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1. 发明授权

US5895915A Bi-directional scanning system with a pixel clock system 失效
标题翻译：具有像素时钟系统的双向扫描系统
公开(公告)号：US5895915A
公开(公告)日：1999-04-20
申请号：US899805
申请日：1997-07-24
申请人： Herman DeWeerd , Brian Stokes , Hans Bengtsson , Peter Honkanen
发明人： Herman DeWeerd , Brian Stokes , Hans Bengtsson , Peter Honkanen
IPC分类号： G01N21/64 , G02B21/00 , G02B26/10 , G06T1/00 , H04N1/113 , H01J3/14
CPC分类号： G02B26/10
摘要： A bi-directional optical scanning system includes a spring-stiffened, taut-band mechanical subsystem that translates rotational motion of a servo-controlled actuator to translational (scan line or "fast axis") motion of a sample relative to a stationary objective lens. A first taut steel band attaches to a first end of a shuttle that moves the sample over the fast axis. The band then wraps partially in one direction around a light-weight wheel that is rotated by the servo-controlled actuator. The second end of the band attaches to a pre-loaded spring that is, in turn, attached to the wheel. A second taut steel band wraps partially around the wheel in the opposite direction, with one end of the band attached to the wheel and the other end attached to a second end of the shuttle. When the wheel rotates in one direction, the first band pulls the shuttle, and thus, the sample, in the forward scan direction. When the wheel rotates in the opposite direction, the second band pulls the shuttle and the sample in the backward scan direction. As the wheel rotates, the first band fits into a slit in the second band where the two bands would otherwise overlap. Each band thus remains tightly wrapped around the wheel. The wrap angle associated with the overlay of the first band on the wheel is carefully chosen to ensure that the band does not slip relative to the wheel in response to forces associated with the acceleration of the sample or differences in thermal expansion of the wheel and the band. There is thus a known relationship between the rotational movement of the wheel and the translational movement of the sample even under varying environmental conditions.
摘要翻译：双向光学扫描系统包括弹簧加强的拉紧机械子系统，其将伺服控制致动器的旋转运动转换为相对于静止物镜的样品的平移（扫描线或“快轴”）运动。第一个紧紧的钢带附着在将快速轴线移动样品的梭子的第一端。然后，该带部分地围绕由伺服控制的致动器旋转的轻量轮缠绕在一个方向上。带的第二端连接到预加载的弹簧，该弹簧依次连接到车轮上。第二个紧紧的钢带以相反的方向部分地围绕车轮缠绕，带的一端附接到车轮，另一端附接到梭的第二端。当车轮沿一个方向旋转时，第一条带沿着正向扫描方向拉动梭子，从而拉动样品。当轮沿相反方向旋转时，第二带沿向后扫描方向拉动梭子和样品。当轮旋转时，第一带适合于第二带中的狭缝，其中两个带将重叠。因此，每个带子保持紧紧地缠绕在车轮周围。仔细选择与车轮上的第一带的覆盖层相关联的包角，以确保响应于与样品的加速度或轮的热膨胀差异相关的力，带相对于车轮不滑动，带。因此，即使在变化的环境条件下，车轮的旋转运动和样品的平移运动之间也存在已知的关系。

