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1. 发明授权

US5994355A 1, 2, 4-Triazin-3-one derivatives, production and use thereof 失效
标题翻译： 1,2,4-三嗪-3-酮衍生物，的制备和用途
公开(公告)号：US5994355A
公开(公告)日：1999-11-30
申请号：US810499
申请日：1997-02-28
申请人： Hideki Miki , Koichi Iwanaga , Toshimi Matsuno , Isao Aoki
发明人： Hideki Miki , Koichi Iwanaga , Toshimi Matsuno , Isao Aoki
IPC分类号： A01N43/707 , C07C281/10 , C07C281/14 , C07C323/48 , C07D213/61 , C07D253/06 , C07D253/07 , C07D253/075 , C07D271/06 , C07D277/32 , C07D333/28 , C07D401/04 , C07D401/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/53
CPC分类号： C07D253/06 , A01N43/707 , C07C281/10 , C07C281/14 , C07C323/48 , C07D213/61 , C07D253/07 , C07D253/075 , C07D271/06 , C07D277/32 , C07D333/28 , C07D401/04 , C07D401/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides a novel triazine derivative of the formula ##STR1## wherein ring A is an optionally substituted aromatic group; X is an oxygen or sulfur atom;R.sup.1 and R.sup.6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom;R.sup.2 and R.sup.3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent .dbd.S;R.sup.4 and R.sup.5 are each independently a hydrogen atom, a halogen-atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom;R.sup.1 and R.sup.2, and R.sup.5 and R.sup.6 may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position -2 or 4 and X is an oxygen atom, R.sup.4 and R.sup.5 do not conjoin to form a chemical bond, or a salt thereof. The invention also encompasses an antiprotozoan composition comprising the novel triazine derivative or a salt thereof.
摘要翻译：本发明提供下式的新型三嗪衍生物，其中环A为任选取代的芳族基团; X是氧或硫原子; R 1和R 6各自是氢原子或可以通过杂原子结合的任选取代的烃残基或杂环基; R2和R3各自独立地为氢原子，卤素原子或通过碳，氧或硫原子结合的基团，或者一起表示= S; R4和R5各自独立地为氢原子，卤素原子或通过碳，氧，氮或硫原子键合的基团; R 1和R 2以及R 5和R 6可以各自结合在一起形成化学键; 其中环A为至少具有-2或4位的卤素原子且X为氧原子的苯基，R4和R5不结合形成化学键或其盐。本发明还包括含有新颖的三嗪衍生物或其盐的抗原生动物组合物。

2. 发明授权

US06211178B1 Triazine derivative, production and use thereof 失效
标题翻译：三嗪衍生物，其生产和使用
公开(公告)号：US06211178B1
公开(公告)日：2001-04-03
申请号：US09335918
申请日：1999-06-18
申请人： Hideki Miki , Koichi Iwanaga , Toshimi Matsuno , Isao Aoki
发明人： Hideki Miki , Koichi Iwanaga , Toshimi Matsuno , Isao Aoki
IPC分类号： A61K3153
CPC分类号： C07D253/06 , A01N43/707 , C07C281/10 , C07C281/14 , C07C323/48 , C07D213/61 , C07D253/07 , C07D253/075 , C07D271/06 , C07D277/32 , C07D333/28 , C07D401/04 , C07D401/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides a novel triazine derivative of the formula wherein ring A is an optionally substituted aromatic group which be; X is an oxygen or sulfur atom; R1 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom; R2 and R3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent ═S; R4 and R5 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R1 and R2, and R5 and R6, may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position-2 or 4 and X is an oxygen atom, R4 and R5 do not conjoinedly represent a chemical bond and an antiprotozoan composition containing the same or salt thereof.
摘要翻译：本发明提供了一种新的三氟乙烯衍生物，其中A为任选取代的芳基，X为氧或硫原子; R 1和R 6各自为氢原子或任选取代的烃残基或可结合的杂环基通过杂原子; R 2和R 3各自独立地为氢原子，卤素原子或通过碳，氧或硫原子结合的基团，或一起表示= S; R 4和R 5各自独立地为氢原子卤素原子或通过碳，氧，氮或硫原子结合的基团; R 1和R 2以及R 5和R 6可以各自键合在一起形成化学键; 条件是当环A为至少具有2或4位的卤素原子且X为氧原子的苯基时，R 4和R 5不连结地表示化学键，而含有该化合键的抗原生动物组合物或其盐。

