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1. 发明授权

US06911214B2 Flavoring systems for pharmaceutical compositions and methods of making such compositions 有权
公开(公告)号：US06911214B2
公开(公告)日：2005-06-28
申请号：US09946085
申请日：2001-09-04
申请人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
发明人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
IPC分类号： A61K9/00 , A61K47/00 , A61K9/20 , A61K9/48 , A61K9/68
CPC分类号： A61K47/46 , A61K9/0095 , A61K47/02 , A61K47/12
摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

2. 发明授权

US06838091B2 Formulations comprising lipid-regulating agents 失效
标题翻译：含有脂质调节剂的制剂
公开(公告)号：US06838091B2
公开(公告)日：2005-01-04
申请号：US09215831
申请日：1998-12-18
申请人： John M. Lipari , Dawn M. Raymond , Tom Reiland , Yeshwant D. Sanzgiri
发明人： John M. Lipari , Dawn M. Raymond , Tom Reiland , Yeshwant D. Sanzgiri
IPC分类号： A61K9/107 , A61K36/47 , A61K47/14 , A61K9/48 , A61K31/19 , A61K31/215
CPC分类号： A61K47/14 , A61K9/107
摘要： The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one monoglyceride as the primary solvent medium for said agent. One or more emulsifiers may be added to the formulation.
摘要翻译：本发明涉及包含溶解在至少一种单酸甘油酯作为所述药剂的主要溶剂介质的脂质调节剂的制剂。可以向制剂中加入一种或多种乳化剂。

3. 发明授权

US08501219B2 Flavoring systems for pharmaceutical compositions and methods of making such compositions 有权
公开(公告)号：US08501219B2
公开(公告)日：2013-08-06
申请号：US12687479
申请日：2010-01-14
申请人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
发明人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
IPC分类号： A61K47/00 , A61K9/00
CPC分类号： A61K47/46 , A61K9/0095 , A61K47/02 , A61K47/12
摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.

4. 发明申请

US20100280055A1 Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions 有权
标题翻译：药物组合物调味剂系统及其制备方法
公开(公告)号：US20100280055A1
公开(公告)日：2010-11-04
申请号：US12687479
申请日：2010-01-14
申请人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
发明人： Laman Alani , Donald P. Gauwitz , Dilip Kaul , John M. Lipari , Soumojeet Ghosh , Kennan C. Marsh , Richard H. Whelan , Vanik D. Petrossian
IPC分类号： A61K31/513 , A61K31/427 , A61P31/18
CPC分类号： A61K47/46 , A61K9/0095 , A61K47/02 , A61K47/12
摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
摘要翻译：公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。还公开了制备这种液体药物组合物的方法。

5. 发明授权

US07014864B1 Formulations comprising lipid-regulating agents 失效
标题翻译：含有脂质调节剂的制剂
公开(公告)号：US07014864B1
公开(公告)日：2006-03-21
申请号：US09216242
申请日：1998-12-18
申请人： John M. Lipari , Dawn M. Raymond , Tom Reiland
发明人： John M. Lipari , Dawn M. Raymond , Tom Reiland
IPC分类号： A61K31/19 , A61K9/48 , A61K31/215
CPC分类号： A61K31/19 , A61K9/4858 , A61K31/215
摘要： The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one structured lipid as the primary solvent medium for said agent. One or more emulsifiers may be added to the formulation.
摘要翻译：本发明涉及包含溶解在至少一种结构化脂质中作为所述药剂的主要溶剂介质的脂质调节剂的制剂。可以向制剂中加入一种或多种乳化剂。

6. 发明授权

US06284767B1 Retroviral protease inhibiting compounds 有权
公开(公告)号：US06284767B1
公开(公告)日：2001-09-04
申请号：US09207873
申请日：1998-12-08
申请人： Hing Leung Sham , Daniel W. Norbeck , Dale J. Kempf , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , John M. Lipari , Laman Alani , Soumojeet Ghosh , Rong R. Gao , Dilip Kaul
发明人： Hing Leung Sham , Daniel W. Norbeck , Dale J. Kempf , Xiaoqi Chen , David A. Betebenner , Thomas R. Herrin , Gondi N. Kumar , John M. Lipari , Laman Alani , Soumojeet Ghosh , Rong R. Gao , Dilip Kaul
IPC分类号： A61K314166
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

7. 发明授权

US06814977B1 Formulations comprising lipid-regulating agents 失效
标题翻译：含有脂质调节剂的制剂
公开(公告)号：US06814977B1
公开(公告)日：2004-11-09
申请号：US09216247
申请日：1998-12-18
申请人： John M. Lipari , Dawn M. Raymond , Tom Reiland
发明人： John M. Lipari , Dawn M. Raymond , Tom Reiland
IPC分类号： A61K3119
CPC分类号： A61K31/19 , A61K9/4858
摘要： The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one medium chain glycerol ester of a fatty acid as the primary solvent medium for said agent. One or more emulsifiers may be added to the formulation.
摘要翻译：本发明涉及包含溶解在作为所述药剂的主要溶剂介质的脂肪酸的至少一种中链甘油酯中的脂质调节剂的制剂。可以向制剂中加入一种或多种乳化剂。

