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1. 发明授权

US06613334B2 Belt for continuously variable transmission 失效
公开(公告)号：US06613334B2
公开(公告)日：2003-09-02
申请号：US09925929
申请日：2001-08-10
申请人： Hideaki Yoshida , Hirofumi Akagi , Ken Kanokogi , Takamichi Shimada
发明人： Hideaki Yoshida , Hirofumi Akagi , Ken Kanokogi , Takamichi Shimada
IPC分类号： F16G122
CPC分类号： F16G5/16
摘要： A belt for continuously variable transmission, wherein the relationship between the thickness of the metal ring assembly and the groove width of the ring slot is established so that a limit rolling angle &agr; defined as a rolling angle of the metal elements provided when a radially outer peripheral surface of the metal ring assembly contacts a radially outer edge of the ring slot in the metal element is in a range of 0.7°

2. 发明授权

US06612954B2 Belt for continuously variable transmission 有权
公开(公告)号：US06612954B2
公开(公告)日：2003-09-02
申请号：US09925623
申请日：2001-08-10
申请人： Hirofumi Akagi , Hideaki Yoshida
发明人： Hirofumi Akagi , Hideaki Yoshida
IPC分类号： F16G516
CPC分类号： F16G5/16
摘要： A belt for a continuously variable transmission includes a metal ring assembly formed of a plurality of endless metal rings laminated one on another, and a large number of metal elements each having a ring slot into which the metal ring assembly is fitted. In the belt, a crowning radius of the metal ring in a free state is set smaller than a crowning radius of a saddle face of the ring slot supporting the innermost metal ring. Thus, the metal ring assembly can be centered to a central portion of the saddle face, whereby a difference between a tensile stress at a central portion of an outer peripheral surface of the metal ring and a tensile stress at opposite ends of the outer peripheral surface can be reduced in an area where the metal belt is wound around a pulley, thereby preventing a reduction in durability.

3. 发明授权

US06273837B1 Belt for continuously variable transmission 失效
标题翻译：皮带用于连续变速传动
公开(公告)号：US06273837B1
公开(公告)日：2001-08-14
申请号：US09404736
申请日：1999-09-24
申请人： Hideaki Yoshida , Takamichi Shimada , Hirofumi Akagi
发明人： Hideaki Yoshida , Takamichi Shimada , Hirofumi Akagi
IPC分类号： F16G100
CPC分类号： F16G5/16
摘要： The durability of the entire metal ring assembly is enhanced by increasing the wear life of the radially inner surface of the metal ring of the innermost layer which is the layer which is most easily fractured. A belt for a continuously variable transmission is formed by supporting a large number of metal elements on a metal ring assembly wherein multiple sheets of endless metal rings are layered. The thickness of the metal ring of the innermost layer is different from the thickness of the metal rings of layers other than the innermost layer. The thickness of the metal ring of the innermost layer is set so that the stress amplitude applied to the radially outer surface of the metal ring of the innermost layer is not more than the stress amplitude applied to the radially outer surfaces of the metal rings of layers other than the innermost layer. By setting the thickness of the metal ring of the innermost layer at 0.042 mm to 0.161 mm when the thickness of the metal rings of layers other than the innermost layer is 0.185 mm, the stress amplitude &sgr;a1 applied to the metal ring of the innermost layer becomes lower than the stress amplitude &sgr;an of 25.65 kgf/- mm2 applied to the other metal rings. Thus the durability of the metal ring of the innermost layer can be enhanced to increase the life span of the entire metal ring assembly.
摘要翻译：通过增加最容易断裂的层的最内层的金属环的径向内表面的磨损寿命来提高整个金属环组件的耐久性。通过在金属环组件上支撑多个金属元件来形成用于无级变速器的带，其中多个环形金属环被层叠。最内层的金属环的厚度不同于最内层以外的层的金属环的厚度。最内层的金属环的厚度被设定为使得施加到最内层的金属环的径向外表面的应力振幅不大于施加到层的金属环的径向外表面的应力振幅而不是最内层。当最内层的金属环的厚度为0.185mm时，通过将最内层的金属环的厚度设定为0.042mm至0.161mm，施加到最内层的金属环的应力幅度σa1变为低于施加到其他金属环的应力幅度25.65kgf / - mm2。因此，可以提高最内层的金属环的耐久性，以增加整个金属环组件的使用寿命。

