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1. 发明申请

US20070004636A1 Method of degrading transcriptional factors of saccharometabolism-associated gene, method for inhibiting the degradation, and agent for inhibiting degradation and degradation inhibitor 审中-公开
标题翻译：降低糖代谢相关基因转录因子的方法，抑制降解的方法和抑制降解抑制剂
公开(公告)号：US20070004636A1
公开(公告)日：2007-01-04
申请号：US10526234
申请日：2003-08-29
申请人： Hirofumi Doi , Gen Kudo
发明人： Hirofumi Doi , Gen Kudo
IPC分类号： C12Q1/37 , A61K38/05 , A61K38/04 , C07K5/06 , C07K5/04
CPC分类号： C07K7/06 , A61K38/00 , C07K5/06043 , C07K5/06191 , C12N9/6472
摘要： Based on the finding that m-calpain or μ-calpain degrades hepatocyte nuclear factor 4α (HNF-4α), hepatocyte nuclear factor 1α (HNF-1α) and insulin promoter factor 1 (IPF-1), which form transcription factor networks involved in expression of glucose metabolism-related genes in pancreatic β cells, the following have been provided: a method for degradation of these transcription factors; a method for inhibiting the degradation and an agent for inhibiting the degradation; a method for enhancing production of the gene product of a gene on which these factors act as transcription factors and an agent for enhancing the same; an agent for preventing and/or treating a disease attributable to the degradation of these transcription factors and a method for preventing and/or treating the disease; a method for identifying a compound that inhibits the degradation of these transcription factors by calpain; a compound obtained by the identification method; and a reagent kit including calpain, these transcription factors, polynucleotides encoding these factors, and a vector containing the polynucleotides.
摘要翻译：基于m-calpain或mu-calpain降解肝细胞核因子4α（HNF-4alpha），肝细胞核因子1alpha（HNF-1alpha）和胰岛素启动子因子1（IPF-1）的发现，其形成转录因子网络葡萄糖代谢相关基因在胰腺β细胞中的表达已经提供：一种降解这些转录因子的方法; 抑制降解的方法和抑制降解的试剂; 用于增强这些因子作为转录因子的基因的基因产物的产生的方法和用于增强其的药剂; 用于预防和/或治疗可归因于这些转录因子降解的疾病的药剂和预防和/或治疗疾病的方法; 用于鉴定通过钙蛋白酶抑制这些转录因子降解的化合物的方法; 通过鉴定方法获得的化合物; 以及包含钙蛋白酶，这些转录因子，编码这些因子的多核苷酸以及含有多核苷酸的载体的试剂盒。

2. 发明授权

US08003346B2 Mutant PCNA 有权
标题翻译：突变型PCNA
公开(公告)号：US08003346B2
公开(公告)日：2011-08-23
申请号：US11994437
申请日：2006-07-04
申请人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
发明人： Tadaaki Tokida , Satoshi Hihara , Takashi Kudou , Akira Kawamura , Hirofumi Doi , Yoshizumi Ishino
IPC分类号： G01N33/52 , C07H17/00 , C07K14/00
CPC分类号： C07K14/4738 , C12N9/1252 , C12N15/69
摘要： The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
摘要翻译：本发明是构建通用性优异且易于使用的DNA复制反应体系。制备作为涉及DNA复制的因素之一的PCNA单体的氨基酸序列，使得导致相互电荷排斥的氨基酸残基构成了当PCNA单体的N末端区域和另一个的C末端区域时引起的位点 PCNA单体作为形成多聚体复合物的界面，单体在界面区域中的分子间相互作用。

