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1. 发明申请

US20110190250A1 EYE DROP WITH DIFLUPREDNATE FOR MACULAR EDEMA TREATMENT 审中-公开
标题翻译：用于乳头状病毒治疗的眼睑下垂
公开(公告)号：US20110190250A1
公开(公告)日：2011-08-04
申请号：US13122467
申请日：2010-07-14
申请人： Hidetoshi Yamashita , Teiko Yamamoto , Sakiko Goto , Sachi Abe , Eriko Kirii , Atsushi Okumura
发明人： Hidetoshi Yamashita , Teiko Yamamoto , Sakiko Goto , Sachi Abe , Eriko Kirii , Atsushi Okumura
IPC分类号： A61K31/56 , A61P27/02
CPC分类号： A61K9/107 , A61K9/0048 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/46
摘要： The present invention aims to provide an eye drop for treating macular edema. The present invention provides an eye drop for treating macular edema, which contains difluprednate as an active ingredient. The eye drop can afford effects such as improvement of visual acuity and decreased foveal retinal thickness in macular edema.
摘要翻译：本发明旨在提供一种治疗黄斑水肿的滴眼剂。本发明提供一种治疗黄斑水肿的滴眼剂，其含有二氟泼尼酯作为活性成分。眼药水可以提供视力改善和黄斑水肿中心凹视网膜厚度下降的效果。

2. 发明申请

US20090053812A1 SCLERAL CELL STRAIN 审中-公开
标题翻译： SCLERAL细胞株
公开(公告)号：US20090053812A1
公开(公告)日：2009-02-26
申请号：US12279443
申请日：2007-02-13
申请人： Hidetoshi Yamashita , Teiko Yamamoto , Yoshiko Kashiwagi
发明人： Hidetoshi Yamashita , Teiko Yamamoto , Yoshiko Kashiwagi
IPC分类号： C12N15/87 , C12N5/06
CPC分类号： C12N5/0621 , C12N2503/00 , C12N2503/02 , C12N2510/04
摘要： The present invention provides a scleral cell strain capable of expressing an exogenous immortalizing gene, and a production method thereof. Since the scleral cell strain of the present invention can produce a sufficient number of cells and has constant and continuous proliferative capacity, it can be advantageously utilized for the elucidation of the pathogenesis of ophthalmic diseases such as scleral inflammation, and the development of a drug for the prophylaxis and/or treatment of said diseases. Moreover, the cell strain is not only highly useful for the biochemical-physiological studies of the sclera, and further for the study of cell differentiation mechanisms, but also possibly usable as a biological material of an artificial sclera.
摘要翻译：本发明提供能够表达外源永生化基因的巩膜细胞株及其制备方法。由于本发明的巩膜细胞株能够产生足够数量的细胞并且具有恒定且连续的增殖能力，因此可以有利地用于阐明眼科疾病如巩膜炎症的发病机理，以及用于所述疾病的预防和/或治疗。此外，细胞株不仅对巩膜的生物化学生理学研究非常有用，进一步用于研究细胞分化机制，而且还可用作人造巩膜的生物材料。

3. 发明申请

US20090068744A1 VITREOUS CELL LINE 审中-公开
标题翻译： VITREOUS细胞系
公开(公告)号：US20090068744A1
公开(公告)日：2009-03-12
申请号：US12279432
申请日：2007-02-13
申请人： Hidetoshi Yamashita , Teiko Yamamoto , Kouichi Nishitsuka , Yoshiko Kashiwagi , Naoki Tojo
发明人： Hidetoshi Yamashita , Teiko Yamamoto , Kouichi Nishitsuka , Yoshiko Kashiwagi , Naoki Tojo
IPC分类号： C12N5/10 , C12N15/85
CPC分类号： C12N5/0621 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/23 , C12N2501/25 , C12N2501/905 , C12N2503/00 , C12N2503/02 , C12N2510/04
摘要： The present invention provides a vitreous cell line capable of expressing an exogenous immortalizing gene, and a production method thereof. Since the vitreous cell line of the present invention can produce a sufficient number of cells and has constant and continuous proliferative capacity, it can be advantageously utilized for the elucidation of the pathogenesis of retinal vitreous diseases, and the development of a drug for the prophylaxis and/or treatment of retinal vitreous diseases. Moreover, the cell line is not only highly useful for the biochemical-physiological studies of the vitreous body, and further for the study of cell differentiation mechanisms, but also possibly usable as a biological material of an artificial vitreous body.
摘要翻译：本发明提供能够表达外源永生化基因的玻璃体细胞系及其制备方法。由于本发明的玻璃体细胞系可以产生足够数量的细胞并且具有恒定和连续的增殖能力，因此可以有利地用于阐明视网膜玻璃体疾病的发病机理，并且开发用于预防和 /或治疗视网膜玻璃体疾病。此外，细胞系不仅对玻璃体的生物化学生理学研究非常有用，进一步用于研究细胞分化机制，而且还可用作人造玻璃体的生物材料。

