专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080319047A1 Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes 失效
标题翻译：新型葡萄糖醇衍生物，其药物及其盐，以及含有糖尿病的治疗剂
公开(公告)号：US20080319047A1
公开(公告)日：2008-12-25
申请号：US11658765
申请日：2005-07-27
申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuharu Kato , Masahiro Sakaitani , Sang-Hak Lee
发明人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuharu Kato , Masahiro Sakaitani , Sang-Hak Lee
IPC分类号： C07D409/10 , A61K31/381 , A61P3/10
CPC分类号： C07D409/10
摘要： The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.
摘要翻译：本发明提供了具有降低血糖水平并且具有药物所需的优选性能如持久药物活性的功能的葡糖醇衍生物; 以及用于预防或治疗高血糖疾病如糖尿病，糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中m是选自1-3的整数; R1至R4各自独立地为任选取代的烷基等; Ar1是任选取代的萘基; 和A是任选取代的杂芳基，该化合物的前药或其药学上可接受的盐。还提供了含有化合物的药物，药物组合物等。

2. 发明授权

US07943748B2 Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes 失效
标题翻译：葡萄糖醇衍生物，其前药及其盐，以及含有糖尿病的治疗剂
公开(公告)号：US07943748B2
公开(公告)日：2011-05-17
申请号：US11658765
申请日：2005-07-27
申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuhara Kato , Masahiro Sakaitani , Sang-Hak Lee
发明人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuhara Kato , Masahiro Sakaitani , Sang-Hak Lee
IPC分类号： C07H1/00 , A01N43/04 , A61K31/70
CPC分类号： C07D409/10
摘要： The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.
摘要翻译：本发明提供了具有降低血糖水平并且具有药物所需的优选性能如持久药物活性的功能的葡糖醇衍生物; 以及用于预防或治疗高血糖疾病如糖尿病，糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中m是选自1-3的整数; R1至R4各自独立地为任选取代的烷基等; Ar1是任选取代的萘基; 和A是任选取代的杂芳基，该化合物的前药或其药学上可接受的盐。还提供了含有化合物的药物，药物组合物等。

3. 发明授权

US08048897B2 Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes 有权
标题翻译：环己烷衍生物，其前药及其盐，以及含有其的用于糖尿病的治疗剂
公开(公告)号：US08048897B2
公开(公告)日：2011-11-01
申请号：US11658400
申请日：2005-07-26
申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
发明人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
IPC分类号： A61K31/7028 , A61K31/403 , A61P3/10 , C07C63/00 , C07D209/04 , C07D213/62 , C07D231/14 , C07D307/79 , C07D317/48 , C07D333/34 , C07D333/56
CPC分类号： C07D333/32 , C07C35/14 , C07C35/48 , C07C43/23 , C07C43/253 , C07C69/94 , C07C217/58 , C07C235/46 , C07C255/54 , C07C317/22 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D213/64 , C07D231/12 , C07D307/80 , C07D317/54 , C07D333/56 , C07H15/203 , C07H17/00 , C07H17/02
摘要： A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.
摘要翻译：具有降低血糖水平并且具有药物所需的优选性能的持久性药物活性，代谢稳定性和安全性的环己烷衍生物; 以及用于预防或治疗高血糖疾病（例如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病）），糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中A是-O-，-CH2-或-NH-; n是选自0和1之间的整数; R6和R7各自独立地是氢或C1- 6烷基; m是选自1-3中的整数; Q选自下式Q1至Q5; Ar1是任选取代的亚芳基或任选取代的亚杂芳基，条件是杂亚芳基可以键合到芳族碳环或芳族杂环以形成稠合环; Ar 2是任选取代的芳基或任选取代的杂芳基），化合物的前药或其药学上可接受的盐。还提供含有化合物的药物，药物组合物等。

