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1. 发明申请

US20130071866A1 METHOD FOR TESTING THE SEVERTIY OF AN ILLNESS 审中-公开
标题翻译：测试误差的方法
公开(公告)号：US20130071866A1
公开(公告)日：2013-03-21
申请号：US13700334
申请日：2011-05-27
申请人： Hiroshi Kido , Masaji Nishimura , Junji Chida
发明人： Hiroshi Kido , Masaji Nishimura , Junji Chida
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/5735 , G01N2800/00
摘要： An object of the present invention is directed to a method for assaying the severity of an illness in real time and is to provide a testing method capable of assessing the severity of an illness in more detail than the conventional APACHE II and SOFA scores. The established method can accurately measure an ATP level in a sample, thereby accurately and quickly deducing the “state of intracellular energy required for living organisms” from the ATP level, and by extension, determining the severity of an illness. The present invention further provides a novel biomarker ATP-lactate energy risk score (A-LES) value that is capable of determining the severity of an illness by the reevaluation, with the ATP concentration as an index (specifically, on the basis of a lactic acid level (mM)/ATP concentration (mM) ratio), of the level of lactic acid that accumulates in the sample due to the breakdown of in vivo metabolic balance accompanied by the increased severity of the illness. The present invention also provides a novel biomarker ATP-ketone energy risk score (A-KES) value that is capable of determining the severity of an illness by the reevaluation of a ketone body level in the sample with the ATP concentration as an index (specifically, on the basis of a ketone body level (mM)/ATP concentration (mM) ratio).
摘要翻译：本发明的目的是针对实时测定疾病严重性的方法，并提供能够比常规APACHE II和SOFA得分更详细地评估疾病的严重程度的测试方法。已建立的方法可以准确测量样品中的ATP水平，从而准确，快速地从ATP水平推测生物体所需的细胞内能量的状态，并通过扩展来确定疾病的严重程度。本发明还提供了一种新的生物标志物ATP-乳酸能量风险评分（A-LES）值，其能够通过重新评估来确定疾病的严重程度，其中ATP浓度作为指标（具体地，基于乳酸酸浓度（mM）/ ATP浓度（mM）比），由于体内代谢平衡的崩溃伴随着疾病严重程度的增加，样品中积累的乳酸水平。本发明还提供了一种新的生物标志物ATP-酮能量风险评分（A-KES）值，其能够通过以ATP浓度作为指标重新评价样品中的酮体水平来确定疾病的严重程度，基于酮体水平（mM）/ ATP浓度（mM）比）。

2. 发明申请

US20110110971A1 ANTIGEN-AND-DRUG VEHICLE COMPRISING SYNTHETIC PEPTIDE, AND MUCOSAL VACCINE USING THE SAME 有权
标题翻译：包含合成肽的抗病毒药物和使用它的胶原疫苗
公开(公告)号：US20110110971A1
公开(公告)日：2011-05-12
申请号：US12936075
申请日：2009-03-30
申请人： Hiroshi Kido , Tsunetomo Takei , Dai Mizuno
发明人： Hiroshi Kido , Tsunetomo Takei , Dai Mizuno
IPC分类号： A61K39/00 , A61K38/10 , A61K38/16 , A61K39/35 , A61P31/00 , A61P37/08
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/541 , A61K2039/6018 , A61K2039/6031 , C07K7/08 , C07K14/001 , C12N2760/16134
摘要： Disclosed are an antigen-and-drug (AD) vehicle and a mucosal vaccine utilizing a novel synthetic peptide.The antigen-and-drug (AD) vehicle capable of inducing the production of secretory IgA antibodies, which is a complex of a synthetic peptide having the following amino acid sequence: PVHLKRLm (m is 11 to 15 or 16 to 20, e.g., peptide of SEQ. ID. NO: 1) or KnLm (n is 4 to 8 and m is 11 to 20, e.g., peptide of SEQ. ID. NO: 2 or 3), and a lipid(s). The mucosal vaccine is obtainable by allowing a mucosal-immunity-IgA-inducing amount of an antigen to coexist with, contact, be captured by, or be adsorbed onto the AD vehicle.
摘要翻译：公开了使用新型合成肽的抗原和药物（AD）载体和粘膜疫苗。能够诱导产生分泌型IgA抗体的抗原和药物（AD）载体，其是具有以下氨基酸序列的合成肽的复合物：PVHLKRLm（m为11至15或16至20，例如肽 SEQ ID NO：1）或KnLm（n为4至8，m为11至20，例如SEQ ID NO：2或3的肽）和脂质。通过使粘膜免疫-1AA诱导量的抗原与AD载体共存，接触，捕获或被吸附到AD载体上而获得粘膜疫苗。

