, the reagent, and a reaction product of the biological sample and the reagent has a critical surface tension of not smaller than 25.0 mN/m, or a contact angle between the inner wall surface of the reaction container and a solvent of a reaction solution is not larger than 60 degrees.
摘要翻译：能够抑制初始检测失败（气泡附着）的高度可靠的反应容器和装载有反应容器的生物化学和/或免疫学自动分析装置。在由合成树脂制成并用于接收生物样品和试剂的反应容器中，在生物样品和试剂之间产生生化和/或免疫反应，并以预定的方式测量反应和/或状态的程序通过光学装置的时间点，与生物样品，试剂和生物样品和试剂的反应产物接触的反应容器的内壁表面具有不小于25.0mN / m的临界表面张力，或者反应容器的内壁面与反应溶液的溶剂之间的接触角不大于60度。

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