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1. 发明申请

US20120328627A1 CHEMOKINE RECEPTOR ANTAGONISTS AND USE THEREOF 失效
标题翻译：化疗受体拮抗剂及其用途
公开(公告)号：US20120328627A1
公开(公告)日：2012-12-27
申请号：US13596780
申请日：2012-08-28
申请人： Masaya KOKUBO , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya KOKUBO , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/438 , A61K31/5377 , A61P35/00 , A61K39/42 , A61K31/713 , A61P37/06 , A61P31/18 , A61P35/04 , A61P29/00 , A61P19/02 , A61P9/10 , C07D471/10 , A61K39/21
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如，癌症，癌症转移等）或再生治疗剂。

2. 发明授权

US08318931B2 Chemokine receptor antagonists and use thereof 有权
标题翻译：趋化因子受体拮抗剂及其用途
公开(公告)号：US08318931B2
公开(公告)日：2012-11-27
申请号：US12091403
申请日：2006-10-27
申请人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61P35/00 , C07D471/10
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如，癌症，癌症转移等）或再生治疗剂。

3. 发明授权

US08293896B2 Chemokine receptor antagonists and use thereof 有权
公开(公告)号：US08293896B2
公开(公告)日：2012-10-23
申请号：US12091403
申请日：2006-10-27
申请人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61P35/00 , C07D471/10
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

4. 发明授权

US07986985B2 Portable electronic device with a sliding mechanism for a component thereof 有权
标题翻译：具有用于其部件的滑动机构的便携式电子设备
公开(公告)号：US07986985B2
公开(公告)日：2011-07-26
申请号：US12148158
申请日：2008-04-16
申请人： Hirokazu Niitsu , Masaki Uesugi , Yuuichi Oota , Motoyuki Tanaka
发明人： Hirokazu Niitsu , Masaki Uesugi , Yuuichi Oota , Motoyuki Tanaka
IPC分类号： H04W88/02 , H04B1/38
CPC分类号： H04M1/0247 , G06F1/162 , G06F1/1624 , G06F1/1671 , G06F1/1677 , G06F1/169 , G06F2200/1614 , H04M1/021 , H04M1/0235 , H04M1/0241 , H04M1/23 , H04M1/7258 , H04M2250/16 , H04M2250/18 , H04M2250/22
摘要： A cellular phone device has an operation-unit casing, a sliding casing which is coupled to the operation-unit casing with the front face of the sliding casing facing the rear face of the operation-unit casing, and which slides with respect to the operation-unit casing in a direction parallel to the rear face of the operation-unit casing, and a direction input device provided on the rear face of the operation-unit casing. The sliding casing slides with respect to the operation-unit casing between a state where the direction input device is covered by the sliding casing and a state where a covering of the direction input device by the sliding casing is released.
摘要翻译：蜂窝电话装置具有操作单元壳体，滑动壳体，其与所述操作单元壳体联接，所述滑动壳体的前表面面向所述操作单元壳体的后表面，并且相对于所述操作而滑动单元壳体在与操作单元壳体的后表面平行的方向上，以及设置在操作单元壳体的后表面上的方向输入装置。滑动壳体相对于操作单元壳体在方向输入装置被滑动壳体覆盖的状态和滑动壳体的方向输入装置的覆盖物被释放的状态之间滑动。