2. 发明授权

US06269846B1 Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays 失效
标题翻译：将液体样品沉积在基材上，产生有序阵列，沉积阵列的技术
公开(公告)号：US06269846B1
公开(公告)日：2001-08-07
申请号：US09122216
申请日：1998-07-24
申请人： James W. Overbeck , Peter T. Flowers , Jean I. Montagu , Myles L. Mace , Peter Honkanen
发明人： James W. Overbeck , Peter T. Flowers , Jean I. Montagu , Myles L. Mace , Peter Honkanen
IPC分类号： B05C100
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00364 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01L3/0251 , B01L9/52 , B01L9/547 , B01L2200/025 , B01L2300/161 , B01L2400/022 , B01L2400/028 , B82Y30/00 , C40B60/14 , G01N21/6452 , G01N21/6458 , G01N35/1065 , G01N2035/1034 , G01N2035/1037 , G02B21/0036 , G02B21/0048 , G02B21/0072 , G02B21/0076 , G02B21/008 , G02B21/34 , Y10T436/2575
摘要： A fluid deposit assembly mounted on a carrier for depositing minute drops of fluid at selected locations upon a substrate, comprising a deposit element having an exposed tip of diameter of 0.3 mm or less constructed and arranged to carry and deposit drops of fluid upon the substrate, stable lateral reference surfaces or surface portions exposed for engagement by the deposit element, the surfaces or surface portions being constructed and arranged to prevent X, Y displacement of the deposit element relative to the carrier when the deposit element is urged thereagainst and design for urging the deposit element against the reference surfaces or surface portions at least at the time that the deposit element approaches a substrate to deposit a fluid drop. The reference surfaces or surface portions and the design for urging are cooperating to precisely position the deposit tip in a precisely desired position as it contacts the substrate. The deposit element is shown as the tip of an axially moveable pin. The reference surface portion is shown, among others, as a surface of revolution whose axis is disposed at a predetermined position relative to the carrier. A mobile supply in the form of a multiwell plate is moved under computer control to be a close companion of the deposit device, enabling rapid deposit action and avoidance of evaporative effects that can alter the consistency of dots in the array being formed. The device can deposit one dot on top of another from fluid in a mobile multiwell plate that moves to be close to the deposit device.
摘要翻译：一种安装在载体上的流体沉积组件，用于在基板上的选定位置处沉积微滴流体，包括具有直径为0.3mm或更小的露出尖端的沉积元件，该沉积元件构造和布置成将流体的液滴携带并沉积在基底上，稳定的横向参考表面或暴露以由沉积元件接合的表面部分，所述表面或表面部分被构造和布置成防止当沉积元件被推动时沉积元件相对于载体的X，Y位移，并设计成用于推动至少在沉积元件接近基底以沉积流体液滴时，沉积元件抵靠参考表面或表面部分。参考表面或表面部分以及用于施加的设计被配合以将沉积尖端精确地定位在接触基板的精确期望位置。沉积元件被示出为可轴向移动的销的尖端。参考表面部分除其他外被示出为其轴线相对于载体设置在预定位置的旋转表面。多孔板形式的移动电源在计算机控制下移动成为沉积装置的紧密配合，使得能够快速沉积动作并避免可能改变正在形成的阵列中的点的一致性的蒸发效应。该装置可以将移动的多孔板中的流体上的另一个点放置在靠近沉积装置的位置。

3. 发明申请

US20050112654A1 System, method, and product for dynamic noise reduction in scanning of biological material 有权
标题翻译：用于生物材料扫描的动态降噪的系统，方法和产品
公开(公告)号：US20050112654A1
公开(公告)日：2005-05-26
申请号：US10973418
申请日：2004-10-27
申请人： Nathan Weiner , Peter Honkanen , Timothy Woolaver
发明人： Nathan Weiner , Peter Honkanen , Timothy Woolaver
IPC分类号： C40B50/14 , G01N21/27 , G01N21/64 , G01N27/447 , G01N35/00 , G01N35/04 , G06F19/20 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00 , G06K9/00
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B82Y30/00 , B82Y35/00 , C40B50/14 , G01N21/276 , G01N27/44717 , G01N27/44721 , G01N2035/00158 , G01N2035/0494 , G06F19/20
摘要： Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning system is described that includes an excitation signal generator that provides an excitation signal having one or more representative excitation values representative of an excitation beam; an excitation reference provider that provides at least one excitation reference value; a normalization factor generator that compares the excitation reference value to at least one representative excitation value, thereby generating a normalization factor; and a comparison processor that adjusts at least one emission value corresponding to the at least one representative excitation value based, at least in part, on the normalization factor.
摘要翻译：描述了用于处理诸如荧光信号的发射信号以补偿诸如激光束的激发光束中的噪声的系统和方法。作为一个示例，描述了包括激励信号发生器的扫描系统，该激励信号发生器提供具有代表激励波束的一个或多个代表性激励值的激励信号; 提供至少一个激励参考值的激励参考提供器; 归一化因子发生器，其将激励参考值与至少一个代表性激励值进行比较，从而产生归一化因子; 以及比较处理器，其至少部分地基于归一化因子来调整对应于至少一个代表性激励值的至少一个发射值。