4. 发明申请

US20080318874A1 Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes 有权
标题翻译：新型环己烷衍生物，其前体药物及其盐，以及含有糖尿病的治疗剂
公开(公告)号：US20080318874A1
公开(公告)日：2008-12-25
申请号：US11658400
申请日：2005-07-26
申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
发明人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
IPC分类号： A61K31/7028 , C07G3/00 , C07D209/04 , A61K31/403 , A61K31/05 , A61P3/10
CPC分类号： C07D333/32 , C07C35/14 , C07C35/48 , C07C43/23 , C07C43/253 , C07C69/94 , C07C217/58 , C07C235/46 , C07C255/54 , C07C317/22 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D213/64 , C07D231/12 , C07D307/80 , C07D317/54 , C07D333/56 , C07H15/203 , C07H17/00 , C07H17/02
摘要： A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.
摘要翻译：具有降低血糖水平并且具有药物所需的优选性能的持久性药物活性，代谢稳定性和安全性的环己烷衍生物; 以及用于预防或治疗高血糖疾病（例如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病）），糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中A是-O-，-CH2-或-NH-; n是选自0和1之间的整数; R6和R7各自独立地是氢或C1- 6烷基; m是选自1-3中的整数; Q选自下式Q1至Q5; Ar1是任选取代的亚芳基或任选取代的亚杂芳基，条件是杂亚芳基可以键合到芳族碳环或芳族杂环以形成稠合环; Ar 2是任选取代的芳基或任选取代的杂芳基），化合物的前药或其药学上可接受的盐。还提供含有化合物的药物，药物组合物等。

5. 发明授权

US06720433B2 Ethylamine derivatives 失效
标题翻译：乙胺衍生物
公开(公告)号：US06720433B2
公开(公告)日：2004-04-13
申请号：US10356558
申请日：2003-02-03
申请人： Hiroharu Matsuoka , Tsutomu Sato
发明人： Hiroharu Matsuoka , Tsutomu Sato
IPC分类号： C07D30738
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0827
摘要： Ethylamine derivatives that function as a motilin receptor antagonist and are useful as medicines are represented by the general formula (1): wherein R1 represents a phenyl group or the like, R2 represents a hydrogen atom and the like, R3 represents a hydrogen atom and the like, R4 represents a hydrogen atom and the like, R5 represents an alkyl group and the like, R7 represents a hydrogen atom and the like and R8 represents a heterocyclic ring and the like; or a hydrate or pharmaceutically acceptable salt thereof.
摘要翻译：作为胃动素受体拮抗剂起作用并用作药物的乙胺衍生物由通式（1）表示：其中R1表示苯基等，R2表示氢原子等，R3表示氢原子， R 4表示氢原子等，R 5表示烷基等，R 7表示氢原子等，R 8表示杂环等。或其水合物或药学上可接受的盐。

6. 发明授权

US07018981B2 Cyclic motilin receptor antagonists 失效
标题翻译：循环胃动素受体拮抗剂
公开(公告)号：US07018981B2
公开(公告)日：2006-03-28
申请号：US10362574
申请日：2001-08-23
申请人： Hiroharu Matsuoka , Tsutomu Sato
发明人： Hiroharu Matsuoka , Tsutomu Sato
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0205 , C07K5/0215
摘要： The present invention aims to provide cyclic peptide derivatives having motilin receptor antagonist activity and are useful as pharmaceuticals. The present invention provides compounds of general formula (1): wherein R1 represents an optionally substituted phenyl group or the like; R2 represents an amino group or the like; R3 to R6 represent a hydrogen atom, a methyl group or the like; R7 represents a hydrogen atom or the like; V to Z represent a carbonyl group or a methylene group; m represents an integer of 0–2; and n represents an integer of 0–3; or a hydrate or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明旨在提供具有胃动素受体拮抗剂活性的环肽衍生物，并且可用作药物。本发明提供通式（1）的化合物：其中R 1表示任选取代的苯基等; R 2表示氨基等; R 3至R 6表示氢原子，甲基等; R 7表示氢原子等; V至Z表示羰基或亚甲基; m表示0-2的整数; n表示0〜3的整数。或其水合物或其药学上可接受的盐。