4. 发明授权

US6090004A Belt for a continuously variable transmission 有权
标题翻译：皮带用于无级变速器
公开(公告)号：US6090004A
公开(公告)日：2000-07-18
申请号：US168935
申请日：1998-10-09
申请人： Shigeru Kanehara , Hideaki Yoshida , Hirofumi Akagi , Tooru Yagasaki , Tooru Fujii , Shinya Kuwabara
发明人： Shigeru Kanehara , Hideaki Yoshida , Hirofumi Akagi , Tooru Yagasaki , Tooru Fujii , Shinya Kuwabara
IPC分类号： F16G5/16 , F16G1/21
CPC分类号： F16G5/163 , F16G5/16
摘要： A belt for a continuously variable transmission in which an aggregate of metal rings formed by laminating a plurality of pieces of endless metal rings support a plurality of metal blocks. When the ratio .xi. of the coefficient of friction is set to be 2.0>.xi.>0.65, the amount of change in the tension on the metal ring of the innermost position decreases correspondingly. In particular, when the ratio .xi. of the coefficient of friction is set to be 1.0, resulting in the coefficient of friction .mu..sub.s between a ring and a block being equal to the coefficient of friction .mu..sub.SS between a ring and a ring, the amount of change in the tension on all metal rings become uniform, and each metal ring shares an amount of change in the tension which is 8% of the entire amount. This makes it possible to decrease the amount of change in the tension on the metal ring of the innermost position and, hence, to increase the durability of the aggregate of metal rings as a whole.
摘要翻译：一种用于无级变速器的带，其中通过层叠多个环形金属环形成的金属环的集合体支撑多个金属块。当摩擦系数xi设定为2.0> xi> 0.65时，最内侧的金属环上的张力的变化量相应地减小。特别地，当摩擦系数xi设定为1.0时，导致环与块之间的摩擦系数μs等于环与环之间的摩擦系数μSS，则该量所有金属环上的张力变化变得均匀，并且每个金属环共享一定量的张力变化量，其总量为8％。由此，能够减少最内侧的金属环上的张力变化量，能够提高金属环的集合体的整体的耐久性。

5. 发明授权

US5800298A Metal V-belt type continuously variable transmission 失效
标题翻译：金属V型皮带式无级变速器
公开(公告)号：US5800298A
公开(公告)日：1998-09-01
申请号：US818792
申请日：1997-03-14
申请人： Shigeru Kanehara , Hideaki Yoshida , Hirofumi Akagi , Hideaki Aoyama , Takamichi Shimada
发明人： Shigeru Kanehara , Hideaki Yoshida , Hirofumi Akagi , Hideaki Aoyama , Takamichi Shimada
IPC分类号： F16H55/49 , F16H9/12 , F16H9/24 , F16H37/02 , F16H55/56 , F16H61/662
CPC分类号： F16H61/66272 , F16H37/022 , F16H9/24
摘要： In a metal V-belt type continuously variable transmission having a driving pulley and a driven pulley, the inclination angle .alpha. of a V-groove in the pulleys is set in a range represented by tan.sup.-1 .mu.a tan.sup.-1 .mu.s. If the transmittable torque Tin is increased, the tensile force of the endless belt is increased to produce slipping between the endless belt and the pulley. However, according to the present invention, by decreasing the inclination angle .alpha. to reduce the tensile force of the endless belt, the transmittable torque Tin can be increased while preventing slipping of the endless belt.
摘要翻译：在具有驱动滑轮和从动皮带轮的金属V型皮带型无级变速器中，将滑轮中的V形槽的倾斜角α设定在由tan-1 mu a tan-1μs表示的范围内。如果可传递扭矩Tin增加，则环形带的张力增加，从而在环形带和带轮之间产生滑动。然而，根据本发明，通过减小倾斜角α以减小环形带的张力，可以增加可传递扭矩Tin，同时防止环形带的滑动。

