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1. 发明授权

US08303820B2 Method of purifying cytidine diphosphate choline 有权
标题翻译：胞苷二磷酸胆碱的纯化方法
公开(公告)号：US08303820B2
公开(公告)日：2012-11-06
申请号：US12063318
申请日：2006-08-10
申请人： Hideki Murata , Tsuyoshi Mokudai , Michio Shiomi
发明人： Hideki Murata , Tsuyoshi Mokudai , Michio Shiomi
IPC分类号： B01D19/30 , B01D15/36 , B01J39/12 , C12P19/30 , C07H19/10
CPC分类号： C12P19/32 , C07H19/10
摘要： A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.
摘要翻译：一种纯化胞苷二磷酸胆碱的方法，其包括使用H型强酸性阳离子交换树脂使含有核酸类似物的胞苷二磷酸胆碱溶液与pH值不小于0.5且不大于5.0的条件接触，并将胞苷二磷酸用水或离子浓度不超过0.1mol / L的水溶液吸附到树脂上的胆碱分离和纯化胞苷二磷酸胆碱。

2. 发明申请

US20090286284A1 METHOD OF PURIFYING CYTIDINE DIPHOSPHATE CHOLINE 有权
标题翻译：净化二硫代磷酸胆碱的方法
公开(公告)号：US20090286284A1
公开(公告)日：2009-11-19
申请号：US12063318
申请日：2006-08-10
申请人： Hideki Murata , Tsuyoshi Mokudai , Michio Shiomi
发明人： Hideki Murata , Tsuyoshi Mokudai , Michio Shiomi
IPC分类号： C12P19/40 , C07H19/048
CPC分类号： C12P19/32 , C07H19/10
摘要： A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.
摘要翻译：一种纯化胞苷二磷酸胆碱的方法，其包括使用H型强酸性阳离子交换树脂使含有核酸类似物的胞苷二磷酸胆碱溶液与pH值不小于0.5且不大于5.0的条件接触，并将胞苷二磷酸用水或离子浓度不超过0.1mol / L的水溶液吸附到树脂上的胆碱分离和纯化胞苷二磷酸胆碱。

3. 发明授权

US5378832A Polysaccharide and a method of producing it 失效
标题翻译：多糖及其生产方法
公开(公告)号：US5378832A
公开(公告)日：1995-01-03
申请号：US94091
申请日：1993-07-20
申请人： Ryuichiro Kurane , Yasuhiro Nohata , Michio Shiomi , Shuichi Ishino , Akira Yotsuji , Hideki Murata , Seiji Sugimoto
发明人： Ryuichiro Kurane , Yasuhiro Nohata , Michio Shiomi , Shuichi Ishino , Akira Yotsuji , Hideki Murata , Seiji Sugimoto
IPC分类号： B01F17/56 , C08B37/00 , C12P19/04 , C12N1/20
CPC分类号： C12P19/04 , C08B37/006 , Y10S435/829
摘要： The present invention provides a polymer comprising a polysaccharide having excellent water absorption properties, moisture absorption properties, moisture retention properties and thickening properties. Said polysaccharide has the following properties: (A) the principal constituents of the sugar composition are rhamnose, fucose, glucose and glucuronic acid which are present in a molar ratio of (1-4):2:(1-8):(1-4); (B) elemental analysis (wt %):C: 36 .+-.3H: 7 .+-.1O: 56 .+-.4,containing 9-13% of crystalline water(C) solubility:slightly soluble in water; soluble in alkalies; insoluble in methanol, ethanol and acetone;(D) UV absorption spectrum:no absorption detected at 280 nm characteristic of proteins (peptides) or at 260 nm characteristic of nucleic acids; and(E) IR absorption spectrum:an absorption pattern characteristic of polysaccharides is observed near 800-1200.sup.-iSaid polysaccharide is produced by a fermentation method using a natural medium or a synthetic medium of Alcaligenes microorganism.
摘要翻译： PCT No.PCT / JP92 / 00695 Sec。 371日期：1993年7月20日 102（e）日期1993年7月20日PCT提交1993年7月20日PCT公布。公开号WO93 / 11163 日期：6月10日，1993。本发明提供了包含具有优异的吸水性，吸湿性，保湿性和增稠性的多糖的聚合物。所述多糖具有以下性质：（A）糖组合物的主要成分是以（1-4）：2：（1-8）：（1）的摩尔比存在的鼠李糖，岩藻糖，葡萄糖和葡萄糖醛酸 -4）; （B）元素分析（重量％）：C：36 +/- 3 H：7 +/- 1 O：56 +/- 4，含有9-13％的结晶水（C）溶解度：微溶于水; 溶于碱; 不溶于甲醇，乙醇和丙酮; （D）紫外线吸收光谱：蛋白质（肽）的特征性或280nm特征性的核酸在280nm处未检测到吸收; 和（E）IR吸收光谱：在800-1200-i附近观察到多糖的吸收图案特征。所述多糖通过使用天然培养基或产碱杆菌微生物的合成培养基的发酵方法产生。

