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1. 发明申请

US20050221153A1 Fuel cells 审中-公开
标题翻译：燃料电池
公开(公告)号：US20050221153A1
公开(公告)日：2005-10-06
申请号：US10520267
申请日：2003-12-16
申请人： Hiromi Sugimoto , Itaru Shibata , Mitsugu Yamanaka
发明人： Hiromi Sugimoto , Itaru Shibata , Mitsugu Yamanaka
IPC分类号： H01M4/86 , B32B15/04 , H01M8/02 , H01M8/06 , H01M8/12 , H01M8/24
CPC分类号： H01M8/0232 , H01M4/9033 , H01M4/9066 , H01M8/025 , H01M8/0625 , H01M8/1231
摘要： A gas permeable substrate comprises a porous metallic plate having a plurality of pores which form openings in an uppers surface and/or a lower surface thereof, and particles filled in the pores. In the gas permeable substrate, at least one of the upper surface and the lower surface of the porous metallic plate is substantially smooth.
摘要翻译：透气性基材包括具有多个孔的多孔金属板，其在上表面和/或下表面形成开口，以及填充在孔中的颗粒。在透气基材中，多孔金属板的上表面和下表面中的至少一个基本上是平滑的。

2. 发明授权

US07226691B2 Unit cell solid oxide fuel cell and related method 有权
标题翻译：单体固体氧化物燃料电池及相关方法
公开(公告)号：US07226691B2
公开(公告)日：2007-06-05
申请号：US10642734
申请日：2003-08-19
申请人： Itaru Shibata , Shigeo Ibuka , Mitsugu Yamanaka , Hiromi Sugimoto
发明人： Itaru Shibata , Shigeo Ibuka , Mitsugu Yamanaka , Hiromi Sugimoto
IPC分类号： H01M4/86 , H01M4/88 , H01M8/12 , B05D5/12
CPC分类号： H01M8/1226 , H01M4/861 , H01M8/0241 , H01M8/1213 , Y02P70/56
摘要： A unit cell for a solid oxide fuel cell is provided with a substrate including a portion having a first porosity, a battery element formed on the substrate and having an electrode layer and an electrolyte layer, and a low porosity layer provided in at least one of the substrate and the battery element to have a second porosity lower than the first porosity. Sizes of a plurality of pores of the low porosity layer falls in a value equal to or less than 10 μm to laminate a part of the battery element on the low porosity layer.
摘要翻译：固体氧化物型燃料电池用单电池具备：基板，具有第一孔隙率的部分，形成在基板上的电池元件，具有电极层和电解质层;以及低孔隙率层，所述基板和所述电池元件具有低于所述第一孔隙率的第二孔隙率。低孔隙率层的多个孔的尺寸落入等于或小于10μm的值，以将电池元件的一部分层压在低孔隙率层上。

3. 发明申请

US20100322980A1 PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 有权
标题翻译：用于治疗由CRTH2介导的疾病的吡咯烷衍生物
公开(公告)号：US20100322980A1
公开(公告)日：2010-12-23
申请号：US12868663
申请日：2010-08-25
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K9/00 , A61K31/505 , A61K31/5377 , A61K31/506
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

4. 发明授权

US07812160B2 Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 有权
标题翻译：可用于治疗由CRTH2介导的疾病的嘧啶衍生物
公开(公告)号：US07812160B2
公开(公告)日：2010-10-12
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： C07D239/42 , C07D239/34 , C07D239/48 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , A61K31/505 , A61K31/506 , A61P11/06
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

5. 发明申请

US20090286771A1 2-Phenoxy- and 2-Phenylsulfonamide Derivatives with CCR3 Antagonistic Activity for the Treatment of Inflammatory or Immunological Disorders 审中-公开
标题翻译：具有CCR3拮抗活性的2-苯氧基 - 和2-苯基磺酰胺衍生物用于治疗炎症或免疫疾病
公开(公告)号：US20090286771A1
公开(公告)日：2009-11-19
申请号：US12504606
申请日：2009-07-16
申请人： Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
发明人： Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
IPC分类号： A61K31/496 , A61K31/439 , A61K31/551 , A61K31/55 , A61P9/10 , A61P25/28 , A61P31/18
CPC分类号： C07D487/04 , A61K31/439 , C07C311/29 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/48 , C07D211/54 , C07D223/12 , C07D241/04 , C07D243/08 , C07D257/04 , C07D295/13 , C07D295/22 , C07D295/26 , C07D303/06 , C07D303/36 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D453/02 , C07D487/02 , C07D487/08
摘要： Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
摘要翻译：本文提供具有CCR3拮抗活性的2-苯氧基 - 和2-苯基磺酰胺衍生物。这些化合物可用于治疗与CCR3活性相关的疾病，包括但不限于特应性皮炎，过敏性鼻炎，类风湿性关节炎，格雷夫氏病，艾滋病毒感染，阿尔茨海默病，动脉粥样硬化和其他炎症和/或免疫学疾病。

