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1. 发明申请

US20120128749A1 COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 审中-公开
标题翻译：组合物及其生产方法
公开(公告)号：US20120128749A1
公开(公告)日：2012-05-24
申请号：US13361150
申请日：2012-01-30
申请人： Hideyasu Tsuji , Yasuhiro Tsuji , Toru Oka , Shigeru Sugi , Masumi Torii , Haruka Miyao , Yoshimitsu Nakayama , Tomoyuki Torii , Masahito Mori
发明人： Hideyasu Tsuji , Yasuhiro Tsuji , Toru Oka , Shigeru Sugi , Masumi Torii , Haruka Miyao , Yoshimitsu Nakayama , Tomoyuki Torii , Masahito Mori
IPC分类号： A01N25/02 , A01P1/00 , A01P3/00 , A01P17/00 , A01P7/04 , A61P31/10 , A61K8/02 , B08B7/02 , A61K9/14 , A61P31/04 , B82Y40/00 , B82Y5/00 , B82Y99/00
CPC分类号： B01J13/0052 , A01N25/04 , A01N25/34 , A23L2/54 , A01N27/00 , A01N31/06 , A01N43/78 , A01N65/26 , A01N65/36 , A01N65/00
摘要： Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble drug in a solution containing the drug; and a dispersion in which a hydrophobic drug can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water; and a process for producing a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water, which utilizes an ultra-fine bubble generation apparatus.
摘要翻译：公开了一种组合物，其能够更有效地开发含有药物的溶液中的水溶性药物的功效; 以及其中疏水性药物可以稳定分散而不需要使用任何表面活性剂的分散体。具体公开的是包含模粒径为500nm以下的超细小气泡，药物和水的组合物; 以及利用超微细气泡产生装置制造包含模式粒径为500nm以下的超细小气泡，药物和水的组合物的方法。

2. 发明申请

US20130045934A1 EXTRACTION METHOD USING ULTRA FINE BUBBLES AND LIQUID EXTRACTS OBTAINED THEREOF 审中-公开
标题翻译：使用超细微泡的提取方法及其获得的液体提取物
公开(公告)号：US20130045934A1
公开(公告)日：2013-02-21
申请号：US13583367
申请日：2011-03-03
申请人： Hideyasu Tsuji , Yasuhiro Tsuji , Toru Oka , Haruka Miyao , Denny Liauw
发明人： Hideyasu Tsuji , Yasuhiro Tsuji , Toru Oka , Haruka Miyao , Denny Liauw
IPC分类号： A61K31/7024 , A61P37/08 , A23L1/28 , A61P25/20 , A61P35/04 , A61P35/00 , A61K31/235 , A61P3/08
CPC分类号： B01D11/0265 , B01D11/0211
摘要： The present invention provides an extraction method that either does not use emulsifiers, organic solvents, and the like or can reduce the amount used of emulsifiers, organic solvents, and the like. In addition, the extraction method of present invention can also efficiently extract various components from various materials to be extracted, and can highly maintain potency and the like of the extracted components, in particular if the components are active agents. Furthermore, the extraction method of present invention has excellent safety. The extraction method of present invention is achieved by bringing materials to be extracted into contact with liquid containing ultra fine bubbles for extraction treatment. The ultra fine bubbles utilized during the extraction process preferably have a mode diameter of 500 nm or smaller and a concentration of 1,000,000 or more per 1 ml of liquid.
摘要翻译：本发明提供了不使用乳化剂，有机溶剂等或可以减少乳化剂，有机溶剂等使用量的提取方法。此外，本发明的提取方法还可以从各种待提取的材料中有效地提取各种成分，并且可以高度保持提取的组分的效力等，特别是如果组分是活性剂。此外，本发明的提取方法具有优异的安全性。本发明的提取方法是通过将待提取的材料与含有超细气泡的液体接触进行萃取处理来实现的。在提取过程中使用的超细小气泡优选具有500nm或更小的模式直径和每1ml液体1,000,000或更多的浓度。

3. 发明申请

US20050106186A1 Percutaneous preparations 失效
标题翻译：经皮制剂
公开(公告)号：US20050106186A1
公开(公告)日：2005-05-19
申请号：US10502951
申请日：2003-02-13
申请人： Yasuhiro Tsuji , Kei Tamura , Yuuhiro Yamazaki , Yoshihiro Sawai
发明人： Yasuhiro Tsuji , Kei Tamura , Yuuhiro Yamazaki , Yoshihiro Sawai
IPC分类号： A61K9/70 , A61K31/663 , A61K47/04 , A61K47/06 , A61K47/22 , A61K47/26 , A61P3/14 , A61P19/08 , A61P19/10 , A61P43/00 , A61K31/675 , A61K9/00 , A61K31/66
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K31/663 , A61K47/06 , A61K47/22 , A61K47/26
摘要： A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.
摘要翻译：含有双膦酸衍生物如米多昔康酸等的双膦酸衍生物或其药学上可接受的盐，其衍生物或药学上可接受的盐的增溶剂，和两性增溶助剂，其可以任选地含有悬浮型碱如多元醇，高级脂肪酸酯，液体烃或植物油等。该制剂具有优异的经皮渗透性，减轻患者的负担，即使在长时间的施用中也不会降低患者的依从性，并且可以在短时间内达到治疗效果。

