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1. 发明授权

US07655442B2 Method for stabilizing macrolide compounds 失效
标题翻译：稳定大环内酯类化合物的方法
公开(公告)号：US07655442B2
公开(公告)日：2010-02-02
申请号：US10587042
申请日：2005-01-28
申请人： Hiroshi Ishihara , Susumu Takeda , Tomonari Yamada , Yoshiaki Asahi
发明人： Hiroshi Ishihara , Susumu Takeda , Tomonari Yamada , Yoshiaki Asahi
IPC分类号： C12P19/62
CPC分类号： C12N1/20 , C07D313/00 , C12P17/162
摘要： The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compound expressed by the formula (1) and a cyclodextrin are both present, and a method for producing a macrolide compound, in which a cyclodextrin is made to be present in a culture broth of actinomycetes having an ability of producing the macrolide compound.
摘要翻译：本发明提供了一种稳定大环内酯类化合物的方法和一种制备该化合物的有效方法。具体地说，提供了稳定大环内酯类化合物的方法，其中存在12元环大环内酯化合物，如式（1）表示的化合物和环糊精两者，以及大环内酯类化合物的制备方法，使得环糊精存在于具有产生大环内酯化合物的能力的放线菌的培养肉汤中。

2. 发明申请

US20070155696A1 Method for stabilizing macrolide compounds 失效
标题翻译：稳定大环内酯类化合物的方法
公开(公告)号：US20070155696A1
公开(公告)日：2007-07-05
申请号：US10587042
申请日：2005-01-28
申请人： Hiroshi Ishihara , Susumu Takeda , Tomonari Yamada , Yoshiaki Asahi
发明人： Hiroshi Ishihara , Susumu Takeda , Tomonari Yamada , Yoshiaki Asahi
IPC分类号： A61K31/724 , C08B30/18 , C08B37/16
CPC分类号： C12N1/20 , C07D313/00 , C12P17/162
摘要： The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compound expressed by the formula (1) and a cyclodextrin are both present, and a method for producing a macrolide compound, in which a cyclodextrin is made to be present in a culture broth of actinomycetes having an ability of producing the macrolide compound.
摘要翻译：本发明提供了一种稳定大环内酯类化合物的方法和一种制备该化合物的有效方法。具体地说，提供了稳定大环内酯类化合物的方法，其中存在12元环大环内酯化合物，如式（1）表示的化合物和环糊精两者，以及大环内酯类化合物的制备方法，使得环糊精存在于具有产生大环内酯化合物的能力的放线菌的培养肉汤中。

3. 发明授权

US07026352B1 Physiologically active substances 有权
标题翻译：生理活性物质
公开(公告)号：US07026352B1
公开(公告)日：2006-04-11
申请号：US10470806
申请日：2002-02-01
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： A61K31/365 , C07D313/00
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法

4. 发明申请

US20060079572A1 Novel bioactive substance 有权
标题翻译：新型生物活性物质
公开(公告)号：US20060079572A1
公开(公告)日：2006-04-13
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： A61K31/365 , C07D313/00
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

5. 发明授权

US07667052B2 Bioactive substance 有权
标题翻译：生物活性物质
公开(公告)号：US07667052B2
公开(公告)日：2010-02-23
申请号：US11213962
申请日：2005-08-30
申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori
IPC分类号： C07D313/00 , C07D407/06 , A61K31/365
CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02
摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
摘要翻译：本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

6. 外观设计

USD685680S1 Four wheeled vehicle 有权
公开(公告)号：USD685680S1
公开(公告)日：2013-07-09
申请号：US29437467
申请日：2012-11-16
申请人： Susumu Takeda
设计人： Susumu Takeda

7. 发明申请

US20120180067A1 INFORMATION PROCESSING APPARATUS AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：信息处理设备和计算机程序产品
公开(公告)号：US20120180067A1
公开(公告)日：2012-07-12
申请号：US13347416
申请日：2012-01-10
申请人： Kenji FUNAOKA , Nobuaki Tojo , Susumu Takeda , Akira Kuroda , Hidenori Matsuzaki
发明人： Kenji FUNAOKA , Nobuaki Tojo , Susumu Takeda , Akira Kuroda , Hidenori Matsuzaki
IPC分类号： G06F9/46
CPC分类号： G06F8/456
摘要： According to an embodiment, based on task border information, and first-type dependency relationship information containing N number of nodes corresponding to data accesses to one set of data, containing edges representing dependency relationship between the nodes, and having at least one node with an access reliability flag indicating reliability/unreliability of corresponding data access; task border edges, of edges extending over task borders, are identified that have an unreliable access node linked to at least one end, and presentation information containing unreliable access nodes is generated. According to dependency existence information input corresponding to the set of data, conversion information indicating absence of data access to the unreliable access nodes is output. According to the conversion information, the first-type dependency relationship information is converted into second-type dependency relationship information containing M number of nodes (0≦M≦N) corresponding to data accesses to the set of data and containing edges representing inter-node dependency relationship.
摘要翻译：根据实施例，基于任务边界信息和包含对应于对一组数据的数据访问的N个节点的第一类型依赖关系信息，其包含表示节点之间的依赖关系的边缘，并且具有至少一个具有指示相应数据访问的可靠性/不可靠性的访问可靠性标志; 识别出任务边界在任务边界上延伸的边缘，其具有链接到至少一个端点的不可靠访问节点，并且生成包含不可靠访问节点的呈现信息。根据与该组数据相对应的依赖存在信息，输出指示不存在不可靠访问节点的数据访问的转换信息。根据转换信息，将第一类型依赖关系信息转换成与数据访问相对应的M个节点（0＆nlE; M＆nlE; N）的第二类型依赖关系信息，并且包含表示节点间的边缘依赖关系。