5. 发明授权

US07875745B2 Compounds having lysophosphatidic acid receptor antagonism and uses thereof 有权
标题翻译：具有溶血磷脂酸受体拮抗作用的化合物及其用途
公开(公告)号：US07875745B2
公开(公告)日：2011-01-25
申请号：US10583469
申请日：2004-12-17
申请人： Motoyuki Tanaka , Shinji Nakade , Yoshikazu Takaoka
发明人： Motoyuki Tanaka , Shinji Nakade , Yoshikazu Takaoka
IPC分类号： C07C53/134 , A61K31/19
CPC分类号： C07D231/12 , C07C59/66 , C07C69/734 , C07C69/92 , C07D207/337 , C07D261/08 , C07D403/06 , C07D409/06 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I): (wherein the symbols in formula were described in the description), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention binds to and is antagonistic to an LPA receptor (particularly, EDG-2), it is useful for prevention and/or treatment of urinary system disease (prostatic hypertrophy or neurogenic bladder dysfunction disease, spinal cord neoplasm, nucleous hernia, spinal canal stenosis, diseases caused by diabetes, occlusion disease of lower urinary tract, inflammatory disease of lower urinary tract, and polyuria), carcinoma-associated disease, proliferative disease, inflammation system disease, immune system disease, disease by secretory dysfunction, brain-related disease and/or chronic disease.
摘要翻译：本发明涉及由式（I）表示的化合物：其中式中的符号在描述中描述），其盐，其溶剂化物或其前药。由于本发明的化合物与LPA受体（特别是EDG-2）结合并拮抗，因此可用于预防和/或治疗泌尿系统疾病（前列腺肥大或神经源性膀胱功能障碍性疾病，脊髓肿瘤，核疝，椎管狭窄，糖尿病引起的疾病，下尿路闭塞性疾病，下尿路炎症和多尿症），癌相关疾病，增殖性疾病，炎症系统疾病，免疫系统疾病，分泌功能障碍脑相关疾病和/或慢性疾病。

6. 发明申请

US20090236833A1 Head-protecting airbag 有权
标题翻译：头部保护安全气囊
公开(公告)号：US20090236833A1
公开(公告)日：2009-09-24
申请号：US12382581
申请日：2009-03-19
申请人： Motoyuki TANAKA , Yoshio Mizuno
发明人： Motoyuki TANAKA , Yoshio Mizuno
IPC分类号： B60R21/16
CPC分类号： B60R21/232 , B60R2021/23316
摘要： A head-protecting airbag is deployable downward from an upper periphery of a window of vehicle to cover the window. The airbag includes a primary inflatable portion that includes a protection portion for receiving an occupant's head and a secondary inflatable portion that admits inflation gas of the primary inflatable portion and is inflatable secondarily for preventing a pressure increase of the primary inflatable portion. The primary inflatable portion and the secondary inflatable portion are, communicated with a tubular conduit that is arranged along the lower periphery of the airbag. The protection portion includes an inlet-side inflatable portion communicated with the conduit and an upper inflatable portion located above the conduit. The conduit includes a main region located facing the outlet port and an enlarged-diameter region that is located facing the inlet port and has a greater opening dimension than the main region.
摘要翻译：头部保护气囊从车窗的上部周边向下展开以覆盖窗户。该安全气囊包括主充气部分，其包括用于容纳乘客头部的保护部分和允许主充气部分的充气气体并可再次充气以便防止主充气部分的压力增加的次充气部分。主充气部分和次充气部分与沿着气囊的下周边布置的管状导管连通。保护部分包括与导管连通的入口侧可充气部分和位于导管上方的上部可充气部分。导管包括面向出口定位的主区域和位于面向入口并且具有比主区域更大的开口尺寸的扩径区域。

7. 发明申请

US20090118279A1 COMPOUND CONTAINING BASIC GROUP AND USE THEREOF 有权
标题翻译：包含基本组合的化合物及其用途
公开(公告)号：US20090118279A1
公开(公告)日：2009-05-07
申请号：US12091403
申请日：2006-10-27
申请人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya Kokubo , Motoyuki Tanaka , Hiroshi Ochiai , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/5377 , C07D471/10 , A61P35/00 , A61K31/438
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof.The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如，癌症，癌症转移等）或再生治疗剂。