8. 发明授权

US6155093A Method of fabricating metal electronic enclosures 失效
标题翻译：制造金属电子外壳的方法
公开(公告)号：US6155093A
公开(公告)日：2000-12-05
申请号：US336226
申请日：1999-06-18
申请人： John M. Lipari
发明人： John M. Lipari
IPC分类号： B23P15/00 , B21D28/02
CPC分类号： B23P15/00
摘要： A method of forming metal enclosures specifically for electrical or electronic components which require precision in the formation of enclosure wells for containing the components. In accordance with the present invention the method comprises the steps of initially taking a metal blank having a depth thickness at least sufficient to accommodate a pre-determined enclosure well depth therein; determining the shape and depth of varying dimensions of the predetermined enclosure well; using a coining press and dies to separately cold form the determined shapes and depths which in toto form the desired well, and wherein each of the cold formings causes extrusion of a portion of metal to extend beyond the original depth thickness; after each cold forming with the coining press of the separate shapes and depth, using a metal removal device such as a grinder to remove the metal extrusion portion.
摘要翻译：形成专门用于电气或电子部件的金属外壳的方法，其需要精确地形成用于容纳部件的封闭井。根据本发明，该方法包括以下步骤：首先采用具有至少足以容纳其中预定的封闭井深度的深度厚度的金属坯料; 确定预定外壳的不同尺寸的形状和深度; 使用压印机和模具分开冷成型确定的形状和深度，以形成所需的孔，并且其中每个冷成型件导致一部分金属的挤出延伸超过原始深度厚度; 在使用分离形状和深度的压印机进行每次冷成型之后，使用诸如研磨机的金属去除装置来移除金属挤出部分。

9. 发明授权

US6008192A Hydrophilic binary systems for the administration of lipophilic compounds 失效
标题翻译：用于亲脂性化合物的亲水二元体系
公开(公告)号：US6008192A
公开(公告)日：1999-12-28
申请号：US41881
申请日：1998-03-12
申请人： Laman A. Al-Razzak , Panayiotis Pericleous Constantinides , Dilip Kaul , John M. Lipari , Lisa L. McChesney-Harris , Bashar Y. Abdullah
发明人： Laman A. Al-Razzak , Panayiotis Pericleous Constantinides , Dilip Kaul , John M. Lipari , Lisa L. McChesney-Harris , Bashar Y. Abdullah
IPC分类号： A61K9/107 , A61K9/48 , A61K38/00 , A61K38/13 , A61K47/00 , A61K47/10 , A61K47/14 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/44 , A61P31/00 , A61P31/04 , A61P31/12 , A61P37/06 , A61K9/10 , A61K9/50
CPC分类号： A61K9/1075 , A61K38/13 , A61K47/10 , A61K47/26 , A61K47/44 , A61K9/4858 , Y10S514/885 , Y10S514/975
摘要： Binary pharmaceutical compositions comprising (i) a cyclosporine compound, (ii) a hydrophilic phase and (iii) a surfactant provide bioavailability of the active ingredient which is equivalent to that provided by ternary compositions, but without the need for a lipophilic phase.
摘要翻译：包含（i）环孢菌素化合物，（ii）亲水相和（iii）表面活性剂的二元药物组合物提供活性成分的生物利用度，其等同于三元组合物提供的活性成分，但不需要亲脂相。

10. 发明授权

US4383992A Water-soluble steroid compounds 失效
标题翻译：水溶性类固醇化合物
公开(公告)号：US4383992A
公开(公告)日：1983-05-17
申请号：US346501
申请日：1982-02-08
申请人： John M. Lipari
发明人： John M. Lipari
IPC分类号： A61K31/565 , A61K31/57 , A61K47/48 , C08B37/00 , A61K31/56
CPC分类号： B82Y5/00 , A61K31/565 , A61K31/57 , A61K47/48969 , C08B37/0015 , Y10S514/914
摘要： Beta-cyclodextrin forms a water-soluble complex or inclusion compound with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure of beta-cyclodextrin. The resulting inclusion compounds can be used for a variety of applications including aqueous topical ophthalmic preparations and topical dermatological ointments.
摘要翻译： β-环糊精与β-环糊精的环形分子结构中分子结构小于内腔的类固醇化合物形成水溶性络合物或包合物。所得的包合物可用于各种应用，包括水性局部眼用制剂和局部皮肤病软膏。

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