8. 发明申请

US20050245514A1 Novel physiologically active substances 有权
标题翻译：新型生理活性物质
公开(公告)号：US20050245514A1
公开(公告)日：2005-11-03
申请号：US10522731
申请日：2003-07-31
申请人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
发明人： Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Kanada , Susumu Takeda , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Tomohiro Sameshima
IPC分类号： C07D313/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D407/06 , C12P17/08 , C12P17/16 , A61K31/5377 , A61K31/365 , A61K31/4025 , A61K31/452 , A61K31/496 , C07D413/02 , C07D45/02
CPC分类号： C07D407/06 , C07D313/00 , C12P17/08 , C12P17/16 , C12P17/162
摘要： Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17, R20, R21 and R21′ are the same or different and each represents hydrogen, etc. Because of inhibiting angiogenesis and inhibiting the production of VEGF particularly in hypoxia, the compounds (I) are useful as remedies for solid cancer.
摘要翻译：由以下通式（I）表示的化合物，其药学上可接受的盐或其水合物：其中W表示和R 3，R 7，R 7， SUP> 16，R 17，R 20，R 21和R 21'是相同或不同，各自表示氢等。由于抑制血管生成并抑制VEGF的产生，特别是在缺氧中，所以化合物（I）可用作固体癌的治疗方法。

9. 发明授权

US5161872A Indicator needle of automotive instrument and method of manufacturing the same 失效
标题翻译：汽车仪表指针及其制造方法
公开(公告)号：US5161872A
公开(公告)日：1992-11-10
申请号：US800354
申请日：1991-12-02
申请人： Takami Sasaki , Hirofumi Imaizumi , Satoshi Yamada , Masahiro Yasutake , Susumu Takeda
发明人： Takami Sasaki , Hirofumi Imaizumi , Satoshi Yamada , Masahiro Yasutake , Susumu Takeda
IPC分类号： G01D13/28
CPC分类号： G01D13/28 , Y10S362/80
摘要： An indicator needle is provided with a base having a groove having a U-shaped cross section, which groove has an opening in an upper surface thereof and extends in a longitudinal direction of the indicator, and a light transmitting lens which plugs the opening of the upper surface of the base. A plurality of light emitting diodes are arranged in the groove of the base. Base ribs each having a triangular cross section and formed integrally with the base so as to cross the groove of the base are provided in the groove of the base, as well. Light generated from the light emitting diodes directly illuminates the lens, or is reflected by the base ribs to illuminates the same.
摘要翻译：指示针设置有具有U形横截面的凹槽的基部，该凹槽在其上表面中具有开口并沿着指示器的纵向方向延伸;以及透光透镜，其将基座的上表面。多个发光二极管布置在基座的凹槽中。也可以在底座的凹槽中设置各自具有三角形横截面并且与基座一体形成以跨过基部的凹槽的基座肋。从发光二极管产生的光直接照亮透镜，或被基座肋条反射以照亮透镜。

10. 发明授权

US4567935A Molten metal level control in continuous casting 失效
标题翻译：熔铸金属水平控制在连铸
公开(公告)号：US4567935A
公开(公告)日：1986-02-04
申请号：US661518
申请日：1984-10-16
申请人： Susumu Takeda , Allen W. Mann , David G. Goodrich , Theodore C. Zinniger
发明人： Susumu Takeda , Allen W. Mann , David G. Goodrich , Theodore C. Zinniger
IPC分类号： B22D11/18 , G05D9/12 , B22D11/16
CPC分类号： B22D11/181 , G05D9/12
摘要： This invention is directed to the process and system for controlling the level of molten metal in a plurality of vertically oriented, continuous or semicontinuous casting units, particularly electromagnetic casting units. The flows of molten metal to the individual casting units are adjusted automatically in response to a control set point signal from a master controller in order to maintain essentially the same molten metal level in all of the casting units. Improved startup and termination procedures are also given.
摘要翻译：本发明涉及用于控制多个垂直取向，连续或半连续的铸造单元，特别是电磁铸造单元中的熔融金属的水平的方法和系统。根据来自主控制器的控制设定点信号，自动调节熔融金属到各个铸造单元的流动，以便在所有铸造单元中保持基本相同的熔融金属水平。还提供了改进的启动和终止程序。

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