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1. 发明授权

US08680092B2 Nitrogenous heterocyclic compound and medicinal use thereof 失效
标题翻译：氮杂环化合物及其医药用途
公开(公告)号：US08680092B2
公开(公告)日：2014-03-25
申请号：US11816940
申请日：2006-02-24
申请人： Hiroshi Ochiai , Akira Ohhata , Yoshikazu Takaoka , Shiro Shibayama
发明人： Hiroshi Ochiai , Akira Ohhata , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61P11/00 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/06 , A61P43/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K39/21 , A61K39/395 , A61K45/00
CPC分类号： A61K45/06 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by formula (I): (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof. The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.
摘要翻译：由式（I）表示的化合物：其中符号与说明书中定义相同，其盐，其N-氧化物，其溶剂合物或其前药，及其药物用途。由式（I）表示的化合物具有CXCR4拮抗活性。因此，其可用作例如CXCR4介导的疾病如炎症/免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化和移植器官的排斥反应）的预防和/或治疗剂，过敏性疾病，感染疾病（例如人类免疫缺陷病毒感染和获得性免疫缺陷综合征），精神神经病，脑疾病，心脏/血管疾病，代谢疾病，癌症疾病（例如癌症，癌症转移）或再生治疗剂。

2. 发明申请

US20090233908A1 NITROGENOUS HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF 失效
标题翻译：硝基杂环化合物及其药物用途
公开(公告)号：US20090233908A1
公开(公告)日：2009-09-17
申请号：US11816940
申请日：2006-02-24
申请人： Hiroshi Ochiai , Akira Ohhata , Yoshikazu Takaoka , Shiro Shibayama
发明人： Hiroshi Ochiai , Akira Ohhata , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/55 , C07D403/14 , C07D401/14 , A61K31/506
CPC分类号： A61K45/06 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by formula (I): (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof.The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.
摘要翻译：由式（I）表示的化合物：其中符号与说明书中定义相同，其盐，其N-氧化物，其溶剂合物或其前药，及其药物用途。由式（I）表示的化合物具有CXCR4拮抗活性。因此，其可用作例如CXCR4介导的疾病如炎症/免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化和移植器官的排斥反应）的预防和/或治疗剂，过敏性疾病，感染疾病（例如人类免疫缺陷病毒感染和获得性免疫缺陷综合征），精神神经病，脑疾病，心脏/血管疾病，代谢疾病，癌症疾病（例如癌症，癌症转移）或再生治疗剂。

3. 发明申请

US20050222138A1 Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient 失效
标题翻译：含氮双环化合物和含有与活性成分相同的药物
公开(公告)号：US20050222138A1
公开(公告)日：2005-10-06
申请号：US10502884
申请日：2003-01-30
申请人： Akira Ohhata , Yoshikazu Takaoka , Mikio Ogawa , Hisao Nakai , Susumu Yamamoto , Hiroshi Ochiai
发明人： Akira Ohhata , Yoshikazu Takaoka , Mikio Ogawa , Hisao Nakai , Susumu Yamamoto , Hiroshi Ochiai
IPC分类号： A61K31/4035 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/496 , A61K31/497 , A61K31/536 , A61K31/5377 , A61K31/541 , A61K31/5415 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , C07D217/04 , C07D491/107 , C07D279/16
CPC分类号： C07D217/04 , A61K31/4035 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/496 , A61K31/497 , A61K31/536 , A61K31/5377 , A61K31/541 , A61K31/5415
摘要： A nitrogen-containing bicyclic compound of formula (I) or a pharmaceutically acceptable salt thereof (wherein the symbols have the same meanings as described in the specification). The compound of formula (I) has an inhibitory activity against PDE7 and it is useful for the prevention and/or treatment of various diseases, i.e. autoimmune diseases (ulcerative colitis, Crohn's disease, rheumatism, psoriasis, multiple sclerosis, collagenosis, etc.), inflammatory diseases (obstructive pulmonary disease, sepsis, pancreatitis, sarcoidosis, nephritis, hepatitis, enteritis, etc.), allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, seasonal conjunctivitis, atopic dermatitis, etc.), rejection of organ transplants, serious graft versus host disease (GVHD), diabetic disease, osteoporosis, bone fracture, restenosis, atherosclerosis, obesity, ischemic reperfusion injury, depression, Parkinson's disease, dementia, leukemia, etc.
摘要翻译：式（I）的含氮双环化合物或其药学上可接受的盐（其中符号具有与说明书中所述相同的含义）。式（I）化合物对PDE7具有抑制活性，可用于预防和/或治疗各种疾病，即自身免疫性疾病（溃疡性结肠炎，克罗恩病，风湿病，牛皮癣，多发性硬化症，胶原病等），炎性疾病（阻塞性肺病，败血症，胰腺炎，结节病，肾炎，肝炎，肠炎等），过敏性疾病（哮喘，过敏性鼻炎，过敏性结膜炎，季节性结膜炎，特应性皮炎等），器官移植排斥，严重的移植物抗宿主病（GVHD），糖尿病，骨质疏松症，骨折，再狭窄，动脉粥样硬化，肥胖，缺血再灌注损伤，抑郁症，帕金森病，痴呆，白血病等。