6. 发明授权

US08716451B2 Stabilized human IgG2 and IgG3 antibodies 有权
标题翻译：稳定的人IgG2和IgG3抗体
公开(公告)号：US08716451B2
公开(公告)日：2014-05-06
申请号：US11794950
申请日：2006-01-12
申请人： Nobuaki Takahashi , Hideaki Yoshida
发明人： Nobuaki Takahashi , Hideaki Yoshida
IPC分类号： C07K16/00 , C12N15/00
CPC分类号： C07K16/00 , C07K16/2878 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/94
摘要： It is intended to provide highly stable variants of human antibody IgG2 and IgG3 subclasses. The present invention provides an IgG heavy chain comprising the constant region of a human IgG2 heavy chain having at least a substitution of Y for F at the 300th position, L for V at the 309th position, or A for T at the 339th position designated by the EU index of Kabat et al. and an IgG heavy chain comprising the constant region of a human IgG3 heavy chain having at least a substitution of K for N at the 392nd position or V for M at the 397th position designated by the EU index of Kabat et al. The present invention also provides monoclonal antibodies comprising these heavy chains.
摘要翻译：旨在提供人抗体IgG2和IgG3亚类的高度稳定的变体。本发明提供一种IgG重链，其包含人IgG2重链的恒定区，其在第300位具有至少取代F的F，在第309位具有至少取代F的L，在第309位具有至少取代F的第三十九位，欧盟指数Kabat等和IgG重链，其包含人类IgG3重链的恒定区，在Kabat等人的EU指数指定的第397位具有至少在第392位具有K取代为N或V代表M。本发明还提供了包含这些重链的单克隆抗体。

7. 发明申请

US20130053547A1 AGONIST ANTIBODY TO HUMAN THROMBOPOIETIN RECEPTOR 审中-公开
标题翻译：人类抗抑郁药受体的激素抗体
公开(公告)号：US20130053547A1
公开(公告)日：2013-02-28
申请号：US13543183
申请日：2012-07-06
申请人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
发明人： Masayuki KAI , Kazuhiro Motoki , Shiro Kataoka , Hideaki Yoshida , Tetsuya Hagiwara
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/524 , C07K14/715 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/72 , C07K2317/74 , Y10S424/801 , Y10S424/809
摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.
摘要翻译：本发明提供了对人类血小板生成素受体（人c-Mpl）的激动剂抗体，以及包含其用于治疗血小板减少症的药物组合物。所公开的激动剂抗体包含（1）包含重链和轻链恒定区的抗体恒定区，每个区可任选地含有结构域取代，或可含有氨基酸残基的缺失，替换，添加或插入，和（2）抗体可变能够结合并激活人血小板生成素受体的区域。激动剂抗体进一步诱导浓度为10,000ng / ml或更低的集落形成，并且具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。

8. 发明申请

US20120330169A1 BLOOD PRESSURE INFORMATION MEASUREMENT DEVICE CUFF AND BLOOD PRESSURE INFORMATION MEASUREMENT DEVICE PROVIDED THEREWITH 有权
标题翻译：血液压力信息测量装置和血液压力信息测量装置
公开(公告)号：US20120330169A1
公开(公告)日：2012-12-27
申请号：US13538371
申请日：2012-06-29
申请人： Yoshihiko Sano , Hideaki Yoshida , Minoru Taniguchi
发明人： Yoshihiko Sano , Hideaki Yoshida , Minoru Taniguchi
IPC分类号： A61B5/022
CPC分类号： A61B5/02233 , A61B5/02141
摘要： In a blood pressure information measurement device cuff, a first flexion point and a second flexion point at which a curvature radius changes are provided in a curler, and a straight line-shaped connection portion is provided between the first flexion point and the second flexion point so as to be located inside a curve formed by extending a first curved portion and a second curved portion that are located at the ends of the curler at the first flexion point and the second flexion point, according to the respective curvatures. Through this, it is possible to provide a blood pressure information measurement device cuff, and a blood pressure information measurement device provided with such a cuff, that can reduce error in a blood pressure measurement by reducing errors in changes in the volume of a fluid bladder.
摘要翻译：在血压信息测量装置袖带中，在卷曲器中设置曲率半径变化的第一屈曲点和第二屈曲点，并且在第一屈曲点和第二屈曲点之间设置直线状连接部以便位于通过根据各自的曲率在第一弯曲点和第二屈曲点处延伸位于卷曲器的端部处的第一弯曲部分和第二弯曲部分所形成的曲线内部。通过这种方式，可以提供一种血压信息测量装置袖带和具有这种袖带的血压信息测量装置，其可以通过减少流体囊体积的变化的误差来减少血压测量的误差。