3. 发明授权

US5985875A 1,2,4-triazine-3, 5-dione derivatives, their production and use thereof 失效
标题翻译： 1,2,4-三嗪-3,5-二酮衍生物，其制备和用途
公开(公告)号：US5985875A
公开(公告)日：1999-11-16
申请号：US921047
申请日：1997-08-29
申请人： Hideki Miki , Isao Aoki , Koichi Iwanaga , Toshikatsu Hayashi
发明人： Hideki Miki , Isao Aoki , Koichi Iwanaga , Toshikatsu Hayashi
IPC分类号： C07D253/075 , C07D401/10 , A61K31/53
CPC分类号： C07D253/075 , C07D401/10
摘要： The present invention relates to compounds represented by the formula: ##STR1## wherein R.sup.1 is (1) an optionally substituted alkyl group which may be bonded through a hetero atom, (2) an optionally substituted acyl group, (3) an alkylsulfonyl group, (4) an alkylsulfinyl group, or (5) an optionally substituted sulfamoyl group; A is --N.dbd. or -CH.dbd.; R.sup.2 is a hydrogen atom or an alkyl group which may optionally be substituted with halogen and which may be bonded through a hetero atom;X.sup.1 is halogen or a lower alkyl group;X.sup.2 is a hydrogen atom or a fluorine atom;R.sup.3 is a hydrogen atom, halogen or a lower alkyl group;and R.sup.4 is a hydrogen atom, an optionally substituted alkyl group or an acyl group, provided that when R.sup.1 is (1) a C.sub.1-4 alkanoyl group, (2) benzoyl, (3) trifluoroacetyl, (4) sulfamoyl which may optionally be substituted with a C.sub.1-4 alkyl group, (5) a C.sub.1-4 alkyl group which may optionally be substituted with hydroxy, halogen or a C.sub.1-3 alkoxy group, (6) amino which is substituted with a C.sub.14 alkyl group, A is --CH.dbd., R.sup.2 is a hydrogen atom, X.sup.1 is a chlorine atom, R.sup.3 is a chlorine atom, and X.sup.2 is a hydrogen atom, then R.sup.4 is an optionally substituted alkyl group or an optionally substituted acyl group; or salts thereof, their production and use thereof. These compounds and salts thereof are useful as anti-protozoal agents.
摘要翻译：本发明涉及由下式表示的化合物：其中R1是（1）可以通过杂原子键合的任选取代的烷基，（2）任选取代的酰基，（3）烷基磺酰基，（4）烷基亚磺酰基，或（5）任选取代的氨磺酰基; A是-N =或-CH =; R2是氢原子或可以被卤素取代的烷基，可以通过杂原子键合; X1是卤素或低级烷基; X2是氢原子或氟原子; R3是氢原子，卤素或低级烷基; 并且R 4为氢原子，任选取代的烷基或酰基，条件是当R 1为（1）C 1-4烷酰基时，（2）苯甲酰基，（3）三氟乙酰基，（4）氨磺酰基，其可任选地为被C 1-4烷基取代，（5）可任意被羟基，卤素或C 1-3烷氧基取代的C 1-4烷基，（6）被C 14烷基取代的氨基，A是 -CH =，R2为氢原子，X1为氯原子，R3为氯原子，X2为氢原子，R4为任意取代的烷基或任选取代的酰基; 或其盐，其生产和使用。这些化合物及其盐可用作抗原生动物剂。

4. 发明申请

US20120172599A1 SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME 有权
标题翻译：二阶非线性光学化合物和包含其的非线性光学元件
公开(公告)号：US20120172599A1
公开(公告)日：2012-07-05
申请号：US13391948
申请日：2010-08-24
申请人： Akira Otomo , Isao Aoki , Hideki Miki , Hidehisa Tazawa , Shiyoshi Yokoyama
发明人： Akira Otomo , Isao Aoki , Hideki Miki , Hidehisa Tazawa , Shiyoshi Yokoyama
IPC分类号： C07D307/68 , C07D333/22 , C07D471/06 , C07D409/06 , C07F7/18
CPC分类号： G02B1/045 , C07C223/06 , C07D307/30 , C07D307/68 , C07D333/22 , C07D409/06 , C07D409/12 , C07D409/14 , C07D471/06 , C07F7/1804 , C09B23/0066 , C09B23/0075 , C09B69/008 , C09B69/107 , G02B1/046 , G02B6/105 , G02F1/0063 , G02F1/3611 , G02F1/3612 , G02F1/3614 , G02F1/3615
摘要： Problem to Be Solved: to provide a chromophore having a far superior nonlinear optical activity to conventional chromophores and to provide a nonlinear optical element comprising said chromophore.Solution: a chromophore comprising a donor structure D, a π-conjugated bridge structure B, and an acceptor structure A, the donor structure D comprising an aryl group substituted with a substituted oxy group; and a nonlinear optical element comprising said chromophore.
摘要翻译：要解决的问题：提供对常规发色团具有非常优异的非线性光学活性的发色团，并提供包含所述发色团的非线性光学元件。溶液：包含供体结构D，共轭桥结构B和受体结构A的发色团，包含被取代氧基取代的芳基的供体结构D; 和包含所述发色团的非线性光学元件。

