会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明授权
    • Chromanone derivatives
    • 色酮衍生物
    • US4261988A
    • 1981-04-14
    • US20119
    • 1979-03-13
    • Arno WiddigHans-Joachim KabbeMartin ScheerRudiger Sitt
    • Arno WiddigHans-Joachim KabbeMartin ScheerRudiger Sitt
    • A61K31/35A61K31/352A61P19/06C07D311/22C07D311/24C07D311/32C07D311/92C07D311/96C07D405/04C07D491/10C07D491/107
    • C07D491/10C07D311/22C07D311/24C07D311/32C07D311/92C07D311/96
    • Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R.sup.1 and R.sup.2 independently denote radicals including hydrogen, alkyl, aryl and heterocyclic radical or together complete a carbocyclic or heterocylic ring, R.sup.3 denotes a radical ##STR2## in which R.sup.9, R.sup.10 and R.sup.11 include hydrogen, cyano, nitro, alkyl and aryl or, in pairs, complete carbocyclic rings, X denotes cyano, nitro or substituted carbonyl, sulphonyl or phosphonyl group, R.sup.4 is hydrogen or a radical defined for R.sup.1 or R.sup.3, and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 include hydrogen, nitro, cyano, carboxyl, alkyl and aryl or, in pairs, complete carbocyclic rings, with the proviso that R.sup.1 and R.sup.9 are not both phenyl if X denotes CO--C.sub.6 H.sub.6. The compounds exhibit considerably higher hypocholesterolaemic activity than the known clofibrate and in addition exhibit a pronounced nutritive effect, e.g., in a medicated fodder or premix.
    • 用于治疗胆固醇血症的化合物具有通式(I)或其盐,其中R 1和R 2独立地表示包括氢,烷基,芳基和杂环基团的基团,或者一起完成碳环或杂环,R3表示 其中R9,R10和R11包括氢,氰基,硝基,烷基和芳基,或成对地成为完全碳环,X表示氰基,硝基或取代的羰基,磺酰基或膦酰基,R4是氢或基团 对于R 1或R 3而言,R 5,R 6,R 7和R 8包括氢,硝基,氰基,羧基,烷基和芳基,或成对地成为完全碳环,条件是如果X表示CO,则R 1和R 9不是苯基 -C6H6。 化合物显示比已知的氯贝特明显更高的降血胆固醇血症活性,并且还显示出明显的营养作用,例如在药物饲料或预混物中。