3. 发明申请

US20110183331A1 RNA IN SITU HYBRIDIZATION 有权
标题翻译： RNA in SITU HYBRIDIZATION
公开(公告)号：US20110183331A1
公开(公告)日：2011-07-28
申请号：US12993338
申请日：2009-05-19
申请人： Hirofumi Doi , Masahiro Matsuoka , Tatsuhiro Nakano , Chizuru Nagayoshi
发明人： Hirofumi Doi , Masahiro Matsuoka , Tatsuhiro Nakano , Chizuru Nagayoshi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6841 , C12Q2543/10 , C12Q2527/125 , C12Q2545/101
摘要： Disclosed is a method for identifying the presence of a target gene mRNA, which comprises hybridizing one or more oligonucleic acid probes with the target gene mRNA expressed in a tissue sample, and detecting a low-molecular-weight compound label added to at least one of the bases of the oligonucleic acid probes, wherein the oligonucleic acid probes are contacted with the tissue sample for hybridization with the target gene mRNA after pretreating (prehybridizing) one or more dummy oligonucleic acids with the tissue sample, or a mixture of the oligonucleic acid probes and the dummy oligonucleic acids is contacted with the sample tissue to hybridize the oligonucleic acid probes with the target gene mRNA, and wherein the dummy oligonucleic acids are substantially equal in length with the oligonucleic acid probes, and are neither hybridizable with regions of the target gene mRNA with which the oligonucleic acid probes hybridize nor with the oligonucleic acid probes.
摘要翻译：公开了一种鉴定目标基因mRNA的存在的方法，其包括将一种或多种寡核酸探针与组织样品中表达的靶基因mRNA杂交，并检测添加到以下的至少一种的低分子量化合物标记：寡核酸探针的碱基，其中寡聚核酸探针与组织样品接触，用于与组织样品预处理（预杂交）（预杂交）一种或多种假寡聚核酸或寡核酸探针的混合物与靶基因mRNA杂交使虚拟寡核酸与样品组织接触，将寡核酸探针与靶基因mRNA杂交，并且其中虚拟寡核酸与寡核酸探针的长度基本相等，并且不与靶基因的区域杂交寡聚核酸探针与其杂交的mRNA也不与低聚核酸探针杂交。

4. 发明申请

US20100231070A1 ACTUATOR 失效
标题翻译：执行机构
公开(公告)号：US20100231070A1
公开(公告)日：2010-09-16
申请号：US12305872
申请日：2007-04-19
申请人： Kenta Hatano , Hirofumi Doi , Toshihiko Miyake
发明人： Kenta Hatano , Hirofumi Doi , Toshihiko Miyake
IPC分类号： H02K7/06
CPC分类号： H02K7/06
摘要： An actuator having an output axis which is moved linearly by a rotatory force, and a boss for holding the above-mentioned output axis in such a way that the output axis can move linearly includes a connecting member for propagating the linear motion of the above-mentioned output axis to an external device. The above-mentioned connecting member is comprised of a joint connected to the above-mentioned output axis, and a link plate having an end rotatably connected to the above-mentioned joint, and another end rotatably connected to the external device. A mechanism for preventing rotation of the above-mentioned output axis is constructed of only a connecting portion for connecting the above-mentioned joint, the above-mentioned link plate, and the above-mentioned external device to one another.
摘要翻译：具有通过旋转力线性移动的输出轴的致动器和用于保持上述输出轴线的凸起，使得输出轴线性线性地移动，具有用于传播上述输出轴的直线运动的连接部件，提到的输出轴到外部设备。上述连接构件包括连接到上述输出轴线的接头和具有可旋转地连接到上述接头的端部的连接板，以及可旋转地连接到外部设备的另一端。用于防止上述输出轴的旋转的机构仅由用于将上述接头，上述连接板和上述外部装置彼此连接的连接部分构成。

5. 发明申请

US20070134663A1 Interaction inhibitors, method of detecting interaction inhibitor and kit detecting interaction inhibitor 审中-公开
标题翻译：相互作用抑制剂，相互作用抑制剂检测方法和试剂盒检测相互作用抑制剂
公开(公告)号：US20070134663A1
公开(公告)日：2007-06-14
申请号：US10568578
申请日：2004-08-13
申请人： Satoshi Hihara , Hirofumi Doi
发明人： Satoshi Hihara , Hirofumi Doi
IPC分类号： C12Q1/68 , C12Q1/48 , C12N9/99
CPC分类号： G01N33/6875 , C12Q1/485 , G01N2500/02
摘要： The task is to provide protein interaction inhibitors and/or detection method for interaction inhibitors related to regulation of T cell activation and production of IL-2. The present invention provides inhibitors of interaction between PKC theta and KPNA1, and inhibitors of interaction between KPNA1 and NF-kappaB. Inhibitors of interaction is defined as an candidate compound demonstrating the inhibition of interaction by assaying whether interaction has occurred or not between 2 types of protein and the candidate compound under the conditions allowing interaction of each combination. The detection kit is equipped with samples providing proteins of combinations to be interacted.
摘要翻译：任务是提供蛋白质相互作用抑制剂和/或与调节T细胞活化和产生IL-2相关的相互作用抑制剂的检测方法。本发明提供PKCθ与KPNA1之间相互作用的抑制剂，以及KPNA1与NF-κB之间相互作用的抑制剂。相互作用的抑制剂被定义为通过测定在允许每种组合的相互作用的条件下，在两种类型的蛋白质和候选化合物之间是否发生相互作用来证明相互作用的抑制的候选化合物。检测试剂盒配备提供待相互作用的组合蛋白质的样品。