4. 发明授权

US07378428B2 Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient 失效
标题翻译：含氮双环化合物和含有与活性成分相同的药物
公开(公告)号：US07378428B2
公开(公告)日：2008-05-27
申请号：US10502884
申请日：2003-01-30
申请人： Akira Ohhata , Yoshikazu Takaoka , Mikio Ogawa , Hisao Nakai , Susumu Yamamoto , Hiroshi Ochiai
发明人： Akira Ohhata , Yoshikazu Takaoka , Mikio Ogawa , Hisao Nakai , Susumu Yamamoto , Hiroshi Ochiai
IPC分类号： C07D279/16 , A61K31/5415 , A61K31/4035
CPC分类号： C07D217/04 , A61K31/4035 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/496 , A61K31/497 , A61K31/536 , A61K31/5377 , A61K31/541 , A61K31/5415
摘要： A nitrogen-containing bicyclic compound of formula (I) or a pharmaceutically acceptable salt thereof (wherein the symbols have the same meanings as described in the specification). The compound of formula (I) has an inhibitory activity against PDE7 and it is useful for the prevention and/or treatment of various diseases, i.e. autoimmune diseases (ulcerative colitis, Crohn's disease, rheumatism, psoriasis, multiple sclerosis, collagenosis, etc.), inflammatory diseases (obstructive pulmonary disease, sepsis, pancreatitis, sarcoidosis, nephritis, hepatitis, enteritis, etc.), allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, seasonal conjunctivitis, atopic dermatitis, etc.), rejection of organ transplants, serious graft versus host disease (GVHD), diabetic disease, osteoporosis, bone fracture, restenosis, atherosclerosis, obesity, ischemic reperfusion injury, depression, Parkinson's disease, dementia, leukemia, etc.
摘要翻译：式（I）的含氮双环化合物或其药学上可接受的盐（其中符号具有与说明书中所述相同的含义）。式（I）化合物对PDE7具有抑制活性，可用于预防和/或治疗各种疾病，即自身免疫性疾病（溃疡性结肠炎，克罗恩病，风湿病，牛皮癣，多发性硬化症，胶原病等），炎性疾病（阻塞性肺病，败血症，胰腺炎，结节病，肾炎，肝炎，肠炎等），过敏性疾病（哮喘，过敏性鼻炎，过敏性结膜炎，季节性结膜炎，特应性皮炎等），器官移植排斥，严重的移植物抗宿主病（GVHD），糖尿病，骨质疏松症，骨折，再狭窄，动脉粥样硬化，肥胖，缺血再灌注损伤，抑郁症，帕金森病，痴呆，白血病等。

5. 发明授权

US08614323B2 Chemokine receptor antagonists and use thereof 失效
标题翻译：趋化因子受体拮抗剂及其用途
公开(公告)号：US08614323B2
公开(公告)日：2013-12-24
申请号：US13596780
申请日：2012-08-28
申请人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： C07D471/10
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如，癌症，癌症转移等）或再生治疗剂。

6. 发明申请

US20090169567A1 BASIC GROUP-CONTAINING COMPOUND AND USE THEREOF 失效
标题翻译：含基本组合物及其用途
公开(公告)号：US20090169567A1
公开(公告)日：2009-07-02
申请号：US12094100
申请日：2006-11-17
申请人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： C07D471/10 , A61K31/438 , A61K31/537 , C07D498/10 , A61K39/42 , A61K31/7105 , A61K39/21 , A61P31/18
CPC分类号： C07D403/12 , C07D233/64 , C07D401/12 , C07D403/14 , C07D471/10 , C07D498/10
摘要： A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac /vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.
摘要翻译：由通式（I）表示的化合物：其盐，其溶剂化物或前药，其中所有符号如本说明书中所定义，具有对CXCR4的拮抗活性，因此可用作预防和/或治疗剂 CXCR4介导的疾病，例如炎症和免疫疾病（例如类风湿性关节炎，关节炎，全身性红斑狼疮，视网膜病变，黄斑变性，肺纤维化，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心脏/血管疾病（例如动脉硬化，心肌梗塞，心动过速，脑梗死，慢性动脉闭塞性疾病等），代谢疾病和癌性疾病（例如，癌症，癌症转移等），癌性疾病或感染的预防和/或治疗剂，或再生治疗剂。