3. 发明申请

US20100323904A1 Transcription chip 审中-公开
标题翻译：转录片
公开(公告)号：US20100323904A1
公开(公告)日：2010-12-23
申请号：US10556679
申请日：2004-05-13
申请人： Hiroshi Kido , Mineyoshi Hiyoshi , Miwa Bando , Moritoshi Kinoshita , Yoji Fukuda , Hiroshi Mizuguchi
发明人： Hiroshi Kido , Mineyoshi Hiyoshi , Miwa Bando , Moritoshi Kinoshita , Yoji Fukuda , Hiroshi Mizuguchi
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/6837 , C12Q2565/531
摘要： A transcription chip comprising a substrate and, immobilized thereon, at least one polynucleotide including an element sequence to which a transcription factor can be bound.
摘要翻译：一种转录芯片，其包含底物并在其上固定至少一种多核苷酸，其包含能够结合转录因子的元件序列。

4. 发明申请

US20100194305A1 ELECTRONIC BALLAST FOR DISCHARGE LAMP 有权
标题翻译：放电灯电子镇流器
公开(公告)号：US20100194305A1
公开(公告)日：2010-08-05
申请号：US12669538
申请日：2008-07-25
申请人： Shinji Makimura , Hiroshi Kido
发明人： Shinji Makimura , Hiroshi Kido
IPC分类号： H05B41/26
CPC分类号： H05B41/2806 , H05B41/2828 , Y02B20/22 , Y10S315/05
摘要： An electronic ballast for a discharge lamp includes a predictive circuit and a correction circuit in addition to a power conversion circuit including an inverter circuit and a resonant circuit, a drive circuit and a frequency control circuit. The inverter circuit applies load voltage across a load circuit including the lamp via the resonant circuit. The predictive circuit predicts a resonance frequency of the combination of the resonant circuit and the load circuit after ignition of the lamp. The resonance frequency is predicted based on an input signal representing the load voltage in the period of time from the start of sweep of the inverter circuit's operating frequency through a time point immediately after ignition of the lamp. The correction circuit changes the end frequency of the sweep to the resonance frequency.
摘要翻译：用于放电灯的电子镇流器除了包括逆变器电路和谐振电路，驱动电路和频率控制电路的功率转换电路之外还包括预测电路和校正电路。逆变器电路通过谐振电路在包括灯的负载电路两端施加负载电压。预测电路预测了在点灯之后谐振电路和负载电路的组合的谐振频率。基于表示在从逆变器电路的工作频率开始扫描直到灯点火之后的时间点的时间段内的负载电压的输入信号来预测谐振频率。校正电路将扫描的结束频率改变为谐振频率。