4. 发明授权

US07932351B2 Activin receptor-like kinase-1 proteins having serine-threonine kinase domains 失效
标题翻译：具有丝氨酸 - 苏氨酸激酶结构域的激活素受体样激酶-1蛋白
公开(公告)号：US07932351B2
公开(公告)日：2011-04-26
申请号：US11656720
申请日：2007-01-23
申请人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
发明人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
IPC分类号： C07K14/71 , A61K39/00 , C12P21/02 , C07H21/04 , C12N5/00 , C12N15/09 , C12N15/12
CPC分类号： C07K14/71 , A61K38/00
摘要： A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-beta-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
摘要翻译：已经鉴定了激活素样激酶的新受体家族。新型蛋白质具有激活素/ TGF-β-I受体功能，并具有相应的诊断/治疗效用。它们可以具有丝氨酸/苏氨酸激酶结构域，子域VIB中的DFKSRN或DLKSKN序列和/或亚域VIII中的GTKRYM序列。

5. 发明申请

US20100330657A1 Activin receptor-like kinases, proteins having serine threonine kinase domains and their use 失效
标题翻译：活化素受体样激酶，具有丝氨酸苏氨酸激酶结构域的蛋白质及其用途
公开(公告)号：US20100330657A1
公开(公告)日：2010-12-30
申请号：US11981260
申请日：2007-10-31
申请人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
发明人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
IPC分类号： C12N1/21 , C07K16/18 , C07K14/00 , C07H21/04 , C12N15/63
CPC分类号： C07K14/71 , A61K38/00
摘要： A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-β-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
摘要翻译：已经鉴定了激活素样激酶的新受体家族。新型蛋白质具有激活素/ TGF-β1型受体功能，并具有相应的诊断/治疗效用。它们可以具有丝氨酸/苏氨酸激酶结构域，子域VIB中的DFKSRN或DLKSKN序列和/或亚域VIII中的GTKRYM序列。

6. 发明申请

US20060210304A1 Electrophotographic image forming apparatus, and process cartridge 有权
公开(公告)号：US20060210304A1
公开(公告)日：2006-09-21
申请号：US11437684
申请日：2006-05-22
申请人： Yoshiaki Nakashima , Takeshi Setoriyama , Shuji Nishitani , Hidetoshi Yamashita , Kazunari Murayama , Nobuharu Hoshi , Tatsuya Suzuki , Hideki Maeshima
发明人： Yoshiaki Nakashima , Takeshi Setoriyama , Shuji Nishitani , Hidetoshi Yamashita , Kazunari Murayama , Nobuharu Hoshi , Tatsuya Suzuki , Hideki Maeshima
IPC分类号： G03G21/18
CPC分类号： G03G21/1839
摘要： A plurality of process cartridges, each including an electrophotographic photosensitive drum, and a process device actable on the photosensitive drum, are detachably mountable to an electrophotographic image forming apparatus for forming an image of a recording medium. The image forming apparatus includes an opening and closing member; an intermediate transfer member or a recording medium bearing member provided in the opening and closing member such that the intermediate transfer member can face the process cartridges under a condition in which the opening and closing member is closed, and the intermediate transfer member can be separated from the process cartridges under a condition in which the opening and closing member is open; and a moving guide for holding the process cartridges. The moving guide is moved in interlocking relationship with a closing motion of the opening and closing member from a load position, to which the process cartridges are loaded, to a mount position, in which the process cartridges are capable of performing an image forming operation, such that the process cartridges mounted to the load position can be moved to the mount position.

7. 发明授权

US07092657B2 Electrophotographic image forming apparatus, and process cartridge 有权
标题翻译：电子照相成像设备和处理盒
公开(公告)号：US07092657B2
公开(公告)日：2006-08-15
申请号：US10926098
申请日：2004-08-26
申请人： Yoshiaki Nakashima , Takeshi Setoriyama , Shuji Nishitani , Hidetoshi Yamashita , Kazunari Murayama , Nobuharu Hoshi , Tatsuya Suzuki , Hideki Maeshima
发明人： Yoshiaki Nakashima , Takeshi Setoriyama , Shuji Nishitani , Hidetoshi Yamashita , Kazunari Murayama , Nobuharu Hoshi , Tatsuya Suzuki , Hideki Maeshima
IPC分类号： G03G21/16
CPC分类号： G03G21/1839
摘要： A plurality of process cartridges, each including an electrophotographic photosensitive drum, and a process device actable on the photosensitive drum, are detachably mountable to an electrophotographic image forming apparatus for forming an image of a recording medium. The image forming apparatus includes an opening and closing member; an intermediate transfer member or a recording medium bearing member provided in the opening and closing member such that the intermediate transfer member can face the process cartridges under a condition in which the opening and closing member is closed, and the intermediate transfer member can be separated from the process cartridges under a condition in which the opening and closing member is open; and a moving guide for holding the process cartridges. The moving guide is moved in interlocking relationship with a closing motion of the opening and closing member from a load position, to which the process cartridges are loaded, to a mount position, in which the process cartridges are capable of performing an image forming operation, such that the process cartridges mounted to the load position can be moved to the mount position.
摘要翻译：每个包括电子照相感光鼓和可在感光鼓上操作的处理装置的处理盒可拆卸地安装到用于形成记录介质的图像的电子照相图像形成装置中。图像形成装置包括打开和关闭部件; 设置在打开和关闭构件中的中间转印构件或记录介质承载构件，使得中间转印构件可以在打开和关闭构件关闭的状态下面对处理盒，并且中间转印构件可以与所述处理盒在所述打开和关闭构件打开的条件下; 以及用于保持处理盒的移动引导件。移动引导件与打开和关闭构件从装载位置的处理盒的装载位置的关闭运动互锁地移动到处理盒能够执行图像形成操作的安装位置，使得安装到加载位置的处理盒可以移动到安装位置。