6. 发明授权

US07053510B2 Electrical actuator 失效
公开(公告)号：US07053510B2
公开(公告)日：2006-05-30
申请号：US10118904
申请日：2002-04-10
申请人： Hirofumi Doi
发明人： Hirofumi Doi
IPC分类号： H02K5/00
CPC分类号： H02K5/00
摘要： An electrical actuator has a DC motor which is provided with a rotor having a permanent magnet for forming a plurality of magnetic poles around a periphery thereof and a stator having a plurality of energizing coils and being disposed around a periphery of the rotor to thereby generate a rotary force for the rotor. In mounting this DC motor on a heat-generating member which generates radiant heat, a member for shielding radiant heat from a heat-generating member is disposed between the DC motor and the heat generating member. In this manner, the radiant heat from the heat-generating member is prevented from reaching the DC motor, whereby the problems in the DC motor associated with the radiant heat can be prevented.

7. 发明授权

US06571469B2 Method for manufacturing modular board 有权
公开(公告)号：US06571469B2
公开(公告)日：2003-06-03
申请号：US09844245
申请日：2001-04-26
申请人： Masanobu Okada , Kazuyoshi Nakaya , Hiroyuki Nakaji , Hirofumi Doi , Iku Nagai , Junichi Nakasone
发明人： Masanobu Okada , Kazuyoshi Nakaya , Hiroyuki Nakaji , Hirofumi Doi , Iku Nagai , Junichi Nakasone
IPC分类号： H01K310
CPC分类号： H01L23/49805 , H01L21/4853 , H01L2924/0002 , H01R43/0256 , H05K1/141 , H05K3/0052 , H05K3/3442 , H05K3/3478 , H05K3/368 , H05K3/403 , H05K3/42 , H05K2201/09181 , H05K2201/10984 , H05K2203/041 , H05K2203/043 , Y02P70/613 , Y10T29/49117 , Y10T29/49165 , Y10T29/49789 , Y10T29/4979 , H01L2924/00
摘要： A blanking plate is attached to the bottom surfaces of a split board and a remaining board, which are separated from one bare board. After depositing solder paste on a back electrode of the split board, a solder ball is attached on the solder paste. The split board is then heated to melt the solder ball. The molten solder flows along the back electrode and an edge electrode into a through-hole. A portion of the molten solder swells out of the bottom surface of the bare board, and solidifies and bonds to the back electrode and the edge electrode.

8. 发明授权

US06182057B2 Device, method, and program storage medium for executing genetic algorithm 失效
标题翻译：用于执行遗传算法的设备，方法和程序存储介质
公开(公告)号：US06182057B2
公开(公告)日：2001-01-30
申请号：US08990050
申请日：1997-12-12
申请人： Yasuhiro Kikuchi , Hirofumi Doi
发明人： Yasuhiro Kikuchi , Hirofumi Doi
IPC分类号： G06F1518
CPC分类号： G06N3/126
摘要： A genetic algorithm executing device, in which search of a genetic algorithm is improved, sets a distribution of characters at each position of character strings represent candidates of solution, obtain the degree of disorder at each position by the distributions of characters, set a larger mutation rate at the position of which degree of disorder is higher. This device performs a mutation operation on the character strings according to the mutation rates. This device generates the new character strings by selecting positions of which degrees of disorder are higher than a predetermined value, and changing the character at the selected positions.
摘要翻译：遗传算法执行装置，其中改进了遗传算法的搜索，设置了字符串每个位置处的字符分布表示解的候选，通过字符分布获得每个位置的无序程度，设置较大的突变在无序程度较高的位置的比率。该装置根据突变率对字符串进行突变操作。该装置通过选择无序程度高于预定值的位置并改变所选位置的字符来生成新的字符串。