7. 发明申请

US20120207765A1 CHEMOKINE RECEPTOR ANTAGONISTS AND USE THEREOF 失效
标题翻译：化疗受体拮抗剂及其用途
公开(公告)号：US20120207765A1
公开(公告)日：2012-08-16
申请号：US13415399
申请日：2012-03-08
申请人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/454 , A61K39/42 , A61K31/7052 , A61K39/21 , C07D403/12 , A61K31/4178 , C07D221/20 , A61K31/438 , C07D403/14 , A61K31/55 , C07D265/14 , A61K31/537 , A61P11/06 , A61P31/18 , A61P37/06 , A61P35/00 , A61P19/02 , A61P11/00 , C07D401/14
CPC分类号： C07D403/12 , C07D233/64 , C07D401/12 , C07D403/14 , C07D471/10 , C07D498/10
摘要： A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.
摘要翻译：由通式（I）表示的化合物：其盐，其溶剂化物或前药，其中所有符号如本说明书中所定义，具有对CXCR4的拮抗活性，因此可用作预防和/或治疗剂 CXCR4介导的疾病，例如炎症和免疫疾病（例如类风湿性关节炎，关节炎，全身性红斑狼疮，视网膜病变，黄斑变性，肺纤维化，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心脏/血管疾病（例如动脉硬化，心肌梗塞，心动过速，脑梗死，慢性动脉闭塞性疾病等），代谢疾病和癌性疾病（例如，癌症，癌症转移等），癌性疾病或感染的预防和/或治疗剂，或再生治疗剂。

8. 发明授权

US08168783B2 Chemokine receptor antagonists and use thereof 失效
标题翻译：趋化因子受体拮抗剂及其用途
公开(公告)号：US08168783B2
公开(公告)日：2012-05-01
申请号：US12094100
申请日：2006-11-17
申请人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： C07D471/10
CPC分类号： C07D403/12 , C07D233/64 , C07D401/12 , C07D403/14 , C07D471/10 , C07D498/10
摘要： A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.
摘要翻译：由通式（I）表示的化合物：其盐，其溶剂化物或前药，其中所有符号如本说明书中所定义，具有对CXCR4的拮抗活性，因此可用作预防和/或治疗剂 CXCR4介导的疾病，例如炎症和免疫疾病（例如类风湿性关节炎，关节炎，全身性红斑狼疮，视网膜病变，黄斑变性，肺纤维化，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心脏/血管疾病（例如动脉硬化，心肌梗塞，心动过速，脑梗死，慢性动脉闭塞性疾病等），代谢疾病和癌性疾病（例如，癌症，癌症转移等），癌性疾病或感染的预防和/或治疗剂，或再生治疗剂。

9. 发明授权

US08519124B2 Chemokine receptor antagonists and use thereof 失效
标题翻译：趋化因子受体拮抗剂及其用途
公开(公告)号：US08519124B2
公开(公告)日：2013-08-27
申请号：US13415399
申请日：2012-03-08
申请人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： C07D221/20 , C07D265/14 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D403/12 , C07D233/64 , C07D401/12 , C07D403/14 , C07D471/10 , C07D498/10
摘要： A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.
摘要翻译：由通式（I）表示的化合物：其盐，其溶剂化物或前药，其中所有符号如本说明书中所定义，具有对CXCR4的拮抗活性，因此可用作预防和/或治疗剂 CXCR4介导的疾病，例如炎症和免疫疾病（例如类风湿性关节炎，关节炎，全身性红斑狼疮，视网膜病变，黄斑变性，肺纤维化，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心脏/血管疾病（例如动脉硬化，心肌梗塞，心动过速，脑梗死，慢性动脉闭塞性疾病等），代谢疾病和癌性疾病（例如，癌症，癌症转移等），癌性疾病或感染的预防和/或治疗剂，或再生治疗剂。

10. 发明申请

US20120328627A1 CHEMOKINE RECEPTOR ANTAGONISTS AND USE THEREOF 失效
标题翻译：化疗受体拮抗剂及其用途
公开(公告)号：US20120328627A1
公开(公告)日：2012-12-27
申请号：US13596780
申请日：2012-08-28
申请人： Masaya KOKUBO , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya KOKUBO , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/438 , A61K31/5377 , A61P35/00 , A61K39/42 , A61K31/713 , A61P37/06 , A61P31/18 , A61P35/04 , A61P29/00 , A61P19/02 , A61P9/10 , C07D471/10 , A61K39/21
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如，癌症，癌症转移等）或再生治疗剂。

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