4. 发明授权

US06893875B2 Method for assay of analyte by adjustment of chemiluminescence 失效
标题翻译：通过调整化学发光测定分析物的方法
公开(公告)号：US06893875B2
公开(公告)日：2005-05-17
申请号：US09307721
申请日：1999-05-10
申请人： Yasuhiro Tsuji , Keiichi Kamisango , Mitsuo Otsuka
发明人： Yasuhiro Tsuji , Keiichi Kamisango , Mitsuo Otsuka
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/58
CPC分类号： G01N33/582 , C12Q1/6816 , G01N21/76 , Y10S436/80 , Y10S436/805 , Y10S436/825 , Y10T436/13 , C12Q2565/107 , C12Q2563/103 , C12Q2527/125
摘要： A method for assay of an analyte by use of a material labeled with a chemiluminescent substance, which comprises adding a quencher and/or decreasing the specific activity of a chemiluminescent substance labeled probe, thereby decreasing the quantity of chemiluminescence.
摘要翻译：一种通过使用由化学发光物质标记的材料来分析分析物的方法，其包括加入淬灭剂和/或降低化学发光物质标记的探针的比活性，从而减少化学发光的量。

5. 发明授权

US4566453A Vascular anastomosis apparatus 失效
标题翻译：血管吻合装置
公开(公告)号：US4566453A
公开(公告)日：1986-01-28
申请号：US559207
申请日：1983-12-08
申请人： Masafumi Kumano , Ikue Kawashima , Masayuki Hirama , Yasuhiro Tsuji
发明人： Masafumi Kumano , Ikue Kawashima , Masayuki Hirama , Yasuhiro Tsuji
IPC分类号： A61B17/00 , A61B17/11 , A61B18/20 , A61B17/36
CPC分类号： A61B18/20 , A61B17/11 , A61B2017/00508
摘要： A vascular anastomosis apparatus using a carbon dioxide laser is proposed. The vascular anastomosis apparatus satisfies three conditions: a long focal distance of not less than 10 cm which is suitable for surgical operations under microscopic observation; a beam spot diameter of 0.1 to 0.3 mm when a laser beam is converged; and a stable, small beam output of not more than 100 mW. A visible guide beam having the same focusing point as that of the carbon dioxide laser beam is used in the vascular anastomosis apparatus.
摘要翻译：提出了一种使用二氧化碳激光的血管吻合装置。血管吻合装置满足三个条件：适用于显微镜观察手术的长焦距不小于10厘米; 当激光束会聚时，光点直径为0.1至0.3mm; 并且稳定的小光束输出不超过100mW。在血管吻合装置中使用具有与二氧化碳激光束相同的聚焦点的可见导光束。

6. 发明授权

US5952238A Method of assaying specimen substance by controlling dose of chemiluminescence 失效
标题翻译：通过调整化学发光测定分析物的方法
公开(公告)号：US5952238A
公开(公告)日：1999-09-14
申请号：US875592
申请日：1997-10-08
申请人： Yasuhiro Tsuji , Keiichi Kamisango , Mitsuo Otsuka
发明人： Yasuhiro Tsuji , Keiichi Kamisango , Mitsuo Otsuka
IPC分类号： C12Q1/68 , G01N21/76 , G01N33/58
CPC分类号： G01N33/582 , C12Q1/6816 , G01N21/76 , Y10S436/80 , Y10S436/805 , Y10S436/825 , Y10T436/13
摘要： A method for assay of an analyte by use of a material labeled with a chemiluminescent substance, which comprises adding a quencher and/or decreasing the specific activity of a chemiluminescent substance labeled probe, thereby decreasing the quantity of chemiluminescence.
摘要翻译： PCT No.PCT / JP96 / 00218 Sec。 371日期1997年10月8日第 102（e）日期1997年10月8日PCT提交1996年2月2日PCT公布。出版物WO96 / 24044 日期1996年8月8日一种使用标记有化学发光物质的材料测定分析物的方法，其包括加入猝灭剂和/或降低化学发光物质标记的探针的比活性，从而减少化学发光的量。