9. 发明申请

US20100007228A1 STRUCTURE OF MOTOR TERMINAL 有权
标题翻译：电机端子结构
公开(公告)号：US20100007228A1
公开(公告)日：2010-01-14
申请号：US12524386
申请日：2007-10-30
申请人： Kenta Hatano , Naoki Miyamoto , Toshiyuki Umemoto , Hirofumi Doi
发明人： Kenta Hatano , Naoki Miyamoto , Toshiyuki Umemoto , Hirofumi Doi
IPC分类号： H02K11/00
CPC分类号： H05K3/308 , H02K5/225 , H02K11/33 , H02K2211/03 , H05K3/3447 , H05K2201/1003 , H05K2201/10295 , H05K2201/10333 , H05K2201/10446 , H05K2201/10757
摘要： A terminal structure for a vehicle-mounted motor includes a motor body having a motor terminal 28 connected to a coil, and a circuit body 5 holding a circuit board 18 for controlling a rotation of the motor body and is assembled in the motor body, wherein a stress relaxation section 35 is provided in an intermediate of an intermediate conductor 34, in order to reduce stress acting on the intermediate conductor 34 connecting the motor terminal 28 and the circuit board 18 and to thereby improve the conductive reliability of electrical joint.
摘要翻译：一种用于车载电动机的端子结构，包括具有连接到线圈的电动机端子28的电动机主体和保持用于控制电动机主体的旋转并且组装在电动机主体中的电路板18的电路体5，其中在中间导体34的中间设置有应力缓和部35，以便减小作用在连接电动机端子28和电路基板18的中间导体34上的应力，从而提高电接头的导电可靠性。

10. 发明申请

US20070259805A1 Remedy For Melanoma 审中-公开
标题翻译：治疗黑色素瘤
公开(公告)号：US20070259805A1
公开(公告)日：2007-11-08
申请号：US11658652
申请日：2005-08-03
申请人： Hirofumi Doi , Seiji Saito , Kenji Murakami , Yukako Kurita
发明人： Hirofumi Doi , Seiji Saito , Kenji Murakami , Yukako Kurita
IPC分类号： A61K38/00 , C12N5/06 , G01N33/53
CPC分类号： G01N33/566
摘要： The present invention was aimed at reducing transcription activating activity of MITF-M to inhibit production of BCL2 gene product and thereby to allow treatment and/or prevention of melanoma The present invention provided a method of inhibiting production of BCL2 gene product and an agent for inhibiting the same, which inhibit binding of protein selected from a group consisting of HLF, ELK4 and CLOCK to MITF-M, a method of inducing cell death of melanoma cells, an agent for inducing the same, an agent for treating and/or preventing diseases accompanied by enhanced production of BCL2 gene product, such as melanoma, a method of treating and/or preventing the diseases, a method of identifying any one of the following compounds: a compound that inhibits the aforementioned binding; a compound that inhibits production of BCL2 gene product; and a compound that increases sensitivity of melanoma to melanoma drugs, as well as a reagent kit.
摘要翻译：本发明旨在降低MITF-M的转录激活活性以抑制BCL2基因产物的产生，从而能够治疗和/或预防黑素瘤本发明提供了抑制BCL2基因产物的生成和抑制作用的方法相同的，其抑制了选自由HLF，ELK4和CLOCK组成的组的蛋白质与MITF-M的结合，诱导黑素瘤细胞的细胞死亡的方法，诱导它们的药剂，用于治疗和/或预防疾病的药剂伴随着BCL2基因产物如黑素瘤的增强生产，治疗和/或预防疾病的方法，鉴定任何一种以下化合物的方法：抑制上述结合的化合物; 抑制BCL2基因产物生成的化合物; 以及增加黑素瘤对黑素瘤药物敏感性以及试剂盒的化合物。

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