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    • 8. 发明申请
    • Method For Synthesizing Derivative, Compound Library and Method For Constructing the Same, and Method For Screening
    • 合成衍生物,化合物库及其构建方法的方法和筛选方法
    • US20080167201A1
    • 2008-07-10
    • US11663082
    • 2005-09-27
    • Masaya ImotoHiromichi OhtaKenji Miyamoto
    • Masaya ImotoHiromichi OhtaKenji Miyamoto
    • C40B30/10C12P1/00C12P1/04C12P1/02C40B50/06C40B40/04C40B30/00
    • C12P17/16C07D405/06G01N2500/00
    • [Object] To provide a method for synthesizing derivatives of natural compounds; a method for constructing a compound library containing derivatives of natural compounds; a compound library containing derivatives of natural compounds; and a screening method using a compound library, which are useful for a HTS random screening, a search for drugs or agricultural chemicals, or a search for a lead compound of a drug or an agricultural chemical.[Solving Means] A derivative of an organic compound can be synthesized by culturing a microorganism producing the organic compound in a predetermined culture broth, and reacting the organic compound obtained by the culturing with a reaction reagent for synthesizing the derivative of the organic compound in the culturing broth. By constructing a library containing the thus obtained organic compound derivative, a HTS (high-throughput) random screening, a search for a drug or agricultural chemical, or a search for a lead compound of a drug or agricultural chemical can be performed.
    • 提供合成天然化合物衍生物的方法; 一种构建含有天然化合物衍生物的化合物文库的方法; 含有天然化合物衍生物的化合物库; 以及使用化合物文库的筛选方法,其可用于HTS随机筛选,寻找药物或农药,或搜索药物或农药的铅化合物。 [解决方案]有机化合物的衍生物可以通过在预定的培养肉汤中培养产生有机化合物的微生物来合成,并将通过培养获得的有机化合物与用于合成有机化合物的衍生物的反应试剂反应 培养肉汤 通过构建含有这样得到的有机化合物衍生物的文库,可以进行HTS(高通量)随机筛选,药物或农药的检索,或者寻找药物或农药的铅化合物。
    • 9. 发明授权
    • Boot for constant velocity universal joint
    • 启动恒速万向节
    • US06715771B2
    • 2004-04-06
    • US10116034
    • 2002-04-05
    • Kenji MiyamotoKazuya Watanabe
    • Kenji MiyamotoKazuya Watanabe
    • F16J1552
    • F16J3/041
    • A boot for a constant velocity universal joint includes a minor-diameter cylindrical member, a major-diameter cylindrical member, and a bellows member. At least the bellows member is formed of a thermoplastic elastomer exhibiting a kinetic friction coefficient of less than 0.6 when water intervenes in-between, and including crests. In the cross section of the bellows member involving the central axis, the peaks of the crests, excepting the crest neighboring the major-diameter cylindrical member as well as the crest neighboring the minor-diameter cylindrical member, are disposed on an inner diametric side with respect to a line connecting the peak of the crest neighboring the major-diameter cylindrical member with the peak of the crest neighboring the minor-diameter cylindrical member. Not only it is possible to downsize the boot, but also it is possible to inhibit abnormal noises from generating when water intervenes in-between.
    • 用于等速万向接头的护罩包括一个小直径的圆柱形构件,一个大直径圆柱形构件和一个波纹管构件。 至少波纹管构件由热塑性弹性体形成,当水介入其中并包括波峰时,表现出小于0.6的动摩擦系数。 在涉及中心轴线的波纹管构件的横截面中,除了与大直径圆柱形构件相邻的顶部以及邻近小直径圆柱形构件的波峰之外的波峰的峰部设置在内径侧, 相对于将相邻于大直径圆柱形构件的波峰的峰值与邻近小直径圆柱形构件的波峰的峰连接的线。 不仅可以减小起重机的尺寸,还可以抑制水中介之间产生的异常噪音。