7. 发明授权

US06586630B1 Ethylamine derivatives 失效
标题翻译：乙胺衍生物
公开(公告)号：US06586630B1
公开(公告)日：2003-07-01
申请号：US09787674
申请日：2001-03-21
申请人： Hiroharu Matsuoka , Tsutomu Sato
发明人： Hiroharu Matsuoka , Tsutomu Sato
IPC分类号： C07C23305
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0827
摘要： The object of the present invention is to provide ethylamine derivatives that function as a motilin receptor antagonist and that are useful as medicines. The invention provides compounds represented by the general formula (1): wherein R1 represents a phenyl group or the like, R2 represents a hydrogen atom and the like, R3 represents a hydrogen atom and the like, R4 represents a hydrogen atom and the like, R5 represents an alkyl group and the like, R7 represents a hydrogen atom and the like and R8 represents a heterocyclic ring and the like; or a hydrate or pharmaceutically acceptable salt thereof and a medicine which comprises the above compound or a hydrate or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明的目的是提供作为胃动素受体拮抗剂起作用的乙胺衍生物，作为药物有用。本发明提供由通式（1）表示的化合物：其中，R1表示苯基等，R2表示氢原子等，R 3表示氢原子等，R 4表示氢原子等，R 5表示烷基等，R 7表示氢原子等，R 8表示杂环等 ; 或其水合物或药学上可接受的盐和包含上述化合物或其水合物或药学上可接受的盐作为活性成分的药物。

8. 发明授权

US07553969B1 Substituted phenethylamine derivatives 失效
标题翻译：取代苯乙胺衍生物
公开(公告)号：US07553969B1
公开(公告)日：2009-06-30
申请号：US09890219
申请日：2000-01-28
申请人： Hiroharu Matsuoka , Tsutomu Sato , Tadakatsu Takahashi , Dong Ick Kim , Kyung Yun Jung , Chan Hee Park
发明人： Hiroharu Matsuoka , Tsutomu Sato , Tadakatsu Takahashi , Dong Ick Kim , Kyung Yun Jung , Chan Hee Park
IPC分类号： C07D211/72 , C07C233/00
CPC分类号： C07D295/185 , A61K38/00 , C07B2200/07 , C07C215/52 , C07C229/06 , C07C229/12 , C07C229/36 , C07C229/48 , C07C237/08 , C07C237/10 , C07C237/20 , C07C271/18 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D295/26 , C07K5/06191 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Substituted phenethylamine compounds of Formula (1) that function as motilin receptor antagonists:Formula (1).
摘要翻译：作为胃动素受体拮抗剂的式（1）的取代苯乙胺化合物：式（1）。

9. 发明授权

US07767651B2 Spiroketal derivatives and use thereof as diabetic medicine 有权
标题翻译：螺缩酮衍生物及其作为糖尿病药物的用途
公开(公告)号：US07767651B2
公开(公告)日：2010-08-03
申请号：US11815074
申请日：2006-01-27
申请人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
发明人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D491/153 , C07D493/10 , C07H19/01
摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
摘要翻译：本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ ΟO）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

10. 发明授权

US08207134B2 Fused ring spiroketal derivative and use thereof as anti-diabetic drug 失效
标题翻译：稠环螺旋酮衍生物及其作为抗糖尿病药物的用途
公开(公告)号：US08207134B2
公开(公告)日：2012-06-26
申请号：US12375378
申请日：2007-07-27
申请人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
发明人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
IPC分类号： A01N43/04 , A61K31/70 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07H19/01
摘要： Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(═O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
摘要翻译：提供由式（I）表示的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，可被取代的C 1-6烷基，可被取代的C 7-14芳烷基和-C（= O）Rx; n表示选自1和2的整数; 并且环Ar选自由下式（a）至（f）表示的基团。或其前药或其药学上可接受的盐，以及药物和含有这种化合物或其前药的药物组合物或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式