5. 发明授权

US5182702A Inverter device 失效
标题翻译：逆变器装置
公开(公告)号：US5182702A
公开(公告)日：1993-01-26
申请号：US633612
申请日：1990-12-24
申请人： Akinori Hiramatsu , Futoshi Okamoto , Hiroshi Kido , Hiroyuki Sako , Yukio Yamanaka , Koji Yamada
发明人： Akinori Hiramatsu , Futoshi Okamoto , Hiroshi Kido , Hiroyuki Sako , Yukio Yamanaka , Koji Yamada
IPC分类号： H02M1/00 , H02M1/42 , H02M3/338 , H05B41/28
CPC分类号： H02M1/425 , H02M3/3387 , H05B41/28 , Y02B70/126 , Y10S315/07
摘要： An inverter device has a full-wave rectifier providing a pulsating DC voltage from an input AC voltage, a smoothing circuit. The smoothing circuit includes a choke coil, a smoothing capacitor and a switching element chopping the pulsating DC voltage through the choke coil into a smoothed DC voltage at the smoothing capacitor. An inverter is included to have the element common to the smoothing circuit and operating to switch the smoothed DC voltage to apply a resulting voltage to a load circuit including a load, inductance and capacitor. The inductance and capacitor define an oscillation circuit providing to the load an oscillating current composed of first and second currents of opposite directions. The oscillating current alternating to flow for a nominal on-time duration determined by a circuit constant of the oscillation circuit itself. A controller is included to detect the termination of the second current and excites the common switching element at a timing dependent upon the termination of the second current so as to start flowing the first current. The controller includes a timer for separately controlling an actual on-time duration for flowing the first current within the nominal on-time duration, whereby enabling to regulate the accumulated DC voltage in the smoothing capacitor at a desired level by controlling to vary the actual on-time duration of the common switching element.

6. 发明授权

US4274081A Data input apparatus 失效
标题翻译：数据输入装置
公开(公告)号：US4274081A
公开(公告)日：1981-06-16
申请号：US64507
申请日：1979-08-07
申请人： Nobutaka Nomura , Hiroshi Kido , Kazunari Yamada
发明人： Nobutaka Nomura , Hiroshi Kido , Kazunari Yamada
IPC分类号： G06F3/02 , G06F3/023 , G06F3/14
CPC分类号： G06F3/0238
摘要： A data input apparatus comprises a display device for displaying guidance information which designates types of data to be inputted as well as the order therefor, a key set having a plurality of keys arrayed in a matrix and a corresponding number of mats defining the functions of the individual keys which can be imparted with new definitions by changing over the associated mats, and a circuit adapted to select and change the mats defining the keys so that the various types of data indicated by the guidance information can be inputted in the order given by the guidance information. The mats can thus be replaced by other proper ones automatically without resorting to manual operation.
摘要翻译：数据输入装置包括显示装置，用于显示指定要输入的数据的类型的指导信息及其顺序，具有矩阵排列的多个键的键组和相应数量的定义可以通过改变关联的垫子来赋予新定义的单个键，以及适于选择和改变定义键的垫的电路，使得能够以由引导信息指示的顺序输入由引导信息指示的各种类型的数据指导信息。因此，这些垫可以由其他适当的垫子自动更换，而无需手动操作。

7. 发明申请

US20130045232A1 MUCOSAL VACCINES 有权
标题翻译：粘液疫苗
公开(公告)号：US20130045232A1
公开(公告)日：2013-02-21
申请号：US13582160
申请日：2011-03-01
申请人： Hiroshi Kido , Dai Mizuno
发明人： Hiroshi Kido , Dai Mizuno
IPC分类号： A61K39/39 , A61P37/04 , A61P37/08 , A61K39/35
CPC分类号： C07K14/005 , A61K9/0043 , A61K39/00 , A61K39/12 , A61K39/145 , A61K47/32 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/466
摘要： A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxylvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.
摘要翻译：一种在能够发挥有效免疫诱导和感染预防作用的水平中产生抗原特异性粘膜IgA和血液IgG的粘膜疫苗，其包括：（a）由合成肽和脂质组成的AD载体），其中由氨基酸序列KnLm（其中n为4至8且m为11至20）组成的合成肽; （b）羧基乙烯基聚合物; 和（c）抗原性蛋白质，其量不足以产生足够的粘膜IgA和血液IgG，用于在自身使用时发挥有效的免疫诱导和感染预防作用。本发明的粘膜疫苗具有比现有技术的粘膜疫苗更有效的抗体生成能力，结果即使使用极少量的抗原也能发挥优异的效果。