4. 发明授权

US06218803B1 Position sensing with variable capacitance transducers 有权
标题翻译：带可变电容传感器的位置传感器
公开(公告)号：US06218803B1
公开(公告)日：2001-04-17
申请号：US09326374
申请日：1999-06-04
申请人： Jean I. Montagu , Peter Honkanen , Nathan K. Weiner
发明人： Jean I. Montagu , Peter Honkanen , Nathan K. Weiner
IPC分类号： G01D524
CPC分类号： G01D5/2405 , G01D5/2412
摘要： For enabling precise operation of an oscillating device, such as a galvanometric optical scanner, a capacitive position transducer is provided with strategically located internal capacitive fiducial features that interact with the armature of the transducer beyond the central range of excursion of the transducer, typically beyond the normal operating range of the device. Electric pulses obtained at instants of interaction with the fiducials enable determination of position drift caused e.g. by change in environmental conditions. The pulses can be detected by simple circuits to produce recalibration of the amplitude and null position of the instrument on an automatic or elective basis.
摘要翻译：为了能够精确地操作诸如电流计量光学扫描器的振荡装置，电容式位置传感器被提供有具有战略位置的内部电容基准特征，其与换能器的电枢超出换能器偏心的中心范围相互作用，通常超出设备的正常工作范围。在与基准相互作用的瞬间获得的电脉冲使得能够确定例如引起的位置漂移。通过改变环境条件。可以通过简单的电路检测脉冲，以便在自动或选择性基础上对仪器的幅度和零点位置进行重新校准。

5. 发明授权

US08679262B2 Continual flow pin washer 有权
标题翻译：连续流动销垫圈
公开(公告)号：US08679262B2
公开(公告)日：2014-03-25
申请号：US13589671
申请日：2012-08-20
申请人： Peter Honkanen , Albert Bukys , Dave Bradbury
发明人： Peter Honkanen , Albert Bukys , Dave Bradbury
IPC分类号： B08B3/04 , B08B5/04
CPC分类号： B08B3/04 , B01L3/0244 , B01L99/00 , B41J29/17 , G01N35/1004 , G01N2035/1037
摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
摘要翻译：提供了多腔沉积针清洗台。洗涤站包括通过多个洗涤管连接的下室和上排水槽。清洗液被提供到下室，并通过清洗管进入上排水槽。清洗管适用于每个洗涤周期用单个管清洁单个沉积销。

6. 发明授权

US08246760B2 Continual flow pin washer 有权
标题翻译：连续流动销垫圈
公开(公告)号：US08246760B2
公开(公告)日：2012-08-21
申请号：US13232593
申请日：2011-09-14
申请人： Peter Honkanen , Albert Bukys , Dave Bradbury
发明人： Peter Honkanen , Albert Bukys , Dave Bradbury
IPC分类号： B08B3/00
CPC分类号： B08B3/04 , B01L3/0244 , B01L99/00 , B41J29/17 , G01N35/1004 , G01N2035/1037
摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
摘要翻译：提供了多腔沉积针清洗台。洗涤站包括通过多个洗涤管连接的下室和上排水槽。清洗液被提供到下室，并通过清洗管进入上排水槽。清洗管适用于每个洗涤周期用单个管清洁单个沉积销。

7. 发明申请

US20120000493A1 CONTINUAL FLOW PIN WASHER 有权
标题翻译：连续流量针式清洗机
公开(公告)号：US20120000493A1
公开(公告)日：2012-01-05
申请号：US13232593
申请日：2011-09-14
申请人： Peter Honkanen , Albert Bukys , Dave Bradbury
发明人： Peter Honkanen , Albert Bukys , Dave Bradbury
IPC分类号： B08B3/00
CPC分类号： B08B3/04 , B01L3/0244 , B01L99/00 , B41J29/17 , G01N35/1004 , G01N2035/1037
摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
摘要翻译：提供了多腔沉积针清洗台。洗涤站包括通过多个洗涤管连接的下室和上排水槽。清洗液被提供到下室，并通过清洗管进入上排水槽。清洗管适用于每个洗涤周期用单个管清洁单个沉积销。

