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    • 10. 发明授权
    • Process for the manufacture of
1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts
    • 1-取代-4-氟-1,4-二氮杂双环[2.2.2]辛烷盐的制备方法
    • US5631372A
    • 1997-05-20
    • US642994
    • 1996-05-06
    • Andrew J. PossGeorge A. ShiaDennis M. Lavery
    • Andrew J. PossGeorge A. ShiaDennis M. Lavery
    • C07D487/08C07D247/00C07D243/14C07D245/04C07F9/06
    • C07D487/08
    • A process for producing 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts having the formula ##STR1## wherein the Z substituent is OH, OR, OC(O)R, SO.sub.3, SO.sub.2 R, NO.sub.2, NO, or PO(OR).sub.2, wherein R is an aryl or C.sub.1 -C.sub.8 alkyl group; n is 0, 1 or 2; each of R.sub.1, R.sub.2, R.sub.3, P.sub.4 and R.sub.5 independently represent hydrogen, C.sub.1 to C.sub.8 alkyl, or aryl 1-substituted-1,4-diazoniabicyclo[2.2.2]octane or 1,4-diazoniabicyclo[2.2.2]octane mono-N-oxide is reacted to attach the Z group and then the result is reacted with molecular fluorine in the presence of a solvent that substantially does not react with fluorine and a fluoride scavenger that results in an X counter ion. These compounds are useful as fluorinating agents for the introduction of fluorine into organic compounds.
    • 一种制备具有式“IMAGE”的1-取代-4-氟-1,4-二氮鎓双环[2.2.2]辛烷盐的方法,其中Z取代基是OH,OR,OC(O)R,SO 3,SO 2 R,NO 2 ,NO或PO(OR)2,其中R是芳基或C 1 -C 8烷基; n为0,1或2; R1,R2,R3,P4和R5各自独立地表示氢,C1至C8烷基或芳基1-取代-1,4-二氮鎓双环[2.2.2]辛烷或1,4-二氮鎓双环[2.2.2]辛烷单 N-氧化物反应以连接Z基团,然后在基本上不与氟反应的溶剂和导致X抗衡离子的氟化物清除剂的存在下,使分子氟与分子氟反应。 这些化合物可用作将氟引入有机化合物中的氟化剂。