4. 发明申请

US20090082594A1 CRYSTALS OF L-ORNITHINE AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译： L-ORNITHINE的晶体及其生产方法
公开(公告)号：US20090082594A1
公开(公告)日：2009-03-26
申请号：US11719122
申请日：2005-11-14
申请人： Hideki Murata , Ikuhiro Nakatani , Mariko Shitashige , Kenji Tajima
发明人： Hideki Murata , Ikuhiro Nakatani , Mariko Shitashige , Kenji Tajima
IPC分类号： C07C229/26
CPC分类号： C07C227/42 , C07C229/26
摘要： The present invention provides crystals of L-ornithine and a process for producing the crystals of L-ornithine including the steps of (i) exposing L-ornithine or a salt thereof, a composition comprising L-ornithine or a salt thereof, or a solution containing L-ornithine, a salt thereof, or the composition to a cation exchange resin to adsorb L-ornithine onto the cation exchange resin; (ii) eluting L-ornithine from the cation exchange resin on which L-ornithine is adsorbed with an aqueous alkaline solution, and removing an alkaline component from the resulting eluate to prepare an aqueous L-ornithine solution; and (iii) mixing the aqueous L-ornithine solution with a hydrophilic organic solvent, and crystallizing L-ornithine from the resulting mixed solution.
摘要翻译：本发明提供L-鸟氨酸的晶体和L-鸟氨酸晶体的制造方法，其特征在于，包括以下步骤：（i）使L-鸟氨酸或其盐，包含L-鸟氨酸或其盐的组合物或溶液将含有L-鸟氨酸的盐或其组合物或阳离子交换树脂，将L-鸟氨酸吸附到阳离子交换树脂上; （ii）从碱性水溶液中吸附L-鸟氨酸的阳离子交换树脂中洗脱L-鸟氨酸，从得到的洗脱液中除去碱性成分，制备L-鸟氨酸水溶液; 和（iii）将L-鸟氨酸水溶液与亲水性有机溶剂混合，并从所得混合溶液中结晶L-鸟氨酸。

5. 发明申请

US20050119199A1 Method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate 失效
标题翻译：稳定还原烟酰胺腺嘌呤二核苷酸或还原烟酰胺腺嘌呤二核苷酸磷酸的方法
公开(公告)号：US20050119199A1
公开(公告)日：2005-06-02
申请号：US10502922
申请日：2003-12-03
申请人： Hideo Kawabe , Hideki Murata , Hiroshi Nagano
发明人： Hideo Kawabe , Hideki Murata , Hiroshi Nagano
IPC分类号： A61K31/7084 , A61K31/70 , A01N43/04
CPC分类号： A61K31/7084 , A61K2300/00
摘要： It is an object of the present invention to provide a method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate [hereinafter abbreviated as NAD(P)H] and a preparation containing NAD(P)H stabilized by the method. As the method of stabilizing NAD(P)H, a method of adding astaxanthin to NAD(P)H is provided.
摘要翻译：本发明的目的是提供一种稳定还原型烟酰胺腺嘌呤二核苷酸或还原型烟酰胺腺嘌呤二核苷酸磷酸酯（以下简称为NAD（P）H）的方法和通过该方法稳定化的含有NAD（P）H的制剂。作为稳定NAD（P）H的方法，提供了将虾青素加入到NAD（P）H中的方法。