8. 发明申请

US20110234104A1 LOAD DETERMINATION DEVICE AND ILLUMINATION APPARATUS USING SAME 有权
标题翻译：使用相同的负载确定装置和照明装置
公开(公告)号：US20110234104A1
公开(公告)日：2011-09-29
申请号：US13071762
申请日：2011-03-25
申请人： Masanori MISHIMA , Hiroshi Kido , Shohei Yamamoto , Masanao Okawa , Hirofumi Konishi , Katunobu Hamamoto
发明人： Masanori MISHIMA , Hiroshi Kido , Shohei Yamamoto , Masanao Okawa , Hirofumi Konishi , Katunobu Hamamoto
IPC分类号： H01J7/42
CPC分类号： H05B33/0848 , H05B33/08 , H05B33/0896 , Y02B20/32
摘要： An illumination load determination device includes an illumination load; a voltage applying unit for applying a voltage to the illumination load; a connection unit for connecting the illumination load and the voltage applying unit; a detection unit for detecting at least one of a current flowing through the illumination load and a voltage across the illumination load when the voltage is applied to the illumination load from the voltage applying unit via the connection unit; and a determination unit for determining a type of the illumination load based on an output from the detection unit. The determination unit has a comparator for comparing a detection value detected by the detection unit to a predetermined threshold, and determines that the illumination load has a capacitance based on an output of the comparator. The voltage applying unit lights on the determined illumination load with a rated driving voltage.
摘要翻译：照明负载确定装置包括照明负载; 电压施加单元，用于向照明负载施加电压; 用于连接照明负载和电压施加单元的连接单元; 检测单元，用于当电压经由连接单元从电压施加单元施加到照明负载时，检测流过照明负载的电流和照明负载两端的电压中的至少一个; 以及确定单元，用于基于来自检测单元的输出来确定照明负载的类型。确定单元具有用于将由检测单元检测的检测值与预定阈值进行比较的比较器，并且基于比较器的输出确定照明负载具有电容。电压施加单元以额定驱动电压对确定的照明负载点亮。

9. 发明授权

US07772783B2 Dimmable electronic ballast for electrodeless discharge lamp and luminaire 有权
标题翻译：可调光电子镇流器，用于无电极放电灯和灯具
公开(公告)号：US07772783B2
公开(公告)日：2010-08-10
申请号：US12067287
申请日：2005-09-28
申请人： Shinji Makimura , Hiroshi Kido
发明人： Shinji Makimura , Hiroshi Kido
IPC分类号： H05B41/24
CPC分类号： H05B41/2806 , H05B41/3925 , Y02B20/22 , Y10S315/04
摘要： A dimmable electronic ballast for an electrodeless discharge lamp comprises an inverter circuit, a resonance circuit, an induction coil and a start circuit. The start circuit has a variable time constant. The start circuit sweeps a drive frequency of the inverter circuit through a time constant for start or restart so that the voltage applied across the coil is raised from voltage lower than start voltage and restart voltage for starting and restarting the lamp to voltage higher than the start voltage and the restart voltage. The time constant for start during a start period for starting the lamp is larger than the time constant for restart during a restart period for restarting the lamp.
摘要翻译：一种无电极放电灯的可调光电子镇流器包括逆变器电路，谐振电路，感应线圈和启动电路。启动电路具有可变时间常数。启动电路通过时间常数扫描逆变器电路的驱动频率，以启动或重新启动，使得施加在线圈上的电压从低于启动电压的电压升高，并将启动和重新启动灯的电压重新启动到高于启动的电压电压和重启电压。启动灯的启动期间启动的时间常数大于重新启动灯的重启期间的重启时间常数。

10. 发明申请

US20100062454A1 Method for predicting risk of acquiring influenza 审中-公开
标题翻译：预测感冒风险的方法
公开(公告)号：US20100062454A1
公开(公告)日：2010-03-11
申请号：US12461983
申请日：2009-08-31
申请人： Hiroshi Kido , Kaoru Terashima
发明人： Hiroshi Kido , Kaoru Terashima
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/56983 , G01N33/582 , G01N2333/11 , G01N2800/50
摘要： An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject.
摘要翻译：本发明的目的是提供一种用于预测感冒风险的方法，其特征在于价格低廉，侵入性低，适用于全自动化。本发明提供了一种预测获得流感的风险的方法，其包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。

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