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1. 发明授权

US07968707B2 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US07968707B2
公开(公告)日：2011-06-28
申请号：US11679227
申请日：2007-02-27
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D219/04 , C07D291/06 , C07D243/04 , C07D265/12 , C07D413/12 , C07D239/02
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

2. 发明授权

US06472529B2 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US06472529B2
公开(公告)日：2002-10-29
申请号：US09837280
申请日：2001-04-18
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D23332
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

3. 发明授权

US06313296B1 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US06313296B1
公开(公告)日：2001-11-06
申请号：US09511390
申请日：2000-02-23
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D23902
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

4. 发明授权

US07279582B2 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US07279582B2
公开(公告)日：2007-10-09
申请号：US10280652
申请日：2002-10-25
申请人： Eric J. Stoner , Arthur J. Cooper , Lawrence Kolaczkowski , Ketan M. Patel , Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Daniel A. Dickman , Patricia A. Oliver , Jien-Heh J. Tien
发明人： Eric J. Stoner , Arthur J. Cooper , Lawrence Kolaczkowski , Ketan M. Patel , Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Daniel A. Dickman , Patricia A. Oliver , Jien-Heh J. Tien
IPC分类号： C07D233/32 , C07D239/10 , C07D239/12
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

5. 发明授权

US06284767B1 Retroviral protease inhibiting compounds 有权
公开(公告)号：US06284767B1
公开(公告)日：2001-09-04
申请号：US09207873
申请日：1998-12-08
申请人： Hing Leung Sham , Daniel W. Norbeck , Dale J. Kempf , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , John M. Lipari , Laman Alani , Soumojeet Ghosh , Rong R. Gao , Dilip Kaul
发明人： Hing Leung Sham , Daniel W. Norbeck , Dale J. Kempf , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , John M. Lipari , Laman Alani , Soumojeet Ghosh , Rong R. Gao , Dilip Kaul
IPC分类号： A61K314166
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

6. 发明授权

US4456593A Ristocetin .psi.-aglycone as an antibacterial agent 失效
标题翻译：赖斯托菌素作为抗菌剂，将其作为抗菌剂
公开(公告)号：US4456593A
公开(公告)日：1984-06-26
申请号：US391079
申请日：1982-06-22
申请人： Thomas R. Herrin , Alford M. Thomas
发明人： Thomas R. Herrin , Alford M. Thomas
IPC分类号： A61K38/00 , C07K9/00 , A61K37/00 , C07C103/52
CPC分类号： C07K9/008 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： Described is the use of .psi.-aglycone and other derivatives of ristocetin A as antibacterial agents.
摘要翻译：描述了使用psi-曲康酮和其他衍生物的瑞斯托菌素A作为抗菌剂。

7. 发明授权

US4273866A Ligand analog-irreversible enzyme inhibitor conjugates and methods for use 失效
标题翻译：配体类似物不可逆酶抑制剂缀合物及其使用方法
公开(公告)号：US4273866A
公开(公告)日：1981-06-16
申请号：US9007
申请日：1979-02-05
申请人： Houston F. Voss , Jacob Plattner , Thomas R. Herrin
发明人： Houston F. Voss , Jacob Plattner , Thomas R. Herrin
IPC分类号： C07F9/40 , C12Q1/46 , G01N33/532 , G01N33/542 , G01N33/54 , C12N9/99
CPC分类号： G01N33/542 , C07F9/4075 , G01N33/532 , Y10S435/81 , Y10S435/962 , Y10S436/825
摘要： The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.
摘要翻译：本发明包括用于测定测试样品中配体的方法，包括与测试样品混合配体类似物不可逆酶抑制剂缀合物和可与该配体结合的结合蛋白和配体类似物不可逆酶抑制剂缀合物，其中配体类似物由结合蛋白结合的可逆酶抑制剂缀合物与测试样品中配体的量相关，所述结合蛋白在结合到缀合物的配体类似物部分时使不可逆酶抑制剂失活; 混合由结合蛋白未结合的配体模拟不可逆酶抑制剂缀合物不可逆地抑制的酶; 并将底物与酶混合并监测酶底物反应。本发明还包括在实施该方法中用作试剂的配体类似物不可逆酶抑制剂缀合物。本发明的方法和试剂特别可用于确定生物流体中的药物，激素等。