8. 发明授权

US06271365B1 Activin like receptor--Isolated kinase proteins ALK-2, ALK-4, ALK-5, and nucleic acid molecules encoding them 有权
标题翻译：活化素样受体 - 分离的激酶蛋白ALK-2，ALK-4，ALK-5和编码它们的核酸分子
公开(公告)号：US06271365B1
公开(公告)日：2001-08-07
申请号：US09395115
申请日：1999-09-14
申请人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
发明人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
IPC分类号： C12N1512
CPC分类号： C07K14/71 , A61K38/00
摘要： The invention involves three members of the activin like receptor kinase family, and the nucleic acids encoding these.
摘要翻译：本发明涉及激活素样受体激酶家族的三个成员和编码它们的核酸。

9. 发明授权

US08130251B2 Method and apparatus for forming image 有权
标题翻译：用于形成图像的方法和装置
公开(公告)号：US08130251B2
公开(公告)日：2012-03-06
申请号：US12358665
申请日：2009-01-23
申请人： Hidetoshi Yamashita
发明人： Hidetoshi Yamashita
IPC分类号： B41J2/435
CPC分类号： G03G15/043 , G03G15/0435 , G03G15/326
摘要： An image forming apparatus includes a light source that emits a laser beam, a separating unit that separates the laser beam emitted from the light source into a first laser beam, and a second laser beam. a first photoelectric converting unit, a second photoelectric converting unit, and a control unit that executes a first light-intensity correction for correcting the light intensity of the second laser beam per scan by each scanning line, and a second light-intensity correction for adjusting a performance in forming the image data based on a current correction value for correcting a light intensity of the laser beam based on a first voltage and a second voltage and a drive current preliminarily-set with respect to the laser beam to cause the light source to emit the laser beam.
摘要翻译：图像形成装置包括发射激光束的光源，将从光源发射的激光束分离成第一激光束的分离单元和第二激光束。第一光电转换单元，第二光电转换单元和控制单元，其执行用于校正每条扫描线每次扫描的第二激光束的光强度的第一光强度校正，以及用于调整第二光强度校正基于用于校正基于相对于激光束预先设定的第一电压和第二电压以及驱动电流的激光束的光强度的当前校正值来形成图像数据的性能，以使光源发射激光束。

10. 发明授权

US08077359B2 Image processing system and image forming apparatus incorporating same 有权
标题翻译：图像处理系统和包含其的图像形成装置
公开(公告)号：US08077359B2
公开(公告)日：2011-12-13
申请号：US12137072
申请日：2008-06-11
申请人： Yumiko Kishi , Toshio Ohide , Tatsuo Ohyama , Hidetoshi Yamashita , Nobuyoshi Kaima
发明人： Yumiko Kishi , Toshio Ohide , Tatsuo Ohyama , Hidetoshi Yamashita , Nobuyoshi Kaima
IPC分类号： G06T5/00
CPC分类号： H04N1/3935 , H04N1/58
摘要： A novel image processing system includes a pixel position indicator and a pixel inserting unit. The pixel position indicator is configured to indicate insertion positions in the image data. The pixel inserting unit is configured to enlarge a size of the image data by inserting an additional pixel at each of the insertion positions and accordingly shifting the original pixels in a given direction. The additional pixel has a value lower than a given threshold. Each insertion position is at an approximate center of an area formed of pixels having values higher than the given threshold. A novel image forming apparatus incorporates such an image processing system and an electrophotographic system. The electrophotographic system is configured to form an image by irradiating a photoconductive surface with a laser beam according to the processed image data.
摘要翻译：一种新颖的图像处理系统包括像素位置指示器和像素插入单元。像素位置指示器被配置为指示图像数据中的插入位置。像素插入单元被配置为通过在每个插入位置处插入附加像素来放大图像数据的大小，并且因此沿给定方向移位原始像素。附加像素具有低于给定阈值的值。每个插入位置在由具有高于给定阈值的像素形成的区域的大致中心处。一种新颖的图像形成装置结合了这种图像处理系统和电子照相系统。电照相系统被配置为根据处理的图像数据通过用激光束照射光电导表面来形成图像。

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