5. 发明授权

US06294536B1 Triazine derivatives, their production and use 失效
标题翻译：三嗪衍生物，其生产和使用
公开(公告)号：US06294536B1
公开(公告)日：2001-09-25
申请号：US09445159
申请日：2000-03-01
申请人： Hideki Miki , Isao Aoki , Toshikatsu Hayashi
发明人： Hideki Miki , Isao Aoki , Toshikatsu Hayashi
IPC分类号： A61K3153
CPC分类号： C07D253/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D409/10 , C07D413/10
摘要： The present invention relates to compounds represented by the formula: wherein ring H represents an optionally substituted aromatic heterocyclic group or an optionally substituted alicyclic hydrocarbon group; X and Y independently represent a single bond, —O—, a group of the formula: —S(O)m— wherein m is 0, 1 or 2, a group of the formula: —NR8— wherein R8 represents a hydrogen atom, an alkyl group or an acyl group, —CO— or an optionally substituted methylene group; —A—B— represents —N═CH—, —CH═N—, —N═N— or —CH═CH—; R1 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group which may be bonded through a hetero atom or an acyl group; R2 and R3 independently represent a hydrogen atom, a halogen atom or an optionally substituted alkyl group; R4 represents a hydrogen atom or a halogen atom; R5 represents a hydrogen atom, an optionally substituted alkyl group or an acyl group; R6 and R7 independently represent a hydrogen atom or R6 and R7 may form a chemical bond together with each other; and D represents —CH2— or —CO—; or a salt thereof. These compounds and salts thereof are useful as anti-protozoal agents.
摘要翻译：本发明涉及由下式表示的化合物：其中环H表示任选取代的芳族杂环基或任选取代的脂环族烃基; X和Y独立地表示单键，-O-，下式-S（O）m - 的基团，其中m为0,1或2，式-NR8-的基团，其中R8表示氢原子，烷基或酰基，-CO-或任选取代的亚甲基; -A-B-表示-N = CH-，-CH = N-，-N = N-或-CH = CH-; R1表示氢原子，卤素原子，可以通过杂原子或酰基键合的任意取代的烷基; R2和R3独立地表示氢原子，卤素原子或任选取代的烷基; R4表示氢原子或卤素原子; R5代表氢原子，任选取代的烷基或酰基; R6和R7独立地表示氢原子或R6，R7可以彼此形成化学键; 和D表示-CH 2 - 或-CO-; 或其盐。这些化合物及其盐可用作抗原生动物剂。

6. 发明授权

US08846955B2 Second-order nonlinear optical compound and nonlinear optical element comprising the same 有权
标题翻译：二阶非线性光学复合物和包含其的非线性光学元件
公开(公告)号：US08846955B2
公开(公告)日：2014-09-30
申请号：US13391948
申请日：2010-08-24
申请人： Akira Otomo , Isao Aoki , Hideki Miki , Hidehisa Tazawa , Shiyoshi Yokoyama
发明人： Akira Otomo , Isao Aoki , Hideki Miki , Hidehisa Tazawa , Shiyoshi Yokoyama
IPC分类号： C07D409/00 , C07D333/22 , C07D307/02 , G02F1/361 , C09B23/01 , C09B69/00
CPC分类号： G02B1/045 , C07C223/06 , C07D307/30 , C07D307/68 , C07D333/22 , C07D409/06 , C07D409/12 , C07D409/14 , C07D471/06 , C07F7/1804 , C09B23/0066 , C09B23/0075 , C09B69/008 , C09B69/107 , G02B1/046 , G02B6/105 , G02F1/0063 , G02F1/3611 , G02F1/3612 , G02F1/3614 , G02F1/3615
摘要： Problem to Be Solved: to provide a chromophore having a far superior nonlinear optical activity to conventional chromophores and to provide a nonlinear optical element comprising said chromophore.Solution: a chromophore comprising a donor structure D, a π-conjugated bridge structure B, and an acceptor structure A, the donor structure D comprising an aryl group substituted with a substituted oxy group; and a nonlinear optical element comprising said chromophore.
摘要翻译：要解决的问题：提供对常规发色团具有非常优异的非线性光学活性的发色团，并提供包含所述发色团的非线性光学元件。溶液：包含供体结构D，共轭桥结构B和受体结构A的发色团，包含被取代氧基取代的芳基的供体结构D; 和包含所述发色团的非线性光学元件。