8. 发明授权

US4550163A Ligand analog-irreversible enzyme inhibitor conjugates 失效
标题翻译：配体类似物不可逆酶抑制剂缀合物
公开(公告)号：US4550163A
公开(公告)日：1985-10-29
申请号：US228414
申请日：1981-01-26
申请人： Houston F. Voss , Jacob Plattner , Thomas R. Herrin
发明人： Houston F. Voss , Jacob Plattner , Thomas R. Herrin
IPC分类号： C07F9/40 , G01N33/532 , G01N33/542 , C07F9/60
CPC分类号： G01N33/542 , C07F9/4075 , G01N33/532
摘要： The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.
摘要翻译：本发明包括用于测定测试样品中配体的方法，包括与测试样品混合配体类似物不可逆酶抑制剂缀合物和可与该配体结合的结合蛋白和配体类似物不可逆酶抑制剂缀合物，其中配体类似物由结合蛋白结合的可逆酶抑制剂缀合物与测试样品中配体的量相关，所述结合蛋白在结合到缀合物的配体类似物部分时使不可逆酶抑制剂失活; 混合由结合蛋白未结合的配体模拟不可逆酶抑制剂缀合物不可逆地抑制的酶; 并将底物与酶混合并监测酶底物反应。本发明还包括在实施该方法中用作试剂的配体类似物不可逆酶抑制剂缀合物。本发明的方法和试剂特别可用于确定生物流体中的药物，激素等。

9. 发明授权

US4543412A Phenobarbital enzyme inhibitors 失效
标题翻译：苯巴比妥酶抑制剂
公开(公告)号：US4543412A
公开(公告)日：1985-09-24
申请号：US548743
申请日：1983-11-04
申请人： Charles A. Flentge , Thomas R. Herrin
发明人： Charles A. Flentge , Thomas R. Herrin
IPC分类号： C07F9/40 , C07F9/553 , C07F9/6512 , A61K31/675 , A61K31/69 , C07F5/02 , C07F9/65
CPC分类号： C07F9/65127 , C07F9/4075 , C07F9/5532
摘要： Phenobarbital conjugates for use as enzyme inhibitors having the formula: ##STR1## wherein Z is a biologically compatible counter ion, n and m is an integer from 2 to 6 and R and R.sub.1 are each lower alkyl.
摘要翻译：苯巴比妥缀合物用作具有下式的酶抑制剂：其中Z是生物相容的抗衡离子，n和m是2-6的整数，R和R 1各自是低级烷基。

10. 发明授权

US4150125A Triglyceride ester of phosphonoacetic acid having antiviral activity 失效
标题翻译：具有抗病毒活性的膦酰基乙酸的甘油三酸酯
公开(公告)号：US4150125A
公开(公告)日：1979-04-17
申请号：US907368
申请日：1978-05-19
申请人： Thomas R. Herrin , John S. Fairgrieve
发明人： Thomas R. Herrin , John S. Fairgrieve
IPC分类号： C07F9/10 , C07F9/38 , A01N9/36 , A61K31/66 , C07C67/00 , C07C69/02
CPC分类号： C07F9/10 , C07F9/3808
摘要： A triglyceride carrying, in the .beta.-position, the anionic moiety of phosphonoacetic acid has been found to exhibit excellent activity against viral infections caused by a herpes virus.
摘要翻译：已经发现在β位中携带膦酰基乙酸的阴离子部分的甘油三酸酯对由疱疹病毒引起的病毒感染表现出优异的活性。

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