7. 发明授权

US4446239A Light scattering immunoassay involving particles with selective frequency band apparatus 失效
标题翻译：涉及具有选择性频带装置的颗粒的光散射免疫测定
公开(公告)号：US4446239A
公开(公告)日：1984-05-01
申请号：US368610
申请日：1982-04-15
申请人： Yasuhiro Tsuji , Kiyoshige Wakabayashi
发明人： Yasuhiro Tsuji , Kiyoshige Wakabayashi
IPC分类号： G01N21/49 , G01N15/14 , G01N21/47 , G01N33/543 , G01N33/54
CPC分类号： G01N33/54313 , G01N21/47 , Y10S436/805 , Y10S436/807 , Y10S436/817
摘要： A technique for measuring the degree of an antigen-antibody reaction by preparing a suspension of insoluble microscopic carrier particles of at least one type carrying an antigen, an antibody or a hapten, forming an agglutination promoting or inhibiting reaction system among the insoluble carrier particles based on an antigen-antibody reaction using the suspension and one or more antigen, antibody or hapten, irradiating the solution of the reaction system with laser light and detecting the light scattered from the reaction system at one or more specific angles, detecting a signal indicative of one or more specific frequency bands from the resulting scatter spectrum, and thenceforth calculating the quantity of antigen, antibody or hapten in a specimen on the basis of the detected signal. The intensity spectrum output of filter 11 for frequency band selection is in the form of a square root and is converted into the original intensity spectrum by means of a squaring circuit 12. The output of the squaring circuit is recorded by a recorder 10.
摘要翻译：一种用于通过制备至少一种携带抗原，抗体或半抗原的不溶性微观载体颗粒的悬浮液来测量抗原 - 抗体反应程度的技术，其形成不溶性载体颗粒之间的凝集促进或抑制反应系统在使用悬浮液和一种或多种抗原，抗体或半抗原的抗原 - 抗体反应上，用激光照射反应体系的溶液，并以一个或多个特定角度检测从反应体系散射的光，检测指示来自所得散射光谱的一个或多个特定频带，然后基于检测到的信号计算样品中的抗原，抗体或半抗原的量。用于频带选择的滤波器11的强度谱输出是平方根的形式，并通过平方电路12转换成原强度谱。平方电路的输出由记录器10记录。

8. 发明授权

US07820197B2 Percutaneous preparations 失效
标题翻译：经皮制剂
公开(公告)号：US07820197B2
公开(公告)日：2010-10-26
申请号：US10502951
申请日：2003-02-13
申请人： Yasuhiro Tsuji , Kei Tamura , Yuuhiro Yamazaki , Yoshihiro Sawai
发明人： Yasuhiro Tsuji , Kei Tamura , Yuuhiro Yamazaki , Yoshihiro Sawai
IPC分类号： A61F13/00 , A61K31/66
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K31/663 , A61K47/06 , A61K47/22 , A61K47/26
摘要： A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.
摘要翻译：含有双膦酸衍生物如米多昔康酸等的双膦酸衍生物或其药学上可接受的盐，其衍生物或药学上可接受的盐的增溶剂，和两性增溶助剂，其可以任选地含有悬浮型碱如多元醇，高级脂肪酸酯，液体烃或植物油等。该制剂具有优异的经皮渗透性，减轻患者的负担，即使在长时间的施用中也不会降低患者的依从性，并且可以在短时间内达到治疗效果。

9. 发明授权

US4429583A Liquid uptake and discharge apparatus 失效
标题翻译：液体吸收和排出装置
公开(公告)号：US4429583A
公开(公告)日：1984-02-07
申请号：US362161
申请日：1982-03-26
申请人： Mitsuo Watanabe , Shigeyuki Kimura , Hideki Konishi , Yasuhiro Tsuji , Kiyoshige Wakabayashi
发明人： Mitsuo Watanabe , Shigeyuki Kimura , Hideki Konishi , Yasuhiro Tsuji , Kiyoshige Wakabayashi
IPC分类号： G01N33/48 , B01L3/02 , G01N35/10 , G01F11/06
CPC分类号： B01L3/0227 , B01L3/0206
摘要： An apparatus for taking up and discharging liquid has at least one piston cylinder which responds to a command by taking up or discharging liquid, the arrangement being such that the number of liquid uptake operations is preset, with the piston cylinder being instructed to perform the discharge operation when the number of uptake operations actually performed is detected to exceed said preset number. A plurality of different liquid specimens can be mixed, and the mixture diluted when so desired, through a simple operation which assures great accuracy.
摘要翻译：用于吸收和排出液体的装置具有至少一个活塞缸，其通过吸取或排出液体来响应命令，该排列使得预先设定液体摄取操作的数量，同时指示活塞气缸进行排放当检测到实际执行的摄取操作的数量超过所述预设数量时的操作。可以混合多种不同的液体样品，并且当需要时通过简单的操作稀释混合物，这确保了高精度。

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