6. 发明授权

US06461773B1 Electrolyte for electrochemical device 有权
标题翻译：电解液用于电化学装置
公开(公告)号：US06461773B1
公开(公告)日：2002-10-08
申请号：US09850191
申请日：2001-05-08
申请人： Shoichi Tsujioka , Hironari Takase , Mikihiro Takahashi , Hiromi Sugimoto
发明人： Shoichi Tsujioka , Hironari Takase , Mikihiro Takahashi , Hiromi Sugimoto
IPC分类号： H01M618
CPC分类号： H01G9/038 , H01G11/56 , H01G11/62 , H01M10/052 , H01M10/0525 , H01M10/0568 , Y02E60/13
摘要： The invention relates to an electrolyte for an electrochemical device. This electrolyte includes a first compound that is an ionic metal complex represented by the general formula (1); and at least one compound selected from special second to fourth compounds, fifth to ninth compounds respectively represented by the general formulas Aa+(PF6−)a, Aa+(ClO4−)a, Aa+(BF4−)a, Aa+(AsF6−)a, and Aa+(SbF6−)a, and special tenth to twelfth compounds, The electrolyte is superior in cycle characteristics and shelf life as compared with conventional electrolytes.
摘要翻译：本发明涉及一种用于电化学装置的电解质。该电解质包含作为由通式（1）表示的离子性金属络合物的第一化合物。和分别由通式Aa +（PF6-）a，Aa +（ClO4-）a，Aa +（BF4-）a，Aa +（AsF6-）a）表示的至少一种选自特殊的第二至第四化合物，第五至第九化合物的化合物，和Aa +（SbF6-）a，以及特殊的第十至第十二种化合物。与常规电解质相比，电解质的循环特性和保质期优越。

7. 发明申请

US20070129355A1 Pyrimidine derivatives useful for the treatment of diseases mediated by crth2 有权
标题翻译：可用于治疗由crth2介导的疾病的嘧啶衍生物
公开(公告)号：US20070129355A1
公开(公告)日：2007-06-07
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

8. 发明授权

US06403744B1 Fluorine-containing copolymer and composition for preparing low reflectance film 有权
标题翻译：含氟共聚物和制备低反射膜的组合物
公开(公告)号：US06403744B1
公开(公告)日：2002-06-11
申请号：US09640536
申请日：2000-08-17
申请人： Shuyo Akama , Hiromi Sugimoto , Kentaro Tsutsumi
发明人： Shuyo Akama , Hiromi Sugimoto , Kentaro Tsutsumi
IPC分类号： C08F21418
CPC分类号： C08F214/182 , C08F214/188
摘要： The invention relates to a fluorine-containing copolymer. This copolymer contains 1-99 mol % of a special first repeating unit of a cyclic perfluoro group; and 99-1 mol % of a second repeating unit of a bivalent organic group. The copolymer has a number average molecular weight of from 1,000 to 1,000,000 determined in a gel permeation chromatography using polystyrene as a standard material thereof. The invention further relates to a composition for forming a low reflectance film. This composition contains as a film-forming component a fluorine-containing polymer containing the first repeating unit. This polymer can be the above copolymer. A film formed by applying the composition to a substrate provides low reflectance and is improved in hardness.
摘要翻译：本发明涉及一种含氟共聚物。该共聚物含有1-99mol％的环状全氟基团的特殊的第一重复单元; 和99-1摩尔％的二价有机基团的第二重复单元。该共聚物的数均分子量为1,000〜1,000,000，在使用聚苯乙烯作为标准材料的凝胶渗透色谱中测定。本发明还涉及用于形成低反射率膜的组合物。该组合物含有含有第一重复单元的含氟聚合物作为成膜组分。该聚合物可以是上述共聚物。通过将组合物施加到基材上形成的膜提供低反射率并且硬度提高。

9. 发明授权

US5578361A Water-repellent composite grains, method for producing same, and water-repellent article using same 失效
标题翻译：防水复合颗粒，其制造方法和使用其的防水制品
公开(公告)号：US5578361A
公开(公告)日：1996-11-26
申请号：US377562
申请日：1995-01-24
申请人： Shoichi Tsujioka , Hiromi Sugimoto , Yasushi Kita , Naoki Okada
发明人： Shoichi Tsujioka , Hiromi Sugimoto , Yasushi Kita , Naoki Okada
IPC分类号： C03C17/00 , B05D1/36 , B05D5/08 , B32B5/16 , C08K9/04 , C23C16/00
CPC分类号： C03C17/007 , C03C2217/42 , Y10T428/2438 , Y10T428/2998 , Y10T428/31544
摘要： The invention relates to water-repellent composite grains. Each composite grain includes: a first grain; and a low molecular weight polytetrafluoroethylene (PTFE) covering the first grain. The first grain is higher than the PTFE in mechanical strength. With this, the composite grains are improved in mechanical strength. A water-repellent article is produced by anchoring the composite grains to a substrate through an adhesive layer formed on the substrate. The composite grains are partly exposed on the adhesive layer and partly submerged in the adhesive layer. With this, the water-repellent article is made minutely rough. The water-repellent article is improved in mechanical strength and water repellency.
摘要翻译：本发明涉及防水复合颗粒。每个复合颗粒包括：第一颗粒; 和覆盖第一颗粒的低分子量聚四氟乙烯（PTFE）。第一颗粒的机械强度高于PTFE。由此，复合粒子的机械强度提高。通过将形成在基材上的粘合剂层将复合粒子固定在基材上，制造防水制品。复合颗粒部分地暴露在粘合剂层上并部分浸没在粘合剂层中。由此，防水制品被精细地粗糙化。防水制品的机械强度和防水性提高。

10. 发明授权

US07960393B2 Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 有权
标题翻译：可用于治疗由CRTH2介导的疾病的嘧啶衍生物
公开(公告)号：US07960393B2
公开(公告)日：2011-06-14
申请号：US12868663
申请日：2010-08-25
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/505 , A61K31/506 , A61P11/06 , C07D239/34 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

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