8. 发明授权

US07476341B2 Process for producing photo-conductor layers for constituting radiation imaging panels 失效
标题翻译：用于制造用于构成放射线成像面板的光导体层的制造方法
公开(公告)号：US07476341B2
公开(公告)日：2009-01-13
申请号：US11236597
申请日：2005-09-28
申请人： Motoyuki Tanaka , Shigeru Nakamura , Kiyoteru Miyake
发明人： Motoyuki Tanaka , Shigeru Nakamura , Kiyoteru Miyake
IPC分类号： H01L21/00 , B22F3/10
CPC分类号： G21K4/00 , H01L27/14676 , H01L31/18 , Y10S430/101
摘要： A photo-conductor layer for constituting a radiation imaging panel, which photo-conductor layer is capable of recording radiation image information as an electrostatic latent image, is produced. The photo-conductor layer contains a Bi12MO20 sintered material, in which M represents at least one kind of element selected from the group consisting of Ge, Si, and Ti. Sintering processing for the formation of the Bi12MO20 sintered material is performed in an inert gas, atmosphere. Alternatively, the sintering processing is performed at a sintering temperature falling within the range of 800° C. to 900° C. and in an atmosphere, in which an oxygen partial pressure PO2 (Pa) satisfies the condition 10−3≦PO2≦10−1.
摘要翻译：产生用于构成能够记录作为静电潜像的放射线图像信息的光导体层的放射线图像面板的光导体层。光导体层包含Bi12MO20烧结材料，其中M表示选自Ge，Si和Ti中的至少一种元素。用于形成Bi12MO20烧结材料的烧结处理在惰性气体，大气中进行。或者，烧结处理在800℃〜900℃的烧结温度下进行，在氧分压PO2（Pa）满足条件10-3 <= PO2 < = 10-1。

9. 发明申请

US20070015091A1 Photoconductive sheet and radiation imaging panel 审中-公开
标题翻译：光导片和辐射成像面板
公开(公告)号：US20070015091A1
公开(公告)日：2007-01-18
申请号：US11474341
申请日：2006-06-26
申请人： Kiyoteru Miyake , Motoyuki Tanaka
发明人： Kiyoteru Miyake , Motoyuki Tanaka
IPC分类号： G03C5/00
CPC分类号： G01T1/246
摘要： A photoconductive layer for use in a radiation imaging panel which records an electrostatic latent image representing a radiographic image, formed of a bismuth-mixed metal oxide Bi12MO20 so as to exhibit a first light reflectance at a first wavelength of 750 nm and a second light reflectance at a second wavelength of 350 nm, where M is at least one of Ge, Si, and Ti, and the first light reflectance is seven or more times greater than the second light reflectance.
摘要翻译：一种用于辐射成像面板的光电导层，其记录表示由铋混合金属氧化物Bi 12 MO 20形成的放射线照相图像的静电潜像，以便在750nm的第一波长的第一光反射率和350nm的第二波长的第二光反射率，其中M是Ge，Si和Ti中的至少一个，并且第一光反射率是七倍或更多倍比第二光反射率。

10. 发明申请

US20060210910A1 Photo-conductor layer for constituting radiation imaging panels 失效
标题翻译：用于构成放射成像面板的光导体层
公开(公告)号：US20060210910A1
公开(公告)日：2006-09-21
申请号：US11375205
申请日：2006-03-15
申请人： Motoyuki Tanaka
发明人： Motoyuki Tanaka
IPC分类号： G03C5/16
CPC分类号： C09K11/59 , C09K11/66 , C09K11/67 , H01L27/14663 , H01L27/14665 , H01L27/14676 , H01L31/032
摘要： A photo-conductor layer for constituting a radiation imaging panel, which photo-conductor layer is capable of recording radiation image information as an electrostatic latent image, contains a polycrystal constituted of BixMOy, in which M represents at least one kind of element selected from the group consisting of Ge, Si, and Ti, x represents a number satisfying the condition 12.05≦x≦13.1, and y represents a stoichiometric oxygen atom number determined by M and x. The photo-conductor layer has a high sensitivity.
摘要翻译：用于构成能够记录作为静电潜像的放射线图像信息的光导体层的放射线摄像面板的光导体层包含由Bi×MO＆lt; / SUB，其中M表示选自Ge，Si和Ti中的至少一种元素，x表示满足条件12.05 <= x <= 13.1的数，y表示化学计量的氧原子数由M和x决定。光导体层具有高灵敏度。

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