6. 发明授权

US4415644A Electrostatic image developing toner and a method for the production thereof 失效
标题翻译：静电图像显影调色剂及其制备方法
公开(公告)号：US4415644A
公开(公告)日：1983-11-15
申请号：US296067
申请日：1981-08-25
申请人： Kiyoshi Tamaki , Hideki Murata , Sadatugu Terada , Tsuneo Wada , Akitoshi Matsubara , Hiroyuki Takagiwa
发明人： Kiyoshi Tamaki , Hideki Murata , Sadatugu Terada , Tsuneo Wada , Akitoshi Matsubara , Hiroyuki Takagiwa
IPC分类号： C08F2/00 , C08F2/18 , C08F2/20 , G03G9/087 , G03G9/08
CPC分类号： C08F2/18 , G03G9/08702
摘要： An electrostatic image developing toner comprising polymer particles produced by suspension polymerization of a polymerizable monomer in the presence of an emulsification-preventing agent. Such toners produce images of high image density.
摘要翻译：一种静电图像显影调色剂，其包含通过可聚合单体在乳化防止剂的存在下的悬浮聚合制备的聚合物颗粒。这种调色剂产生高图像密度的图像。

7. 发明授权

US4243601A Cyano substituted diphenoquinones and a process for preparing them 失效
标题翻译：氰基取代的二苯醌及其制备方法
公开(公告)号：US4243601A
公开(公告)日：1981-01-06
申请号：US18261
申请日：1979-03-07
申请人： Zen-ichi Yoshida , Shigeo Yoneda , Hideki Murata , Yutaka Yasuda , Saburo Nagakura
发明人： Zen-ichi Yoshida , Shigeo Yoneda , Hideki Murata , Yutaka Yasuda , Saburo Nagakura
IPC分类号： G03G5/00 , C07C67/00 , C07C253/00 , C07C255/31 , C07C255/46 , G03G5/06 , C07C120/00 , C07C121/48
CPC分类号： G03G5/0618
摘要： Novel cyano substituted diphenoquinones of the formula, ##STR1## wherein X is a bromine atom or a cyano group, are useful as oxidizing agents and electron acceptors in charge-transfer complex formation owing to their high redox potentials. They may be easily prepared by oxidizing the corresponding cyano substituted biphenols with dinitrogen tetraoxide in an inert organic solvent.
摘要翻译：由于其高氧化还原电位，新型氰基取代的联苯醌类化合物其中X是溴原子或氰基，可用作电荷转移络合物形成中的氧化剂和电子受体。它们可以通过在惰性有机溶剂中用四氧化二氮氧化相应的氰基取代的联苯酚来容易地制备。

8. 发明授权

US08119373B2 Method for purifying histidine from a cell culture 有权
标题翻译：从细胞培养物中纯化组氨酸的方法
公开(公告)号：US08119373B2
公开(公告)日：2012-02-21
申请号：US12282815
申请日：2007-03-15
申请人： Hideki Murata , Noboru Fujii , Kenji Tajima
发明人： Hideki Murata , Noboru Fujii , Kenji Tajima
IPC分类号： C12P13/24
CPC分类号： C12P13/24 , B01J39/05
摘要： In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 420 μm or more and which has an ability to adsorb histidine and then an eluent is passed through the column whereby accomplishing the separation and purification of histidine, and preferably in the step mentioned above, a strong acid cation exchange resin is employed as a carrier particle whereby accomplishing the separation and purification of histidine.
摘要翻译：在从含有氨基酸的培养物中分离和纯化组氨酸的方法中，将含有组氨酸和微生物细胞的培养物装入填充有粒径为420μm以上的载体颗粒的柱的顶部，并且具有吸附组氨酸，然后使洗脱液通过柱，从而完成组氨酸的分离和纯化，优选在上述步骤中，使用强酸阳离子交换树脂作为载体颗粒，从而完成组氨酸的分离和纯化。