7. 发明授权

US08552198B2 Benzimidazole compound crystal 有权
公开(公告)号：US08552198B2
公开(公告)日：2013-10-08
申请号：US13591992
申请日：2012-08-22
申请人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
发明人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , A61K31/4439 , C07B2200/13
摘要： A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.

8. 发明授权

US07776450B2 Thermal spraying powder comprising chromium carbide and alloy containing cobalt or nickel, thermal spray coating, and hearth roll 有权
标题翻译：包括碳化铬和含有钴或镍的合金的热喷涂粉末，热喷涂和炉底辊
公开(公告)号：US07776450B2
公开(公告)日：2010-08-17
申请号：US12056370
申请日：2008-03-27
申请人： Hiroaki Mizuno , Satoshi Tawada , Isao Aoki , Noriyuki Yasuo , Tatsuo Suidzu , Sho Hashimoto
发明人： Hiroaki Mizuno , Satoshi Tawada , Isao Aoki , Noriyuki Yasuo , Tatsuo Suidzu , Sho Hashimoto
IPC分类号： B32B5/16
CPC分类号： C23C4/06 , B22F1/0096 , B22F3/115 , C22C1/0433 , C22C1/051 , C22C1/1084 , Y10T428/12014 , Y10T428/12181 , Y10T428/12493 , Y10T428/12847 , Y10T428/26 , Y10T428/264 , Y10T428/2982 , Y10T428/31678
摘要： A thermal spraying powder contains 30 to 50% by mass of chromium carbide with the remainder being an alloy containing chromium, aluminum, yttrium, and at least one of cobalt and nickel. The thermal spraying powder has an average particle size of 20 to 60 μm. The thermal spraying powder may contain 20% by mass or less of yttrium oxide in place of a part of the alloy. A thermal spray coating obtained by thermal spraying of the thermal spraying powder, particularly, a thermal spray coating obtained by high-velocity flame spraying of the thermal spraying powder is suitable for the purpose of a hearth roll.
摘要翻译：热喷涂粉末含有30〜50质量％的碳化铬，余量为含有铬，铝，钇，钴和镍中的至少一种的合金。热喷涂粉末的平均粒径为20〜60μm。热喷涂粉末可以含有20质量％以下的氧化钇代替合金的一部分。通过热喷涂粉末，特别是通过热喷涂粉末的高速火焰喷涂获得的热喷涂得到的热喷涂，适用于炉底辊的目的。

9. 发明授权

US07569697B2 Benzimidazole compound crystal 有权
标题翻译：苯并咪唑化合物晶体
公开(公告)号：US07569697B2
公开(公告)日：2009-08-04
申请号：US12006845
申请日：2008-01-07
申请人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
发明人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
IPC分类号： C07D401/04 , A61K31/44
CPC分类号： C07D401/12 , A61K31/4439 , C07B2200/13
摘要： A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl],sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.
摘要翻译：本发明的（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑或其盐的新晶体对于优良的抗溃疡剂是有用的。

10. 发明申请

US20080132547A1 Benzimidazole compound crystal 有权
标题翻译：苯并咪唑化合物晶体
公开(公告)号：US20080132547A1
公开(公告)日：2008-06-05
申请号：US12006845
申请日：2008-01-07
申请人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
发明人： Akira Fujishima , Isao Aoki , Keiji Kamiyama
IPC分类号： A61K31/4439 , C07D417/02 , A61P1/04
CPC分类号： C07D401/12 , A61K31/4439 , C07B2200/13
摘要： A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl],sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.
摘要翻译：本发明的（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑或其盐的新晶体对于优良的抗溃疡剂是有用的。

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