9. 发明申请

US20120302901A1 BLOOD PRESSURE INFORMATION MEASUREMENT DEVICE 有权
标题翻译：血压信息测量装置
公开(公告)号：US20120302901A1
公开(公告)日：2012-11-29
申请号：US13567525
申请日：2012-08-06
申请人： Tatsuya Kobayashi , Kenji Fujii , Hideaki Yoshida
发明人： Tatsuya Kobayashi , Kenji Fujii , Hideaki Yoshida
IPC分类号： A61B5/0235 , A61B5/025
CPC分类号： A61B5/02233 , A61B5/022 , A61B5/02225 , A61B5/0235 , A61B5/7203
摘要： A blood pressure information measurement device includes a main body, including an inflation pump and an exhaust valve, and a cuff, including an air bladder for pulse wave measurement and an air bladder for blood pressure value measurement. The air bladder for pulse wave measurement and the air bladder for blood pressure value measurement are wrapped around a proximal side and a distal side of the upper arm, respectively. A first piping portion connects the air bladder for blood pressure value measurement to the inflation pump and the exhaust valve. A second piping portion branching from the first piping portion connects the air bladder for pulse wave measurement to the first piping portion. The second piping portion includes a 2-port valve that switches between connecting and disconnecting the air bladder for pulse wave measurement and the first piping portion, and a pressure sensor for measuring a pulse wave.
摘要翻译：血压信息测量装置包括包括充气泵和排气阀的主体和包括用于脉搏波测量的气囊和用于血压值测量的气囊的袖带。用于脉搏波测量的气囊和用于血压值测量的气囊分别围绕上臂的近侧和远侧缠绕。第一管道部分将用于血压值测量的气囊连接到充气泵和排气阀。从第一管道部分分支的第二管道部分将用于脉搏波测量的气囊连接到第一管道部分。第二管道部分包括在连接和断开用于脉搏波测量的气囊和第一管道部分之间切换的2通阀，以及用于测量脉搏波的压力传感器。

10. 发明授权

US08226623B2 Spread out-type paper diaper 有权
标题翻译：散布纸尿布
公开(公告)号：US08226623B2
公开(公告)日：2012-07-24
申请号：US10594663
申请日：2005-03-30
申请人： Hideaki Yoshida
发明人： Hideaki Yoshida
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61F13/495
摘要： A comfortably wearable development type paper diaper comprises a back sheet, a first absorbent, a second absorbent and a liquid-permeable top sheet in the recited order. The first absorbent extends, when worn, from the back side through the crotch to the abdomen side of the user. The second absorbent extends, when worn, from the back side to the crotch of the user. A leakage preventing sheet allowing no liquid permeation is interposed between the first absorbent and the second absorbent. The second absorbent leaves the first absorbent from the crotch to the back side thereby to form a pocket PO for holding the excrement between the first absorbent and the second absorbent. The leakage preventing sheet is arranged to contact in the pocket PO with the second absorbent. The top sheet is so conformed to the shape of the pocket PO as to cover the leakage preventing sheet.
摘要翻译：一种舒适可佩戴的显影型纸尿布包括按照顺序的背片，第一吸收剂，第二吸收剂和透液性顶片。第一种吸收剂在穿戴时从背侧延伸穿过裆部到使用者的腹部侧。第二吸收剂在穿戴时从使用者的背侧延伸到裆部。在第一吸收剂和第二吸收剂之间插入不能透液的防漏片。第二吸收剂将第一吸收剂从裆部离开到后侧，从而形成用于将排泄物保持在第一吸收剂和第二吸收剂之间的口袋PO。泄漏防止片被布置成在袋PO中与第二吸收剂接触。顶片符合口袋PO的形状，以覆盖防漏片。

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