9. 发明申请

US20050153406A1 Process for producing solution containing ubiquinone-10 审中-公开
标题翻译：生产含有泛醌-10的溶液的方法
公开(公告)号：US20050153406A1
公开(公告)日：2005-07-14
申请号：US10522658
申请日：2003-07-25
申请人： Hideki Murata , Hiroyuki Yonemitsu
发明人： Hideki Murata , Hiroyuki Yonemitsu
IPC分类号： C12P7/66 , C12N1/21
CPC分类号： C12P7/66
摘要： In accordance with the present invention, a process for producing a ubiquinone-10-containing solution is provided, which comprises the following steps: [1] adding a methanol solution to a culture obtained by culturing a microorganism having an ability to produce ubiquinone-10 in a medium, a processed product of the culture, or a partially purified product of ubiquinone-10, to a final concentration of 50 to 100 v/v % and then retaining the resulting mixture at a temperature of 0° C. or above to 30° C. or below; [2] separating and recovering an insoluble matter from the solution obtained at the step [1]; [3] adding a methanol solution of a concentration of 85 to 100 v/v % to the insoluble matter obtained in the step [2] and retaining the resulting mixture at a temperature of more than 30° C. and 80° C. or below; and [4] removing an insoluble matter from the solution obtained in the step [3].
摘要翻译：根据本发明，提供了含有泛醌-10的溶液的制备方法，其包括以下步骤：[1]向通过培养具有生产泛醌-10的能力的微生物获得的培养液中加入甲醇溶液在培养基中，培养物的加工产物或泛醌-10的部分纯化产物至终浓度为50至100v / v％，然后将所得混合物保持在0℃或更高的温度至 30℃以下; [2]从在步骤[1]获得的溶液中分离和回收不溶物; [3]将浓度为85〜100v / v％的甲醇溶液加入到步骤[2]中得到的不溶性物质中，并将所得混合物保持在大于30℃和80℃的温度，或下面; 和[4]从步骤[3]中得到的溶液中除去不溶物。

10. 发明授权

US6142730A Gas turbine cooling stationary blade 有权
标题翻译：燃气轮机冷却固定叶片
公开(公告)号：US6142730A
公开(公告)日：2000-11-07
申请号：US202690
申请日：1998-12-21
申请人： Yasuoki Tomita , Kenichi Arase , Hiroki Fukuno , Hideki Murata , Kiyoshi Suenaga , Tsuyoshi Kitamura
发明人： Yasuoki Tomita , Kenichi Arase , Hiroki Fukuno , Hideki Murata , Kiyoshi Suenaga , Tsuyoshi Kitamura
IPC分类号： F01D9/02 , F01D5/18 , F01D9/04 , F01D9/06 , F02C7/18
CPC分类号： F01D9/065 , F01D5/187 , F05D2240/81 , Y02T50/676
摘要： In a cooled gas turbine stationary blade, both steam cooling and air cooling are utilized to reduce the amount of cooling air. In the stationary blade having outer and inner shrouds 1, 21 and steam passages 10A, 10B, 10C, 10D and 10E which are communicated with each other and in which a sealing air feed tube 2 passes through a central portion thereof, steam covers 3, 4 are provided in the outer shroud 1, and steam S is introduced from a steam feed port 5. The steam S passes through serpentine passages 10A to 10E and is recovered from the steam outlet 12 after cooling the central portion of the outer shroud 1 by means of an impingement plate 8. A portion of the steam of the passage 10A is introduced from the impingement plate 25 to a steam sump 24 to cool the central portion of the inner shroud 21 and pass through the passage 10D to be recovered from the steam outlet port 12. On the other hand, cooling air is fed from cooling air feed ports 6 and 26 to peripheral portions of the outer and inner shrouds 1, 21, and is discharged to the outside from the rear sides thereof, respectively, and the cooling air is further fed from a cooling air feeding port 7 to the passage 10E on the rear edge of the blade to cool the rear edge of the blade. Only the narrow portions where it is difficult for the steam to pass are air-cooled to thereby reduce the amount of the cooling air.
摘要翻译： PCT No.PCT / JP98 / 01959 Sec。 371 1998年12月21日第 102（e）日期1998年12月21日PCT提交1998年4月28日PCT公布。公开号WO98 / 50685 PCT 日期1998年11月12日在冷却式燃气轮机固定叶片中，蒸汽冷却和空气冷却都用于减少冷却空气的量。在具有彼此连通并且密封空气供给管2穿过其中心部分的外护罩1和21以及蒸汽通道10A，10B，10C，10D和10E的固定刀片中，蒸汽罩3， 4设置在外护罩1中，并且蒸汽S从蒸汽供给口5引入。蒸汽S通过蛇形通道10A至10E，并且在冷却外护罩1的中心部分之后从蒸汽出口12回收，冲击板8的装置。通道10A的蒸汽的一部分从冲击板25引入蒸汽槽24，以冷却内护罩21的中心部分，并通过通道10D以从蒸汽中回收另一方面，冷却空气从冷却空气供给口6和26被供给到外护罩1和外护罩21的周边部分，并且分别从其后侧排出到外部，冷却空气很冷她从冷却空气供给口7进入叶片后缘的通道10E，以冷却叶片的后边缘。只有蒸汽难以通过的狭窄部分被空气冷却，从而减少冷却空气的量。

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