8. 发明申请

US20050136534A1 Apparatus and method for dispensing fluid, semi-solid and solid samples 有权
标题翻译：用于分配流体，半固体和固体样品的装置和方法
公开(公告)号：US20050136534A1
公开(公告)日：2005-06-23
申请号：US10972792
申请日：2004-10-25
申请人： John Austin , Peter Honkanen
发明人： John Austin , Peter Honkanen
IPC分类号： A61L2/00 , B01L3/02 , B01L9/00 , C12M1/34 , C12Q1/68 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/10
CPC分类号： G01N35/1074 , B01J2219/00315 , B01J2219/00364 , B01J2219/00387 , B01J2219/00533 , B01J2219/00567 , B01J2219/00691 , B01L3/0244 , B01L9/52 , B01L9/523 , B01L2200/025 , B01L2200/142 , B01L2300/022 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , C40B60/14 , C40B70/00 , G01N35/1009 , G01N35/1011 , G01N2035/00158 , G01N2035/1037 , Y10T436/2575
摘要： The invention relates generally to the field of automated collection and deposition of fluid, semi-solid, and solid samples of biological or chemical materials. More specifically, the invention relates to the field of microarrayers, which are devices for autonomously depositing minute droplets of biological or chemical fluid samples in ordered arrays onto substrates. The invention also relates to tissue arrayers, which are devices for the collection and deposition of solid and semi-solid tissue samples in ordered arrays. Other aspects of the invention relate to fluidics robots, which are devices for the autonomous collection, dispensing and processing of biological or chemical fluid samples. The invention improves the throughput of microarrayers, tissue arrayers, and fluidics robots by providing methods and apparatuses to precisely and repeatably load supplies into the machines.
摘要翻译：本发明一般涉及生物或化学材料的流体，半固体和固体样品的自动收集和沉积领域。更具体地，本发明涉及微阵列领域，微阵列是用于将有序阵列的生物或化学流体样品的微滴自主沉积到基底上的装置。本发明还涉及组织排列器，其是用于以有序阵列收集和沉积固体和半固体组织样品的装置。本发明的其它方面涉及流体学机器人，它们是用于自主收集，分配和处理生物或化学流体样品的装置。本发明通过提供方法和设备来精确地和可重复地将供给装载到机器中来提高微阵列，组织排出器和流体机器人的产量。

9. 发明授权

US08811704B2 Method of and system for enhanced dynamic range assay analysis 有权
标题翻译：增强动态范围测定分析方法和系统
公开(公告)号：US08811704B2
公开(公告)日：2014-08-19
申请号：US13439643
申请日：2012-04-04
申请人： Peter Honkanen , Scott Douglas , Ralph H. Jung, Jr.
发明人： Peter Honkanen , Scott Douglas , Ralph H. Jung, Jr.
IPC分类号： G06K9/00
CPC分类号： G06T5/007 , G01N21/253 , G01N21/76 , G06T2207/10144 , G06T2207/20208 , G06T2207/20221 , H04N5/2355 , H04N5/35581 , H04N5/361
摘要： The disclosed systems and methods allow composite images with enhanced dynamic range to be generated that result in more accurate, reliable, and efficient chemical and/or biological analyses. The disclosed systems include an image detector; a timer for tracking exposure time of the image detector; and computer readable medium, including instructions that when executed cause a computer system to generate a composite image using the multiple images of pixels.
摘要翻译：所公开的系统和方法允许产生具有增强的动态范围的合成图像，其导致更准确，可靠和有效的化学和/或生物分析。所公开的系统包括图像检测器; 用于跟踪图像检测器的曝光时间的定时器; 和计算机可读介质，包括当执行时使得计算机系统使用多个像素图像来生成合成图像的指令。

10. 发明授权

US08020571B2 Continual flow pin washer 有权
标题翻译：连续流动销垫圈
公开(公告)号：US08020571B2
公开(公告)日：2011-09-20
申请号：US12252487
申请日：2008-10-16
申请人： Peter Honkanen , Albert Bukys , Dave Bradbury
发明人： Peter Honkanen , Albert Bukys , Dave Bradbury
IPC分类号： B08B3/04 , B08B5/04
CPC分类号： B08B3/04 , B01L3/0244 , B01L99/00 , B41J29/17 , G01N35/1004 , G01N2035/1037
摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
摘要翻译：提供了多腔沉积针清洗台。洗涤站包括通过多个洗涤管连接的下室和上排水槽。清洗液被提供到下室，并通过清洗管进入上排水槽。清洗管适用于每个洗涤周期用单个管清洁单个沉积销。

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